Click here to switch to the map view.

The map label for this gene is crp [H]

Identifier: 55981406

GI number: 55981406

Start: 1364230

End: 1364880

Strand: Direct

Name: crp [H]

Synonym: TTHA1437

Alternate gene names: 55981406

Gene position: 1364230-1364880 (Clockwise)

Preceding gene: 55981401

Following gene: 55981407

Centisome position: 73.75

GC content: 71.12

Gene sequence:

>651_bases
GTGAAGGGAAGCCCCCTGTTCCACGGCCTGGCCCCGGAGGAGGTGGACCTGGCCCTGAGCTACTTCCAGCGGCGCCTTTA
CCCTCAGGGGAAGCCCATCTTTTACCAGGGGGACCTGGGGCAGGCCCTCTACCTGGTGGCCTCGGGGAAGGTCCGCCTCT
TCCGCACCCACCTCGGGGGCCAGGAAAGGACCCTGGCCCTCCTTGGGCCGGGGGAGCTTTTCGGGGAGATGAGCCTCCTG
GACGAGGGGGAGAGGAGCGCCAGCGCCGTGGCCGTGGAGGACACCGAGCTCCTCGCCCTCTTCCGCGAGGACTACCTGGC
CCTGATCCGGCGCCTCCCCCTGGTGGCCCACAACCTGGCCGCCCTCCTCGCCCGGCGCCTCCGGGAGGCCGACTTGGAGC
TTGACCTCCTCTCCTTTGAGGAGGCCCGGAACCGGGTGGCCTACGCCCTCCTCAAGCTCCTCCGCCAGGGGCTCGGCCCC
CTCTTCCAGATCCGCCACCACGAGCTCGCCGCCCTGGCGGGGACCAGCCGGGAAACCGTCTCCCGGGTCCTCCACGCCCT
GGCCGAGGAGGGGGTGGTCAGGCTCGGCCCCGGGACGGTGGAGGTGCGGGAAGCGGCGCTTCTTGAGGAGATCGCCTTCG
GGCTTGCCTAG

Upstream 100 bases:

>100_bases
GGCCGTTGCCGTAGCTGTAGCCGAGGCCTCGAGCCTCGAGGACCGGGCGCACCCTCTCATCCTCTAGGCAAAAGATGAAG
TTTCCGTTAGACTCTTGGCG

Downstream 100 bases:

>100_bases
GAGGAAGCGGTGCGCCTGCGCGTGGACGTGATCCCAGGGGAACACCTCGCCTACCCGGACGTGGTGCTGGTGGTGGACGT
GATCCGGGCCACCACCACGG

Product: Crp family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLL
DEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGP
LFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA

Sequences:

>Translated_216_residues
MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLL
DEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGP
LFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA
>Mature_216_residues
MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLL
DEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGP
LFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=191, Percent_Identity=29.8429319371728, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 23819; Mature: 23819

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEEEECCCC
QERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLA
CCCEEEEECCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGPLFQIRHHELAALAGTSRETV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
SRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEEEECCCC
QERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLA
CCCEEEEECCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGPLFQIRHHELAALAGTSRETV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
SRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]