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The map label for this gene is fadE [H]

Identifier: 55980861

GI number: 55980861

Start: 852474

End: 854207

Strand: Direct

Name: fadE [H]

Synonym: TTHA0892

Alternate gene names: 55980861

Gene position: 852474-854207 (Clockwise)

Preceding gene: 55980860

Following gene: 55980863

Centisome position: 46.09

GC content: 67.94

Gene sequence:

>1734_bases
ATGACCGAGGAAAAAAAGCTCTGGCAGAAAGGCGGCGGCTGGCTTCTTGAGGTCCCGGAGCGGGTCTACACCCCGGAGGA
CTTTGACGAGAGCGTCAAGGAGATCGCCCGCACCACCCGTACCTTCGTGGAGCGGGAGGTGCTTCCCCTCCTGGAGCGGA
TGGAGCACGGGGAGCTTGAGCTCAACGTGCCCCTGATGCGCAAGGCGGGGGAGCTCGGGCTTCTGGCCATTGACGTTCCC
GAGGAGTACGGCGGCCTGGACCTGCCCAAGGTGATCTCCACCGTGGTGGCCGAGGAGCTTTCCGGAAGCGGGGGCTTCTC
CGTCACCTACGGCGCCCACACCTCCATCGGCACCCTGCCCCTCGTCTACTTCGGCACCGAGGAGCAGAAGCGCAAGTACC
TTCCCAAGCTCGCAAGCGGCGAGTGGATCGCCGCCTACTGCCTCACGGAGCCGGGCTCGGGCTCCGACGCCCTCGCCGCC
AAGACCCGGGCCACGCTCTCCGAGGACGGCAAGCACTACATCCTGAACGGGGTGAAGCAGTGGATCTCCAACGCGGGCTT
CGCCCACCTCTTCACCGTCTTCGCCAAGGTGGACGGGGAGCACTTCACCGCCTTCCTGGTGGAGCGGGACACCCCGGGCC
TCTCCTTCGGCCCCGAGGAGAAGAAGATGGGCATCAAGGCCTCCAGCACCCGGCAGGTGATCCTGGAGGACGTCAAGGTG
CCCGTGGAGAACGTCCTCGGGGAGATCGGCAAGGGGCACAAGATCGCCTTCAACGTCCTCAACGTGGGCCGCTACAAGCT
CGGGGCGGGGGCCGTGGGCGGGGCGAAAAGGGCCTTAGAGCTTTCCGCCCAGTACGCCACCCAGAGGGTGCAGTTCGGCC
GCCCCATCGGCCGCTTCGGCCTCATCCAGCAGAAGCTCGGCGAGATGGCGAGCCGCATCTACGCCGCGGAGAGCGCCGTC
TACCGCACCGTGGGCCTCATTGACGAGGCCCTTTTGGGCAAGAAGGGCCCGGAAGCGGTGATGGCGGGCATTGAGGAGTA
CGCCGTGGAGGCCAGCATCATCAAGGTGCTGGGCTCCGAGGTTCTGGACTACGTGGTGGACGAGGGGGTGCAGATCCACG
GGGGCTACGGCTACTCCCAGGAGTACCCCATTGAGAGGGCCTACCGCGACGCCCGCATCAACCGCATCTTTGAGGGCACC
AACGAGATCAACCGCCTCCTCATCCCCGGCATGCTCCTCCGCCGGGCCCTGAAGGGCCAGCTCCCCCTCATGCAGGCCGC
CCAGCGCCTTCAGAAGGAGCTTCTGGAGCCGAGCTTTGAGGAGCCCGAGGACCTCGAGCTCCACCAGGTCCAAAACCTGA
AGAAGCTCGCCCTCATGGTGGCGGGCCTCGCCGTGCAGAAGTACGGTCAGGGCGTGGAGGAGGAGCAGGAGGTGCTGGGG
GCCGTGGCCGACATCCTCATTGACGCCTACGCCGCAGAGAGCGCCCTCCTCCGGGCCAGGCGGCTTGGCGGGCTTGCCCC
GGTCCTTGCCCGCATCTACCTGGCCCAGGCCCTGGACCGGGCCCAGGCGGGGGCGCTTTCCGTGCTGCCCCGCCTCGTGG
AAGGGGACGAGGCCCGGGTGGTCTACTCCGCCGCCCGCAGGCTCACGAAGCGCGAGCCCGTGGACCTCGTGGCCCTGCGC
CGCCAGGCGGCGGAGGCGGTGCTGGAGGCCGGGGGCTACCCCATCCCGCGCTGA

Upstream 100 bases:

>100_bases
CCCGGCGGGGTGGGGGGTACGGCCTCGTCACCATGTGCATCGGCGGCGGCATGGGCGCCGCGGGCGTGTTTGAGGTCTAT
CCGGCTTAAGGAGGAGAACC

Downstream 100 bases:

>100_bases
CGCCAGCGTGGGGTGATCTTACCCCCCGTGCGGGCTTGCCCCGCACGGGGGCTCTTTAGCGCTCCAGGCGCCACCTCGGG
CCCTCCTTGGTGTCCTCCAC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTEEKKLWQKGGGWLLEVPERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELELNVPLMRKAGELGLLAIDVP
EEYGGLDLPKVISTVVAEELSGSGGFSVTYGAHTSIGTLPLVYFGTEEQKRKYLPKLASGEWIAAYCLTEPGSGSDALAA
KTRATLSEDGKHYILNGVKQWISNAGFAHLFTVFAKVDGEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKV
PVENVLGEIGKGHKIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFGLIQQKLGEMASRIYAAESAV
YRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSEVLDYVVDEGVQIHGGYGYSQEYPIERAYRDARINRIFEGT
NEINRLLIPGMLLRRALKGQLPLMQAAQRLQKELLEPSFEEPEDLELHQVQNLKKLALMVAGLAVQKYGQGVEEEQEVLG
AVADILIDAYAAESALLRARRLGGLAPVLARIYLAQALDRAQAGALSVLPRLVEGDEARVVYSAARRLTKREPVDLVALR
RQAAEAVLEAGGYPIPR

Sequences:

>Translated_577_residues
MTEEKKLWQKGGGWLLEVPERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELELNVPLMRKAGELGLLAIDVP
EEYGGLDLPKVISTVVAEELSGSGGFSVTYGAHTSIGTLPLVYFGTEEQKRKYLPKLASGEWIAAYCLTEPGSGSDALAA
KTRATLSEDGKHYILNGVKQWISNAGFAHLFTVFAKVDGEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKV
PVENVLGEIGKGHKIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFGLIQQKLGEMASRIYAAESAV
YRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSEVLDYVVDEGVQIHGGYGYSQEYPIERAYRDARINRIFEGT
NEINRLLIPGMLLRRALKGQLPLMQAAQRLQKELLEPSFEEPEDLELHQVQNLKKLALMVAGLAVQKYGQGVEEEQEVLG
AVADILIDAYAAESALLRARRLGGLAPVLARIYLAQALDRAQAGALSVLPRLVEGDEARVVYSAARRLTKREPVDLVALR
RQAAEAVLEAGGYPIPR
>Mature_576_residues
TEEKKLWQKGGGWLLEVPERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELELNVPLMRKAGELGLLAIDVPE
EYGGLDLPKVISTVVAEELSGSGGFSVTYGAHTSIGTLPLVYFGTEEQKRKYLPKLASGEWIAAYCLTEPGSGSDALAAK
TRATLSEDGKHYILNGVKQWISNAGFAHLFTVFAKVDGEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKVP
VENVLGEIGKGHKIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFGLIQQKLGEMASRIYAAESAVY
RTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSEVLDYVVDEGVQIHGGYGYSQEYPIERAYRDARINRIFEGTN
EINRLLIPGMLLRRALKGQLPLMQAAQRLQKELLEPSFEEPEDLELHQVQNLKKLALMVAGLAVQKYGQGVEEEQEVLGA
VADILIDAYAAESALLRARRLGGLAPVLARIYLAQALDRAQAGALSVLPRLVEGDEARVVYSAARRLTKREPVDLVALRR
QAAEAVLEAGGYPIPR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=471, Percent_Identity=42.2505307855626, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI4557235, Length=471, Percent_Identity=40.7643312101911, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI76496475, Length=471, Percent_Identity=40.7643312101911, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI4557233, Length=398, Percent_Identity=38.4422110552764, Blast_Score=266, Evalue=6e-71,
Organism=Homo sapiens, GI187960098, Length=390, Percent_Identity=36.9230769230769, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4557231, Length=390, Percent_Identity=36.9230769230769, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=34.1025641025641, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4501859, Length=392, Percent_Identity=35.7142857142857, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI226958412, Length=389, Percent_Identity=34.4473007712082, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=36.7521367521368, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4501857, Length=396, Percent_Identity=31.5656565656566, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=32.8912466843501, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=33.5211267605634, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI211971008, Length=419, Percent_Identity=25.7756563245823, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI48976061, Length=419, Percent_Identity=25.7756563245823, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI38505218, Length=311, Percent_Identity=27.9742765273312, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI87081958, Length=347, Percent_Identity=32.2766570605187, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786223, Length=357, Percent_Identity=28.8515406162465, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI87081702, Length=441, Percent_Identity=28.1179138321995, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082384, Length=311, Percent_Identity=25.4019292604502, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=510, Percent_Identity=37.843137254902, Blast_Score=301, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17569725, Length=396, Percent_Identity=36.8686868686869, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71985192, Length=355, Percent_Identity=40.2816901408451, Blast_Score=242, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17534899, Length=402, Percent_Identity=35.5721393034826, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=35.6410256410256, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=36.3636363636364, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17538396, Length=420, Percent_Identity=33.5714285714286, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=383, Percent_Identity=34.9869451697128, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=397, Percent_Identity=32.4937027707809, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=41.6309012875536, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=268, Percent_Identity=36.5671641791045, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=30.5699481865285, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=285, Percent_Identity=35.4385964912281, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17505929, Length=398, Percent_Identity=25.1256281407035, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=341, Percent_Identity=27.8592375366569, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=30.8333333333333, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=299, Percent_Identity=26.4214046822742, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540912, Length=352, Percent_Identity=26.4204545454545, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=389, Percent_Identity=23.6503856041131, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=389, Percent_Identity=23.6503856041131, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17531913, Length=185, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281363737, Length=474, Percent_Identity=40.7172995780591, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI21356377, Length=392, Percent_Identity=38.0102040816327, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24646207, Length=395, Percent_Identity=39.746835443038, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=37.7892030848329, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=34.8404255319149, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=34.1902313624679, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI19920834, Length=373, Percent_Identity=30.0268096514745, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24652780, Length=473, Percent_Identity=24.3128964059197, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550141, Length=340, Percent_Identity=25.2941176470588, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221473076, Length=340, Percent_Identity=25.2941176470588, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 63164; Mature: 63033

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEKKLWQKGGGWLLEVPERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELE
CCCHHHHHHCCCCEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LNVPLMRKAGELGLLAIDVPEEYGGLDLPKVISTVVAEELSGSGGFSVTYGAHTSIGTLP
ECCHHHHCCCCCCEEEEECCHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCE
LVYFGTEEQKRKYLPKLASGEWIAAYCLTEPGSGSDALAAKTRATLSEDGKHYILNGVKQ
EEEECCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
WISNAGFAHLFTVFAKVDGEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKV
HHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCC
PVENVLGEIGKGHKIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFG
CHHHHHHHHCCCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LIQQKLGEMASRIYAAESAVYRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLDYVVDEGVQIHGGYGYSQEYPIERAYRDARINRIFEGTNEINRLLIPGMLLRRALKGQ
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
LPLMQAAQRLQKELLEPSFEEPEDLELHQVQNLKKLALMVAGLAVQKYGQGVEEEQEVLG
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AVADILIDAYAAESALLRARRLGGLAPVLARIYLAQALDRAQAGALSVLPRLVEGDEARV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
VYSAARRLTKREPVDLVALRRQAAEAVLEAGGYPIPR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEEKKLWQKGGGWLLEVPERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELE
CCHHHHHHCCCCEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LNVPLMRKAGELGLLAIDVPEEYGGLDLPKVISTVVAEELSGSGGFSVTYGAHTSIGTLP
ECCHHHHCCCCCCEEEEECCHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCE
LVYFGTEEQKRKYLPKLASGEWIAAYCLTEPGSGSDALAAKTRATLSEDGKHYILNGVKQ
EEEECCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
WISNAGFAHLFTVFAKVDGEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKV
HHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCC
PVENVLGEIGKGHKIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFG
CHHHHHHHHCCCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LIQQKLGEMASRIYAAESAVYRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLDYVVDEGVQIHGGYGYSQEYPIERAYRDARINRIFEGTNEINRLLIPGMLLRRALKGQ
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
LPLMQAAQRLQKELLEPSFEEPEDLELHQVQNLKKLALMVAGLAVQKYGQGVEEEQEVLG
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AVADILIDAYAAESALLRARRLGGLAPVLARIYLAQALDRAQAGALSVLPRLVEGDEARV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
VYSAARRLTKREPVDLVALRRQAAEAVLEAGGYPIPR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]