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The map label for this gene is aroQ

Identifier: 55981323

GI number: 55981323

Start: 1294002

End: 1294451

Strand: Direct

Name: aroQ

Synonym: TTHA1354

Alternate gene names: 55981323

Gene position: 1294002-1294451 (Clockwise)

Preceding gene: 55981322

Following gene: 55981324

Centisome position: 69.96

GC content: 68.22

Gene sequence:

>450_bases
ATGGTCCTCATCCTGAACGGCCCCAACCTGAACCTTCTGGGCAGGCGGGAACCCGAGGTCTACGGGCGCACCACCCTGGA
GGAGCTCGAGGCCCTCTGCGAGGCCTGGGGGGCGGAGCTCGGCCTCGGGGTGGTCTTCCGGCAGACGAACTACGAAGGCC
AGCTCATTGAGTGGGTGCAGCAGGCCCACCAGGAGGGGTTCTTGGCCATCGTCCTCAACCCCGGGGCGCTCACCCACTAC
TCCTACGCCCTCCTGGACGCCATCCGTGCCCAACCCCTCCCCGTGGTGGAGGTCCACCTCACCAACCTCCACGCCCGGGA
GGAGTTCCGCCGCCACTCCGTGACCGCTCCGGCCTGCCGGGGGATCGTCTCCGGCTTCGGGCCCCTCTCCTACAAGCTCG
CCCTGGTCTACCTGGCGGAAACCCTGGAGGTAGGGGGCGAAGGTTTCTGA

Upstream 100 bases:

>100_bases
CCGCCCCTACGACTTCTTCCCCTTCACCCACCACGTGGAGGTCCTCTCCCTGCTCCGCCTTTAGCCGGCCCGGGGTATCC
TGGAAGGCAAAGGAGCCCCC

Downstream 100 bases:

>100_bases
ATTTCTTCCCGTTTATTCGCAAAGCCCCCCGGTGCTATAATGGAAGACGGCGTCTAAACGCCTTCTAGGAGCGCTATGGC
CCAGGTACTGCCTGTAGAAA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type II DHQase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQQAHQEGFLAIVLNPGALTHY
SYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACRGIVSGFGPLSYKLALVYLAETLEVGGEGF

Sequences:

>Translated_149_residues
MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQQAHQEGFLAIVLNPGALTHY
SYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACRGIVSGFGPLSYKLALVYLAETLEVGGEGF
>Mature_149_residues
MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQQAHQEGFLAIVLNPGALTHY
SYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACRGIVSGFGPLSYKLALVYLAETLEVGGEGF

Specific function: Catalyzes a trans-dehydration via an enolate intermediate

COG id: COG0757

COG function: function code E; 3-dehydroquinate dehydratase II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-II 3-dehydroquinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROQ_THET2 (Q72IZ2)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004958.1
- ProteinModelPortal:   Q72IZ2
- SMR:   Q72IZ2
- STRING:   Q72IZ2
- GeneID:   2776264
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0757
- HOGENOM:   HBG284657
- OMA:   IMVINGP
- ProtClustDB:   PRK05395
- BioCyc:   TTHE262724:TT_C0989-MONOMER
- HAMAP:   MF_00169
- InterPro:   IPR001874
- InterPro:   IPR018509
- Gene3D:   G3DSA:3.40.50.9100
- PANTHER:   PTHR21272
- PIRSF:   PIRSF001399
- ProDom:   PD004527
- TIGRFAMs:   TIGR01088

Pfam domain/function: PF01220 DHquinase_II; SSF52304 DHquinase_II

EC number: =4.2.1.10

Molecular weight: Translated: 16454; Mature: 16454

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01029 DEHYDROQUINASE_II

Important sites: ACT_SITE 21-21 ACT_SITE 99-99 BINDING 73-73 BINDING 79-79 BINDING 86-86 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQ
CEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
QAHQEGFLAIVLNPGALTHYSYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACR
HHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHH
GIVSGFGPLSYKLALVYLAETLEVGGEGF
HHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVLILNGPNLNLLGRREPEVYGRTTLEELEALCEAWGAELGLGVVFRQTNYEGQLIEWVQ
CEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
QAHQEGFLAIVLNPGALTHYSYALLDAIRAQPLPVVEVHLTNLHAREEFRRHSVTAPACR
HHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHH
GIVSGFGPLSYKLALVYLAETLEVGGEGF
HHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA