Click here to switch to the map view.

The map label for this gene is trpG

Identifier: 55981812

GI number: 55981812

Start: 1727463

End: 1728077

Strand: Reverse

Name: trpG

Synonym: TTHA1843

Alternate gene names: 55981812

Gene position: 1728077-1727463 (Counterclockwise)

Preceding gene: 55981813

Following gene: 55981811

Centisome position: 93.42

GC content: 67.97

Gene sequence:

>615_bases
ATGGCTGCTAACGGAGCGAAGGGGAGAAAGGTTATGAGGGTCTTGGTGGTGGACAACTACGACAGCTTCACCTACAACCT
GGTGCAGTACCTGGGGGAGCTCGGGGCGGAGCCCATCGTGTGGCGGAACGACCGCTTCCGGCTGGAGGAGGTGGAGGCCC
TGGACCCGGACCGGATCCTCATCAGCCCGGGGCCTTGCACCCCCTTTGAGGCGGGGCTTTCCGTCCCCTTGGTCCAGCGC
TACGCCCCCCGCTACCCCATCCTGGGGGTCTGCCTCGGACACCAGGCCATCGGGGCGGCCTTCGGGGGGAAGGTGGTCCC
CGCCCCCGTCCTCATGCACGGCAAGGTGAGCCCCATCCACCACGACGGCACCGGGGTCTTCCGGGGGCTAGATAGCCCCT
TCCCCGCCACCCGCTACCACTCCCTGGCGGTGGTGGAGGTGCCGGAGGCCCTCGTGGTGAACGCCTGGGCGGAGGAGGCG
GGGGGGCGGACGGTGATGGGCTTCCGCCACCGGGACTACCCCACCCACGGGGTGCAGTTCCACCCGGAAAGCTACCTTAC
GGAGGCGGGTAAACTCATCCTCAAGAACTTCCTGGAGGACCCATGGACGCGGTGA

Upstream 100 bases:

>100_bases
GAACAAGGCGCGGGCGCTCCTCAAGGCGGTGGAGATGGCGGAGGCGGGGCTGTGATCCCACCCCATGCCGGCAGGGGCCC
GGTAAGGAGGCCTGGTAGGC

Downstream 100 bases:

>100_bases
AGAAGGCCATTCTGGGCGAGGTTTTGGAGGAAGAGGAGGCCTACGAGGTCATGCGGGCCCTGATGGCGGGGGAGGTCTCC
CCGGTGCGGGCGGCGGGGCT

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amido-transferase

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAANGAKGRKVMRVLVVDNYDSFTYNLVQYLGELGAEPIVWRNDRFRLEEVEALDPDRILISPGPCTPFEAGLSVPLVQR
YAPRYPILGVCLGHQAIGAAFGGKVVPAPVLMHGKVSPIHHDGTGVFRGLDSPFPATRYHSLAVVEVPEALVVNAWAEEA
GGRTVMGFRHRDYPTHGVQFHPESYLTEAGKLILKNFLEDPWTR

Sequences:

>Translated_204_residues
MAANGAKGRKVMRVLVVDNYDSFTYNLVQYLGELGAEPIVWRNDRFRLEEVEALDPDRILISPGPCTPFEAGLSVPLVQR
YAPRYPILGVCLGHQAIGAAFGGKVVPAPVLMHGKVSPIHHDGTGVFRGLDSPFPATRYHSLAVVEVPEALVVNAWAEEA
GGRTVMGFRHRDYPTHGVQFHPESYLTEAGKLILKNFLEDPWTR
>Mature_203_residues
AANGAKGRKVMRVLVVDNYDSFTYNLVQYLGELGAEPIVWRNDRFRLEEVEALDPDRILISPGPCTPFEAGLSVPLVQRY
APRYPILGVCLGHQAIGAAFGGKVVPAPVLMHGKVSPIHHDGTGVFRGLDSPFPATRYHSLAVVEVPEALVVNAWAEEAG
GRTVMGFRHRDYPTHGVQFHPESYLTEAGKLILKNFLEDPWTR

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=115, Percent_Identity=36.5217391304348, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=57.7540106951872, Blast_Score=221, Evalue=2e-59,
Organism=Escherichia coli, GI1787517, Length=188, Percent_Identity=41.4893617021277, Blast_Score=143, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=201, Percent_Identity=42.7860696517413, Blast_Score=171, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324361, Length=214, Percent_Identity=31.7757009345794, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPG_THET8 (P05379)

Other databases:

- EMBL:   X07744
- EMBL:   AP008226
- RefSeq:   YP_145109.1
- ProteinModelPortal:   P05379
- SMR:   P05379
- STRING:   P05379
- GeneID:   3169403
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1843
- NMPDR:   fig|300852.3.peg.1319
- eggNOG:   COG0512
- HOGENOM:   HBG292341
- OMA:   YNVVQYL
- ProtClustDB:   PRK05670
- BioCyc:   TTHE300852:TTHA1843-MONOMER
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =4.1.3.27

Molecular weight: Translated: 22515; Mature: 22384

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 91-91 ACT_SITE 181-181 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANGAKGRKVMRVLVVDNYDSFTYNLVQYLGELGAEPIVWRNDRFRLEEVEALDPDRIL
CCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCEEE
ISPGPCTPFEAGLSVPLVQRYAPRYPILGVCLGHQAIGAAFGGKVVPAPVLMHGKVSPIH
ECCCCCCHHHCCCCCHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCCCCEEECCCCCCEE
HDGTGVFRGLDSPFPATRYHSLAVVEVPEALVVNAWAEEAGGRTVMGFRHRDYPTHGVQF
ECCCHHCCCCCCCCCCCHHCCEEEEECCCCEEEECHHHHCCCCEEEEEECCCCCCCCEEE
HPESYLTEAGKLILKNFLEDPWTR
CCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AANGAKGRKVMRVLVVDNYDSFTYNLVQYLGELGAEPIVWRNDRFRLEEVEALDPDRIL
CCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCEEE
ISPGPCTPFEAGLSVPLVQRYAPRYPILGVCLGHQAIGAAFGGKVVPAPVLMHGKVSPIH
ECCCCCCHHHCCCCCHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCCCCEEECCCCCCEE
HDGTGVFRGLDSPFPATRYHSLAVVEVPEALVVNAWAEEAGGRTVMGFRHRDYPTHGVQF
ECCCHHCCCCCCCCCCCHHCCEEEEECCCCEEEECHHHHCCCCEEEEEECCCCCCCCEEE
HPESYLTEAGKLILKNFLEDPWTR
CCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2844259