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The map label for this gene is sdhB [H]

Identifier: 55981422

GI number: 55981422

Start: 1381034

End: 1381732

Strand: Reverse

Name: sdhB [H]

Synonym: TTHA1453

Alternate gene names: 55981422

Gene position: 1381732-1381034 (Counterclockwise)

Preceding gene: 55981423

Following gene: 55981411

Centisome position: 74.7

GC content: 66.24

Gene sequence:

>699_bases
ATGCAGGTCACGCTGAAGGTCCTCCGCTTTGACCCCGCCAAGGACAAGAAGCCCCGCTGGGAGACCTACCAGGTGGAGGC
CGAGCCCTGGGACCGGGTCCTGGACCTCCTGCACAAGGTCAAGTGGTACCAGGACGGCTCCTTAGCCTTCCGAAGGAGCT
GCGGCCACGGCATCTGCGGGTCCGACGCCATGCTCATCAACGGCAGGAACCGCCTGGCCTGCAAGACCCTGGTCCGGGAT
CTGGGGAACGTGATCACCGTGGAGCCCATCCGGGGCCTCCCGGTGGAGAAGGACCTCATCGTGGACATGGAGCCCTTCTT
CGCCGCCTACCGGGCGGTGAAGCCCTACCTCATCAACGACGAGCCCCCGCCCCAGCGGGAGAGGCTCCAGTCCCCCGAGG
AAAGGGAGCGGTTTGACCAGGGCACCAAGTGCATCCTCTGCGCAAGCTGCACCACGAGCTGCCCCGTCTTCTGGGTGAAC
GGCACCTACATCGGTCCCGCCGCCATCGTCCAGGCCCACCGCTTTATCTTTGACTCCCGCGACCGGGGCAAGAGGGAGCG
TTTCCAGGTTCTGGGCTCGGGGGGCGGGGTCTGGCGGTGCCGCACCGCCTACAACTGCACCGAGGCCTGCCCCCGGGACA
TCCCCGTGACCCAGCTCATAGAAGAGGTCAAGCGGGCGATCCTCATGGACCGCTTCTAG

Upstream 100 bases:

>100_bases
CCTGGCCTACAAGGTGGAAGACGGCAAGGTTTGCTTCCGCTACAAGCCCGTGGTCCTGGGCCGCTTTGAGCCCAAGCCCC
GGACCTACTAGGAGGGAGGC

Downstream 100 bases:

>100_bases
GGCTGATGCCTTGTTTCCTTCGCCCGGCCCCCTTGAGAACCCTTTGCTGGGACCCCCATGCTGGCGCAAGCCAGCATGGG
GTAAAAGGGGCGCGCCCCGG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MQVTLKVLRFDPAKDKKPRWETYQVEAEPWDRVLDLLHKVKWYQDGSLAFRRSCGHGICGSDAMLINGRNRLACKTLVRD
LGNVITVEPIRGLPVEKDLIVDMEPFFAAYRAVKPYLINDEPPPQRERLQSPEERERFDQGTKCILCASCTTSCPVFWVN
GTYIGPAAIVQAHRFIFDSRDRGKRERFQVLGSGGGVWRCRTAYNCTEACPRDIPVTQLIEEVKRAILMDRF

Sequences:

>Translated_232_residues
MQVTLKVLRFDPAKDKKPRWETYQVEAEPWDRVLDLLHKVKWYQDGSLAFRRSCGHGICGSDAMLINGRNRLACKTLVRD
LGNVITVEPIRGLPVEKDLIVDMEPFFAAYRAVKPYLINDEPPPQRERLQSPEERERFDQGTKCILCASCTTSCPVFWVN
GTYIGPAAIVQAHRFIFDSRDRGKRERFQVLGSGGGVWRCRTAYNCTEACPRDIPVTQLIEEVKRAILMDRF
>Mature_232_residues
MQVTLKVLRFDPAKDKKPRWETYQVEAEPWDRVLDLLHKVKWYQDGSLAFRRSCGHGICGSDAMLINGRNRLACKTLVRD
LGNVITVEPIRGLPVEKDLIVDMEPFFAAYRAVKPYLINDEPPPQRERLQSPEERERFDQGTKCILCASCTTSCPVFWVN
GTYIGPAAIVQAHRFIFDSRDRGKRERFQVLGSGGGVWRCRTAYNCTEACPRDIPVTQLIEEVKRAILMDRF

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=227, Percent_Identity=42.2907488986784, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=43.4042553191489, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI1790596, Length=227, Percent_Identity=37.8854625550661, Blast_Score=173, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17533915, Length=230, Percent_Identity=37.8260869565217, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322987, Length=229, Percent_Identity=40.174672489083, Blast_Score=172, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=39.8268398268398, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=37.2294372294372, Blast_Score=153, Evalue=8e-38,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26635; Mature: 26635

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTLKVLRFDPAKDKKPRWETYQVEAEPWDRVLDLLHKVKWYQDGSLAFRRSCGHGICG
CCEEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
SDAMLINGRNRLACKTLVRDLGNVITVEPIRGLPVEKDLIVDMEPFFAAYRAVKPYLIND
CCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCEEECCHHHHHHHHHCCCEEECC
EPPPQRERLQSPEERERFDQGTKCILCASCTTSCPVFWVNGTYIGPAAIVQAHRFIFDSR
CCCCHHHHCCCCHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECHHHHHHHHHHHHCCC
DRGKRERFQVLGSGGGVWRCRTAYNCTEACPRDIPVTQLIEEVKRAILMDRF
CCCHHHHHHEEECCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVTLKVLRFDPAKDKKPRWETYQVEAEPWDRVLDLLHKVKWYQDGSLAFRRSCGHGICG
CCEEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
SDAMLINGRNRLACKTLVRDLGNVITVEPIRGLPVEKDLIVDMEPFFAAYRAVKPYLIND
CCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCEEECCHHHHHHHHHCCCEEECC
EPPPQRERLQSPEERERFDQGTKCILCASCTTSCPVFWVNGTYIGPAAIVQAHRFIFDSR
CCCCHHHHCCCCHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECHHHHHHHHHHHHCCC
DRGKRERFQVLGSGGGVWRCRTAYNCTEACPRDIPVTQLIEEVKRAILMDRF
CCCHHHHHHEEECCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]