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The map label for this gene is sbm [H]

Identifier: 55981007

GI number: 55981007

Start: 984890

End: 985318

Strand: Reverse

Name: sbm [H]

Synonym: TTHA1038

Alternate gene names: 55981007

Gene position: 985318-984890 (Counterclockwise)

Preceding gene: 55981008

Following gene: 55981006

Centisome position: 53.27

GC content: 69.46

Gene sequence:

>429_bases
ATGCAGGGCGTGGATCGGCGCATACGGGTGCTCATCGCCAAGCCGGGCCTGGACGGGCACGACCGCGGGGCCAAGGTGGT
GGCCCGGGCCCTGAGGGACGCGGGGATGGAGGTGATCTACACCGGGCTCCGCCAGACCCCGGAGATGATCGTCTCCGCCG
CCATCCAGGAGGACGTGGACGCCATCGGGCTTTCCATCCTCTCCGGGGCCCACATGCACTACTTCCGCGAGGTGAAGCGC
CTTCTGGACGAGCAGGGGGCCTCGGACATCCTCCTCTTCGGCGGAGGGATCATCCCCGACGAGGACGTGCCCAAGCTGAA
GGCGCTGGGCGTGGCCGCCGTCTTCGGTCCCGGGACCAGCACCCAGGAGATCGTGGACTTCCTGAGGCGAGCGGTGCCGG
AGCGCTGGAAGGCCCAGGGGCTCGCATGA

Upstream 100 bases:

>100_bases
GAGTGCGCCCTGGCCTACTGCACCCTGGGGGAGATGATGGACGTGCTTCGGGAGGTCTACGGCACCTACCAGGAGCCGGC
CTACGTGTAGGAGGGGTAAG

Downstream 100 bases:

>100_bases
AGGCCATCCAGCTCTACTACCCCCCGGAGTGGGCCCACTGCTACGGGTGCGGCTACTTGAACGCCCACGGGCTCCACATC
CAGACCTACTGGGACCCGGA

Product: methylmalonyl-CoA mutase subunit alpha, chain B

Products: succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MQGVDRRIRVLIAKPGLDGHDRGAKVVARALRDAGMEVIYTGLRQTPEMIVSAAIQEDVDAIGLSILSGAHMHYFREVKR
LLDEQGASDILLFGGGIIPDEDVPKLKALGVAAVFGPGTSTQEIVDFLRRAVPERWKAQGLA

Sequences:

>Translated_142_residues
MQGVDRRIRVLIAKPGLDGHDRGAKVVARALRDAGMEVIYTGLRQTPEMIVSAAIQEDVDAIGLSILSGAHMHYFREVKR
LLDEQGASDILLFGGGIIPDEDVPKLKALGVAAVFGPGTSTQEIVDFLRRAVPERWKAQGLA
>Mature_142_residues
MQGVDRRIRVLIAKPGLDGHDRGAKVVARALRDAGMEVIYTGLRQTPEMIVSAAIQEDVDAIGLSILSGAHMHYFREVKR
LLDEQGASDILLFGGGIIPDEDVPKLKALGVAAVFGPGTSTQEIVDFLRRAVPERWKAQGLA

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=119, Percent_Identity=44.5378151260504, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789284, Length=114, Percent_Identity=45.6140350877193, Blast_Score=99, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25144500, Length=133, Percent_Identity=40.6015037593985, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: NA

Molecular weight: Translated: 15357; Mature: 15357

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGVDRRIRVLIAKPGLDGHDRGAKVVARALRDAGMEVIYTGLRQTPEMIVSAAIQEDVD
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIGLSILSGAHMHYFREVKRLLDEQGASDILLFGGGIIPDEDVPKLKALGVAAVFGPGTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHEEECCCCC
TQEIVDFLRRAVPERWKAQGLA
HHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MQGVDRRIRVLIAKPGLDGHDRGAKVVARALRDAGMEVIYTGLRQTPEMIVSAAIQEDVD
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIGLSILSGAHMHYFREVKRLLDEQGASDILLFGGGIIPDEDVPKLKALGVAAVFGPGTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHEEECCCCC
TQEIVDFLRRAVPERWKAQGLA
HHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Co [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-methylmalonyl-CoA [C]

Specific reaction: L-methylmalonyl-CoA = succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]