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The map label for this gene is trpE

Identifier: 55981813

GI number: 55981813

Start: 1728123

End: 1729511

Strand: Reverse

Name: trpE

Synonym: TTHA1844

Alternate gene names: 55981813

Gene position: 1729511-1728123 (Counterclockwise)

Preceding gene: 55981814

Following gene: 55981812

Centisome position: 93.5

GC content: 69.11

Gene sequence:

>1389_bases
ATGGAGCGGATCCGACCTTACCGCAAAACCTTCCTCGCGGACCTGGAGACCCCGGTGACCGCCTACCTGAAGCTTGCCGA
GAAGGCTCCGGTGAGCTTCCTTTTGGAGTCGGTGGAGCGGGGGCGCCAAAGCCGCTTCTCCATCGTGGGGGTGGGGGCGC
GGCGCACCTTCCGCCTGAAGGACGGGGTCTTCACGGTGAACGGGGAGCGGGTGGAAACCCGTGATCCCTTGCGCGCCCTC
TACGAGAGGGTCTACGCCCCCTTGGAGCGCCACCCCGACCTCCCCCCCTTCTTCGGCGGGGTGGTGGGCTACGCCGCCTA
CGACCTCGTCCGCTACTACGAAAGGCTTCCGAGCCTCAAGCCCGACGACCTCGGCCTCCCCGACCTCCTCTTCGTGGAGC
CCGAGGTGGTGGCCGTCTTTGACCACCTGAAGAACCTCCTCCACCTCGTGGCCCCAGGGAGGGACCCCGAGGAGGCGGAG
GCCCGCCTCTTTTGGGCGGAGAGGCGGCTCAAGGGCCCCTTGCCCGGGGTGCCGGGGGAGAGGGCGGGGGGGAGGGCCCG
CTTCCAGGCGGACTTTTCCCGGGAGGCCTACCTGGAGGCGGTGAGGAGGGCCCTGGACTACATCCGGGCGGGGGACATCT
TCCAGGTGGTCCTCTCCTTGAGGCTCTCCTCCCCCCTCACCGTCCACCCCTTCGCCCTCTACCGGGCGCTGAGGAGCGTG
AACCCGAGCCCCTACATGGGCTACCTGGACCTGGGGGAGGTGGTCTTGGTCTCGGCGAGCCCGGAAAGCCTCCTCCGCTC
GGACGGCCGAAGGGTGGTCACCCGGCCCATCGCGGGCACGAGGCCGAGGGGGAAGGACGAGGAGGAGGACAAAAGGCTTG
CCGAGGAGCTCCTTAGGGACGAGAAGGAGGTCGCGGAGCACGTGATGCTTCTGGACCTCTCCCGCAACGACATCGGCCGG
GTCGCCGCCTTCGGCACGGTGCGGGTCCTCGAGCCCCTCCACGTGGAGCACTACTCCCACGTGATGCACCTGGTCTCCAC
GGTGGAGGGCATCTTGGCCGAGGGGAAGACCCCCCTGGACGCCCTGGCCAGCGTGCTGCCCATGGGGACGGTCTCCGGGG
CCCCGAAGATCCGGGCCATGGAGATCATTGAAGAACTGGAGCCCCACCGCCGGGGGCCCTACGGGGGAAGCTTCGGCTAC
CTCGCCTACGACGGGGCCATGGACATGGCCCTCACCCTGCGCACCTTCGTGGTGGCGAAGGGGTGGATGCACGTCCAGGC
GGGGGCGGGGATCGTGGCGGACTCGGTGCCGGAGAGGGAGTACGAGGAGTGCTGGAACAAGGCGCGGGCGCTCCTCAAGG
CGGTGGAGATGGCGGAGGCGGGGCTGTGA

Upstream 100 bases:

>100_bases
GCCATGGCCCTTCCCTCCGCCCTCTGGTGGCCCGGCTAGGCCCCGGGGCGGGAGGCCTTTCCCCGGGGCACACCCCGGGG
CTTTGTTTTTGGGGGACGGC

Downstream 100 bases:

>100_bases
TCCCACCCCATGCCGGCAGGGGCCCGGTAAGGAGGCCTGGTAGGCATGGCTGCTAACGGAGCGAAGGGGAGAAAGGTTAT
GAGGGTCTTGGTGGTGGACA

Product: anthranilate synthase component I TrpE

Products: NA

Alternate protein names: Anthranilate synthase component I

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MERIRPYRKTFLADLETPVTAYLKLAEKAPVSFLLESVERGRQSRFSIVGVGARRTFRLKDGVFTVNGERVETRDPLRAL
YERVYAPLERHPDLPPFFGGVVGYAAYDLVRYYERLPSLKPDDLGLPDLLFVEPEVVAVFDHLKNLLHLVAPGRDPEEAE
ARLFWAERRLKGPLPGVPGERAGGRARFQADFSREAYLEAVRRALDYIRAGDIFQVVLSLRLSSPLTVHPFALYRALRSV
NPSPYMGYLDLGEVVLVSASPESLLRSDGRRVVTRPIAGTRPRGKDEEEDKRLAEELLRDEKEVAEHVMLLDLSRNDIGR
VAAFGTVRVLEPLHVEHYSHVMHLVSTVEGILAEGKTPLDALASVLPMGTVSGAPKIRAMEIIEELEPHRRGPYGGSFGY
LAYDGAMDMALTLRTFVVAKGWMHVQAGAGIVADSVPEREYEECWNKARALLKAVEMAEAGL

Sequences:

>Translated_462_residues
MERIRPYRKTFLADLETPVTAYLKLAEKAPVSFLLESVERGRQSRFSIVGVGARRTFRLKDGVFTVNGERVETRDPLRAL
YERVYAPLERHPDLPPFFGGVVGYAAYDLVRYYERLPSLKPDDLGLPDLLFVEPEVVAVFDHLKNLLHLVAPGRDPEEAE
ARLFWAERRLKGPLPGVPGERAGGRARFQADFSREAYLEAVRRALDYIRAGDIFQVVLSLRLSSPLTVHPFALYRALRSV
NPSPYMGYLDLGEVVLVSASPESLLRSDGRRVVTRPIAGTRPRGKDEEEDKRLAEELLRDEKEVAEHVMLLDLSRNDIGR
VAAFGTVRVLEPLHVEHYSHVMHLVSTVEGILAEGKTPLDALASVLPMGTVSGAPKIRAMEIIEELEPHRRGPYGGSFGY
LAYDGAMDMALTLRTFVVAKGWMHVQAGAGIVADSVPEREYEECWNKARALLKAVEMAEAGL
>Mature_462_residues
MERIRPYRKTFLADLETPVTAYLKLAEKAPVSFLLESVERGRQSRFSIVGVGARRTFRLKDGVFTVNGERVETRDPLRAL
YERVYAPLERHPDLPPFFGGVVGYAAYDLVRYYERLPSLKPDDLGLPDLLFVEPEVVAVFDHLKNLLHLVAPGRDPEEAE
ARLFWAERRLKGPLPGVPGERAGGRARFQADFSREAYLEAVRRALDYIRAGDIFQVVLSLRLSSPLTVHPFALYRALRSV
NPSPYMGYLDLGEVVLVSASPESLLRSDGRRVVTRPIAGTRPRGKDEEEDKRLAEELLRDEKEVAEHVMLLDLSRNDIGR
VAAFGTVRVLEPLHVEHYSHVMHLVSTVEGILAEGKTPLDALASVLPMGTVSGAPKIRAMEIIEELEPHRRGPYGGSFGY
LAYDGAMDMALTLRTFVVAKGWMHVQAGAGIVADSVPEREYEECWNKARALLKAVEMAEAGL

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788114, Length=418, Percent_Identity=36.3636363636364, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1787518, Length=397, Percent_Identity=40.8060453400504, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082077, Length=292, Percent_Identity=29.4520547945205, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786809, Length=274, Percent_Identity=28.1021897810219, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=466, Percent_Identity=40.1287553648069, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324361, Length=410, Percent_Identity=26.3414634146341, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPE_THET8 (P05378)

Other databases:

- EMBL:   X07744
- EMBL:   AP008226
- RefSeq:   YP_145110.1
- ProteinModelPortal:   P05378
- SMR:   P05378
- STRING:   P05378
- GeneID:   3168049
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA1844
- eggNOG:   COG0147
- HOGENOM:   HBG507440
- OMA:   PRFNGGL
- ProtClustDB:   CLSK445246
- BioCyc:   TTHE300852:TTHA1844-MONOMER
- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236
- PRINTS:   PR00095
- TIGRFAMs:   TIGR00564

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =4.1.3.27

Molecular weight: Translated: 51636; Mature: 51636

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIRPYRKTFLADLETPVTAYLKLAEKAPVSFLLESVERGRQSRFSIVGVGARRTFRLK
CCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEECCCEEEEEE
DGVFTVNGERVETRDPLRALYERVYAPLERHPDLPPFFGGVVGYAAYDLVRYYERLPSLK
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PDDLGLPDLLFVEPEVVAVFDHLKNLLHLVAPGRDPEEAEARLFWAERRLKGPLPGVPGE
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RAGGRARFQADFSREAYLEAVRRALDYIRAGDIFQVVLSLRLSSPLTVHPFALYRALRSV
CCCCCEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECHHHHHHHHHCC
NPSPYMGYLDLGEVVLVSASPESLLRSDGRRVVTRPIAGTRPRGKDEEEDKRLAEELLRD
CCCCCCCEECCCCEEEEECCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
EKEVAEHVMLLDLSRNDIGRVAAFGTVRVLEPLHVEHYSHVMHLVSTVEGILAEGKTPLD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ALASVLPMGTVSGAPKIRAMEIIEELEPHRRGPYGGSFGYLAYDGAMDMALTLRTFVVAK
HHHHHHCCCCCCCCCCHHHHHHHHHHCHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHC
GWMHVQAGAGIVADSVPEREYEECWNKARALLKAVEMAEAGL
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERIRPYRKTFLADLETPVTAYLKLAEKAPVSFLLESVERGRQSRFSIVGVGARRTFRLK
CCCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEECCCEEEEEE
DGVFTVNGERVETRDPLRALYERVYAPLERHPDLPPFFGGVVGYAAYDLVRYYERLPSLK
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PDDLGLPDLLFVEPEVVAVFDHLKNLLHLVAPGRDPEEAEARLFWAERRLKGPLPGVPGE
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
RAGGRARFQADFSREAYLEAVRRALDYIRAGDIFQVVLSLRLSSPLTVHPFALYRALRSV
CCCCCEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEECHHHHHHHHHCC
NPSPYMGYLDLGEVVLVSASPESLLRSDGRRVVTRPIAGTRPRGKDEEEDKRLAEELLRD
CCCCCCCEECCCCEEEEECCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
EKEVAEHVMLLDLSRNDIGRVAAFGTVRVLEPLHVEHYSHVMHLVSTVEGILAEGKTPLD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ALASVLPMGTVSGAPKIRAMEIIEELEPHRRGPYGGSFGYLAYDGAMDMALTLRTFVVAK
HHHHHHCCCCCCCCCCHHHHHHHHHHCHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHC
GWMHVQAGAGIVADSVPEREYEECWNKARALLKAVEMAEAGL
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2844259