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The map label for this gene is leuD [H]

Identifier: 55981198

GI number: 55981198

Start: 1167680

End: 1168285

Strand: Direct

Name: leuD [H]

Synonym: TTHA1229

Alternate gene names: 55981198

Gene position: 1167680-1168285 (Clockwise)

Preceding gene: 55981197

Following gene: 55981199

Centisome position: 63.13

GC content: 65.35

Gene sequence:

>606_bases
ATGCTGGAGAAGTTCACCGTGATCCGCGGAAAAGCGGTGCCCTTGAGGGGCGAGGACATTGACACGGACCGGATCCTCCC
CGCCCGCTTCATGAAGGTCCTCACCTTTGAGGGCCTGGGGCAGTACCTCTTCTACGACGAGCGCTTTGACGAGAAGGGGA
ACCCCAAGCCCCACCCCCTGAACGACCCCCGCTACCGGGGGGCCACGATCCTCTTGGTGGAGTCGGGCTTCGGCTCCGGC
TCTAGCCGCGAGCACGCCCCCCAGGCCATCAAGCGGGCGGGGTTTAAGGCCATCATCGGGGAGAGCTTCGCCGAGATCTT
CTTCGGGAACGCCACCGCCATCGGCCTCCCCTGCGTGAGCCTAGCCCCTGAGGACCTGGGCGTCCTCTTCCGCAGCGTGG
AGGAGAACCCGGAGCTGGAGGTGGAGATTGACCTGGTGAACAAAGAGGTGCGCTTCGGGGACCGCACCGCTCCCCTCTTC
ATCCGGGAAGAGGCCCGGGAGGCCCTGGTGGAGGGGCTTTGGGATCCCATCGGGGAGCTTCTGGAGGCCGGGGAGCTTTT
GGACCAGTTTGACCGGAAGCTCCCCTACCCCAGGAGGACGGAATGA

Upstream 100 bases:

>100_bases
ATGAGCCCCCTCATGGTGGCGGCGGCGGCCGTGGCCGGGGAGATCGCCGACGCCCGGGAGGTCTTCGGCCTGGCGGGCGT
CCGCTGAGGAGGGAAAAGCC

Downstream 100 bases:

>100_bases
AGGTGGCCGTGCTCCCCGGGGACGGGATCGGCCCCGAGGTCACCGAGGCCGCCCTGAAGGTCCTGAGGGCCCTGGACGAG
GCCGAGGGCCTGGGCCTCGC

Product: isopropylmalate isomerase small subunit

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLEKFTVIRGKAVPLRGEDIDTDRILPARFMKVLTFEGLGQYLFYDERFDEKGNPKPHPLNDPRYRGATILLVESGFGSG
SSREHAPQAIKRAGFKAIIGESFAEIFFGNATAIGLPCVSLAPEDLGVLFRSVEENPELEVEIDLVNKEVRFGDRTAPLF
IREEAREALVEGLWDPIGELLEAGELLDQFDRKLPYPRRTE

Sequences:

>Translated_201_residues
MLEKFTVIRGKAVPLRGEDIDTDRILPARFMKVLTFEGLGQYLFYDERFDEKGNPKPHPLNDPRYRGATILLVESGFGSG
SSREHAPQAIKRAGFKAIIGESFAEIFFGNATAIGLPCVSLAPEDLGVLFRSVEENPELEVEIDLVNKEVRFGDRTAPLF
IREEAREALVEGLWDPIGELLEAGELLDQFDRKLPYPRRTE
>Mature_201_residues
MLEKFTVIRGKAVPLRGEDIDTDRILPARFMKVLTFEGLGQYLFYDERFDEKGNPKPHPLNDPRYRGATILLVESGFGSG
SSREHAPQAIKRAGFKAIIGESFAEIFFGNATAIGLPCVSLAPEDLGVLFRSVEENPELEVEIDLVNKEVRFGDRTAPLF
IREEAREALVEGLWDPIGELLEAGELLDQFDRKLPYPRRTE

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786258, Length=199, Percent_Identity=41.7085427135678, Blast_Score=142, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321429, Length=200, Percent_Identity=33, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004431
- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 22622; Mature: 22622

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKFTVIRGKAVPLRGEDIDTDRILPARFMKVLTFEGLGQYLFYDERFDEKGNPKPHPL
CCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCC
NDPRYRGATILLVESGFGSGSSREHAPQAIKRAGFKAIIGESFAEIFFGNATAIGLPCVS
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCHHH
LAPEDLGVLFRSVEENPELEVEIDLVNKEVRFGDRTAPLFIREEAREALVEGLWDPIGEL
CCHHHHHHHHHHHCCCCCEEEEEEEECCEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LEAGELLDQFDRKLPYPRRTE
HHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLEKFTVIRGKAVPLRGEDIDTDRILPARFMKVLTFEGLGQYLFYDERFDEKGNPKPHPL
CCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCC
NDPRYRGATILLVESGFGSGSSREHAPQAIKRAGFKAIIGESFAEIFFGNATAIGLPCVS
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCHHH
LAPEDLGVLFRSVEENPELEVEIDLVNKEVRFGDRTAPLFIREEAREALVEGLWDPIGEL
CCHHHHHHHHHHHCCCCCEEEEEEEECCEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LEAGELLDQFDRKLPYPRRTE
HHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA