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The map label for this gene is thrS [H]

Identifier: 55981844

GI number: 55981844

Start: 1760105

End: 1762084

Strand: Direct

Name: thrS [H]

Synonym: TTHA1875

Alternate gene names: 55981844

Gene position: 1760105-1762084 (Clockwise)

Preceding gene: 55981836

Following gene: 55981845

Centisome position: 95.15

GC content: 67.47

Gene sequence:

>1980_bases
ATGACGGTCTACCTGCCGGACGGCAAGCCCCTGGAGCTTCCCGAGGGGGCCACGGCGAAGGACGTGGCCCGGGCCCTCGG
GGAGGGCTGGGAGAGGCGGGCGGTGGGGGCCATCGTGGACGGGGAGCTCTACGACCTCCTAAAGCCCCTTCCCCAGGGGG
CGAAGGTGCGCCTCCTCACGGAGAAGGACCCCGAGTTCCAGACCCTCTTCCGCCACACCCTGGCCCACGTCCTGGCCCAG
GCGGTGAAGGAGTTCTTCCGGGAGAAGGGCTACGATCCGGAAAGCGTGAGGCTCGGGGTGGGGCCCGTGATTGAGAAGGG
CTTCTACTACGACATAGAAGCCCCCGAGCCCCTCTCCGACGAGGACCTGCCCGCCATAGAGGCGAAGATGCGGGAGATCC
TCAAGCGGGACCTCCCCCTAAGGCGCTTCGTCCTCTCCCGGGAGGAGGCCTTAGCCCGCTACCGGGGAAAGGACCCCTAC
AAGACGGAGCTCGTCCTGGAGATCCCCGAGGGGGAGGAGATCAGCTTCTACCAGCAGGGGGACGAGGCCTACGGCTTCAC
CGACCTCTGCCGCGGCCCCCACGTCCCCTCCACGGGCCGCATCCCCCCCCACTTCAAGCTCACCCACGTGGCGGGGGCCT
ACTGGCGGGGGGACGAAAACAGGCCCATGCTGCAGCGGGTCTACGGGGTGGCCTTCCGCACCGCCGAGGAACTTAAAGAA
TACCTCTGGCAGCTGGAGGAGGCCAAGAAACGGGACCACCGGCGGCTTGGGCGGGAGCTGGAGCTCTTCCTCATAGACCC
CCTGGTGGGGAAGGGGCTCGTGCTCTGGCTTCCCAAGGGGAACGTGGTCCGGGAGGAGCTCATGGCCTTCATGCGGGAGG
AGCAGGTGAGGCGGGGCTACCAGCTCGTGACCACGCCCCACATCGGGAGCCTGGAGCTCTACAAGACCAGCGGCCACTAC
CCCTACTACGCGGAAAGCCAGTTCCCCCCCATCAGCTTCAAGGAGCGGGGCGAGGAGGAGGAGTACCTCCTCAAGCCCAT
GAACTGCCCCCACCACATCAGGATCTACGCCTATAGGAAGCGCTCCTACCGGGAGCTTCCCCTAAGGCTTGCCGAGTTCG
GCACCGTCTACCGCTACGAGAAGGCGGGGGAGCTTCTTGGCCTCACAAGGGTTAGGGGCTTCACCCAGGACGACGCCCAC
ATCTTCTGCACCCCCGAGGAGGTGAAGGGGGAGTTCCTCGGGGTCTTGGACCTGGTGCTTAAGGTCTTCGCCACCTTGGG
GCTTAAGGACTACCGGGCCCGGATCGGGGTGCGGGACCCGAAAAGCGACAAGTACGTGGGGGACGAGGCCAAGTGGGCCC
TGGCGGAAAGGCAGATTGAGGAGGCGGCGGCCGAGGCCGGGCTCCGGTACACGGTGGAGGAGGGGGACGCCGCCTTCTAC
GGCCCCAAGCTGGACTTCGTGGTGAAGGACGCCCTGGGGCGGGAGTGGCAGCTCGGCACCATCCAGGTGGACTACAACCT
GCCCGAGCGCTTCGGGCTGACCTACGTGGGCAAAGACGGGGAGGAGCACCGCCCCGTGATGCTCCACCGGGCCCCCTTCG
GCTCCCTGGAGCGCTTCATCGGCATCCTCATTGAGCACTTCGCCGGGGACTTCCCCCTGTGGCTCGCCCCGGTGCAGGCG
GTGGTGGTCCCCGTGTCCGAGAAGCAGGAGGACTACGCCCGGGAGGTGGCGGGTAGGCTCAAGGAGGCGGGCCTACGGGC
CGAGGCCGACACCCGGCCCGAGAGGATGCAGGCCCGGATCCGGGACGCCGAGGTGCAGAAGGTGCCCTACATCCTCGTGG
TGGGGGAGCGGGAGAAGGCCGAAGGAGCGGTGAGCGTGCGCCGCCGGAAGAAGGGCAACCTGGGGACGATGCCCCTCGCC
GCCTTCCTGGAGGGGGCCCTCAGGGAGTACCGGGAAAGGCGGCTTGAGCCGGTCTTTTAG

Upstream 100 bases:

>100_bases
TGCCCCGGCCCCGTCAGGCCAGGGTCAGGGGGAGCACGGGAGGCCTGAGCGGGGCCCGAAGCGAGGGCGAAGCCGGGTAA
ATGCCCGTATAGTAGAGGGC

Downstream 100 bases:

>100_bases
GGCATGCGGGCCAGGTCCACCATCTTCACCCTGTTCGTGGAGTACGTCTACCCGGAACGGGCGGCCCGGGTGCGGGACCT
CGTGGCCATGATGGCCGCCC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MTVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLTEKDPEFQTLFRHTLAHVLAQ
AVKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSDEDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPY
KTELVLEIPEGEEISFYQQGDEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKE
YLWQLEEAKKRDHRRLGRELELFLIDPLVGKGLVLWLPKGNVVREELMAFMREEQVRRGYQLVTTPHIGSLELYKTSGHY
PYYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRKRSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAH
IFCTPEEVKGEFLGVLDLVLKVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFY
GPKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFIGILIEHFAGDFPLWLAPVQA
VVVPVSEKQEDYAREVAGRLKEAGLRAEADTRPERMQARIRDAEVQKVPYILVVGEREKAEGAVSVRRRKKGNLGTMPLA
AFLEGALREYRERRLEPVF

Sequences:

>Translated_659_residues
MTVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLTEKDPEFQTLFRHTLAHVLAQ
AVKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSDEDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPY
KTELVLEIPEGEEISFYQQGDEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKE
YLWQLEEAKKRDHRRLGRELELFLIDPLVGKGLVLWLPKGNVVREELMAFMREEQVRRGYQLVTTPHIGSLELYKTSGHY
PYYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRKRSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAH
IFCTPEEVKGEFLGVLDLVLKVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFY
GPKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFIGILIEHFAGDFPLWLAPVQA
VVVPVSEKQEDYAREVAGRLKEAGLRAEADTRPERMQARIRDAEVQKVPYILVVGEREKAEGAVSVRRRKKGNLGTMPLA
AFLEGALREYRERRLEPVF
>Mature_658_residues
TVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLTEKDPEFQTLFRHTLAHVLAQA
VKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSDEDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPYK
TELVLEIPEGEEISFYQQGDEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKEY
LWQLEEAKKRDHRRLGRELELFLIDPLVGKGLVLWLPKGNVVREELMAFMREEQVRRGYQLVTTPHIGSLELYKTSGHYP
YYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRKRSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAHI
FCTPEEVKGEFLGVLDLVLKVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFYG
PKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFIGILIEHFAGDFPLWLAPVQAV
VVPVSEKQEDYAREVAGRLKEAGLRAEADTRPERMQARIRDAEVQKVPYILVVGEREKAEGAVSVRRRKKGNLGTMPLAA
FLEGALREYRERRLEPVF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=665, Percent_Identity=38.3458646616541, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI38570111, Length=665, Percent_Identity=36.5413533834586, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI20070344, Length=655, Percent_Identity=37.7099236641221, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788013, Length=659, Percent_Identity=38.9984825493171, Blast_Score=502, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71984184, Length=645, Percent_Identity=35.6589147286822, Blast_Score=420, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71984192, Length=645, Percent_Identity=35.6589147286822, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322112, Length=649, Percent_Identity=37.1340523882897, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=37.3737373737374, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24583842, Length=646, Percent_Identity=39.3188854489164, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI28574141, Length=646, Percent_Identity=39.3188854489164, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24583839, Length=646, Percent_Identity=39.3188854489164, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 75538; Mature: 75407

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLT
CEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCEEECCHHHHHHHCCCCCCEEEEEE
EKDPEFQTLFRHTLAHVLAQAVKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCEEEECCCCCCCCC
EDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPYKTELVLEIPEGEEISFYQQG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECC
DEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKE
CCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
YLWQLEEAKKRDHRRLGRELELFLIDPLVGKGLVLWLPKGNVVREELMAFMREEQVRRGY
HHHHHHHHHHHHHHHHCCEEEEEEECCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCE
QLVTTPHIGSLELYKTSGHYPYYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRK
EEEECCCCCCEEEEEECCCCCEECCCCCCCCCHHHCCCCHHHHCCCCCCCCEEEEEEEEC
RSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAHIFCTPEEVKGEFLGVLDLVL
CCHHHHHHHHHHHCHHHEEHHCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHH
KVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFY
HHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEE
GPKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFI
CCCHHHHHHHHCCCCEEEEEEEECCCCCHHHCCEEECCCCCCCCCEEEEECCCHHHHHHH
GILIEHFAGDFPLWLAPVQAVVVPVSEKQEDYAREVAGRLKEAGLRAEADTRPERMQARI
HHHHHHHCCCCCHHHHCHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RDAEVQKVPYILVVGEREKAEGAVSVRRRKKGNLGTMPLAAFLEGALREYRERRLEPVF
HHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLT
EEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCEEECCHHHHHHHCCCCCCEEEEEE
EKDPEFQTLFRHTLAHVLAQAVKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCEEEECCCCCCCCC
EDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPYKTELVLEIPEGEEISFYQQG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECC
DEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKE
CCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
YLWQLEEAKKRDHRRLGRELELFLIDPLVGKGLVLWLPKGNVVREELMAFMREEQVRRGY
HHHHHHHHHHHHHHHHCCEEEEEEECCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCE
QLVTTPHIGSLELYKTSGHYPYYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRK
EEEECCCCCCEEEEEECCCCCEECCCCCCCCCHHHCCCCHHHHCCCCCCCCEEEEEEEEC
RSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAHIFCTPEEVKGEFLGVLDLVL
CCHHHHHHHHHHHCHHHEEHHCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHH
KVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFY
HHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEE
GPKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFI
CCCHHHHHHHHCCCCEEEEEEEECCCCCHHHCCEEECCCCCCCCCEEEEECCCHHHHHHH
GILIEHFAGDFPLWLAPVQAVVVPVSEKQEDYAREVAGRLKEAGLRAEADTRPERMQARI
HHHHHHHCCCCCHHHHCHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RDAEVQKVPYILVVGEREKAEGAVSVRRRKKGNLGTMPLAAFLEGALREYRERRLEPVF
HHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA