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The map label for this gene is ilvD [H]

Identifier: 55981203

GI number: 55981203

Start: 1171126

End: 1172793

Strand: Direct

Name: ilvD [H]

Synonym: TTHA1234

Alternate gene names: 55981203

Gene position: 1171126-1172793 (Clockwise)

Preceding gene: 55981202

Following gene: 55981214

Centisome position: 63.31

GC content: 69.72

Gene sequence:

>1668_bases
ATGAGGTCGGACCAGATCAAGAAGGGACTCAAGCAGGCCCCCGCCCGCGCCATGCTCCGGGCGGTGGGGGTAGGGGACGA
GGACTTCGGAAGGCCCTTCGTGGGGGTGGTGAACACCTTCACCGACGGGATGCCCTGCAACTTCCACCTGCGGGAGCTGG
CCCAGCACCTCAAGGCCGGGCTCAAGGAGGCGGGGCTTTTCCCCTTTGAGTTCGGGGCTCCCGCCATCTCCGACGGGATC
AGCATGGGCACCCCGGGCATGCGGGCGAGCCTCGTAAGCCGCGAGGTCATCGCCGACAGCGTGGAGCTCATCGCCCAGGG
CTACCTCTACGACGGCATGGTGGGGCTTTCCGCCTGCGACAAGACCATCCCGGGAACGGCCATGGGGGTGATCCGCAGCG
GCGTCCCCGGCATGATCCTCTACGGGGGGACGATCGCCCCCGGGGAGTGGCAAGGCCGGAAGCTCACCATCGTGGAGGTC
TTTGAGGCGGTGGGGCAAAGGGCCGCGGGGAAGATCAGCGAGGAGGAGCTTTTGGAGATTGAACGCCGGGCCATCCCCGG
CCCCGGGGCCTGCGGCGGCCAGTACACCGCCAACACCATGGCCATGGCCCTCGAGGCCCTGGGCCTCTCCCCCGTGGGCT
ACAACGCCATCCCCGCCGTCCACCCCGAAAAGGAGCGGGCCACCAAGGAGGCGGGGAAAATCCTCGCCTGGGCCATCGCC
CACGACTGGAAGCCCAAGGACTTCCTCACCCGGAAAAGCTTCCTCAACGCCATCGCCGCCGTGGCCGCCACGGGGGGGAG
CACCAACGCCGTCCTCCACCTCCTCGCCCTGGCCAAGGAAGCGGGGGTGGAGCTCAGCCTGGACGACTTTGACCAGATTT
CCCGCAAGACCCCGGTGATCGCGGACCTCCGCCCTTGGGGCACCTACACCGCCTGGGAGCTCTACGAAGCCGGGGGGACA
GCCCTCGTCTTCAAGCGGCTTCTGGAGGCGGGGCTCCTCTTTGGGGAGGAGAAGACCCTCACGGGCCGCACCCTGGCGGA
GGAGGTGGAGCGGGCCTACCGGGAACAAGAGGGGCAGAAGGTGGTCTTCCCCGTGGAGAAGGCCCTCAAGCCCCACGGGG
GGCTCGTGGTGCTCAAGGGAAACCTCGCCCCTAAAGGCGCCGTCCTCAAGCTCGCGGGGACGGAGCGCACCTACTTTGAG
GGCCCGGCCCGGGTCTTTGACTCGGAGGAGGCGGCCATGGAGAAGGTCCTGAAGGGGGAGATCCGGCCTGGGGACGTGGT
GGTCATCCGCTACGTGGGCCCCAAGGGGGCACCGGGGATGCCCGAGATGCTCTCGGTGACGAGCGCCATCGTGGGGGAAG
GCCTGGGGCCGGAGGTGGCCCTCCTCACCGACGGCCGCTTCTCCGGGGGCACCCGCGGCCTCATGATCGGCCACATCGCC
CCCGAGGCCTTCGTGGGCGGGCCCATCGCCCTCCTGGAGGAGGGGGACCGCATCCGGATTGACGTGGAAGGCCGCCGCCT
CGAGGTCCTCCTCCCCGAGGAGGAGCTGGAAAGGCGGAGGGCCCGCTGGCGGCCCCGACCCCCCGCCTTCACCCACGGCC
TCTTCGCCCGCTACGCCGCCCTGGTGCGCCAGGCGGACGAGGGGGCGGTGCTGGAAGACCCGCTCTAG

Upstream 100 bases:

>100_bases
AAGGCCTCCTCCTCACCCCGGAGGAGGCCGCGAGGGCCCTGGTGCGGCTTCTCCCCAAGGCCAGGGCCTTCCACGGAAAG
ATCGCCACCTGGAGGGACGC

Downstream 100 bases:

>100_bases
GGCCTCTGGATCCGGTCCGGGGCCAGGTTCTGGCCCCGCTCCCTTTTGATGTCCTCGGGATTGAAGGGCTCGGCCCGCAC
CTTGAGGAGGGCCATGAGGT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MRSDQIKKGLKQAPARAMLRAVGVGDEDFGRPFVGVVNTFTDGMPCNFHLRELAQHLKAGLKEAGLFPFEFGAPAISDGI
SMGTPGMRASLVSREVIADSVELIAQGYLYDGMVGLSACDKTIPGTAMGVIRSGVPGMILYGGTIAPGEWQGRKLTIVEV
FEAVGQRAAGKISEEELLEIERRAIPGPGACGGQYTANTMAMALEALGLSPVGYNAIPAVHPEKERATKEAGKILAWAIA
HDWKPKDFLTRKSFLNAIAAVAATGGSTNAVLHLLALAKEAGVELSLDDFDQISRKTPVIADLRPWGTYTAWELYEAGGT
ALVFKRLLEAGLLFGEEKTLTGRTLAEEVERAYREQEGQKVVFPVEKALKPHGGLVVLKGNLAPKGAVLKLAGTERTYFE
GPARVFDSEEAAMEKVLKGEIRPGDVVVIRYVGPKGAPGMPEMLSVTSAIVGEGLGPEVALLTDGRFSGGTRGLMIGHIA
PEAFVGGPIALLEEGDRIRIDVEGRRLEVLLPEEELERRRARWRPRPPAFTHGLFARYAALVRQADEGAVLEDPL

Sequences:

>Translated_555_residues
MRSDQIKKGLKQAPARAMLRAVGVGDEDFGRPFVGVVNTFTDGMPCNFHLRELAQHLKAGLKEAGLFPFEFGAPAISDGI
SMGTPGMRASLVSREVIADSVELIAQGYLYDGMVGLSACDKTIPGTAMGVIRSGVPGMILYGGTIAPGEWQGRKLTIVEV
FEAVGQRAAGKISEEELLEIERRAIPGPGACGGQYTANTMAMALEALGLSPVGYNAIPAVHPEKERATKEAGKILAWAIA
HDWKPKDFLTRKSFLNAIAAVAATGGSTNAVLHLLALAKEAGVELSLDDFDQISRKTPVIADLRPWGTYTAWELYEAGGT
ALVFKRLLEAGLLFGEEKTLTGRTLAEEVERAYREQEGQKVVFPVEKALKPHGGLVVLKGNLAPKGAVLKLAGTERTYFE
GPARVFDSEEAAMEKVLKGEIRPGDVVVIRYVGPKGAPGMPEMLSVTSAIVGEGLGPEVALLTDGRFSGGTRGLMIGHIA
PEAFVGGPIALLEEGDRIRIDVEGRRLEVLLPEEELERRRARWRPRPPAFTHGLFARYAALVRQADEGAVLEDPL
>Mature_555_residues
MRSDQIKKGLKQAPARAMLRAVGVGDEDFGRPFVGVVNTFTDGMPCNFHLRELAQHLKAGLKEAGLFPFEFGAPAISDGI
SMGTPGMRASLVSREVIADSVELIAQGYLYDGMVGLSACDKTIPGTAMGVIRSGVPGMILYGGTIAPGEWQGRKLTIVEV
FEAVGQRAAGKISEEELLEIERRAIPGPGACGGQYTANTMAMALEALGLSPVGYNAIPAVHPEKERATKEAGKILAWAIA
HDWKPKDFLTRKSFLNAIAAVAATGGSTNAVLHLLALAKEAGVELSLDDFDQISRKTPVIADLRPWGTYTAWELYEAGGT
ALVFKRLLEAGLLFGEEKTLTGRTLAEEVERAYREQEGQKVVFPVEKALKPHGGLVVLKGNLAPKGAVLKLAGTERTYFE
GPARVFDSEEAAMEKVLKGEIRPGDVVVIRYVGPKGAPGMPEMLSVTSAIVGEGLGPEVALLTDGRFSGGTRGLMIGHIA
PEAFVGGPIALLEEGDRIRIDVEGRRLEVLLPEEELERRRARWRPRPPAFTHGLFARYAALVRQADEGAVLEDPL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=605, Percent_Identity=37.5206611570248, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788157, Length=510, Percent_Identity=31.7647058823529, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI2367371, Length=520, Percent_Identity=31.7307692307692, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1786464, Length=524, Percent_Identity=31.8702290076336, Blast_Score=171, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=549, Percent_Identity=46.6302367941712, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59491; Mature: 59491

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDQIKKGLKQAPARAMLRAVGVGDEDFGRPFVGVVNTFTDGMPCNFHLRELAQHLKAG
CCCHHHHHHHHHCHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LKEAGLFPFEFGAPAISDGISMGTPGMRASLVSREVIADSVELIAQGYLYDGMVGLSACD
HHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHC
KTIPGTAMGVIRSGVPGMILYGGTIAPGEWQGRKLTIVEVFEAVGQRAAGKISEEELLEI
CCCCCHHHHHHHCCCCCEEEECCEECCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHH
ERRAIPGPGACGGQYTANTMAMALEALGLSPVGYNAIPAVHPEKERATKEAGKILAWAIA
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEC
HDWKPKDFLTRKSFLNAIAAVAATGGSTNAVLHLLALAKEAGVELSLDDFDQISRKTPVI
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHCCCCCE
ADLRPWGTYTAWELYEAGGTALVFKRLLEAGLLFGEEKTLTGRTLAEEVERAYREQEGQK
EECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCE
VVFPVEKALKPHGGLVVLKGNLAPKGAVLKLAGTERTYFEGPARVFDSEEAAMEKVLKGE
EEEEHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCC
IRPGDVVVIRYVGPKGAPGMPEMLSVTSAIVGEGLGPEVALLTDGRFSGGTRGLMIGHIA
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECC
PEAFVGGPIALLEEGDRIRIDVEGRRLEVLLPEEELERRRARWRPRPPAFTHGLFARYAA
CHHHCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVRQADEGAVLEDPL
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MRSDQIKKGLKQAPARAMLRAVGVGDEDFGRPFVGVVNTFTDGMPCNFHLRELAQHLKAG
CCCHHHHHHHHHCHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LKEAGLFPFEFGAPAISDGISMGTPGMRASLVSREVIADSVELIAQGYLYDGMVGLSACD
HHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHC
KTIPGTAMGVIRSGVPGMILYGGTIAPGEWQGRKLTIVEVFEAVGQRAAGKISEEELLEI
CCCCCHHHHHHHCCCCCEEEECCEECCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHH
ERRAIPGPGACGGQYTANTMAMALEALGLSPVGYNAIPAVHPEKERATKEAGKILAWAIA
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEC
HDWKPKDFLTRKSFLNAIAAVAATGGSTNAVLHLLALAKEAGVELSLDDFDQISRKTPVI
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHCCCCCE
ADLRPWGTYTAWELYEAGGTALVFKRLLEAGLLFGEEKTLTGRTLAEEVERAYREQEGQK
EECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCE
VVFPVEKALKPHGGLVVLKGNLAPKGAVLKLAGTERTYFEGPARVFDSEEAAMEKVLKGE
EEEEHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCC
IRPGDVVVIRYVGPKGAPGMPEMLSVTSAIVGEGLGPEVALLTDGRFSGGTRGLMIGHIA
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECC
PEAFVGGPIALLEEGDRIRIDVEGRRLEVLLPEEELERRRARWRPRPPAFTHGLFARYAA
CHHHCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVRQADEGAVLEDPL
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA