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The map label for this gene is qacF [H]

Identifier: 55980904

GI number: 55980904

Start: 884181

End: 884498

Strand: Direct

Name: qacF [H]

Synonym: TTHA0935

Alternate gene names: 55980904

Gene position: 884181-884498 (Clockwise)

Preceding gene: 55980899

Following gene: 55980915

Centisome position: 47.8

GC content: 66.98

Gene sequence:

>318_bases
ATGAGCGGGTGGACCTACCTCTTCCTCGCCATCCTCTCCGAGATCCTGGCTTCCAGCGCCCTCAAGGCCTCCCAGGGCTT
CAGCCGCTTCCTCCCGAGCCTCGTGGTGGTGGGGGGCTACGGCCTCGCCTTTTACTTCCTAAGCCTCTCTTTGAAGACCG
TTCCCCTGAGCCTGGCCTACGCCGTCTGGGCCGGGGTGGGGACGGCGGCCATCGCCCTCATCGGGGCCTTTTTCTTCGGG
GAGGCCATCTCCCCCAAGGGGTGGCTCGGCATCGCCCTGGTGGCGGTGGGGGTGGTTCTCATCCGCCTGGCGGACTAG

Upstream 100 bases:

>100_bases
GGATGTGCCGCTTCGCCTCCTGGAAGTAGGCCTCGGAGATGGGCCGCTCCATGCCCCCCACTCTAGCGGCTTTCCCCCGG
GAAAGGGTAGCCTTGGAGGG

Downstream 100 bases:

>100_bases
GGGCGAATGGGCCTAAGCCCCAGGGCCTCGAGGTGGGCCAATAGCGGCCTCAGATCCAAGGCCCCTACGTAGAGAAGCGT
CCGGAAGCCCAGGCCCCCCG

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MSGWTYLFLAILSEILASSALKASQGFSRFLPSLVVVGGYGLAFYFLSLSLKTVPLSLAYAVWAGVGTAAIALIGAFFFG
EAISPKGWLGIALVAVGVVLIRLAD

Sequences:

>Translated_105_residues
MSGWTYLFLAILSEILASSALKASQGFSRFLPSLVVVGGYGLAFYFLSLSLKTVPLSLAYAVWAGVGTAAIALIGAFFFG
EAISPKGWLGIALVAVGVVLIRLAD
>Mature_104_residues
SGWTYLFLAILSEILASSALKASQGFSRFLPSLVVVGGYGLAFYFLSLSLKTVPLSLAYAVWAGVGTAAIALIGAFFFGE
AISPKGWLGIALVAVGVVLIRLAD

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=103, Percent_Identity=35.9223300970874, Blast_Score=71, Evalue=1e-14,
Organism=Escherichia coli, GI1787883, Length=99, Percent_Identity=40.4040404040404, Blast_Score=64, Evalue=1e-12,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 10931; Mature: 10800

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGWTYLFLAILSEILASSALKASQGFSRFLPSLVVVGGYGLAFYFLSLSLKTVPLSLAY
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AVWAGVGTAAIALIGAFFFGEAISPKGWLGIALVAVGVVLIRLAD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGWTYLFLAILSEILASSALKASQGFSRFLPSLVVVGGYGLAFYFLSLSLKTVPLSLAY
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AVWAGVGTAAIALIGAFFFGEAISPKGWLGIALVAVGVVLIRLAD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]