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The map label for this gene is purH [H]

Identifier: 55980899

GI number: 55980899

Start: 879571

End: 881070

Strand: Direct

Name: purH [H]

Synonym: TTHA0930

Alternate gene names: 55980899

Gene position: 879571-881070 (Clockwise)

Preceding gene: 55980898

Following gene: 55980904

Centisome position: 47.55

GC content: 71.0

Gene sequence:

>1500_bases
ATGCGGTCTATGTGGGCCCTTCTTTCCGTCGCGGACAAGCGGGGGATCGTGGACTTCGCCCGGGGGCTTGCGGAGCTTGG
CTTCCGCCTCCTCGCCACGGGGGGGACCTACCGCGCCCTCCGCGAGGCGGGGCTTCCCGTGACCTACATCTCCGACTTCA
CCGGCTTTCCCGAGATCCTGGAGGGGAGGGTCAAGACCCTCCACCCCAAGGTGCACGCCGCCCTCCTCGCCCGCCCGGAC
CAGGAGGAGGAGCTTAAGGCCTTGGGGTTGGAGCGCATCGGGGTCTTGGCGGTGAACCTCTACCCCTTCCGGGAGACGGT
GGCCCGGGGGGCCTCCTTTGCGGAGGCCCTGGAGCAGATTGACATCGGGGGCCCCGCCATGCTCCGGGCGGCGGCCAAGA
ACCACCAGGCGGTGCTTCCCGTGTGCGACCCCGAGGACTACCCCCGGGTCCTGGAGGCGCTCAAGGCGGGGCCCTCCCCG
GACTTCCGCCAAAAGCTCGCCCGCAAGGCCTTCGCCCACACCGCCCTCTACGACGCCGCCATCGCCGAGTGGCTTTCCGG
GGAGAAGTTCCCCGAGGAGAAGCTTTTGGCCCTCAGGCGGGAGGCCTCCTTGCGTTACGGGGAGAACCCCCACCAGGAGG
CGGCCCTCTACCGGGTGGTGGGGGAGAGGGGGCCTCTGCTCGAGGCCCAGGTGCTTCAGGGGAAGGCCATGAGCTTCAAC
AACTACCTGGACGCCGAGGCCGCCTGGAACCTGGTGTCCGAGTTCGCCGAGCCCGCCTGCGTGGCCGTGAAGCACCAGAA
CCCCTGCGGCGTGGCCCTGGGGGAGACCCCCCTGGAGGCCTACCGGAAGGCCTACGAGGCCGACCCCGTCTCCATCTTCG
GCGGCATCGTGGCCTTCAACCGCCCCCTGGACGGCCCCACGGCGGAGGCCCTGGCGGAGGTCTTCCTGGAGGTGGTCCTC
GCCCCCTCCTTTAGCCCCGAGGCCCGGGCGGTCCTCGCCAGGAAGAAGAACCTCCGCCTCCTCCAGGTGCCCTTCCCTGC
CCAAGGGCCCTACCTGGACCTGAGGCGCCTCCGGGGCGGGGTGCTCCTCCAGGACGCGGACACCGAGGACCCCGCGGAGC
CCAAGGTGGTCACGGAGAGGGCCCCCACCCCGGAGGAGTGGCCCGACCTCCGCTTCGCCTGGAAGGTGGTGAAGCACGTG
CGCTCCAATGCCATCGTGGTGGCCAAGGGGGGGATGACCCTGGGGATCGGGGTGGGGCAGACGAACCGCCTCGCCGCCGC
CCGGCACGCCCTGGAGGCGGCCGGGGAAAGGGCCAAGGGCGCCGTCCTGGCCTCCGACGCCTTCTTCCCCTTTGACGACG
TGGTCCGCCTCGCCGCCTCCTACGGCATCGCCGCCATCATCCAGCCCGGGGGGAGCGTGCGGGACCAGGACTCCATCAGG
GCGGCGGAGGAGGCGGGGATCGCCATGGTCTTCACCGGCGTGCGCCACTTCCGCCACTGA

Upstream 100 bases:

>100_bases
AGCACCATGGTCAAGGAGATCGCCCGCTACGGGGGGGATGTCTCCAAGCTCGTACCCCCGGCGACCCTGAGGGCCTTGAA
GGCCAAGTTGGGCCAGTAGA

Downstream 100 bases:

>100_bases
GCCAGGAGCGGGCGGTTGTTTTGCCGGGGCCCCATGCCGGCGCAGACCGGCACGGGGTTTACTTCCCCACGCAGAAGTTC
TGGAAGACCCGGGCCACCAC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MRSMWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEILEGRVKTLHPKVHAALLARPD
QEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQIDIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSP
DFRQKLARKAFAHTALYDAAIAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFN
NYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFNRPLDGPTAEALAEVFLEVVL
APSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGGVLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHV
RSNAIVVAKGGMTLGIGVGQTNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIR
AAEEAGIAMVFTGVRHFRH

Sequences:

>Translated_499_residues
MRSMWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEILEGRVKTLHPKVHAALLARPD
QEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQIDIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSP
DFRQKLARKAFAHTALYDAAIAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFN
NYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFNRPLDGPTAEALAEVFLEVVL
APSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGGVLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHV
RSNAIVVAKGGMTLGIGVGQTNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIR
AAEEAGIAMVFTGVRHFRH
>Mature_499_residues
MRSMWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEILEGRVKTLHPKVHAALLARPD
QEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQIDIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSP
DFRQKLARKAFAHTALYDAAIAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFN
NYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFNRPLDGPTAEALAEVFLEVVL
APSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGGVLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHV
RSNAIVVAKGGMTLGIGVGQTNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIR
AAEEAGIAMVFTGVRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=472, Percent_Identity=40.6779661016949, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI1790439, Length=521, Percent_Identity=49.5201535508637, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71985564, Length=475, Percent_Identity=34.9473684210526, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71985574, Length=309, Percent_Identity=28.4789644012945, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323768, Length=469, Percent_Identity=38.8059701492537, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323056, Length=463, Percent_Identity=39.7408207343413, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24649832, Length=472, Percent_Identity=38.5593220338983, Blast_Score=261, Evalue=7e-70,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 54201; Mature: 54201

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSMWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEIL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCEEECCCCCCCHHHH
EGRVKTLHPKVHAALLARPDQEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQI
HCHHHHHCHHHHHHHHCCCCCHHHHHHHCHHHHCEEEEEEEHHHHHHHCCCHHHHHHHHH
DIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSPDFRQKLARKAFAHTALYDAA
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFN
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
NYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFN
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHCC
RPLDGPTAEALAEVFLEVVLAPSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGG
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCC
VLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHVRSNAIVVAKGGMTLGIGVGQ
EEEECCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEEECCC
TNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIR
CHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
AAEEAGIAMVFTGVRHFRH
HHHHCCEEHHHHHHHHHCC
>Mature Secondary Structure
MRSMWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEIL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCCCEEECCCCCCCHHHH
EGRVKTLHPKVHAALLARPDQEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQI
HCHHHHHCHHHHHHHHCCCCCHHHHHHHCHHHHCEEEEEEEHHHHHHHCCCHHHHHHHHH
DIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSPDFRQKLARKAFAHTALYDAA
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFN
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
NYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFN
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHCC
RPLDGPTAEALAEVFLEVVLAPSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGG
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCC
VLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHVRSNAIVVAKGGMTLGIGVGQ
EEEECCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEEECCC
TNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIR
CHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
AAEEAGIAMVFTGVRHFRH
HHHHCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA