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The map label for this gene is folC [H]

Identifier: 55981309

GI number: 55981309

Start: 1279845

End: 1281017

Strand: Reverse

Name: folC [H]

Synonym: TTHA1340

Alternate gene names: 55981309

Gene position: 1281017-1279845 (Counterclockwise)

Preceding gene: 55981310

Following gene: 55981297

Centisome position: 69.25

GC content: 73.4

Gene sequence:

>1173_bases
GTGACCTACGAGGAGGCTTTGGCCTGGCTCTACGCGAGGCGGCGCACGGGGGAGCGGGGGACCCATAGGGTGCGGGCCCT
CCTCGCCCGGCTCGGCCACCCGGAGGCGGGCTTCCTTGCGGTCCACGTCCTGGGGACCAACGGGAAGGGGAGCGTGGTGG
CCTACCTCGAGGCCGCCTTCCGCGCCGCGGGCCTCGCCTACGGGGCCTACACCAGCCCCCACCTCGTGGACTTCCGAGAG
AGGATCCGCACCCACCTGGGGCCCGTCCCCCGGGAGGCGGTGGTCCGGTTCGTGGCCTGGGCGAGGGAGGAGGCCTGGGA
GGAGCCCCCGGGCTTCTTTGACCTGGCCACCGCCCTCGCCTTCCTCCACTTCCGGGAGAGGGGGGTGGCGCTGGCCGCGG
TGGAGGCGGGGGTAGGGGGGGAGAAGGACGCGACGAACGCCCTTTCCCGCGTGGCCCTCACCGTGCTCACCAACGTGGGG
GAGGACCACCTCGAGGCCCTGGGGGGTACCCTCGAGGCCGTGGCCCGGGAGAAGGCGGGGGCCTTCCGCCCTGGGGTGCC
GGTGGTCACGGGGGCGAGGGGGGTGGGGCTGGAGGTGGCCCGCAAGGTGGCGGAAGAACGGGGGGCGCCCCTTTACGTCC
TGGACCCCGAGGACCCCCTCTTCGCCCTTCCCGCCCCGCCCGGCCTCAGGGGGGCCTACCAGGAGGAAAACGCCCGCCTG
GCCGCCGCCGCCCTGAGGCTTTTGGGCCTTCCCGAGGCGGCCATTGCCCGGGGGCTTCGGGAGGCGCGGCACCCGGGGCG
CATGGAGCGCTTCCTCCTTAAGGGGGTGGAGGTCTATTTGGACGGGGCCCACAACCCTCCGGCGGCGGAGGCCCTGGCCC
GGGAGTTTTCCGCCTACCACCTGGTCTTTGGCGCCTTTCCCCGGAAGGACGTGAAGGGCGTCCTCGCCCACCTCCTCCCC
AAGGCGCGAAGCGTCCGCTACGCCCGGGCGGGGGAAGGGGCCTTGGGCGGGGAGCTCGGGACCCCCTTCTTTGAGGACCC
CTGGGAGGCCCTGGAGGACGCCTTGGCGAGGGCGAGGGAGGACGGGCTTCCGGTTTTGGCCACGGGCTCCCTGTACCTGG
TGGGGAGGCTCAGGGAGCGTTTAGTCGCGGGCCTCGGCGAGGACCTTCCCTGA

Upstream 100 bases:

>100_bases
CCGCAAGGGGAGGCTCGTGGAGGAGGGGAGCCACGAGGAGCTTCTGGCCAAGGGCGGCTACTACGCCGCCTTGTACCGGC
TCCAGTTCCAGGAGGCGTGA

Downstream 100 bases:

>100_bases
GGTGTCGGCGAAGACCACGCGGCGCACCTTCTGGAGCTCCAAAACCACGTAGGGGCTGGTGAGGGCCTGGGTGGTGATGG
CCCCGGGCTTGGGCGCGCCG

Product: folyl-polyglutamate synthetase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTYEEALAWLYARRRTGERGTHRVRALLARLGHPEAGFLAVHVLGTNGKGSVVAYLEAAFRAAGLAYGAYTSPHLVDFRE
RIRTHLGPVPREAVVRFVAWAREEAWEEPPGFFDLATALAFLHFRERGVALAAVEAGVGGEKDATNALSRVALTVLTNVG
EDHLEALGGTLEAVAREKAGAFRPGVPVVTGARGVGLEVARKVAEERGAPLYVLDPEDPLFALPAPPGLRGAYQEENARL
AAAALRLLGLPEAAIARGLREARHPGRMERFLLKGVEVYLDGAHNPPAAEALAREFSAYHLVFGAFPRKDVKGVLAHLLP
KARSVRYARAGEGALGGELGTPFFEDPWEALEDALARAREDGLPVLATGSLYLVGRLRERLVAGLGEDLP

Sequences:

>Translated_390_residues
MTYEEALAWLYARRRTGERGTHRVRALLARLGHPEAGFLAVHVLGTNGKGSVVAYLEAAFRAAGLAYGAYTSPHLVDFRE
RIRTHLGPVPREAVVRFVAWAREEAWEEPPGFFDLATALAFLHFRERGVALAAVEAGVGGEKDATNALSRVALTVLTNVG
EDHLEALGGTLEAVAREKAGAFRPGVPVVTGARGVGLEVARKVAEERGAPLYVLDPEDPLFALPAPPGLRGAYQEENARL
AAAALRLLGLPEAAIARGLREARHPGRMERFLLKGVEVYLDGAHNPPAAEALAREFSAYHLVFGAFPRKDVKGVLAHLLP
KARSVRYARAGEGALGGELGTPFFEDPWEALEDALARAREDGLPVLATGSLYLVGRLRERLVAGLGEDLP
>Mature_389_residues
TYEEALAWLYARRRTGERGTHRVRALLARLGHPEAGFLAVHVLGTNGKGSVVAYLEAAFRAAGLAYGAYTSPHLVDFRER
IRTHLGPVPREAVVRFVAWAREEAWEEPPGFFDLATALAFLHFRERGVALAAVEAGVGGEKDATNALSRVALTVLTNVGE
DHLEALGGTLEAVAREKAGAFRPGVPVVTGARGVGLEVARKVAEERGAPLYVLDPEDPLFALPAPPGLRGAYQEENARLA
AAALRLLGLPEAAIARGLREARHPGRMERFLLKGVEVYLDGAHNPPAAEALAREFSAYHLVFGAFPRKDVKGVLAHLLPK
ARSVRYARAGEGALGGELGTPFFEDPWEALEDALARAREDGLPVLATGSLYLVGRLRERLVAGLGEDLP

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=296, Percent_Identity=34.4594594594595, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI66932990, Length=296, Percent_Identity=34.4594594594595, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788654, Length=401, Percent_Identity=31.9201995012469, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17553150, Length=303, Percent_Identity=32.013201320132, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17553148, Length=303, Percent_Identity=32.013201320132, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71984923, Length=303, Percent_Identity=32.013201320132, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323760, Length=420, Percent_Identity=28.3333333333333, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324815, Length=333, Percent_Identity=30.9309309309309, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24641571, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581568, Length=177, Percent_Identity=31.638418079096, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 41922; Mature: 41791

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYEEALAWLYARRRTGERGTHRVRALLARLGHPEAGFLAVHVLGTNGKGSVVAYLEAAF
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHH
RAAGLAYGAYTSPHLVDFRERIRTHLGPVPREAVVRFVAWAREEAWEEPPGFFDLATALA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FLHFRERGVALAAVEAGVGGEKDATNALSRVALTVLTNVGEDHLEALGGTLEAVAREKAG
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
AFRPGVPVVTGARGVGLEVARKVAEERGAPLYVLDPEDPLFALPAPPGLRGAYQEENARL
CCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHH
AAAALRLLGLPEAAIARGLREARHPGRMERFLLKGVEVYLDGAHNPPAAEALAREFSAYH
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHH
LVFGAFPRKDVKGVLAHLLPKARSVRYARAGEGALGGELGTPFFEDPWEALEDALARARE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DGLPVLATGSLYLVGRLRERLVAGLGEDLP
CCCCEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TYEEALAWLYARRRTGERGTHRVRALLARLGHPEAGFLAVHVLGTNGKGSVVAYLEAAF
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHH
RAAGLAYGAYTSPHLVDFRERIRTHLGPVPREAVVRFVAWAREEAWEEPPGFFDLATALA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FLHFRERGVALAAVEAGVGGEKDATNALSRVALTVLTNVGEDHLEALGGTLEAVAREKAG
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
AFRPGVPVVTGARGVGLEVARKVAEERGAPLYVLDPEDPLFALPAPPGLRGAYQEENARL
CCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHH
AAAALRLLGLPEAAIARGLREARHPGRMERFLLKGVEVYLDGAHNPPAAEALAREFSAYH
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHH
LVFGAFPRKDVKGVLAHLLPKARSVRYARAGEGALGGELGTPFFEDPWEALEDALARARE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DGLPVLATGSLYLVGRLRERLVAGLGEDLP
CCCCEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8419299; 9384377; 2553669 [H]