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The map label for this gene is hemB [H]

Identifier: 55981567

GI number: 55981567

Start: 1521629

End: 1522627

Strand: Reverse

Name: hemB [H]

Synonym: TTHA1598

Alternate gene names: 55981567

Gene position: 1522627-1521629 (Counterclockwise)

Preceding gene: 55981574

Following gene: 55981564

Centisome position: 82.32

GC content: 69.17

Gene sequence:

>999_bases
ATGAGTATAGTGGAAGGCATGGAGCGCCCAAGGAGGCTGCGTTCGCCTCTTCTCCGCCCCCTGGTGGCCGAGGTGGAGCT
TTCCCCAAAGCACCTCATCCTCCCCCTCTTCGTGAAGGAGGGGGGGGAGAAGGAGGAGGTTTCCTCCATGCCCGGGGTCT
TCCGCCACCCCCTCTCCGGGCTTCCCCGCGTGGCGGAGGAGGCCTTGAAGGCGGGCCTCGGCGGGGTCATCCTCTTCGGC
GTCCTGCCCCAGGAGGCCAAGGACCCCATGGGGAGGGGGGCCTACGCCGAGGACGGGGTGGTGCAGCGGGCCATACGGCT
TCTCAAGCGGGAGTTCCCCGAGCTTCTCGTCCTCGCCGACACCTGCCTTTGCGAGTACACGGACCACGGCCACTGCGGCG
TGGTGAAGGAGGGCCCCCTGGGCTTCTACGTGGACAACGACGCCACCTTAGACCTCCTCGCCAGGACCGCCCTCTCCCAG
GCCCAGGCGGGGGCGGACGTGGTGGCCCCGAGCGCCATGATGGACGGGCAGGTTAAGGCCATCCGGGAGGCGTTGGACCG
GGGGGGGTTCGCCCACGTGCCCATCCTCTCCTACGCGGTGAAGTACGCCTCCGCCTTCTACGGGCCCTTCCGGGAGGCGG
CCCAAAGCGCCCCGGGCTTCGGCGACCGCTCGGGCTACCAGATGGACCCCCGGGCGGGCCTGTGGGACGCCCTTCGCGAG
GCGGCTTTGGACGATTTAGAAGGTGCGGACATGCTCATGGTGAAGCCCGCCCTGCCTTATCTGGACGTGCTTTCCGCCCT
GAAGGGACGCTTCGCCAAGCCCCTCTTCGCCTACCAGGTCTCCGGGGAGTACGCCATGCTCAAGGCCGCGGCCCTCAAGG
GGTGGCTGGACGAGAGGCGGGCCGTGCTGGAAAGCCTCTTCGCCCTGCGCCGGGCCGGGGCCCAGGGGATCCTCACCTAC
TACGCCCTCGAGGCCGCCCGCTGGCTGAAGGAGGCCTAG

Upstream 100 bases:

>100_bases
CCACGGTCATCCGCTCCAGGCGCTCCTGCACCTCGGCGGCCTTCTTCTGAGCCTTCTGCGCTTCCTTGAGAAGCTTCTGG
AAGTTCATCGTCCCTCCCCT

Downstream 100 bases:

>100_bases
GCCTCCTTGGGCTTAGGGGCAGGGATGCCCCCCGTGAGGAGGGTGTAGCCCGCAGCGAGGGCCACCATGGCCCCCGCGAG
GAGGAAGACCCTGGGGGCGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSIVEGMERPRRLRSPLLRPLVAEVELSPKHLILPLFVKEGGEKEEVSSMPGVFRHPLSGLPRVAEEALKAGLGGVILFG
VLPQEAKDPMGRGAYAEDGVVQRAIRLLKREFPELLVLADTCLCEYTDHGHCGVVKEGPLGFYVDNDATLDLLARTALSQ
AQAGADVVAPSAMMDGQVKAIREALDRGGFAHVPILSYAVKYASAFYGPFREAAQSAPGFGDRSGYQMDPRAGLWDALRE
AALDDLEGADMLMVKPALPYLDVLSALKGRFAKPLFAYQVSGEYAMLKAAALKGWLDERRAVLESLFALRRAGAQGILTY
YALEAARWLKEA

Sequences:

>Translated_332_residues
MSIVEGMERPRRLRSPLLRPLVAEVELSPKHLILPLFVKEGGEKEEVSSMPGVFRHPLSGLPRVAEEALKAGLGGVILFG
VLPQEAKDPMGRGAYAEDGVVQRAIRLLKREFPELLVLADTCLCEYTDHGHCGVVKEGPLGFYVDNDATLDLLARTALSQ
AQAGADVVAPSAMMDGQVKAIREALDRGGFAHVPILSYAVKYASAFYGPFREAAQSAPGFGDRSGYQMDPRAGLWDALRE
AALDDLEGADMLMVKPALPYLDVLSALKGRFAKPLFAYQVSGEYAMLKAAALKGWLDERRAVLESLFALRRAGAQGILTY
YALEAARWLKEA
>Mature_331_residues
SIVEGMERPRRLRSPLLRPLVAEVELSPKHLILPLFVKEGGEKEEVSSMPGVFRHPLSGLPRVAEEALKAGLGGVILFGV
LPQEAKDPMGRGAYAEDGVVQRAIRLLKREFPELLVLADTCLCEYTDHGHCGVVKEGPLGFYVDNDATLDLLARTALSQA
QAGADVVAPSAMMDGQVKAIREALDRGGFAHVPILSYAVKYASAFYGPFREAAQSAPGFGDRSGYQMDPRAGLWDALREA
ALDDLEGADMLMVKPALPYLDVLSALKGRFAKPLFAYQVSGEYAMLKAAALKGWLDERRAVLESLFALRRAGAQGILTYY
ALEAARWLKEA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=321, Percent_Identity=46.417445482866, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI87081728, Length=322, Percent_Identity=51.8633540372671, Blast_Score=296, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=42.1052631578947, Blast_Score=221, Evalue=9e-59,
Organism=Drosophila melanogaster, GI21358291, Length=300, Percent_Identity=44.3333333333333, Blast_Score=240, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36086; Mature: 35955

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVEGMERPRRLRSPLLRPLVAEVELSPKHLILPLFVKEGGEKEEVSSMPGVFRHPLSG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCHHHHHHCCHHHHCCCCC
LPRVAEEALKAGLGGVILFGVLPQEAKDPMGRGAYAEDGVVQRAIRLLKREFPELLVLAD
CHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TCLCEYTDHGHCGVVKEGPLGFYVDNDATLDLLARTALSQAQAGADVVAPSAMMDGQVKA
HHHHHCCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHCCHHHHCCHHHH
IREALDRGGFAHVPILSYAVKYASAFYGPFREAAQSAPGFGDRSGYQMDPRAGLWDALRE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
AALDDLEGADMLMVKPALPYLDVLSALKGRFAKPLFAYQVSGEYAMLKAAALKGWLDERR
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AVLESLFALRRAGAQGILTYYALEAARWLKEA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIVEGMERPRRLRSPLLRPLVAEVELSPKHLILPLFVKEGGEKEEVSSMPGVFRHPLSG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCHHHHHHCCHHHHCCCCC
LPRVAEEALKAGLGGVILFGVLPQEAKDPMGRGAYAEDGVVQRAIRLLKREFPELLVLAD
CHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TCLCEYTDHGHCGVVKEGPLGFYVDNDATLDLLARTALSQAQAGADVVAPSAMMDGQVKA
HHHHHCCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHCCHHHHCCHHHH
IREALDRGGFAHVPILSYAVKYASAFYGPFREAAQSAPGFGDRSGYQMDPRAGLWDALRE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
AALDDLEGADMLMVKPALPYLDVLSALKGRFAKPLFAYQVSGEYAMLKAAALKGWLDERR
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AVLESLFALRRAGAQGILTYYALEAARWLKEA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]