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The map label for this gene is ddl [H]

Identifier: 55981556

GI number: 55981556

Start: 1510700

End: 1511659

Strand: Reverse

Name: ddl [H]

Synonym: TTHA1587

Alternate gene names: 55981556

Gene position: 1511659-1510700 (Counterclockwise)

Preceding gene: 55981557

Following gene: 55981554

Centisome position: 81.72

GC content: 69.48

Gene sequence:

>960_bases
ATGAGGGTTCTTCTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTTTCCGCGGAAGGGGTTCTGCGCCA
CATCCCCTTCCCCACGGACCTCGCCGTGATCGCCCAGGACGGGCGCTGGCTTCTGGGGGAAAAGGCCTTGACCGCCTTGG
AGGCCAAGGCGGCCCCCGAGGGGGAGCACCCCTTCCCCCCGCCCCTCTCCTGGGAGCGGTACGATGTGGTCTTTCCCTTG
CTCCACGGCCGCTTCGGCGAGGACGGGACGGTCCAGGGGTTTCTGGAGCTTTTGGGCAAGCCCTACGTGGGGGCGGGGGT
GGCGGCGAGCGCCCTCTGCATGGACAAGGACCTGAGCAAGCGGGTCCTCGCCCAGGCGGGGGTGCCCGTGGTCCCCTGGG
TGGCGGTGCGGAAGGGCGAGCCCCCCGTGGTGCCCTTTGACCCCCCCTTCTTCGTCAAGCCGGCCAACACCGGCTCCAGC
GTGGGGATAAGCCGGGTGGAGCGCTTCCAGGACCTGGAGGCCGCCCTGGCCTTGGCCTTCCGCTACGACGAGAAAGCGGT
GGTGGAGAAGGCCCTCTCCCCGGTGCGGGAGCTGGAGGTGGGGGTCTTGGGCAACGTCTTCGGGGAGGCGAGCCCCGTGG
GGGAGGTGCGCTACGAGGCGCCCTTCTACGACTACGAGACCAAGTACACCCCGGGCCGGGCCGAGCTCCTCATCCCCGCG
CCCTTGGACCCCGGCACCCAGGAGACCGTTCAGGAGCTCGCCCTCAAGGCCTACAAGGTGCTCGGGGTGCGGGGGATGGC
CCGGGTGGACTTCTTCCTCGCGGAGGGGGAGCTTTACCTGAACGAGCTCAACACCATCCCCGGCTTCACCCCCACCAGCA
TGTACCCCCGCCTCTTTGAGGCGGGGGGGGTGGCCTACCCGGAGCTTCTCAGGCGCCTGGTGGAGCTCGCCCTCACCTAA

Upstream 100 bases:

>100_bases
GGCGGCCAAGGAGGCGGTTTGGTGCTGGGTGCGGGAGGGTCTCCCCCCCTGCGCCGGGCGCTTCAACGGCCTGGACCTCT
CCTTGGGGTAAGCTCAGGCC

Downstream 100 bases:

>100_bases
GCGCCCCTCGGGCCTCCCAGGCTGGCGCAAGCCGGCCTGGGGCGGTATTAGATGTCCAGCTCGGCGTAGCGGGCGTGCTC
CTCTATGAACTCGCGCCTCG

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPEGEHPFPPPLSWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT

Sequences:

>Translated_319_residues
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPEGEHPFPPPLSWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT
>Mature_319_residues
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPEGEHPFPPPLSWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT

Specific function: Cell wall formation [H]

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786579, Length=349, Percent_Identity=38.9684813753582, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1786280, Length=333, Percent_Identity=36.9369369369369, Blast_Score=185, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185 [H]

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N [H]

EC number: =6.3.2.4 [H]

Molecular weight: Translated: 34666; Mature: 34666

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50975 ATP_GRASP ; PS00843 DALA_DALA_LIGASE_1 ; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPE
CEEEEEECCCCCCHHEEEEECCCHHHHCCCCCCEEEEECCCCEEECHHHHHHHHHCCCCC
GEHPFPPPLSWERYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSK
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSSVGISRVERFQDLEAALALAF
HHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEEC
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFE
CCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCEEEEEHHCCCCCCCCHHHHHHHHH
AGGVAYPELLRRLVELALT
CCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKALTALEAKAAPE
CEEEEEECCCCCCHHEEEEECCCHHHHCCCCCCEEEEECCCCEEECHHHHHHHHHCCCCC
GEHPFPPPLSWERYDVVFPLLHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSK
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RVLAQAGVPVVPWVAVRKGEPPVVPFDPPFFVKPANTGSSVGISRVERFQDLEAALALAF
HHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEEC
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFE
CCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCEEEEEHHCCCCCCCCHHHHHHHHH
AGGVAYPELLRRLVELALT
CCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA