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The map label for this gene is aroA2 [H]

Identifier: 56962993

GI number: 56962993

Start: 1331850

End: 1333190

Strand: Direct

Name: aroA2 [H]

Synonym: ABC1221

Alternate gene names: 56962993

Gene position: 1331850-1333190 (Clockwise)

Preceding gene: 56962991

Following gene: 56962998

Centisome position: 30.95

GC content: 48.47

Gene sequence:

>1341_bases
ATGGTTCAGTTTGATTCACAAGCACGTAGCCCTTGGACGCCTTTAGCAGGCGTCGAACGCCTCCGTTTAACGCCGAGCCA
AAAAAGAATAAACGCTACGTTAGAAGTGCCTGGAAGCAAAAGTGCAACAAATCGCGCATTGCTGTTAGCAGCAGTTGCGT
CAGGCACTTCTACATTAAGGAATGCGTTAAAAAGCGATGACACGTATTGGTGCATCGAGGCGCTAAAAAAAACGGGGGTA
GAAATTGCGGTAGATGGAAGCAATGTGACTGTCTATGGGAGAGGAGGGGTGTTTCATTCTGGCTCCCTTTATATTGGTTC
AGCTGGAACAGCAGGACGTTTTTTGCCTGGAATGTTGGCAGCAGCAACGGGAAACTGGCATGTGGAAGCGAGTCACAGCA
TGAACAAACGCCCGATTGCTCCTTTGGTAAAAACATTACAGGCATTAGGGGCAAACATTCAGTATGGAAGCCGTAGGGGC
CATTATCCCCTTTCCATATCTGGTGAAGGGTTGAACGGGGGAAAAGTGAACATGAGCGGCCAGCTGTCCAGCCAATTTAT
TAGCGGCTGTTTATTGGCGGCCCCATTGGCGAAAAACCCTGTCTCGATCACTGTTAAAGATGGGATTGTCCAACAGGCGT
ATGTGCGAATCACAATCGACTTGATGGCAGCTTTTGGGGTCGAAGTGAAAGCAGCGCCTGATTGGAGCTTGCTTGAAGTG
AACCCTTCCCCTTATGTCGCAAACGACATCGCGATTGAAGCGGATGCCTCAACAGCTTGTTACTTTCTTGCCCTTGCCGC
AATCACAGCAGGGAAAATCCGTATACGCCATTTTTCGACGAAAACAAGCCAGCCAGATATTCTGTTTGTCTCTATCCTGA
AACGAATGGGATGCAACTTTGAAATCGGACCATCGTTTGTTGAAGGAGAAGGACCTACTCGTTTAAGGGGTGGATTTACC
GTTAACATGAATGAGTTATCCGATCAAGCCTTAACGCTTGCCGCAATCTCTCCTTTTGCTGACGGTCCAATTGCCATCGA
AGGGGTTGGCCATATCCGACACCATGAATGTGATCGCATTCGCGCAATTTGCACAGAGTTAAGCCGCTTAGGTATCCGTG
TCGAGGAAAGGCATGATGGATTAACGGTTTATCCAGGCCAGCCGAAGCCAACTGTTGTAAACACTTACGATGACCACCGT
ATGGCGATGGCACTTGCTCTGATTGGCGCAAAAGTAGATGGAATCGAACTAGACGACCCAGGCTGCGTTGCCAAAACATG
CCCCTCTTATTTTTCCATGCTTGCCCAAACAGGAATAGGGGTAAAAGCCGTTTCTCCTTAA

Upstream 100 bases:

>100_bases
CATAAATATCACCTATGTCATCGATTAATAATATTGATTTCATTTATATCATTTCTGTCATTAAAATAAAAGGAAGAACG
AAAACAAAGGAGATTGGACC

Downstream 100 bases:

>100_bases
GCAGCCAACTCATGGAAAAACCCGCCGCAACATGCGGCGGGTTTTTCGTCAAGAAGCTCTTTTTTTATTTAGTGGTGATG
TGGCCTCTGGTGGCAGTGGC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase 2; EPSP synthase 2; EPSPS 2 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MVQFDSQARSPWTPLAGVERLRLTPSQKRINATLEVPGSKSATNRALLLAAVASGTSTLRNALKSDDTYWCIEALKKTGV
EIAVDGSNVTVYGRGGVFHSGSLYIGSAGTAGRFLPGMLAAATGNWHVEASHSMNKRPIAPLVKTLQALGANIQYGSRRG
HYPLSISGEGLNGGKVNMSGQLSSQFISGCLLAAPLAKNPVSITVKDGIVQQAYVRITIDLMAAFGVEVKAAPDWSLLEV
NPSPYVANDIAIEADASTACYFLALAAITAGKIRIRHFSTKTSQPDILFVSILKRMGCNFEIGPSFVEGEGPTRLRGGFT
VNMNELSDQALTLAAISPFADGPIAIEGVGHIRHHECDRIRAICTELSRLGIRVEERHDGLTVYPGQPKPTVVNTYDDHR
MAMALALIGAKVDGIELDDPGCVAKTCPSYFSMLAQTGIGVKAVSP

Sequences:

>Translated_446_residues
MVQFDSQARSPWTPLAGVERLRLTPSQKRINATLEVPGSKSATNRALLLAAVASGTSTLRNALKSDDTYWCIEALKKTGV
EIAVDGSNVTVYGRGGVFHSGSLYIGSAGTAGRFLPGMLAAATGNWHVEASHSMNKRPIAPLVKTLQALGANIQYGSRRG
HYPLSISGEGLNGGKVNMSGQLSSQFISGCLLAAPLAKNPVSITVKDGIVQQAYVRITIDLMAAFGVEVKAAPDWSLLEV
NPSPYVANDIAIEADASTACYFLALAAITAGKIRIRHFSTKTSQPDILFVSILKRMGCNFEIGPSFVEGEGPTRLRGGFT
VNMNELSDQALTLAAISPFADGPIAIEGVGHIRHHECDRIRAICTELSRLGIRVEERHDGLTVYPGQPKPTVVNTYDDHR
MAMALALIGAKVDGIELDDPGCVAKTCPSYFSMLAQTGIGVKAVSP
>Mature_446_residues
MVQFDSQARSPWTPLAGVERLRLTPSQKRINATLEVPGSKSATNRALLLAAVASGTSTLRNALKSDDTYWCIEALKKTGV
EIAVDGSNVTVYGRGGVFHSGSLYIGSAGTAGRFLPGMLAAATGNWHVEASHSMNKRPIAPLVKTLQALGANIQYGSRRG
HYPLSISGEGLNGGKVNMSGQLSSQFISGCLLAAPLAKNPVSITVKDGIVQQAYVRITIDLMAAFGVEVKAAPDWSLLEV
NPSPYVANDIAIEADASTACYFLALAAITAGKIRIRHFSTKTSQPDILFVSILKRMGCNFEIGPSFVEGEGPTRLRGGFT
VNMNELSDQALTLAAISPFADGPIAIEGVGHIRHHECDRIRAICTELSRLGIRVEERHDGLTVYPGQPKPTVVNTYDDHR
MAMALALIGAKVDGIELDDPGCVAKTCPSYFSMLAQTGIGVKAVSP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=429, Percent_Identity=35.6643356643357, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320332, Length=449, Percent_Identity=33.184855233853, Blast_Score=205, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 47376; Mature: 47376

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQFDSQARSPWTPLAGVERLRLTPSQKRINATLEVPGSKSATNRALLLAAVASGTSTLR
CCCCCCCCCCCCCCCCCCHHEECCCCHHHEEEEEECCCCCCCCCCEEEEEEECCCHHHHH
NALKSDDTYWCIEALKKTGVEIAVDGSNVTVYGRGGVFHSGSLYIGSAGTAGRFLPGMLA
HHHHCCCCHHHHHHHHHCCCEEEEECCEEEEEECCCEEECCCEEEECCCCCCCHHHHHHE
AATGNWHVEASHSMNKRPIAPLVKTLQALGANIQYGSRRGHYPLSISGEGLNGGKVNMSG
ECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCEEEECCCCCCCEEEECC
QLSSQFISGCLLAAPLAKNPVSITVKDGIVQQAYVRITIDLMAAFGVEVKAAPDWSLLEV
CHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEEEEHHHCCEEEEECCCCEEEEE
NPSPYVANDIAIEADASTACYFLALAAITAGKIRIRHFSTKTSQPDILFVSILKRMGCNF
CCCCCEECCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHCCCE
EIGPSFVEGEGPTRLRGGFTVNMNELSDQALTLAAISPFADGPIAIEGVGHIRHHECDRI
EECCCEECCCCCCEECCCEEEEHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHH
RAICTELSRLGIRVEERHDGLTVYPGQPKPTVVNTYDDHRMAMALALIGAKVDGIELDDP
HHHHHHHHHCCCEEEECCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCEEECCC
GCVAKTCPSYFSMLAQTGIGVKAVSP
CCHHHHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MVQFDSQARSPWTPLAGVERLRLTPSQKRINATLEVPGSKSATNRALLLAAVASGTSTLR
CCCCCCCCCCCCCCCCCCHHEECCCCHHHEEEEEECCCCCCCCCCEEEEEEECCCHHHHH
NALKSDDTYWCIEALKKTGVEIAVDGSNVTVYGRGGVFHSGSLYIGSAGTAGRFLPGMLA
HHHHCCCCHHHHHHHHHCCCEEEEECCEEEEEECCCEEECCCEEEECCCCCCCHHHHHHE
AATGNWHVEASHSMNKRPIAPLVKTLQALGANIQYGSRRGHYPLSISGEGLNGGKVNMSG
ECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCEEEECCCCCCCEEEECC
QLSSQFISGCLLAAPLAKNPVSITVKDGIVQQAYVRITIDLMAAFGVEVKAAPDWSLLEV
CHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEEEEHHHCCEEEEECCCCEEEEE
NPSPYVANDIAIEADASTACYFLALAAITAGKIRIRHFSTKTSQPDILFVSILKRMGCNF
CCCCCEECCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHCCCE
EIGPSFVEGEGPTRLRGGFTVNMNELSDQALTLAAISPFADGPIAIEGVGHIRHHECDRI
EECCCEECCCCCCEECCCEEEEHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHH
RAICTELSRLGIRVEERHDGLTVYPGQPKPTVVNTYDDHRMAMALALIGAKVDGIELDDP
HHHHHHHHHCCCEEEECCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCEEECCC
GCVAKTCPSYFSMLAQTGIGVKAVSP
CCHHHHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]