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The map label for this gene is icl [H]

Identifier: 55981805

GI number: 55981805

Start: 1718462

End: 1719769

Strand: Direct

Name: icl [H]

Synonym: TTHA1836

Alternate gene names: 55981805

Gene position: 1718462-1719769 (Clockwise)

Preceding gene: 55981804

Following gene: 55981806

Centisome position: 92.9

GC content: 66.82

Gene sequence:

>1308_bases
ATGGAAGGGCTGACCCCCGAGATGCAAAGGGAAGCGGAGGCGCTCCGCCGGGAGTGGGAGACAAACCCGAGGTGGAAGGG
CGTCCGGCGGGACTACCGCCCCGAGGACGTGGTGCGCTTAAGGCCCAGCGTGATGGTGGAGTACACCCTGGCCAAGCGAG
GGGCGGAGAAACTCTGGAAGCTCCTCCACGAAAGGCCCTACGTGCACACCTTCGGGGCCTACACCGGGGCCATGGCGGTG
GAGATGGTGCGGGCCGGGCTGGAGGCCATCTACCTCTCCGGCTGGCAGGTGGCCGCCGACGCCAACCTGGCCTGGCAGAC
CTACCCCGACCAGTCCCTCTATCCCTACAACTCCGTGCCCCAGATCGTGAAGCGCATCAACAACGCCCTCATGCGGGCCG
ACCAGGTGGAGCGGATTGAAGGCCGGGTGACCCGGGACTGGTACGTGCCCATCGTGGCCGACGCCGAGGCGGGCTTCGGC
GGGGCCCTCAACGTGTTTGAGCTCACCAAGGCCATGATTGAGGCAGGGGCCGCCGGGATCCACTACGAGGACCAGCTCGC
CAGCGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTCCTGGTGCCCACGGGCCAGCACATCCGCACCCTCCAGGCGGCCA
GGCTCGCCGCGGACGTGATGGGCGTGCCCACGGTGATCATCGCCCGCACCGACGCCGAGGCCGCCACCCTCATCACCAGC
GACATTGACGAGCGGGACAAGCCCTTCATCCTCCCGGACGAGCGCACACCCGAGGGCTTCTACCGCTTCAAGAACGGGAT
TGAGGCCGGCATCGCCCGGGCCCTGGCCTACGCCCCCTACGCCGACGTGATCTGGATGGAGACCTCCAAGCCCGACCTGG
AGGAGGCCCGGAAGTTCGCCGAGGCGGTGAAGAAGGAGTTCCCCGACAAGCTCCTCGCCTACAACCTCTCCCCCTCCTTC
AACTGGAAAAAGTTCCTGGACGACGAGACCATCGCCAAGTTCAACCGGGAGCTCGGGGAGATGGGGTACAAGTTCCAGTT
CATCACCCTGGCGGGCTGGCACGCCCTGAACTACTACATCTGGGAGCTGGCCAAGGGCTACAAGGAGCGGGGCATGCCCG
CCTTCGTGGAGCTCCAGCAGAAGGAGTTCGCCGCCCAGAAGGAGGGCTTCACCGCCGTCAAGCACCAGCGGGAGGTGGGG
GCCGGGTACTTTGACGAGGTGGTCCTGGCCCTGACCCAGGGGCAGGCCTCCACCCTGGCCCTCAAGGGCTCCACGGAAGA
GGCCCAGTTCAACGAGCCCGTCCACTGA

Upstream 100 bases:

>100_bases
ACCCGGGCGAAACACACCAAAAGGCCGTGTCAAGCCCGGGCGGCTACACCCTACACCGGAAGCGCTTCCCCCCCGAAACT
GGGTCCCGGGAGGTGAAGGA

Downstream 100 bases:

>100_bases
GGTGGCGGTGTGCAAAAAGGCCGGGGTGTGCCCCGGCCTTTTTTGCACCGGCCTGGTAGAGTGTAAGAAGGAATGGATAA
GGCCGCTACACCCTGGCTGC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MEGLTPEMQREAEALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWKLLHERPYVHTFGAYTGAMAV
EMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVPQIVKRINNALMRADQVERIEGRVTRDWYVPIVADAEAGFG
GALNVFELTKAMIEAGAAGIHYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGVPTVIIARTDAEAATLITS
DIDERDKPFILPDERTPEGFYRFKNGIEAGIARALAYAPYADVIWMETSKPDLEEARKFAEAVKKEFPDKLLAYNLSPSF
NWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYIWELAKGYKERGMPAFVELQQKEFAAQKEGFTAVKHQREVG
AGYFDEVVLALTQGQASTLALKGSTEEAQFNEPVH

Sequences:

>Translated_435_residues
MEGLTPEMQREAEALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWKLLHERPYVHTFGAYTGAMAV
EMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVPQIVKRINNALMRADQVERIEGRVTRDWYVPIVADAEAGFG
GALNVFELTKAMIEAGAAGIHYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGVPTVIIARTDAEAATLITS
DIDERDKPFILPDERTPEGFYRFKNGIEAGIARALAYAPYADVIWMETSKPDLEEARKFAEAVKKEFPDKLLAYNLSPSF
NWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYIWELAKGYKERGMPAFVELQQKEFAAQKEGFTAVKHQREVG
AGYFDEVVLALTQGQASTLALKGSTEEAQFNEPVH
>Mature_435_residues
MEGLTPEMQREAEALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWKLLHERPYVHTFGAYTGAMAV
EMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVPQIVKRINNALMRADQVERIEGRVTRDWYVPIVADAEAGFG
GALNVFELTKAMIEAGAAGIHYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGVPTVIIARTDAEAATLITS
DIDERDKPFILPDERTPEGFYRFKNGIEAGIARALAYAPYADVIWMETSKPDLEEARKFAEAVKKEFPDKLLAYNLSPSF
NWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYIWELAKGYKERGMPAFVELQQKEFAAQKEGFTAVKHQREVG
AGYFDEVVLALTQGQASTLALKGSTEEAQFNEPVH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=431, Percent_Identity=60.5568445475638, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786525, Length=267, Percent_Identity=28.4644194756554, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982926, Length=417, Percent_Identity=64.9880095923261, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17561814, Length=417, Percent_Identity=64.9880095923261, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320908, Length=252, Percent_Identity=38.0952380952381, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=247, Percent_Identity=37.246963562753, Blast_Score=153, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 49152; Mature: 49152

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLTPEMQREAEALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHEEEHHHHHHHHHHHHH
LLHERPYVHTFGAYTGAMAVEMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVP
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCEEEEECCCCCCCCCCHHH
QIVKRINNALMRADQVERIEGRVTRDWYVPIVADAEAGFGGALNVFELTKAMIEAGAAGI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
HYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGVPTVIIARTDAEAATLITS
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
DIDERDKPFILPDERTPEGFYRFKNGIEAGIARALAYAPYADVIWMETSKPDLEEARKFA
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
EAVKKEFPDKLLAYNLSPSFNWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYI
HHHHHHCCCHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHH
WELAKGYKERGMPAFVELQQKEFAAQKEGFTAVKHQREVGAGYFDEVVLALTQGQASTLA
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
LKGSTEEAQFNEPVH
EECCCCCCCCCCCCC
>Mature Secondary Structure
MEGLTPEMQREAEALRREWETNPRWKGVRRDYRPEDVVRLRPSVMVEYTLAKRGAEKLWK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHEEEHHHHHHHHHHHHH
LLHERPYVHTFGAYTGAMAVEMVRAGLEAIYLSGWQVAADANLAWQTYPDQSLYPYNSVP
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCEEEEECCCCCCCCCCHHH
QIVKRINNALMRADQVERIEGRVTRDWYVPIVADAEAGFGGALNVFELTKAMIEAGAAGI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
HYEDQLASEKKCGHLGGKVLVPTGQHIRTLQAARLAADVMGVPTVIIARTDAEAATLITS
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
DIDERDKPFILPDERTPEGFYRFKNGIEAGIARALAYAPYADVIWMETSKPDLEEARKFA
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
EAVKKEFPDKLLAYNLSPSFNWKKFLDDETIAKFNRELGEMGYKFQFITLAGWHALNYYI
HHHHHHCCCHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHH
WELAKGYKERGMPAFVELQQKEFAAQKEGFTAVKHQREVGAGYFDEVVLALTQGQASTLA
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
LKGSTEEAQFNEPVH
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]