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The map label for this gene is yqjD [H]

Identifier: 55981117

GI number: 55981117

Start: 1093080

End: 1094657

Strand: Direct

Name: yqjD [H]

Synonym: TTHA1148

Alternate gene names: 55981117

Gene position: 1093080-1094657 (Clockwise)

Preceding gene: 55981115

Following gene: 55981118

Centisome position: 59.09

GC content: 66.41

Gene sequence:

>1578_bases
ATGCCCTGGACTATGGCCGATAACGCGCGGCTCATCCTGGACGAGCTTCTGGCGGAGCTTGAGGAGAGGAGACGGCGGGT
CCTCCAGGGAGGCGGGGAGGAACGCGTCAAAAAGCAACACCAGCAGGGCAAGCTCACCGCAAGGGAGCGGATAGACCTCC
TCCTGGACCCGGGAAGCTTCGTAGAGCTCATGCCCTTCGCCGAGCACCTGGAAACCGGGCTCATGGAGGGGATAGAGGCC
CCCGCGGACGGCGTGGTGACGGGCTACGGCACCATCGGGGGGAGGCTCGTCTTCGTCTTCAGCCAGGACTTCACGGTCTT
GGGCGGCTCCCTGGGCAAGATGCACGGCCGCAAGATCGCGAGCCTCATGGACCTCGCGGCCAAGGTGGGGGCCCCCATCG
TCGGCCTGAACGACTCCGCCGGGGCCCGGATCCAAGAAGGGGTGGACAGCCTCTCGGGCTACGGGGAGGTCTTCTACCGG
AACGCCATCTACTCCGGGGTCGTCCCCCAGATCTCCGCCATCCTGGGGCCTTGCGCCGGGGGCGCCGTCTACAGCCCCGC
CATGACCGACTTCATCCTCATGAGCCGGGGCACGAGCTACATGTTCATCACCGGGCCCGAGGTGATCAAGAGCGTCACCA
AGGAGGAGGTGACCTTTGAGGAGCTCGGGGGGGCCGACGTCCACATGGAAAAAAGCGGGGTGGCCCACCTGGAGGGGAAG
GACGACAAGGAGGTCCTGGACCTCGTCAAGAAGCTCCTCTCCTACCTGCCGCAAAACAGCCGGGAAAAGCCCCCGGTGTT
GGAGCCTCAGGACGACCCCTTCCGCCCCACCCCGGAGCTTCTGGAGATCGTCCACCCCGATGCCCGCCGCCCCTACAACA
TGCACCAGGTGATCCGCACCCTCCTGGACGACGGGGAGTTTCTGGAGATCCAGCCCCGCTACGCCCGGAACATCATCGTG
GGCCTGGGGCGGCTCGGAGGGTACCCCGTGGGGGTCATCGCCAACAACCCCCGCTTCATGGCCGGGGCCCTGGACATCAA
CGCCTCAGACAAGGCGGCCCGCTTCATCCGCACCATGGACGCCTTCAACATCCCCCTCCTCACCCTGGTGGACGTGACGG
GCTTCCTGCCGGGCGTGGCCCAGGAGCACGGCGGGATCATCCGCCACGGGGCCAAGATGCTCTTCGCCTACGCCGAGGCC
ACGGTGCCCAAGATCACCCTCATCGCCCGCAAGGCCTACGGGGGGGCCTACCTCGCCATGAACTCCAAGGACATGGGGGC
GGACGTGGTCCTGGCCTGGCCCACGGCGGCGGTGGCGGTGATGGGGGCGGAGGGTGCGGCGAACATCATCTACCGCAAGG
AGATCCAGTCCTCCCAAAACCCCGAGGAGACCCGGAGGCGGAAGATTGAGGAGTACCGCCGGGCCTTTGACAACCCCTGG
GTGGCGGCGGCCAGGGGGTACATTGACGACGTCATTGACCCCACCCACACCCGGCGCGTCCTCTACCAGCACCTAAGGAT
GCTCTGGGAGAAGCAGGAGGAGAGGCCCAGGAAGAAGCACGACAACATCCCCCTGTGA

Upstream 100 bases:

>100_bases
ACCAGGACCAGGGCCAGCACCGCAGGAAGCCACCTTCTCATGCTTCACCTCCTTTCCGGGATAGGCCCAAGGTTTTCCGG
CCGTCCCCGGCCATTGTATC

Downstream 100 bases:

>100_bases
TGGACAGGGAAGCCTTCGTCCAAACCCTGACCGCCTGCCGCCTCTGCCCCAGGCTCGTGGCCTGGCGGGAGGAGGTCGTG
GGGAGAAAGCGGGCCTTCCG

Product: propionyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MPWTMADNARLILDELLAELEERRRRVLQGGGEERVKKQHQQGKLTARERIDLLLDPGSFVELMPFAEHLETGLMEGIEA
PADGVVTGYGTIGGRLVFVFSQDFTVLGGSLGKMHGRKIASLMDLAAKVGAPIVGLNDSAGARIQEGVDSLSGYGEVFYR
NAIYSGVVPQISAILGPCAGGAVYSPAMTDFILMSRGTSYMFITGPEVIKSVTKEEVTFEELGGADVHMEKSGVAHLEGK
DDKEVLDLVKKLLSYLPQNSREKPPVLEPQDDPFRPTPELLEIVHPDARRPYNMHQVIRTLLDDGEFLEIQPRYARNIIV
GLGRLGGYPVGVIANNPRFMAGALDINASDKAARFIRTMDAFNIPLLTLVDVTGFLPGVAQEHGGIIRHGAKMLFAYAEA
TVPKITLIARKAYGGAYLAMNSKDMGADVVLAWPTAAVAVMGAEGAANIIYRKEIQSSQNPEETRRRKIEEYRRAFDNPW
VAAARGYIDDVIDPTHTRRVLYQHLRMLWEKQEERPRKKHDNIPL

Sequences:

>Translated_525_residues
MPWTMADNARLILDELLAELEERRRRVLQGGGEERVKKQHQQGKLTARERIDLLLDPGSFVELMPFAEHLETGLMEGIEA
PADGVVTGYGTIGGRLVFVFSQDFTVLGGSLGKMHGRKIASLMDLAAKVGAPIVGLNDSAGARIQEGVDSLSGYGEVFYR
NAIYSGVVPQISAILGPCAGGAVYSPAMTDFILMSRGTSYMFITGPEVIKSVTKEEVTFEELGGADVHMEKSGVAHLEGK
DDKEVLDLVKKLLSYLPQNSREKPPVLEPQDDPFRPTPELLEIVHPDARRPYNMHQVIRTLLDDGEFLEIQPRYARNIIV
GLGRLGGYPVGVIANNPRFMAGALDINASDKAARFIRTMDAFNIPLLTLVDVTGFLPGVAQEHGGIIRHGAKMLFAYAEA
TVPKITLIARKAYGGAYLAMNSKDMGADVVLAWPTAAVAVMGAEGAANIIYRKEIQSSQNPEETRRRKIEEYRRAFDNPW
VAAARGYIDDVIDPTHTRRVLYQHLRMLWEKQEERPRKKHDNIPL
>Mature_524_residues
PWTMADNARLILDELLAELEERRRRVLQGGGEERVKKQHQQGKLTARERIDLLLDPGSFVELMPFAEHLETGLMEGIEAP
ADGVVTGYGTIGGRLVFVFSQDFTVLGGSLGKMHGRKIASLMDLAAKVGAPIVGLNDSAGARIQEGVDSLSGYGEVFYRN
AIYSGVVPQISAILGPCAGGAVYSPAMTDFILMSRGTSYMFITGPEVIKSVTKEEVTFEELGGADVHMEKSGVAHLEGKD
DKEVLDLVKKLLSYLPQNSREKPPVLEPQDDPFRPTPELLEIVHPDARRPYNMHQVIRTLLDDGEFLEIQPRYARNIIVG
LGRLGGYPVGVIANNPRFMAGALDINASDKAARFIRTMDAFNIPLLTLVDVTGFLPGVAQEHGGIIRHGAKMLFAYAEAT
VPKITLIARKAYGGAYLAMNSKDMGADVVLAWPTAAVAVMGAEGAANIIYRKEIQSSQNPEETRRRKIEEYRRAFDNPWV
AAARGYIDDVIDPTHTRRVLYQHLRMLWEKQEERPRKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=55.4027504911591, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=53.3081285444234, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=35.3876739562624, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI134142062, Length=405, Percent_Identity=23.4567901234568, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679971, Length=404, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679960, Length=404, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679974, Length=404, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679977, Length=404, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679967, Length=404, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788655, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=54.9212598425197, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=54.9212598425197, Blast_Score=566, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17552936, Length=500, Percent_Identity=34.2, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71997163, Length=423, Percent_Identity=23.6406619385343, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323863, Length=365, Percent_Identity=23.8356164383562, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324343, Length=363, Percent_Identity=21.763085399449, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586065, Length=528, Percent_Identity=33.1439393939394, Blast_Score=258, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57955; Mature: 57824

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWTMADNARLILDELLAELEERRRRVLQGGGEERVKKQHQQGKLTARERIDLLLDPGSF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCEEEECCCCH
VELMPFAEHLETGLMEGIEAPADGVVTGYGTIGGRLVFVFSQDFTVLGGSLGKMHGRKIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCHHHCCCHHHHHHHHHH
SLMDLAAKVGAPIVGLNDSAGARIQEGVDSLSGYGEVFYRNAIYSGVVPQISAILGPCAG
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCC
GAVYSPAMTDFILMSRGTSYMFITGPEVIKSVTKEEVTFEELGGADVHMEKSGVAHLEGK
CCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCHHHCCCCCEEECCCCCEECCCC
DDKEVLDLVKKLLSYLPQNSREKPPVLEPQDDPFRPTPELLEIVHPDARRPYNMHQVIRT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHH
LLDDGEFLEIQPRYARNIIVGLGRLGGYPVGVIANNPRFMAGALDINASDKAARFIRTMD
HHCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHH
AFNIPLLTLVDVTGFLPGVAQEHGGIIRHGAKMLFAYAEATVPKITLIARKAYGGAYLAM
HCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEE
NSKDMGADVVLAWPTAAVAVMGAEGAANIIYRKEIQSSQNPEETRRRKIEEYRRAFDNPW
CCCCCCCCEEEECCHHHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
VAAARGYIDDVIDPTHTRRVLYQHLRMLWEKQEERPRKKHDNIPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCC
>Mature Secondary Structure 
PWTMADNARLILDELLAELEERRRRVLQGGGEERVKKQHQQGKLTARERIDLLLDPGSF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCEEEECCCCH
VELMPFAEHLETGLMEGIEAPADGVVTGYGTIGGRLVFVFSQDFTVLGGSLGKMHGRKIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCHHHCCCHHHHHHHHHH
SLMDLAAKVGAPIVGLNDSAGARIQEGVDSLSGYGEVFYRNAIYSGVVPQISAILGPCAG
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCC
GAVYSPAMTDFILMSRGTSYMFITGPEVIKSVTKEEVTFEELGGADVHMEKSGVAHLEGK
CCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCHHHCCCCCEEECCCCCEECCCC
DDKEVLDLVKKLLSYLPQNSREKPPVLEPQDDPFRPTPELLEIVHPDARRPYNMHQVIRT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHH
LLDDGEFLEIQPRYARNIIVGLGRLGGYPVGVIANNPRFMAGALDINASDKAARFIRTMD
HHCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHH
AFNIPLLTLVDVTGFLPGVAQEHGGIIRHGAKMLFAYAEATVPKITLIARKAYGGAYLAM
HCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEE
NSKDMGADVVLAWPTAAVAVMGAEGAANIIYRKEIQSSQNPEETRRRKIEEYRRAFDNPW
CCCCCCCCEEEECCHHHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
VAAARGYIDDVIDPTHTRRVLYQHLRMLWEKQEERPRKKHDNIPL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]