Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 56963028

GI number: 56963028

Start: 1372818

End: 1374320

Strand: Direct

Name: glpK [H]

Synonym: ABC1256

Alternate gene names: 56963028

Gene position: 1372818-1374320 (Clockwise)

Preceding gene: 56963027

Following gene: 56963029

Centisome position: 31.9

GC content: 46.57

Gene sequence:

>1503_bases
ATGGAGAAAACATATATTTTGGCAATTGACCAGGGAACGACGAGCACACGGTCGATTTTATTTAACCTCGAAGGAGAAAT
CGTCCATACAGTACAAAAGGAATTTAAACAGTATTTTCCCCACCCAGGCTGGGTGGAACACAATGCAAATGAAATTTGGA
ATTCGACGCTCTCTGTCATTTCCGGCCTGTTTACAGAAACAGATGTGGAACCGCGGCAAATTAAAGCGATAGGCATTACG
AATCAGCGGGAAACCACGGTTGTATGGGACAAAGAAACAGGCAAGCCGGTTTACCATGCGCTCGTATGGCAGTCGCGGCA
AACAGAAGACATTTGCAAAACATTGCGTGATGCAGGACACAATGAAACGTTTCGCAGCAAAACGGGCTTGCTGATTGACC
CTTATTTTTCAGGGACAAAAGTAAAATGGATTTTGGACCATGTGGAAGGCGCCCGGGAGCGGGCTGAAAACGGCGAATTG
CTCTTTGGCACAATTGATTCATGGCTGATTTGGAAATTGAGCGGCGGGAAAGCGCACGTAACCGACTATTCAAATGCGGC
ACGGACGCTTATGTATAACATTCATGATTTGCAGTGGGACGAAGAGCTGCTTCGGATTTTGGATATTCCTAAGGCGATGC
TCCCTGAAGTGAAGTCATCGTCAGAAGTATATGCCAATACGGTGGAATACCATTTCTTTGGGGAGCAGATACCGATTGCA
GGTGTCGCGGGTGACCAAAGTGCGGCTTTATTTGGACAAGCTTGTTTTGAAAAAGGCATGGTTAAAAACACATATGGAAC
AGGTTGCTTTATTTTAATGAACACAGGCAATGAAGCCGTTACGTCAGAGAATGGCTTGCTCACAACGATTGCCTGGGGGC
TTGATGGCAAAGTAGAGTATGCATTAGAAGGAAGCATTTTTGTTGCTGGCTCTGCGATCCAATGGCTCCGTGACGGCATC
AAGCTGCTAGAAAGTGCTAAGGACAGCGAAGCATATGCAAAGCGGATTGAATCATCGGAAGGTGTCTATGTTGTTCCTGC
ATTTGTTGGATTAGGAACGCCTTATTGGGACAGCGATGCACGTGGTGCCATGTATGGATTGACAAGAGGAACAACGAGAG
AACACATTGTTCGCGCTACGTTAGAAGCACTAGCGTACCAAACAAAAGACGTGATGGAGGCAATGGAATCGGATTCTGGC
TTAGAGTCGAAAAAACTTCGTGCCGATGGCGGTGTGGTGAAGAACGACTTTTTGATGCAGTTTCAAAGCGATTTGCTTGA
TGCCCCTGTTGAACGCCCAACCATTAATGAGACAACTGCACTTGGCGCAGCCTATTTGGCTGGCTTGGCTGTCGGGGTTT
GGAAAGACAAACAGGAAATTGCCGACAAATGGAAAATCGACCGTTCGTTTGAGCCGGAGATGGAAAAAACAGAGCGGGAA
ACGCTTTATGGTGGCTGGAAAACAGCGATTGAGGCAACAATGGCTTTTAAGCCGACAAAATAA

Upstream 100 bases:

>100_bases
TTCAGAAATGAGGCTAGCCTTGTTTTAAGAAGACAAAAGGCAGGTAAATAAATAAAAGGAACATGCAACCGAAAAAATCA
AGGAGGGCCGAAGATAACGG

Downstream 100 bases:

>100_bases
ATAATATGGTTTTCCATTTAGCTAAAACGCACAGGTGTTATTTCCTTCAGGGGGCCTGTGCGTTTGCTTTTTTCTATGGT
TTCAAAGACGCGTTAGCAGG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MEKTYILAIDQGTTSTRSILFNLEGEIVHTVQKEFKQYFPHPGWVEHNANEIWNSTLSVISGLFTETDVEPRQIKAIGIT
NQRETTVVWDKETGKPVYHALVWQSRQTEDICKTLRDAGHNETFRSKTGLLIDPYFSGTKVKWILDHVEGARERAENGEL
LFGTIDSWLIWKLSGGKAHVTDYSNAARTLMYNIHDLQWDEELLRILDIPKAMLPEVKSSSEVYANTVEYHFFGEQIPIA
GVAGDQSAALFGQACFEKGMVKNTYGTGCFILMNTGNEAVTSENGLLTTIAWGLDGKVEYALEGSIFVAGSAIQWLRDGI
KLLESAKDSEAYAKRIESSEGVYVVPAFVGLGTPYWDSDARGAMYGLTRGTTREHIVRATLEALAYQTKDVMEAMESDSG
LESKKLRADGGVVKNDFLMQFQSDLLDAPVERPTINETTALGAAYLAGLAVGVWKDKQEIADKWKIDRSFEPEMEKTERE
TLYGGWKTAIEATMAFKPTK

Sequences:

>Translated_500_residues
MEKTYILAIDQGTTSTRSILFNLEGEIVHTVQKEFKQYFPHPGWVEHNANEIWNSTLSVISGLFTETDVEPRQIKAIGIT
NQRETTVVWDKETGKPVYHALVWQSRQTEDICKTLRDAGHNETFRSKTGLLIDPYFSGTKVKWILDHVEGARERAENGEL
LFGTIDSWLIWKLSGGKAHVTDYSNAARTLMYNIHDLQWDEELLRILDIPKAMLPEVKSSSEVYANTVEYHFFGEQIPIA
GVAGDQSAALFGQACFEKGMVKNTYGTGCFILMNTGNEAVTSENGLLTTIAWGLDGKVEYALEGSIFVAGSAIQWLRDGI
KLLESAKDSEAYAKRIESSEGVYVVPAFVGLGTPYWDSDARGAMYGLTRGTTREHIVRATLEALAYQTKDVMEAMESDSG
LESKKLRADGGVVKNDFLMQFQSDLLDAPVERPTINETTALGAAYLAGLAVGVWKDKQEIADKWKIDRSFEPEMEKTERE
TLYGGWKTAIEATMAFKPTK
>Mature_500_residues
MEKTYILAIDQGTTSTRSILFNLEGEIVHTVQKEFKQYFPHPGWVEHNANEIWNSTLSVISGLFTETDVEPRQIKAIGIT
NQRETTVVWDKETGKPVYHALVWQSRQTEDICKTLRDAGHNETFRSKTGLLIDPYFSGTKVKWILDHVEGARERAENGEL
LFGTIDSWLIWKLSGGKAHVTDYSNAARTLMYNIHDLQWDEELLRILDIPKAMLPEVKSSSEVYANTVEYHFFGEQIPIA
GVAGDQSAALFGQACFEKGMVKNTYGTGCFILMNTGNEAVTSENGLLTTIAWGLDGKVEYALEGSIFVAGSAIQWLRDGI
KLLESAKDSEAYAKRIESSEGVYVVPAFVGLGTPYWDSDARGAMYGLTRGTTREHIVRATLEALAYQTKDVMEAMESDSG
LESKKLRADGGVVKNDFLMQFQSDLLDAPVERPTINETTALGAAYLAGLAVGVWKDKQEIADKWKIDRSFEPEMEKTERE
TLYGGWKTAIEATMAFKPTK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=510, Percent_Identity=44.9019607843137, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI189409120, Length=506, Percent_Identity=45.0592885375494, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI4504007, Length=506, Percent_Identity=45.0592885375494, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=44.8207171314741, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=31.8897637795276, Blast_Score=305, Evalue=7e-83,
Organism=Escherichia coli, GI1790361, Length=496, Percent_Identity=60.0806451612903, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1789987, Length=479, Percent_Identity=23.1732776617954, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790005, Length=490, Percent_Identity=23.469387755102, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787789, Length=512, Percent_Identity=23.046875, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789168, Length=488, Percent_Identity=22.9508196721311, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=450, Percent_Identity=43.1111111111111, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71986140, Length=522, Percent_Identity=25.095785440613, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71986147, Length=301, Percent_Identity=29.9003322259136, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321755, Length=517, Percent_Identity=35.9767891682785, Blast_Score=300, Evalue=3e-82,
Organism=Drosophila melanogaster, GI17864214, Length=504, Percent_Identity=42.6587301587302, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24654573, Length=432, Percent_Identity=44.4444444444444, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655555, Length=499, Percent_Identity=38.877755511022, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655560, Length=499, Percent_Identity=38.877755511022, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655570, Length=499, Percent_Identity=38.877755511022, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655574, Length=499, Percent_Identity=38.877755511022, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655565, Length=499, Percent_Identity=38.877755511022, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19922058, Length=524, Percent_Identity=32.4427480916031, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=33.4012219959267, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24656367, Length=496, Percent_Identity=28.2258064516129, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI21357867, Length=513, Percent_Identity=27.6803118908382, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24656372, Length=330, Percent_Identity=31.2121212121212, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=27.2413793103448, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55808; Mature: 55808

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTYILAIDQGTTSTRSILFNLEGEIVHTVQKEFKQYFPHPGWVEHNANEIWNSTLSVI
CCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SGLFTETDVEPRQIKAIGITNQRETTVVWDKETGKPVYHALVWQSRQTEDICKTLRDAGH
HHHHHCCCCCHHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
NETFRSKTGLLIDPYFSGTKVKWILDHVEGARERAENGELLFGTIDSWLIWKLSGGKAHV
CCCHHCCCCCEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCEEEE
TDYSNAARTLMYNIHDLQWDEELLRILDIPKAMLPEVKSSSEVYANTVEYHFFGEQIPIA
CCCCCHHHHHEEHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEEEECCCCCEE
GVAGDQSAALFGQACFEKGMVKNTYGTGCFILMNTGNEAVTSENGLLTTIAWGLDGKVEY
EECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEECCCCEEEEEEECCCCEEEE
ALEGSIFVAGSAIQWLRDGIKLLESAKDSEAYAKRIESSEGVYVVPAFVGLGTPYWDSDA
EECCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCC
RGAMYGLTRGTTREHIVRATLEALAYQTKDVMEAMESDSGLESKKLRADGGVVKNDFLMQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCEEHHHHHHH
FQSDLLDAPVERPTINETTALGAAYLAGLAVGVWKDKQEIADKWKIDRSFEPEMEKTERE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHH
TLYGGWKTAIEATMAFKPTK
HHHCCHHHHHHHHEEECCCC
>Mature Secondary Structure
MEKTYILAIDQGTTSTRSILFNLEGEIVHTVQKEFKQYFPHPGWVEHNANEIWNSTLSVI
CCCEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SGLFTETDVEPRQIKAIGITNQRETTVVWDKETGKPVYHALVWQSRQTEDICKTLRDAGH
HHHHHCCCCCHHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
NETFRSKTGLLIDPYFSGTKVKWILDHVEGARERAENGELLFGTIDSWLIWKLSGGKAHV
CCCHHCCCCCEEECCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCEEEE
TDYSNAARTLMYNIHDLQWDEELLRILDIPKAMLPEVKSSSEVYANTVEYHFFGEQIPIA
CCCCCHHHHHEEHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEEEECCCCCEE
GVAGDQSAALFGQACFEKGMVKNTYGTGCFILMNTGNEAVTSENGLLTTIAWGLDGKVEY
EECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEECCCCEEEEEEECCCCEEEE
ALEGSIFVAGSAIQWLRDGIKLLESAKDSEAYAKRIESSEGVYVVPAFVGLGTPYWDSDA
EECCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCC
RGAMYGLTRGTTREHIVRATLEALAYQTKDVMEAMESDSGLESKKLRADGGVVKNDFLMQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCEEHHHHHHH
FQSDLLDAPVERPTINETTALGAAYLAGLAVGVWKDKQEIADKWKIDRSFEPEMEKTERE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHH
TLYGGWKTAIEATMAFKPTK
HHHCCHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA