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The map label for this gene is gyrA [H]

Identifier: 55981324

GI number: 55981324

Start: 1294527

End: 1296944

Strand: Direct

Name: gyrA [H]

Synonym: TTHA1355

Alternate gene names: 55981324

Gene position: 1294527-1296944 (Clockwise)

Preceding gene: 55981323

Following gene: 55981325

Centisome position: 69.98

GC content: 68.24

Gene sequence:

>2418_bases
ATGGCCCAGGTACTGCCTGTAGAAATCACCGAGGAGCTCAAGCAGAGCTTCATCAACTACGCCATGTCCGTCATCGTGGA
CCGGGCCCTGCCCGACGTGCGGGACGGGCTCAAGCCGGTCCAGAGGCGGATCCTCTTCGGCGCCTACCAGGAAGGGGTCC
TGCCGGGGCGCAAGCACGTGAAGAGCGCCAAGATCGTGGGCGAGGTCATGGGCAAGTACCACCCCCACGGGGACGCCGCC
ATCTACGACGCCCTGGTGCGCATGGCCCAGCCCTGGAACCTCCGCTACCCCCTCATTGACGGCCAGGGGAACTTCGGCTC
CATAGACGGCGACCCCCCGGCGGCCCAGCGCTACACCGAGGCCAGGCTTTCCCCCATCGGGGCGGAGATGCTTTTGGACA
TTGACAAGGACACGGTGGACTTCCGCCCCAACTACGACGGCTCCCTCAAGGAGCCCGAGGTCCTGCCCGCCGCCATACCC
AACCTCCTGGTGAACGGGGCGAGCGGCATCGCCGTGGGCATGGCCACGAGCCTCCCGCCCCACAACCTCTCCGAGGTGGT
GGACGCCCTGGTGGCCATGATCGAAAACCCCGCCATCACCCTGGAAGAGGTCATGCGCCACCTCCCCGGCCCCGACTTCC
CCACCGGGGGGAAGCTCTCCAAGAAGGGCATCAAGGAGGCCTACGCCACCGGGCGGGGAAGCCTTAAGGTGCGGGCCAAG
GTGCGGGTGGAGGAGAAGGGGCAGAGGCCCGTCCTGGTGGTGACGGAGATCCCCTACCAGGTGAACAAGGCGAGCCTCAT
CGCCCAGATCGCCGCCCTGGTCAAGGCCAAGAAGATTGAGGACATCGTGGGCCTCCGGGACGAGTCCGACCGGCAGGGCC
TGAGGATCGCCATTGAGCTCAAGCGGGGCGCCAACCCCCAGGTGGTCCTGAACCAGCTCTACAAGCACACCGCCCTCCAG
ACCTCCTTCACGGTGAACCTCCTCGCCATCGTGGACGGGGAGCCCAAGGTCCTCTCCCTCCTGGACCTGATGCGCCACTA
CCTGGACCACCGCAAGGAGGTGGTGCGCCGCCGGAGCCTCTTTGAGCTCAGGAAGGCGGAGGAGCGGGCCCACGTCCTGG
AAGGCCTCCTCATCGCCCTGGACCACATTGACGAGGTCATCGCCCTGATCCGCGGCTCCGAGGACGCCCCCAAGGCCCGC
ATCGCCCTCATGGAACGCTTCGGCCTCTCCGAGGCCCAGGCCCAGGCCATCCTGGACATGCGCCTCCAGCGCCTCGTGGC
CTTGGAACGGGAGAAGCTTTTGGAGGAGTACCGGGGGCTCATGGAGGAGATCGCCCGCCTGAAGGCGATCCTCGAGGACG
AGGCCCGCCTCCTCGCCGAGGTCAAGGCCGACCTCCTCCGGGTCAAGGAGAAGTACGGGGACGCGCGGCGCACCCTCATC
ACCGAGTTTGAGGAGACCTTCAACCCCGAGGACCTGATTGAGGACGAGCCCATGGTCATCACCCTCACGGCCCAGGGCTT
CCTCAAGCGCCTCCCCCTGGAGAGCTACCGGGCCCAGGGCCGGGGGGGGAAGGGCCTTTTGGCGGGCAGGACCAAGGAGG
AAGACGAGGCCACCCACGTCTTCGTGGCCGACGCCCACGACGACCTCCTCCTCTTCACGAACCGGGGCCGGGTCTACCGC
CTCAAGGTCTACGAGCTTCCCGAGATGGGCCGCCAGGCCCGGGGCGTCCACGTGAAAAGCCTCCTCCCCCTCGCCGAGGA
CGAGGAGGTGGCGGCCCTCCTCTCCGTGCGGGGCCTGGACCAGGAAGGCTACCTGGTCTTCGCCACCGAGCGGGGCCTCG
TCAAGCGCACCGCCCTCAAGGAGTACCAGAACCTGGGCCAGGCGGGCCTCATCGCCATAAGGCTCCAGGAGGGGGACCGC
CTGGTGGGGGTCGCCCTCTCCGATCCCGAGGACGAGGCCATCCTGGCCACCCAAGAGGGCCAGGCCATCCGCTTCCCCCT
GGAGGAGGTGCGGGCCACGGGCCGGGACACCCAAGGGGTGATCGGCGTCCGCTTCAAGAAGCCCGAGGACCGCGTGGTCT
CCCTGGTGGTGGTGAAGCCCGGGGAGATGGTGGACCTCCTCTCCGTGAGCACCCGGGGCTACGGCAAGCGCACCCCCCTT
TCCGAGTACCCCCTCCAGGGCCGGGGCGGGATGGGGGTCATCACCTACGCCGTCTCCACCAAGGTGGGGAGGCTCGCCGC
CCTGCTCAAGGTCCGGGGCGGGGAGGACCTCCTGGTCCTCTCCCGTAGGGGCCTCGCCATCCGCACCCCCGTGGCCGAGA
TCCGGCAGTACTCCCGGGCCACCGCCGGCGTCAGGGTGATGAACCTCCCGGAGGACGACGAGGTGGCGAGCGCCTTCGTG
GTGGAGGAGGAAAAGTGA

Upstream 100 bases:

>100_bases
GGAGGTAGGGGGCGAAGGTTTCTGAATTTCTTCCCGTTTATTCGCAAAGCCCCCCGGTGCTATAATGGAAGACGGCGTCT
AAACGCCTTCTAGGAGCGCT

Downstream 100 bases:

>100_bases
TGGAAGAGGTCGTGCTCATCACGGTGCCGAGCGAGGAGGTGGCGAGGACCATCGCCAAGGCCCTGGTGGAGGAGCGCTTG
GCCGCCTGCGTGAACATCGT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAA
IYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIP
NLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAK
VRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQ
TSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKAR
IALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLI
TEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYR
LKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDR
LVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPL
SEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFV
VEEEK

Sequences:

>Translated_805_residues
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAA
IYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIP
NLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAK
VRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQ
TSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKAR
IALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLI
TEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYR
LKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDR
LVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPL
SEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFV
VEEEK
>Mature_804_residues
AQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAI
YDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPN
LLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKV
RVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQT
SFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARI
ALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLIT
EFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYRL
KVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRL
VGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPLS
EYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFVV
EEEK

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=358, Percent_Identity=25.9776536312849, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=364, Percent_Identity=24.7252747252747, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1788562, Length=831, Percent_Identity=48.9771359807461, Blast_Score=763, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=714, Percent_Identity=36.9747899159664, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17535065, Length=178, Percent_Identity=31.4606741573034, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=191, Percent_Identity=29.8429319371728, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=466, Percent_Identity=23.175965665236, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=186, Percent_Identity=28.494623655914, Blast_Score=73, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=236, Percent_Identity=29.2372881355932, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=24.7252747252747, Blast_Score=83, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89121; Mature: 88990

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHV
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHH
ARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPP
HHCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
HNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAK
CCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEE
VRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIEL
EEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
KRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSL
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
RLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
TEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHV
HHHHHCCCHHHHCCCCCEEEEEEHHHHHHHCCCHHHHCCCCCCCCEECCCCCCCCCCCEE
FVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLD
EEEECCCCEEEEECCCCEEEEEEECCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHCCCC
QEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEG
CCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCEEEEECCC
QAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPL
CEEECCHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEHHHHCCCCCCCCCCC
SEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRA
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHH
TAGVRVMNLPEDDEVASAFVVEEEK
HCCEEEEECCCCHHHHEEEEEECCC
>Mature Secondary Structure 
AQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHV
CCEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHH
ARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPP
HHCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
HNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAK
CCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEE
VRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIEL
EEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
KRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSL
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
RLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
TEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHV
HHHHHCCCHHHHCCCCCEEEEEEHHHHHHHCCCHHHHCCCCCCCCEECCCCCCCCCCCEE
FVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLD
EEEECCCCEEEEECCCCEEEEEEECCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHCCCC
QEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEG
CCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCEEEEECCC
QAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPL
CEEECCHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEHHHHCCCCCCCCCCC
SEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRA
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHH
TAGVRVMNLPEDDEVASAFVVEEEK
HCCEEEEECCCCHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]