Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 55981884

GI number: 55981884

Start: 1796623

End: 1797414

Strand: Reverse

Name: uppS [H]

Synonym: TTHA1915

Alternate gene names: 55981884

Gene position: 1797414-1796623 (Counterclockwise)

Preceding gene: 55981885

Following gene: 55981883

Centisome position: 97.17

GC content: 67.55

Gene sequence:

>792_bases
ATGGTCCGCCGCCTCCTCGCCCTTTCCCGCCCCCTCTACTGGCTTTACGAGAAACGCCTCCTGAGGGAGGTCAAGCGGGG
CCCCATGCCCCGGCACCTGGGCCTCATCCTGGACGGAAACCGCCGCTACGCCCGCGCTTTGGGCCTTTCCCCCACCAAGG
GGCACGAGTTCGGGGTGCAGAAGGCCTACGAGGTCCTGGAGTGGTGCCTGGAGATGGGCATCAAGACCGTGACCGTCTGG
GTCTTCTCCACGGACAACTTCAAGCGCCCCCCGGAGGAGGTGGAGACCCTCATGAACCTCTTCCTGCGGGAGGCCGAGCG
GATGGCGGAGGACCACCGGATCCTGGAACACCAGGTGCGGGTGCGCTTCATCGGTAGGCGGGAGGGGTTTTCCCCGGAGG
TGGTCCGGGCCATAGAGCGCCTGGAGCGGAGGACGGAGGGGCACCGGGGCATGTTCCTCAACATCGCCATGGGCTACGGG
GGGCGGGAGGAGATCGTGGACGCCGTGAAGCGGCTCCTTTTGGAGGCGGAGGCCCGGGGCCTCTCCCCCAAGGAGGTGGC
CGAGGGCCTCACCCCGGAGGACATCGCCCGCCACCTCTACACCGCCGGGCTTCCCGACCCCGACTTCATCATCCGCACCT
CGGGGGAGATCCGGCTTTCCGGCTTCCTCCTCTGGCAGTCCGCCTACTCCGAGTTCTACTTCGCCGACGTCCTCTGGCCC
GAGTTCCGCAAGATTGACTTCCTGCGCGCCCTGAGGAGCTACCAGGCCCGCGAGAGGCGGTTTGGGCGTTGA

Upstream 100 bases:

>100_bases
CGGAGATCTACGAGGGCACCTCGGAGATCCAGCGCCTCGTCATCGCCCGGGAGCTCTACCGCTAGCGCGCCCCGCCCTTC
TCCCTTAGGGTGGAAAGGGT

Downstream 100 bases:

>100_bases
CAACTCGCGGCGTTTCGTATACCCTTACGGGCAAGATGCTGGCCCGCGCGAAAAAACTCGGCCGCCGGGGGGTAGGGTAG
CCCTCCAAGGGCTTCTTATC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQKAYEVLEWCLEMGIKTVTVW
VFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVRVRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYG
GREEIVDAVKRLLLEAEARGLSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWP
EFRKIDFLRALRSYQARERRFGR

Sequences:

>Translated_263_residues
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQKAYEVLEWCLEMGIKTVTVW
VFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVRVRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYG
GREEIVDAVKRLLLEAEARGLSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWP
EFRKIDFLRALRSYQARERRFGR
>Mature_263_residues
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQKAYEVLEWCLEMGIKTVTVW
VFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVRVRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYG
GREEIVDAVKRLLLEAEARGLSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWP
EFRKIDFLRALRSYQARERRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=242, Percent_Identity=38.4297520661157, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI45580738, Length=242, Percent_Identity=38.4297520661157, Blast_Score=181, Evalue=6e-46,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=39.2241379310345, Blast_Score=170, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71993029, Length=238, Percent_Identity=36.9747899159664, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=37.2727272727273, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=237, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=38.695652173913, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30893; Mature: 30893

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQ
CHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHH
KAYEVLEWCLEMGIKTVTVWVFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVR
HHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYGGREEIVDAVKRLLLEAEARG
HHEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
LSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWP
CCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHCH
EFRKIDFLRALRSYQARERRFGR
HHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQ
CHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHH
KAYEVLEWCLEMGIKTVTVWVFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVR
HHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYGGREEIVDAVKRLLLEAEARG
HHEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
LSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWP
CCHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHCH
EFRKIDFLRALRSYQARERRFGR
HHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9868782 [H]