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The map label for this gene is serA [H]

Identifier: 55981543

GI number: 55981543

Start: 1496858

End: 1497748

Strand: Reverse

Name: serA [H]

Synonym: TTHA1574

Alternate gene names: 55981543

Gene position: 1497748-1496858 (Counterclockwise)

Preceding gene: 55981544

Following gene: 55981542

Centisome position: 80.97

GC content: 71.72

Gene sequence:

>891_bases
GTGAGGATCTTGGCCCCGAGGCTTAGGGAGGAGGTGTGGGCCGCCCTGCCCGAGGGGGTGGAGGTGCGCTTTCTGGACGA
GCCCTGGCCCAAGGCCTGCGACCTCTTCATCCCCCCTTACGGGCAGGAGGAGGTGGTGCGGCGGGTCCTGGAGGAGGTGG
AGGTCAAGGTGGTCCAGACCCTCTCCGCGGGGGTGGACTGGATCCTTCCCCTCGTCCCCGAGGGGGTGGTGCTCTGCGAC
GGCTCCGGGATCCACGACGCCCCCGTGGCCGAGTGGGTGGTCCTGGCCCTCCTCGCCCTCCTCAAAGACCTCTCCGGCTT
CCTCGAGGCCCAAAAGGAAGGGCGCTGGGCCCCGAGGAGGCTTTCCGACCTGGAGGGGAAGAGGGTCCTCCTCCTGGGCT
ACGGGTCCATCGGGAAGGCGGTGGCGGAAAGGCTTAGGCCTTTTGGGGTGGCGCTCTTCCCCGTGGCCCGCCACCCCCGC
CCCGGGGTCTACACCCGGGAGGACCTGCCCGCCCTCCTGCCCCGGGCGGACGCCGTGGTCCTCCTCCTCCCCCTCACCCC
CGAGACCCGGGGCATCGTGGACCGGGACTTCCTCGCCCGGATGAAGGAGGGGGCCCTCCTGGTGAACGCGGGGAGGGGAG
GGCTCGTGGACACGGAGGCCCTCCTCGAGGCCCTGGAGGCGGGGCGGGTCCGGGCCTTCCTGGACGTCACCGACCCCGAG
CCCCTTCCCCGGGACCACCCCCTCTGGCGGGCTAGGGGGGTGGTCATCACCCCCCACGTGGCCGGGCTTTCCGAGGGGTT
TTCCCGCCGGGTGGCCCGCTTCCTCGCCGAGCAGGTGGGGCGGTACCTCCGGGGAGAGCCTCTTCTGAACGTGGTGCGGG
AGGGGTATTAA

Upstream 100 bases:

>100_bases
AACCTCCGCGCCCGGCGGGCCTTTCAGAAGGCGGGTTTCCGCGAGGTGGGCGTGGTGCCGGGCCCCAGGGGGAGGGAGGA
CGTGCACATGGAGGTGCGCC

Downstream 100 bases:

>100_bases
GGCCACCCCGGGCACTTGGCCCCCCTTGCGGGAAAGGTGCTACCCTGGAGGAGGATGCGGCGCATTGCCCTGCCCGAGGA
CGTGGCCGAGGCTTTGGAGC

Product: dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MRILAPRLREEVWAALPEGVEVRFLDEPWPKACDLFIPPYGQEEVVRRVLEEVEVKVVQTLSAGVDWILPLVPEGVVLCD
GSGIHDAPVAEWVVLALLALLKDLSGFLEAQKEGRWAPRRLSDLEGKRVLLLGYGSIGKAVAERLRPFGVALFPVARHPR
PGVYTREDLPALLPRADAVVLLLPLTPETRGIVDRDFLARMKEGALLVNAGRGGLVDTEALLEALEAGRVRAFLDVTDPE
PLPRDHPLWRARGVVITPHVAGLSEGFSRRVARFLAEQVGRYLRGEPLLNVVREGY

Sequences:

>Translated_296_residues
MRILAPRLREEVWAALPEGVEVRFLDEPWPKACDLFIPPYGQEEVVRRVLEEVEVKVVQTLSAGVDWILPLVPEGVVLCD
GSGIHDAPVAEWVVLALLALLKDLSGFLEAQKEGRWAPRRLSDLEGKRVLLLGYGSIGKAVAERLRPFGVALFPVARHPR
PGVYTREDLPALLPRADAVVLLLPLTPETRGIVDRDFLARMKEGALLVNAGRGGLVDTEALLEALEAGRVRAFLDVTDPE
PLPRDHPLWRARGVVITPHVAGLSEGFSRRVARFLAEQVGRYLRGEPLLNVVREGY
>Mature_296_residues
MRILAPRLREEVWAALPEGVEVRFLDEPWPKACDLFIPPYGQEEVVRRVLEEVEVKVVQTLSAGVDWILPLVPEGVVLCD
GSGIHDAPVAEWVVLALLALLKDLSGFLEAQKEGRWAPRRLSDLEGKRVLLLGYGSIGKAVAERLRPFGVALFPVARHPR
PGVYTREDLPALLPRADAVVLLLPLTPETRGIVDRDFLARMKEGALLVNAGRGGLVDTEALLEALEAGRVRAFLDVTDPE
PLPRDHPLWRARGVVITPHVAGLSEGFSRRVARFLAEQVGRYLRGEPLLNVVREGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=263, Percent_Identity=33.4600760456274, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI23308577, Length=228, Percent_Identity=28.9473684210526, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=30.2040816326531, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=30.2040816326531, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=30.2040816326531, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI61743967, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=244, Percent_Identity=33.6065573770492, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=29.368029739777, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787645, Length=161, Percent_Identity=29.1925465838509, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789279, Length=177, Percent_Identity=30.5084745762712, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=250, Percent_Identity=28.8, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=27.8388278388278, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=281, Percent_Identity=27.0462633451957, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=180, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=31.3953488372093, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=215, Percent_Identity=26.9767441860465, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=230, Percent_Identity=25.6521739130435, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=31.1023622047244, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=31.1023622047244, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=31.1023622047244, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=31.1023622047244, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=31.1023622047244, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=31.8897637795276, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28571528, Length=183, Percent_Identity=37.7049180327869, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=27.6679841897233, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19921140, Length=239, Percent_Identity=32.2175732217573, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=29.7959183673469, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=29.7959183673469, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=29.7959183673469, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=29.7959183673469, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=29.7959183673469, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32745; Mature: 32745

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILAPRLREEVWAALPEGVEVRFLDEPWPKACDLFIPPYGQEEVVRRVLEEVEVKVVQT
CCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHH
LSAGVDWILPLVPEGVVLCDGSGIHDAPVAEWVVLALLALLKDLSGFLEAQKEGRWAPRR
HHHCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LSDLEGKRVLLLGYGSIGKAVAERLRPFGVALFPVARHPRPGVYTREDLPALLPRADAVV
HHCCCCCEEEEEECCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHCCHHHCCCCCEEE
LLLPLTPETRGIVDRDFLARMKEGALLVNAGRGGLVDTEALLEALEAGRVRAFLDVTDPE
EEEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCC
PLPRDHPLWRARGVVITPHVAGLSEGFSRRVARFLAEQVGRYLRGEPLLNVVREGY
CCCCCCCCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MRILAPRLREEVWAALPEGVEVRFLDEPWPKACDLFIPPYGQEEVVRRVLEEVEVKVVQT
CCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHH
LSAGVDWILPLVPEGVVLCDGSGIHDAPVAEWVVLALLALLKDLSGFLEAQKEGRWAPRR
HHHCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LSDLEGKRVLLLGYGSIGKAVAERLRPFGVALFPVARHPRPGVYTREDLPALLPRADAVV
HHCCCCCEEEEEECCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHCCHHHCCCCCEEE
LLLPLTPETRGIVDRDFLARMKEGALLVNAGRGGLVDTEALLEALEAGRVRAFLDVTDPE
EEEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCC
PLPRDHPLWRARGVVITPHVAGLSEGFSRRVARFLAEQVGRYLRGEPLLNVVREGY
CCCCCCCCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]