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The map label for this gene is purL

Identifier: 55981488

GI number: 55981488

Start: 1442843

End: 1445020

Strand: Direct

Name: purL

Synonym: TTHA1519

Alternate gene names: 55981488

Gene position: 1442843-1445020 (Clockwise)

Preceding gene: 55981487

Following gene: 55981489

Centisome position: 78.0

GC content: 69.88

Gene sequence:

>2178_bases
ATGGAGGCCCTCGCCAAGGAGATCGGGATCCCGGAAGGGGAGTACCGGGAGATCGTCCAGAGGCTCGGGCGGGAGCCGAA
CCGGGTGGAGCTCCTCCTCTTCAAGGTGATGTGGAGCGAGCACTGCGCCTACAAGAACTCCCGCCCCCTCCTCAAGGCCC
TCCCCAAGGAGGGGGAGGCCGTCCTCCAGGGCCCCGGGGAGAACGCCGGCGTGGTGCGGGTGGGCGAGGGTTGGGCCGTG
GCCTTCAAGATAGAGAGCCACAACCACCCCTCGGCGGTGGAGCCCTTCCAGGGGGCGGCCACGGGGGTCGGGGGGATCCT
CCGGGACATCATGAGCATGGGAGCCCGCCCCATCGCCCTCCTGGACTCCCTCCGCTTCGGGCCGCCCGAGGAGGCGAGAA
GCCGCTACCTCCTCAAGGGGGTGGTCTCGGGCATCGCCTTTTACGGCAACGCCATCGGGGTGCCCACGGTGGGCGGGGAC
CTCTACTTCCACGAGGGCTACCGGGAAAACCCCCTGGTGAACGCCATGTGCCTCGGCCTCCTGAGGGAGGAGCACCTGAA
GCGAAGCCGGGCTTCCTTGGGCCGCCCCATCTACTACGCCGGGGCCAAGACGGGCCGGGACGGGATCGGCGGGGCGGCCT
TCGCGAGCCGGGAGCTCAAGGAGGAGAAGGCCGAGGACCGGCCCGCGGTCCAGGTGGGGGACCCTTTCCTGGGCAAGCTC
CTCATGGAGGCCACCCTCGAGGCCATAGAGCTGGACCTGGTGGAAGGCGTCCAGGACATGGGGGCGGCGGGGCTCACCAG
TAGCCTCTCGGAGCTCGCCCACAAGTCGGGCCTCGGGGTGGAGCTCCACCTGGACCTCGTCCCCACCCGGGAGGAGGGGA
TGACCCCGGAGGAGCTCCTCCTCTCGGAAAGCCAGGAGCGGATGGTCCTCGTTCCCAAGGAGGGGAAGGAAAAGGCCCTG
GAGGAGGTCTTCGGAAGGTGGGGCCTAGACTGCGTCCCCGTGGCCAGGACCATCCCGGAAAGGGTCTTCCGGGTCCTCTT
TAGGGGCGAGGTGGTGGCGGAGGTGCCCACGGAGGCCTTGGCCGAAGCCCCCACCTACGTGCGGGTGGGGCGGGAGGACC
CCGAGGTGCGGAGGCTTAGGGAAACCCCCATCCCCCCCTTAGAGGCCGACCCCCAGGAGGTCCTAAGGAGGCTCCTCGCC
TCCCCCAACCTGGCGAGCCGGGAGGCGGTCTACGAGCGGTACGACCACCAGGTGGGGACCCGCACCGCCCTCCTCCCCGG
CAAAGGGGACGCCGCGGTCCTCTGGATCAAGGGCACCCGCCTCGGCGTCGCCGCCAAGGTGGACCAAAACCCCCGCTATA
GCCGCCTCCACCCCCGCCTTGGGGCCATGCACGCCCTGGCGGAGGCCTGCCGGAACGTCAGCGTGGTGGGGGCGAAGCCC
CTCGCCTACACCGACGGCCTCAACCTGGGAAGCCCGGAAACCCCGGAGGGCTACCACGAGCTCGCCGAGACCATCGCCGG
GCTCAAGGAGGCGAGCGAGGCCTTGGGCGTCCCCGTGGTCTCGGGGAACGTCTCCCTCTACAACGAAAGCGGGGGCAAGC
GCATCCCCCCCACGGCCATGGTGGGGGTGGTGGGGGTCCTGGAGGTGGACAAGCGGGCGGAGATGGGCTTTAGGCGCCCG
GGGGAGGTCCTCCTCCTCATCGGGGAGGAACGGGGGGAGCTTGGGGCGAGCGAGGTCCTCTACCTCCTCACGGGAAAGGA
GTTCGGCCACCCCCCAAGGCTTGACCTCGGGCGGGAAAAGGCGGTGCAGGAGGCGATCCGGGACCTCATCCAAAGGGGCC
TCACCCGAACGGCCCACGACGTGGCGGAAGGGGGGCTTCTTCTGGCCCTCGCCGAGATGACCTTCCCCTACGGGGTGGGG
GCCACGGTGGAAGTGCGGGAGGAGGGCCTCGAGGCCCTCTTCGGCGAGGCCCCAAGCCGCGTCCTCTTCACCGTGGAGAA
GACCCGCCTCCAGGAGGCCACCCTCCTCCTAGAGGAGCGGGGCCTCCCCTACCGGGTCCTGGGGGAGACGGGGGGGAAGA
GCCTCACGGTCCTCACCCCGGGGGGTGTCCTAGAGTGGAGCCTGGAGGAACTGCTTTCCGCCTGGAAAGCGCCCCTCAGG
GAGGTGCTGGATGGATAA

Upstream 100 bases:

>100_bases
CCTGGGCGGTCCAGTACGTGGGCCTGAGGGAGGTGAACGGGGAGGTGAGGCCCACGGCCAAGGTGAAGGACCACCGGGAG
CTCCTCTCCCTCCTCACGTG

Downstream 100 bases:

>100_bases
GCCCCAGGAGGAGTGCGGCATCCTCGGGCTTTGGAGCGAAGGCCCCGTGGACGTGGCGGGGCTTCTCCACCTCGGCCTCC
TCGCCCTGCAGCACAGGGGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEAVLQGPGENAGVVRVGEGWAV
AFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIALLDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGD
LYFHEGYRENPLVNAMCLGLLREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKL
LMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELLLSESQERMVLVPKEGKEKAL
EEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEALAEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLA
SPNLASREAVYERYDHQVGTRTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKP
LAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAMVGVVGVLEVDKRAEMGFRRP
GEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREKAVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVG
ATVEVREEGLEALFGEAPSRVLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLR
EVLDG

Sequences:

>Translated_725_residues
MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEAVLQGPGENAGVVRVGEGWAV
AFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIALLDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGD
LYFHEGYRENPLVNAMCLGLLREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKL
LMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELLLSESQERMVLVPKEGKEKAL
EEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEALAEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLA
SPNLASREAVYERYDHQVGTRTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKP
LAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAMVGVVGVLEVDKRAEMGFRRP
GEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREKAVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVG
ATVEVREEGLEALFGEAPSRVLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLR
EVLDG
>Mature_725_residues
MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEAVLQGPGENAGVVRVGEGWAV
AFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIALLDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGD
LYFHEGYRENPLVNAMCLGLLREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKL
LMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELLLSESQERMVLVPKEGKEKAL
EEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEALAEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLA
SPNLASREAVYERYDHQVGTRTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKP
LAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAMVGVVGVLEVDKRAEMGFRRP
GEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREKAVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVG
ATVEVREEGLEALFGEAPSRVLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLR
EVLDG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=381, Percent_Identity=27.8215223097113, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17553022, Length=371, Percent_Identity=26.1455525606469, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=807, Percent_Identity=24.4114002478315, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_THET2 (Q72IH7)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005124.1
- ProteinModelPortal:   Q72IH7
- SMR:   Q72IH7
- STRING:   Q72IH7
- GeneID:   2774749
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q72IH7
- ProtClustDB:   PRK01213
- BioCyc:   TTHE262724:TT_C1155-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 78644; Mature: 78644

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEA
CCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCE
VLQGPGENAGVVRVGEGWAVAFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
LDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGDLYFHEGYRENPLVNAMCLGL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKL
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
LMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHH
LSESQERMVLVPKEGKEKALEEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEAL
HCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHCCHHHH
AEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLASPNLASREAVYERYDHQVGT
HCCCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
RTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKP
EEEECCCCCCEEEEEEECCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCC
LAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAM
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCCCCCHHH
VGVVGVLEVDKRAEMGFRRPGEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREK
HHHHHHHHHCHHHHCCCCCCCCEEEEEECCCCCCCHHHEEEEEECCCCCCCCCCCCCHHH
AVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVGATVEVREEGLEALFGEAPSR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCEEHHHHHHHHHHHCCCCCE
VLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLR
EEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
EVLDG
HHHCC
>Mature Secondary Structure
MEALAKEIGIPEGEYREIVQRLGREPNRVELLLFKVMWSEHCAYKNSRPLLKALPKEGEA
CCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCE
VLQGPGENAGVVRVGEGWAVAFKIESHNHPSAVEPFQGAATGVGGILRDIMSMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
LDSLRFGPPEEARSRYLLKGVVSGIAFYGNAIGVPTVGGDLYFHEGYRENPLVNAMCLGL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LREEHLKRSRASLGRPIYYAGAKTGRDGIGGAAFASRELKEEKAEDRPAVQVGDPFLGKL
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
LMEATLEAIELDLVEGVQDMGAAGLTSSLSELAHKSGLGVELHLDLVPTREEGMTPEELL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHH
LSESQERMVLVPKEGKEKALEEVFGRWGLDCVPVARTIPERVFRVLFRGEVVAEVPTEAL
HCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHCCHHHH
AEAPTYVRVGREDPEVRRLRETPIPPLEADPQEVLRRLLASPNLASREAVYERYDHQVGT
HCCCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
RTALLPGKGDAAVLWIKGTRLGVAAKVDQNPRYSRLHPRLGAMHALAEACRNVSVVGAKP
EEEECCCCCCEEEEEEECCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCC
LAYTDGLNLGSPETPEGYHELAETIAGLKEASEALGVPVVSGNVSLYNESGGKRIPPTAM
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCCCCCCHHH
VGVVGVLEVDKRAEMGFRRPGEVLLLIGEERGELGASEVLYLLTGKEFGHPPRLDLGREK
HHHHHHHHHCHHHHCCCCCCCCEEEEEECCCCCCCHHHEEEEEECCCCCCCCCCCCCHHH
AVQEAIRDLIQRGLTRTAHDVAEGGLLLALAEMTFPYGVGATVEVREEGLEALFGEAPSR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCEEHHHHHHHHHHHCCCCCE
VLFTVEKTRLQEATLLLEERGLPYRVLGETGGKSLTVLTPGGVLEWSLEELLSAWKAPLR
EEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
EVLDG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA