Click here to switch to the map view.

The map label for this gene is pth

Identifier: 55981557

GI number: 55981557

Start: 1511669

End: 1512220

Strand: Reverse

Name: pth

Synonym: TTHA1588

Alternate gene names: 55981557

Gene position: 1512220-1511669 (Counterclockwise)

Preceding gene: 55981558

Following gene: 55981556

Centisome position: 81.75

GC content: 71.74

Gene sequence:

>552_bases
GTGTTCCTGGTGGTGGGCCAGGGGAACCCGGGGGAGCGGTACGCCCGCACCCGGCACAACCTCGGCTTCATGGTCCTGGA
CCGCCTGGGCCTTTCCTTCCGCCCCCGGGGCGAGGCGCTCGTGGCGGAGGCGGAGGGCGGGCTTTTCCTCAAGCCCCTCA
CCTACTACAACCTCACGGGGCGGGCGGTGGCCCCCCTCGCCCGCTTTTACAAGATCCCTCCCGAGCGGATCCTGGTGGTC
CACGACGAGATGGACCTCCCTTTGGGGCGGATCCGCTTCAAGGCCGGGGGGAGCGCCGCCGGGAACCGGGGCGTGCTTTC
CATAGAGGAGGCCCTGGGCACCCGGGCCTTCCACCGCCTCCGCCTCGGCATCGGGAAGCCCCCGGACCCCTCCCGGGGGG
CGGAGTACGTGCTCTCCCCCTTCCGCGAGGAGGAGCTTCCCGTGGTGGAGCGGGTCCTCGAGGCGGCCAAGGAGGCGGTT
TGGTGCTGGGTGCGGGAGGGTCTCCCCCCCTGCGCCGGGCGCTTCAACGGCCTGGACCTCTCCTTGGGGTAA

Upstream 100 bases:

>100_bases
CGTGGAGAAGCTCGCCGAGGAAGCGGCGGCCGAGGTGGCGGAGCCCGAGGTCATCAAGAAGGGCAAGGAAGAGGAAGAGG
AGTAGCCCAAGGGTCCGGGC

Downstream 100 bases:

>100_bases
GCTCAGGCCATGAGGGTTCTTCTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTTTCCGCGGAAGGGGT
TCTGCGCCACATCCCCTTCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTGRAVAPLARFYKIPPERILVV
HDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRLRLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAV
WCWVREGLPPCAGRFNGLDLSLG

Sequences:

>Translated_183_residues
MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTGRAVAPLARFYKIPPERILVV
HDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRLRLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAV
WCWVREGLPPCAGRFNGLDLSLG
>Mature_183_residues
MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTGRAVAPLARFYKIPPERILVV
HDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRLRLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAV
WCWVREGLPPCAGRFNGLDLSLG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=183, Percent_Identity=33.879781420765, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=37.4331550802139, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_THET2 (Q72IA8)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005193.1
- ProteinModelPortal:   Q72IA8
- SMR:   Q72IA8
- STRING:   Q72IA8
- GeneID:   2775394
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   FSPKHNA
- PhylomeDB:   Q72IA8
- ProtClustDB:   PRK05426
- BioCyc:   TTHE262724:TT_C1224-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20180; Mature: 20180

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2; PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTG
CEEEEECCCCCHHHHHHHHCCCCEEHHHCCCCCCCCCCEEEEECCCCEEEECEEEECCCC
RAVAPLARFYKIPPERILVVHDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRL
CHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHH
RLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAVWCWVREGLPPCAGRFNGLDL
HHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
SLG
ECC
>Mature Secondary Structure
MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTG
CEEEEECCCCCHHHHHHHHCCCCEEHHHCCCCCCCCCCEEEEECCCCEEEECEEEECCCC
RAVAPLARFYKIPPERILVVHDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRL
CHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHH
RLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAVWCWVREGLPPCAGRFNGLDL
HHCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
SLG
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA