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The map label for this gene is ilvC

Identifier: 55981180

GI number: 55981180

Start: 1152976

End: 1153989

Strand: Reverse

Name: ilvC

Synonym: TTHA1211

Alternate gene names: 55981180

Gene position: 1153989-1152976 (Counterclockwise)

Preceding gene: 55981181

Following gene: 55981179

Centisome position: 62.39

GC content: 68.24

Gene sequence:

>1014_bases
ATGAAGATCTACTACGAGCACGACGCGGACCTTGGCTTCATCCTGGGCAAGAAGGTGGCGGTCTTGGGCTTCGGCTCCCA
GGGGCACGCCCACGCCCTGAACCTCAAGGACTCGGGGGTGGACGTGCGCGTGGGCCTGCGCAAAGGGTCTAGGAGCTGGG
AGAAGGCGGAGGCCGCCGGGCTTAGGGTCCTCCCCGTGGCCGAGGCGGTGCGGGAGGCCGACGTCGTCATGGTCCTCCTC
CCCGACGAGAAGCAGGCCCAGGTCTACCGGGAGGAGGTGGAGCCCAACCTCAAGGAGGGCGGGGCCCTGGCCTTCGCCCA
CGGCTTCAACGTCCACTTCGGCCAGATCAAGCCCCGCAAGGACCTGGACGTCTGGATGGTGGCCCCCAAGGGCCCGGGCC
ACTTGGTGCGCTCGGAGTACCAGAAGGGAAGCGGGGTCCCGGCCCTCGTGGCCGTGCACCAGGACGCCTCGGGAAGCGCC
TTCCCCACCGCCCTCGCCTACGCCAAGGCCATCGGGGCGGCCCGGGCCGGGGTCATCGCCACCACCTTCAAGGACGAGAC
GGAGACGGACCTCTTCGGGGAGCAGGCGGTGCTTTGCGGGGGGCTCACCCGGCTCATCCGGGCGGGGTTTGAGACCCTGG
TGGAGGCGGGCTACCCCCCGGAGATGGCCTACTTTGAGACCGTCCACGAGGTGAAGCTCATCGTGGACCTCATCTACGAG
GCGGGGCTTAAGGGGATGCGCTACTCCATCTCCAACACCGCCGAGTACGGGGACTACACCCGGGGCGACCTCGCCGTGCC
CCTGGAGGAGACCAAGCGCCGCATGCGGGAGATCCTGCGCCAGATCCAGTCCGGGGAGTTCGCCCGGGAGTGGATGCTGG
AGAACCAGGTGGGAAGCCCGGTTCTGGAGGCCAACCGCAAGCGCTGGGCGGCCCACCCCATTGAGGAGGTGGGCTCGAGG
CTTCGCGCCATGATGCCCTTCCTCAAGGCCAGGGTAATGGAGGAGGTAGGCTAA

Upstream 100 bases:

>100_bases
CCTTGAGACCCTACGGGATCCTCGAGGTCATGCGCACCGGCGCGGTGGCCATGAGCCGGGGAGACCGGGTCTTGAAGGTG
CGGGAGAAGAAGGAGGCGGT

Downstream 100 bases:

>100_bases
GGGCTTGGACGGGGCCCCTTCGGGGGCCCCTGTGCGCTTTTAGGGAGGTGAAGGAAGATGGAGAAGGAACGGCACATCCG
GATCTTTGACACCACGCTCA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIYYEHDADLGFILGKKVAVLGFGSQGHAHALNLKDSGVDVRVGLRKGSRSWEKAEAAGLRVLPVAEAVREADVVMVLL
PDEKQAQVYREEVEPNLKEGGALAFAHGFNVHFGQIKPRKDLDVWMVAPKGPGHLVRSEYQKGSGVPALVAVHQDASGSA
FPTALAYAKAIGAARAGVIATTFKDETETDLFGEQAVLCGGLTRLIRAGFETLVEAGYPPEMAYFETVHEVKLIVDLIYE
AGLKGMRYSISNTAEYGDYTRGDLAVPLEETKRRMREILRQIQSGEFAREWMLENQVGSPVLEANRKRWAAHPIEEVGSR
LRAMMPFLKARVMEEVG

Sequences:

>Translated_337_residues
MKIYYEHDADLGFILGKKVAVLGFGSQGHAHALNLKDSGVDVRVGLRKGSRSWEKAEAAGLRVLPVAEAVREADVVMVLL
PDEKQAQVYREEVEPNLKEGGALAFAHGFNVHFGQIKPRKDLDVWMVAPKGPGHLVRSEYQKGSGVPALVAVHQDASGSA
FPTALAYAKAIGAARAGVIATTFKDETETDLFGEQAVLCGGLTRLIRAGFETLVEAGYPPEMAYFETVHEVKLIVDLIYE
AGLKGMRYSISNTAEYGDYTRGDLAVPLEETKRRMREILRQIQSGEFAREWMLENQVGSPVLEANRKRWAAHPIEEVGSR
LRAMMPFLKARVMEEVG
>Mature_337_residues
MKIYYEHDADLGFILGKKVAVLGFGSQGHAHALNLKDSGVDVRVGLRKGSRSWEKAEAAGLRVLPVAEAVREADVVMVLL
PDEKQAQVYREEVEPNLKEGGALAFAHGFNVHFGQIKPRKDLDVWMVAPKGPGHLVRSEYQKGSGVPALVAVHQDASGSA
FPTALAYAKAIGAARAGVIATTFKDETETDLFGEQAVLCGGLTRLIRAGFETLVEAGYPPEMAYFETVHEVKLIVDLIYE
AGLKGMRYSISNTAEYGDYTRGDLAVPLEETKRRMREILRQIQSGEFAREWMLENQVGSPVLEANRKRWAAHPIEEVGSR
LRAMMPFLKARVMEEVG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=38.2252559726962, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=37.2549019607843, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_THET2 (Q72JC8)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004821.1
- ProteinModelPortal:   Q72JC8
- SMR:   Q72JC8
- STRING:   Q72JC8
- GeneID:   2775092
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- PhylomeDB:   Q72JC8
- ProtClustDB:   PRK05479
- BioCyc:   TTHE262724:TT_C0850-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37078; Mature: 37078

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYYEHDADLGFILGKKVAVLGFGSQGHAHALNLKDSGVDVRVGLRKGSRSWEKAEAAG
CEEEEECCCCEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHCC
LRVLPVAEAVREADVVMVLLPDEKQAQVYREEVEPNLKEGGALAFAHGFNVHFGQIKPRK
EEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCCC
DLDVWMVAPKGPGHLVRSEYQKGSGVPALVAVHQDASGSAFPTALAYAKAIGAARAGVIA
CCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEE
TTFKDETETDLFGEQAVLCGGLTRLIRAGFETLVEAGYPPEMAYFETVHEVKLIVDLIYE
EECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AGLKGMRYSISNTAEYGDYTRGDLAVPLEETKRRMREILRQIQSGEFAREWMLENQVGSP
HCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCH
VLEANRKRWAAHPIEEVGSRLRAMMPFLKARVMEEVG
HHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIYYEHDADLGFILGKKVAVLGFGSQGHAHALNLKDSGVDVRVGLRKGSRSWEKAEAAG
CEEEEECCCCEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHCC
LRVLPVAEAVREADVVMVLLPDEKQAQVYREEVEPNLKEGGALAFAHGFNVHFGQIKPRK
EEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCCCC
DLDVWMVAPKGPGHLVRSEYQKGSGVPALVAVHQDASGSAFPTALAYAKAIGAARAGVIA
CCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEE
TTFKDETETDLFGEQAVLCGGLTRLIRAGFETLVEAGYPPEMAYFETVHEVKLIVDLIYE
EECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AGLKGMRYSISNTAEYGDYTRGDLAVPLEETKRRMREILRQIQSGEFAREWMLENQVGSP
HCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCH
VLEANRKRWAAHPIEEVGSRLRAMMPFLKARVMEEVG
HHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA