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The map label for this gene is paaX [H]

Identifier: 55981845

GI number: 55981845

Start: 1762088

End: 1762870

Strand: Direct

Name: paaX [H]

Synonym: TTHA1876

Alternate gene names: 55981845

Gene position: 1762088-1762870 (Clockwise)

Preceding gene: 55981844

Following gene: 55981846

Centisome position: 95.26

GC content: 70.75

Gene sequence:

>783_bases
ATGCGGGCCAGGTCCACCATCTTCACCCTGTTCGTGGAGTACGTCTACCCGGAACGGGCGGCCCGGGTGCGGGACCTCGT
GGCCATGATGGCCGCCCTGGGCTTCTCGGAGATGGCGGTGCGGGCGGCGCTTTCCCGGAGCGCCAAGCGGGGCTGGGTGG
TGCCCAAGCGGGAGGGGCGGGCCGCCTACTACGCCCTCTCCGACCGGGTCTACTGGCAGGTGCGCCAGGTGCGCCGCCGC
CTCTACGGCTCCCTCCCCCCGTGGGACGGGCGCTTCCTCCTCGTCCTTCCCGAGGGGCCCAAGGAGCGGGGGGAGAGGGA
GAGGTTCCGTCGGGAGATGGCCCTTTTGGGCTACGGGGGGCTGCAGAGCGGGGTCTATCTGGGGGTCGGGGCGGACCTCG
AGGCCACCCGGGAGCTCCTCGGCTTCTACGGCCTTAGCGCCACCTGCTTCCAAGGGGAGCTTCTCGGGGGAAAGGAGGAG
GTCCTCAGGGCCTTCCCCCTGGAGGAGGCCAAGGCGGGCTACGGGCGGCTTTCCGCCCTCCTGGGTCAAAGCCCCGAGGA
CCCCGTGGAGGCCTTCCGCCACCTCACCCGGCTCGTCCACGAGGCGAGGAAGCTCCTCTTCCTGGACCCCGGCCTCCCCC
AGGAGCTTTTGGGCCCCGACTTTCCGGGGCCAAAGGTGCGCCGCCTCTTCCTTTCGGCCCGGGAGGAGCTGAGGGCCCGG
GCGGCCCCCTTCCTCAAGGGCCTTTCCCTTCTCCTTTCAGACCTCTCACCCGTTTCCCGGTAG

Upstream 100 bases:

>100_bases
CCGGAAGAAGGGCAACCTGGGGACGATGCCCCTCGCCGCCTTCCTGGAGGGGGCCCTCAGGGAGTACCGGGAAAGGCGGC
TTGAGCCGGTCTTTTAGGGC

Downstream 100 bases:

>100_bases
GCTTAGGGGCATGAGGGGACTTCCCGCCCTTCTGCCCGTTCTTTCCCTGGCCTTGGCCCAGACGGTCATCCCCTTCTGGC
ACACCGCAGGCCCCCCCGGC

Product: repressor, phenylacetic acid catabolic pathway

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MRARSTIFTLFVEYVYPERAARVRDLVAMMAALGFSEMAVRAALSRSAKRGWVVPKREGRAAYYALSDRVYWQVRQVRRR
LYGSLPPWDGRFLLVLPEGPKERGERERFRREMALLGYGGLQSGVYLGVGADLEATRELLGFYGLSATCFQGELLGGKEE
VLRAFPLEEAKAGYGRLSALLGQSPEDPVEAFRHLTRLVHEARKLLFLDPGLPQELLGPDFPGPKVRRLFLSAREELRAR
AAPFLKGLSLLLSDLSPVSR

Sequences:

>Translated_260_residues
MRARSTIFTLFVEYVYPERAARVRDLVAMMAALGFSEMAVRAALSRSAKRGWVVPKREGRAAYYALSDRVYWQVRQVRRR
LYGSLPPWDGRFLLVLPEGPKERGERERFRREMALLGYGGLQSGVYLGVGADLEATRELLGFYGLSATCFQGELLGGKEE
VLRAFPLEEAKAGYGRLSALLGQSPEDPVEAFRHLTRLVHEARKLLFLDPGLPQELLGPDFPGPKVRRLFLSAREELRAR
AAPFLKGLSLLLSDLSPVSR
>Mature_260_residues
MRARSTIFTLFVEYVYPERAARVRDLVAMMAALGFSEMAVRAALSRSAKRGWVVPKREGRAAYYALSDRVYWQVRQVRRR
LYGSLPPWDGRFLLVLPEGPKERGERERFRREMALLGYGGLQSGVYLGVGADLEATRELLGFYGLSATCFQGELLGGKEE
VLRAFPLEEAKAGYGRLSALLGQSPEDPVEAFRHLTRLVHEARKLLFLDPGLPQELLGPDFPGPKVRRLFLSAREELRAR
AAPFLKGLSLLLSDLSPVSR

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=240, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 29226; Mature: 29226

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARSTIFTLFVEYVYPERAARVRDLVAMMAALGFSEMAVRAALSRSAKRGWVVPKREGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCC
AAYYALSDRVYWQVRQVRRRLYGSLPPWDGRFLLVLPEGPKERGERERFRREMALLGYGG
EEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
LQSGVYLGVGADLEATRELLGFYGLSATCFQGELLGGKEEVLRAFPLEEAKAGYGRLSAL
CCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
LGQSPEDPVEAFRHLTRLVHEARKLLFLDPGLPQELLGPDFPGPKVRRLFLSAREELRAR
HCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
AAPFLKGLSLLLSDLSPVSR
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRARSTIFTLFVEYVYPERAARVRDLVAMMAALGFSEMAVRAALSRSAKRGWVVPKREGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCC
AAYYALSDRVYWQVRQVRRRLYGSLPPWDGRFLLVLPEGPKERGERERFRREMALLGYGG
EEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
LQSGVYLGVGADLEATRELLGFYGLSATCFQGELLGGKEEVLRAFPLEEAKAGYGRLSAL
CCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
LGQSPEDPVEAFRHLTRLVHEARKLLFLDPGLPQELLGPDFPGPKVRRLFLSAREELRAR
HCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
AAPFLKGLSLLLSDLSPVSR
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]