Click here to switch to the map view.

The map label for this gene is mprA [H]

Identifier: 55981562

GI number: 55981562

Start: 1515295

End: 1515945

Strand: Reverse

Name: mprA [H]

Synonym: TTHA1593

Alternate gene names: 55981562

Gene position: 1515945-1515295 (Counterclockwise)

Preceding gene: 55981563

Following gene: 55981561

Centisome position: 81.95

GC content: 69.43

Gene sequence:

>651_bases
GTGAGGGTGCTTCTGGTGGAGGACGACCCTGGGGTGCGGGAGGCCTTGGAGCTCGGCCTTTCCCTGGAGGGGCACGAGGT
GCGGGCCGTGGACCGGCCCGAGGAGGCCTTAGGCCTTCTTTCCTGGGCCGAGGTGGTGGTTTTGGACGTGCTCTTGCCCC
AGGGGGACGGGTTTTCCCTTTTGCGCGCGATCCGGGAGCGCTCCGAGGTCCCCGTCCTCATGCTCACCGCGTTGGACGGG
GTGGAGTGGCGGGTGAAGGGCCTTAGGGAGGGGGCCGACGACTACCTGGTGAAGCCCTACAGCCTCCAGGAGCTCCTCGC
CCGCCTCGAGGCCCTGGTCCGCCGGGCGCGGAGGCGCGAGGAGGTCCTCGCCTACAAGGACCTCCGCCTCTACCCCCGGC
GCATGGAGGCCTTCCGCGGGGAAAGGCGCCTCGCCCTCTCCCCCAAGGCCTTCCTCCTCCTGAAGGCCTTTCTCGAGGCC
CCGGAGGAGGTCCTGTCCAAGGAGGCCCTGATGCGGAAGGTCTGGGGGGAGGAGGTGGAGCCCGCCACCTTGGAGGTCCA
CCTCTCCGCCCTGAGAAAGGCCCTGGGGGAGCCCAGTCCCATCCAGACGGTGCGCGGGTATGGCTACCGCCTTTTCCTCC
CTGAGGGCTAG

Upstream 100 bases:

>100_bases
CTAGCCGCATCCACCGGATCTCCCTGGACACCGGGGAGGCCCTTCCGCCCTTGGAGGTCTACGCGCCCGTGCGAGGCCTG
GCCCTTTGGAGGCGGACGCC

Downstream 100 bases:

>100_bases
GCTCTTCGCCCTCCTCCTCCTCGCCCTTCTCCTCCTCCTCGCCCCCTTGGCCTGGCTTTCCGCCCGGGAGGCGGAGCGGG
CCGCGAGCGAGGACCTGAGG

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRVLLVEDDPGVREALELGLSLEGHEVRAVDRPEEALGLLSWAEVVVLDVLLPQGDGFSLLRAIRERSEVPVLMLTALDG
VEWRVKGLREGADDYLVKPYSLQELLARLEALVRRARRREEVLAYKDLRLYPRRMEAFRGERRLALSPKAFLLLKAFLEA
PEEVLSKEALMRKVWGEEVEPATLEVHLSALRKALGEPSPIQTVRGYGYRLFLPEG

Sequences:

>Translated_216_residues
MRVLLVEDDPGVREALELGLSLEGHEVRAVDRPEEALGLLSWAEVVVLDVLLPQGDGFSLLRAIRERSEVPVLMLTALDG
VEWRVKGLREGADDYLVKPYSLQELLARLEALVRRARRREEVLAYKDLRLYPRRMEAFRGERRLALSPKAFLLLKAFLEA
PEEVLSKEALMRKVWGEEVEPATLEVHLSALRKALGEPSPIQTVRGYGYRLFLPEG
>Mature_216_residues
MRVLLVEDDPGVREALELGLSLEGHEVRAVDRPEEALGLLSWAEVVVLDVLLPQGDGFSLLRAIRERSEVPVLMLTALDG
VEWRVKGLREGADDYLVKPYSLQELLARLEALVRRARRREEVLAYKDLRLYPRRMEAFRGERRLALSPKAFLLLKAFLEA
PEEVLSKEALMRKVWGEEVEPATLEVHLSALRKALGEPSPIQTVRGYGYRLFLPEG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=39.1891891891892, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=37.1681415929204, Blast_Score=124, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=41.2844036697248, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.8378378378378, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=33.4862385321101, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=36.2068965517241, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=31.651376146789, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.4444444444444, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=35.1111111111111, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.1310043668122, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=30.0448430493274, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788550, Length=166, Percent_Identity=29.5180722891566, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=25.6302521008403, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24534; Mature: 24534

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLVEDDPGVREALELGLSLEGHEVRAVDRPEEALGLLSWAEVVVLDVLLPQGDGFSL
CEEEEECCCCCHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LRAIRERSEVPVLMLTALDGVEWRVKGLREGADDYLVKPYSLQELLARLEALVRRARRRE
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHH
EVLAYKDLRLYPRRMEAFRGERRLALSPKAFLLLKAFLEAPEEVLSKEALMRKVWGEEVE
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
PATLEVHLSALRKALGEPSPIQTVRGYGYRLFLPEG
CHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCC
>Mature Secondary Structure
MRVLLVEDDPGVREALELGLSLEGHEVRAVDRPEEALGLLSWAEVVVLDVLLPQGDGFSL
CEEEEECCCCCHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LRAIRERSEVPVLMLTALDGVEWRVKGLREGADDYLVKPYSLQELLARLEALVRRARRRE
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHH
EVLAYKDLRLYPRRMEAFRGERRLALSPKAFLLLKAFLEAPEEVLSKEALMRKVWGEEVE
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
PATLEVHLSALRKALGEPSPIQTVRGYGYRLFLPEG
CHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA