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The map label for this gene is bhbA [H]

Identifier: 55981008

GI number: 55981008

Start: 985329

End: 986984

Strand: Reverse

Name: bhbA [H]

Synonym: TTHA1039

Alternate gene names: 55981008

Gene position: 986984-985329 (Counterclockwise)

Preceding gene: 55981009

Following gene: 55981007

Centisome position: 53.36

GC content: 65.76

Gene sequence:

>1656_bases
ATGCGCAGGAAGCACGACTGGCTCAGGGAAACCTATAGGAAGAGCCTGGAGAAGATCCCCGAGCGCCCCGTGGCCCACCG
CACCCTCTCCAATATCGCCCCCGACCCCCTCTACACCCCGGAGGACATCGGGGTCTTGGACCCGGAGTACGAGGAGAAGC
GGGGCTTCCCCGGGGAGTTCCCCTACACCCGGGGGGTCTACGGCTCCATGTACCGGTCCAAACTCTGGACCATGCGCATG
TTCGCCGGCTTCGGCACCGCCGAGCAGACGAACGAGCGCTTCAAGAAGCTCCTGAAGGCGGGGCAGACGGGCCTCAGCGT
GGCCTTTGACCTCCCCACCCTCATGGGCTACGACTCCGACCACCCCCTCTCCAAGGGGGAGGTGGGGAAGTGCGGGGTGG
CGGTCTCTAGCCTCGCCGACATGGAGATCCTCTTTGAGGGGATCAACCTCGAGGAGGTCACCACCTCCATGACCATCAAC
AGCCCCGCCAACGCCATCTGGGCCATGTACCTGGCGGTGGCCAAGAAGCGGGGCTACGACTGGAAGAAGCTCGGGGGCAC
GATCCAAAACGACATCCTCAAGGAGTACATCGCCCAGAAGGAGTTCATCTTCCCCCCCGAGCCCAGCGTGAAGCTGGTCA
TTGACACCTTTGAGTGGGGGCCCAAGAACGTCCCCAAGTGGAACTTCATCTCCGTCTCCGGCTACCACATCCGGGAGGCG
GGCTCCACGGCGGTGCAGGAGCTCGCCTGGACCCTGGCGGACGGCTTTGAGTACGTGGAGGCCGCCCTCAAGCGGGGCCT
GGACATTGACGAGTTCGCCCCAAGGATCAGCTTCTTCTTTGACGTCCACAACGACTTCTTTGAGGAGATCGCCAAGTTCC
GGGCGGCCCGGCGCATCTGGGCCAAGGAGATGCGCTACCGCTACAAGGCCAAGAACCCCCAAAGCTGGATGCTCCGCACC
CACGCCCAGACCGCCGGGGTCTCCCTCACCGCGCAGCAGCCCCTGAACAACATCGCCCGGGTGGCCATCCAGGCCCTGGC
GGCGGTCCTCGGCGGCACAAACAGCCTCCACACCGACGCCTACGACGAGGCCCTGGCCCTGCCCACGGAGGAGAGCGCCA
CCATCGCCCTGCGCACCCAGCAGATCATCGCCTACGAGACCGGGGTCACCCACACCATTGACCCCCTGGCGGGGAGCTAC
TACGTGGAGTGGCTCACCGACGAGATGGAGCGGCAGGCCATGGAGATCATTGAGGAGATCCGCCGCATGGGGGGCGTGGT
GCGGGCCATTGAGGAGGGGTACTTCCTCCGGGAGCTCGCCGAGGCCAGCTACCGCTACCAGCAGGAGGTGGAGCGGAAGG
AGCGGATCATCGTGGGGGTGAACGCCTTCACCGACGAGATTCCCCTGAAGGTGCCCATCCAGCTCGTGGACCCCGAGGTG
GAAAGGGTCCAGGCGGAGCGGCTCGCCCGGGTGCGGCGGGAGCGCGACCCCAAGCGGGTGGAGGAGGCCCTTCAGGGCCT
AAGGCGCGCTGCGGTAGAGGGGCAGAACACCATGCCCCACTTCGTGGAGTGCGCCCTGGCCTACTGCACCCTGGGGGAGA
TGATGGACGTGCTTCGGGAGGTCTACGGCACCTACCAGGAGCCGGCCTACGTGTAG

Upstream 100 bases:

>100_bases
CATCCACGTGGAGCCCGAGGGCGAGCGGAAGCGGACAAACCCCTGACGCTCTTTTCCTGCCCGGCAAAAAAGCGTAAACT
ATGGGGCAAAGGAGGCCCCC

Downstream 100 bases:

>100_bases
GAGGGGTAAGATGCAGGGCGTGGATCGGCGCATACGGGTGCTCATCGCCAAGCCGGGCCTGGACGGGCACGACCGCGGGG
CCAAGGTGGTGGCCCGGGCC

Product: methylmalonyl-CoA mutase subunit alpha

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MRRKHDWLRETYRKSLEKIPERPVAHRTLSNIAPDPLYTPEDIGVLDPEYEEKRGFPGEFPYTRGVYGSMYRSKLWTMRM
FAGFGTAEQTNERFKKLLKAGQTGLSVAFDLPTLMGYDSDHPLSKGEVGKCGVAVSSLADMEILFEGINLEEVTTSMTIN
SPANAIWAMYLAVAKKRGYDWKKLGGTIQNDILKEYIAQKEFIFPPEPSVKLVIDTFEWGPKNVPKWNFISVSGYHIREA
GSTAVQELAWTLADGFEYVEAALKRGLDIDEFAPRISFFFDVHNDFFEEIAKFRAARRIWAKEMRYRYKAKNPQSWMLRT
HAQTAGVSLTAQQPLNNIARVAIQALAAVLGGTNSLHTDAYDEALALPTEESATIALRTQQIIAYETGVTHTIDPLAGSY
YVEWLTDEMERQAMEIIEEIRRMGGVVRAIEEGYFLRELAEASYRYQQEVERKERIIVGVNAFTDEIPLKVPIQLVDPEV
ERVQAERLARVRRERDPKRVEEALQGLRRAAVEGQNTMPHFVECALAYCTLGEMMDVLREVYGTYQEPAYV

Sequences:

>Translated_551_residues
MRRKHDWLRETYRKSLEKIPERPVAHRTLSNIAPDPLYTPEDIGVLDPEYEEKRGFPGEFPYTRGVYGSMYRSKLWTMRM
FAGFGTAEQTNERFKKLLKAGQTGLSVAFDLPTLMGYDSDHPLSKGEVGKCGVAVSSLADMEILFEGINLEEVTTSMTIN
SPANAIWAMYLAVAKKRGYDWKKLGGTIQNDILKEYIAQKEFIFPPEPSVKLVIDTFEWGPKNVPKWNFISVSGYHIREA
GSTAVQELAWTLADGFEYVEAALKRGLDIDEFAPRISFFFDVHNDFFEEIAKFRAARRIWAKEMRYRYKAKNPQSWMLRT
HAQTAGVSLTAQQPLNNIARVAIQALAAVLGGTNSLHTDAYDEALALPTEESATIALRTQQIIAYETGVTHTIDPLAGSY
YVEWLTDEMERQAMEIIEEIRRMGGVVRAIEEGYFLRELAEASYRYQQEVERKERIIVGVNAFTDEIPLKVPIQLVDPEV
ERVQAERLARVRRERDPKRVEEALQGLRRAAVEGQNTMPHFVECALAYCTLGEMMDVLREVYGTYQEPAYV
>Mature_551_residues
MRRKHDWLRETYRKSLEKIPERPVAHRTLSNIAPDPLYTPEDIGVLDPEYEEKRGFPGEFPYTRGVYGSMYRSKLWTMRM
FAGFGTAEQTNERFKKLLKAGQTGLSVAFDLPTLMGYDSDHPLSKGEVGKCGVAVSSLADMEILFEGINLEEVTTSMTIN
SPANAIWAMYLAVAKKRGYDWKKLGGTIQNDILKEYIAQKEFIFPPEPSVKLVIDTFEWGPKNVPKWNFISVSGYHIREA
GSTAVQELAWTLADGFEYVEAALKRGLDIDEFAPRISFFFDVHNDFFEEIAKFRAARRIWAKEMRYRYKAKNPQSWMLRT
HAQTAGVSLTAQQPLNNIARVAIQALAAVLGGTNSLHTDAYDEALALPTEESATIALRTQQIIAYETGVTHTIDPLAGSY
YVEWLTDEMERQAMEIIEEIRRMGGVVRAIEEGYFLRELAEASYRYQQEVERKERIIVGVNAFTDEIPLKVPIQLVDPEV
ERVQAERLARVRRERDPKRVEEALQGLRRAAVEGQNTMPHFVECALAYCTLGEMMDVLREVYGTYQEPAYV

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=543, Percent_Identity=44.3830570902394, Blast_Score=465, Evalue=1e-131,
Organism=Escherichia coli, GI1789284, Length=530, Percent_Identity=45.8490566037736, Blast_Score=460, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25144500, Length=511, Percent_Identity=45.4011741682975, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 62848; Mature: 62848

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKHDWLRETYRKSLEKIPERPVAHRTLSNIAPDPLYTPEDIGVLDPEYEEKRGFPGEF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCC
PYTRGVYGSMYRSKLWTMRMFAGFGTAEQTNERFKKLLKAGQTGLSVAFDLPTLMGYDSD
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCC
HPLSKGEVGKCGVAVSSLADMEILFEGINLEEVTTSMTINSPANAIWAMYLAVAKKRGYD
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHCCCC
WKKLGGTIQNDILKEYIAQKEFIFPPEPSVKLVIDTFEWGPKNVPKWNFISVSGYHIREA
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEHHH
GSTAVQELAWTLADGFEYVEAALKRGLDIDEFAPRISFFFDVHNDFFEEIAKFRAARRIW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEMRYRYKAKNPQSWMLRTHAQTAGVSLTAQQPLNNIARVAIQALAAVLGGTNSLHTDA
HHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
YDEALALPTEESATIALRTQQIIAYETGVTHTIDPLAGSYYVEWLTDEMERQAMEIIEEI
HHHHHCCCCCCCCEEEEEHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGVVRAIEEGYFLRELAEASYRYQQEVERKERIIVGVNAFTDEIPLKVPIQLVDPEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCCEECEEECCCHH
ERVQAERLARVRRERDPKRVEEALQGLRRAAVEGQNTMPHFVECALAYCTLGEMMDVLRE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VYGTYQEPAYV
HHCCCCCCCCC
>Mature Secondary Structure
MRRKHDWLRETYRKSLEKIPERPVAHRTLSNIAPDPLYTPEDIGVLDPEYEEKRGFPGEF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCC
PYTRGVYGSMYRSKLWTMRMFAGFGTAEQTNERFKKLLKAGQTGLSVAFDLPTLMGYDSD
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCC
HPLSKGEVGKCGVAVSSLADMEILFEGINLEEVTTSMTINSPANAIWAMYLAVAKKRGYD
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHCCCC
WKKLGGTIQNDILKEYIAQKEFIFPPEPSVKLVIDTFEWGPKNVPKWNFISVSGYHIREA
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEHHH
GSTAVQELAWTLADGFEYVEAALKRGLDIDEFAPRISFFFDVHNDFFEEIAKFRAARRIW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKEMRYRYKAKNPQSWMLRTHAQTAGVSLTAQQPLNNIARVAIQALAAVLGGTNSLHTDA
HHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
YDEALALPTEESATIALRTQQIIAYETGVTHTIDPLAGSYYVEWLTDEMERQAMEIIEEI
HHHHHCCCCCCCCEEEEEHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGVVRAIEEGYFLRELAEASYRYQQEVERKERIIVGVNAFTDEIPLKVPIQLVDPEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCCEECEEECCCHH
ERVQAERLARVRRERDPKRVEEALQGLRRAAVEGQNTMPHFVECALAYCTLGEMMDVLRE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VYGTYQEPAYV
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]