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The map label for this gene is csd [H]

Identifier: 55981704

GI number: 55981704

Start: 1626428

End: 1627642

Strand: Direct

Name: csd [H]

Synonym: TTHA1735

Alternate gene names: 55981704

Gene position: 1626428-1627642 (Clockwise)

Preceding gene: 55981703

Following gene: 55981705

Centisome position: 87.93

GC content: 68.4

Gene sequence:

>1215_bases
ATGGACCTAAGCGCCCTGAGGGAGGACTTCCCCCTCTTCGCCCAGCGCCCGGAGCTCGTCTACCTGGACTCCGCCGCCAC
GAGCCAGAAGCCCAGGCGGGTCATAGAGGCCCTGAGGCGCTACTACGAGACCTTGAACGCCAACGTCCACCGGGGGGCCT
ACCGGCTCTCCGCCGAGGCCACCGAGGCCTACGAGGAGGCGCGGAGGCGCCTGGCCCGCTTTCTCAACGCCGAGCCCAAG
GAGATCGTCTTTGTGCGCAACACCACCGAGGCCATGAACCTGGTGGCCTACGCCTGGGGCCTTAGGAACCTTAAGGAGGG
GGACGAGGTCCTGGTCACGGAGATGGAGCACCATGCGGGCCTCGTCCCCTGGCACCTGGTGGCAGGCCTCACCGGGGCCA
AGGTGAAGGCCATCCCCCTCACCGAGGAGGGAAGGCTGGACCTAAGCGCCCTGGAGGACCTTCTCACGGAGAGGACCCGG
GTGGTCTCCCTGGTCCACATGTCCAACGTCCTCGGCACCATCAACCCCGTGGCCGAGATCGCAAGGAGGGCCAAGGAGGC
CGGGGCCCTCGTGGTGGTGGACGGGGCCCAGTCCGCCCCCCACCTCCCCGTGGACGTCAAGGCCCTTGGCGCCGACTTCT
TCGCCCTTTCCGGGCACAAGATGCTGGGGCCCACGGGGGCCGGGGTCCTTTGGGGGCGGTACGAGGTCCTGGAGGGGATG
ATGCCCTTTTTGGGGGGCGGGGAGATGATCCTCGAGGTCCACGTGGACCGGTCCACCTACGCCCCCCCGCCCCAGCGCTT
TGAGGCGGGCACCCCCCCCATCGCCGAGGCCATCGCCCTGGGGGAGGCCGCCTGCTACCTCATGGAGGTGGGGATGGAAA
AGGTCTTCGCCCACGACCGGGCCCTTCTGGACTACGCCCTAAAGCGCCTGGAAGAGGTGCCGCGCCTCCGGGTCTACGGG
CCTAAGGGACTGGACCGGGGCGGGGTCATCCCCTTCACCTTAGGCCGCCTCCACGCCCACGACCTCGCCACCTTCCTGGA
CCAGGAGGGGATCGCCGTGAGGGCGGGCCACCACTGCGCCCAGCCCCTCCACCGGAAGCTCGGCCTTGCGGCCACGGCCC
GGGCGAGCTTCTACCTCTACAACACGAAGGAAGAGGTGGACCGCTTCGTGGAAGCCCTTCTAAGGATAGAGGCCAAGTAC
CGGGCCTGGCTATAA

Upstream 100 bases:

>100_bases
GGAAATAGACAAGGAGACCTTTGAGCGCATGAAACGGGACCTCGCCTAAGCGCCCGTCTGGGCCCCTCTAAGGGGTAGGG
GCAGGGCGTAAACTTAGGGC

Downstream 100 bases:

>100_bases
TGGACCAATGAGCGTCCTTGACGAGCTTTACCGGGAAATCCTCCTGGACCACTACCAGAGCCCCAGGAACTTCGGGGTCC
TGCCCCAGGCCACCAAGCAG

Product: iron-sulfur cluster biosynthesis protein IscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDLSALREDFPLFAQRPELVYLDSAATSQKPRRVIEALRRYYETLNANVHRGAYRLSAEATEAYEEARRRLARFLNAEPK
EIVFVRNTTEAMNLVAYAWGLRNLKEGDEVLVTEMEHHAGLVPWHLVAGLTGAKVKAIPLTEEGRLDLSALEDLLTERTR
VVSLVHMSNVLGTINPVAEIARRAKEAGALVVVDGAQSAPHLPVDVKALGADFFALSGHKMLGPTGAGVLWGRYEVLEGM
MPFLGGGEMILEVHVDRSTYAPPPQRFEAGTPPIAEAIALGEAACYLMEVGMEKVFAHDRALLDYALKRLEEVPRLRVYG
PKGLDRGGVIPFTLGRLHAHDLATFLDQEGIAVRAGHHCAQPLHRKLGLAATARASFYLYNTKEEVDRFVEALLRIEAKY
RAWL

Sequences:

>Translated_404_residues
MDLSALREDFPLFAQRPELVYLDSAATSQKPRRVIEALRRYYETLNANVHRGAYRLSAEATEAYEEARRRLARFLNAEPK
EIVFVRNTTEAMNLVAYAWGLRNLKEGDEVLVTEMEHHAGLVPWHLVAGLTGAKVKAIPLTEEGRLDLSALEDLLTERTR
VVSLVHMSNVLGTINPVAEIARRAKEAGALVVVDGAQSAPHLPVDVKALGADFFALSGHKMLGPTGAGVLWGRYEVLEGM
MPFLGGGEMILEVHVDRSTYAPPPQRFEAGTPPIAEAIALGEAACYLMEVGMEKVFAHDRALLDYALKRLEEVPRLRVYG
PKGLDRGGVIPFTLGRLHAHDLATFLDQEGIAVRAGHHCAQPLHRKLGLAATARASFYLYNTKEEVDRFVEALLRIEAKY
RAWL
>Mature_404_residues
MDLSALREDFPLFAQRPELVYLDSAATSQKPRRVIEALRRYYETLNANVHRGAYRLSAEATEAYEEARRRLARFLNAEPK
EIVFVRNTTEAMNLVAYAWGLRNLKEGDEVLVTEMEHHAGLVPWHLVAGLTGAKVKAIPLTEEGRLDLSALEDLLTERTR
VVSLVHMSNVLGTINPVAEIARRAKEAGALVVVDGAQSAPHLPVDVKALGADFFALSGHKMLGPTGAGVLWGRYEVLEGM
MPFLGGGEMILEVHVDRSTYAPPPQRFEAGTPPIAEAIALGEAACYLMEVGMEKVFAHDRALLDYALKRLEEVPRLRVYG
PKGLDRGGVIPFTLGRLHAHDLATFLDQEGIAVRAGHHCAQPLHRKLGLAATARASFYLYNTKEEVDRFVEALLRIEAKY
RAWL

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=417, Percent_Identity=25.8992805755396, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI156713448, Length=324, Percent_Identity=27.1604938271605, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=47.1321695760599, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1789175, Length=391, Percent_Identity=43.4782608695652, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI48994898, Length=392, Percent_Identity=27.2959183673469, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=218, Percent_Identity=28.8990825688073, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193211090, Length=383, Percent_Identity=24.2819843342037, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=27.8061224489796, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI20129463, Length=396, Percent_Identity=26.2626262626263, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44759; Mature: 44759

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSALREDFPLFAQRPELVYLDSAATSQKPRRVIEALRRYYETLNANVHRGAYRLSAEA
CCHHHHHHCCCHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHH
TEAYEEARRRLARFLNAEPKEIVFVRNTTEAMNLVAYAWGLRNLKEGDEVLVTEMEHHAG
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCC
LVPWHLVAGLTGAKVKAIPLTEEGRLDLSALEDLLTERTRVVSLVHMSNVLGTINPVAEI
CCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ARRAKEAGALVVVDGAQSAPHLPVDVKALGADFFALSGHKMLGPTGAGVLWGRYEVLEGM
HHHHHHCCCEEEEECCCCCCCCCEEHHHHCCCEEEECCCCEECCCCCCHHHHHHHHHHHH
MPFLGGGEMILEVHVDRSTYAPPPQRFEAGTPPIAEAIALGEAACYLMEVGMEKVFAHDR
HHHCCCCEEEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLDYALKRLEEVPRLRVYGPKGLDRGGVIPFTLGRLHAHDLATFLDQEGIAVRAGHHCA
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHH
QPLHRKLGLAATARASFYLYNTKEEVDRFVEALLRIEAKYRAWL
HHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLSALREDFPLFAQRPELVYLDSAATSQKPRRVIEALRRYYETLNANVHRGAYRLSAEA
CCHHHHHHCCCHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHH
TEAYEEARRRLARFLNAEPKEIVFVRNTTEAMNLVAYAWGLRNLKEGDEVLVTEMEHHAG
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCC
LVPWHLVAGLTGAKVKAIPLTEEGRLDLSALEDLLTERTRVVSLVHMSNVLGTINPVAEI
CCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ARRAKEAGALVVVDGAQSAPHLPVDVKALGADFFALSGHKMLGPTGAGVLWGRYEVLEGM
HHHHHHCCCEEEEECCCCCCCCCEEHHHHCCCEEEECCCCEECCCCCCHHHHHHHHHHHH
MPFLGGGEMILEVHVDRSTYAPPPQRFEAGTPPIAEAIALGEAACYLMEVGMEKVFAHDR
HHHCCCCEEEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLDYALKRLEEVPRLRVYGPKGLDRGGVIPFTLGRLHAHDLATFLDQEGIAVRAGHHCA
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHH
QPLHRKLGLAATARASFYLYNTKEEVDRFVEALLRIEAKYRAWL
HHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]