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The map label for this gene is fadA [H]

Identifier: 55980860

GI number: 55980860

Start: 851269

End: 852462

Strand: Direct

Name: fadA [H]

Synonym: TTHA0891

Alternate gene names: 55980860

Gene position: 851269-852462 (Clockwise)

Preceding gene: 55980859

Following gene: 55980861

Centisome position: 46.02

GC content: 69.85

Gene sequence:

>1194_bases
ATGCGGGAAGCGGTCATCGTAAGCGCAGTGCGGAGCCCCGTGGCCCGGGGCAAGAAGAACGGGGCCTTGGCCACCCTCCA
CCCCGTGGACCTCTCCGCCCAGGTGATGCGGGCGGCGGTGGAGCGGGTGGGCCTGGACCCCAAGGAGCTTGAGGACGTCC
TCTGGGGGTGCGCCATGCCCGAGGCGGCCCAGGGGCTGAACATCGCCAGGCTCGCCCTCCTCCGGGCGGGCTTCCCGGTG
GAGGTGGCGGGGGCCACCATCAACCGCTTCTGCTCCAGCGGCCTCCAGACCATCGCCATGGCCGCCCAGGCGGTGATGAC
GGGGATGGCGGACGCCGTCTTGGCGGGCGGGGTGGAGATGATGAGCCAGGTGCCCATGTCGGGCTTCCACACCAGGCTCC
ACCCCGACCTCACCCCCACGGAGTGGAGCCCCGAGACCTACTCCACCTACATCGGCATGGGCTTCACCGCCGAAAGGGTG
GCGGAGCGCTTCGGCATAAGCCGCGAGGACCAGGACAGGTGGGCCTTGAGGAGCCACCAGAAGGCGGCCCAGGCCTGGGC
CGAGGGGCGCTTCCCTGAAGTGGTCCCCATCCGGGTGCCTAAGGTCACCTACCGCGGGACCAAGAAGGAGGTGGAGGAGG
TCGTCTTTGATCGGGACGAGACGGTCCGCCCCGACACCAGCCTCGAGGCCCTGGCCAAGCTGAGGCCCGCCTTTAAGAAG
AACGGCACCGTGACCGCGGGCAACTCCAGCCCCTACTCCGACGGGGCGGCGGCGGTGGTGGTCATGAGCCGGGAGAAGGC
GGAGGCCCTGGGCCTCAAGCCCCTCGCCCGCTTTGTGAGCTTCGCCGTGGCCGGGGTGGAGCCCGACGTGATGGGGATCG
GCCCGGTGAAGGCGGTGCCCAAGGCGCTGCAGCGCGCGGGGCTTACCCTGGACCAGATCGCCCTCATTGAGTTCAACGAG
GCCTTCGCCGCCCAGGTCCTGGCGGTGATGCGGGTCCTGGAGATGCCCGAGGAGAAAACGAACGTCAACGGCGGGGCCAT
CGCCTTAGGCCACCCCCTGGGGGCCACGGGGGCCAAGCTCACCGCACAGCTCTTGAGCGAGCTATCCCGGCGGGGTGGGG
GGTACGGCCTCGTCACCATGTGCATCGGCGGCGGCATGGGCGCCGCGGGCGTGTTTGAGGTCTATCCGGCTTAA

Upstream 100 bases:

>100_bases
CGCGAGGCCTTCTTGAAGCTCCTCGGCACCCGGAAGACCCAGGAGCGCATCGCCTACACCTTGAAGACGGGGAAGCCTCT
CAGGAACTAAGGGGGAGAAG

Downstream 100 bases:

>100_bases
GGAGGAGAACCATGACCGAGGAAAAAAAGCTCTGGCAGAAAGGCGGCGGCTGGCTTCTTGAGGTCCCGGAGCGGGTCTAC
ACCCCGGAGGACTTTGACGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MREAVIVSAVRSPVARGKKNGALATLHPVDLSAQVMRAAVERVGLDPKELEDVLWGCAMPEAAQGLNIARLALLRAGFPV
EVAGATINRFCSSGLQTIAMAAQAVMTGMADAVLAGGVEMMSQVPMSGFHTRLHPDLTPTEWSPETYSTYIGMGFTAERV
AERFGISREDQDRWALRSHQKAAQAWAEGRFPEVVPIRVPKVTYRGTKKEVEEVVFDRDETVRPDTSLEALAKLRPAFKK
NGTVTAGNSSPYSDGAAAVVVMSREKAEALGLKPLARFVSFAVAGVEPDVMGIGPVKAVPKALQRAGLTLDQIALIEFNE
AFAAQVLAVMRVLEMPEEKTNVNGGAIALGHPLGATGAKLTAQLLSELSRRGGGYGLVTMCIGGGMGAAGVFEVYPA

Sequences:

>Translated_397_residues
MREAVIVSAVRSPVARGKKNGALATLHPVDLSAQVMRAAVERVGLDPKELEDVLWGCAMPEAAQGLNIARLALLRAGFPV
EVAGATINRFCSSGLQTIAMAAQAVMTGMADAVLAGGVEMMSQVPMSGFHTRLHPDLTPTEWSPETYSTYIGMGFTAERV
AERFGISREDQDRWALRSHQKAAQAWAEGRFPEVVPIRVPKVTYRGTKKEVEEVVFDRDETVRPDTSLEALAKLRPAFKK
NGTVTAGNSSPYSDGAAAVVVMSREKAEALGLKPLARFVSFAVAGVEPDVMGIGPVKAVPKALQRAGLTLDQIALIEFNE
AFAAQVLAVMRVLEMPEEKTNVNGGAIALGHPLGATGAKLTAQLLSELSRRGGGYGLVTMCIGGGMGAAGVFEVYPA
>Mature_397_residues
MREAVIVSAVRSPVARGKKNGALATLHPVDLSAQVMRAAVERVGLDPKELEDVLWGCAMPEAAQGLNIARLALLRAGFPV
EVAGATINRFCSSGLQTIAMAAQAVMTGMADAVLAGGVEMMSQVPMSGFHTRLHPDLTPTEWSPETYSTYIGMGFTAERV
AERFGISREDQDRWALRSHQKAAQAWAEGRFPEVVPIRVPKVTYRGTKKEVEEVVFDRDETVRPDTSLEALAKLRPAFKK
NGTVTAGNSSPYSDGAAAVVVMSREKAEALGLKPLARFVSFAVAGVEPDVMGIGPVKAVPKALQRAGLTLDQIALIEFNE
AFAAQVLAVMRVLEMPEEKTNVNGGAIALGHPLGATGAKLTAQLLSELSRRGGGYGLVTMCIGGGMGAAGVFEVYPA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=46.7336683417085, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=42.643391521197, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=39.1414141414141, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=37.6558603491272, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4504327, Length=441, Percent_Identity=36.0544217687075, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI194353979, Length=246, Percent_Identity=36.1788617886179, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=46.6165413533835, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=47.029702970297, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=44.6078431372549, Blast_Score=300, Evalue=8e-83,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=43.0693069306931, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=37.7358490566038, Blast_Score=236, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=39.2405063291139, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=36, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=35.7142857142857, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=33.4851936218679, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=30.7888040712468, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=38.3663366336634, Blast_Score=235, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=35.3086419753086, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=42.5692695214106, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=40.9547738693467, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=37.7833753148615, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17137578, Length=439, Percent_Identity=33.4851936218679, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42084; Mature: 42084

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSAVRSPVARGKKNGALATLHPVDLSAQVMRAAVERVGLDPKELEDVLWGCAMP
CCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
EAAQGLNIARLALLRAGFPVEVAGATINRFCSSGLQTIAMAAQAVMTGMADAVLAGGVEM
HHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MSQVPMSGFHTRLHPDLTPTEWSPETYSTYIGMGFTAERVAERFGISREDQDRWALRSHQ
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
KAAQAWAEGRFPEVVPIRVPKVTYRGTKKEVEEVVFDRDETVRPDTSLEALAKLRPAFKK
HHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NGTVTAGNSSPYSDGAAAVVVMSREKAEALGLKPLARFVSFAVAGVEPDVMGIGPVKAVP
CCCEECCCCCCCCCCCEEEEEEECHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
KALQRAGLTLDQIALIEFNEAFAAQVLAVMRVLEMPEEKTNVNGGAIALGHPLGATGAKL
HHHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCCCHHHH
TAQLLSELSRRGGGYGLVTMCIGGGMGAAGVFEVYPA
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEECCC
>Mature Secondary Structure
MREAVIVSAVRSPVARGKKNGALATLHPVDLSAQVMRAAVERVGLDPKELEDVLWGCAMP
CCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
EAAQGLNIARLALLRAGFPVEVAGATINRFCSSGLQTIAMAAQAVMTGMADAVLAGGVEM
HHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MSQVPMSGFHTRLHPDLTPTEWSPETYSTYIGMGFTAERVAERFGISREDQDRWALRSHQ
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
KAAQAWAEGRFPEVVPIRVPKVTYRGTKKEVEEVVFDRDETVRPDTSLEALAKLRPAFKK
HHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NGTVTAGNSSPYSDGAAAVVVMSREKAEALGLKPLARFVSFAVAGVEPDVMGIGPVKAVP
CCCEECCCCCCCCCCCEEEEEEECHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
KALQRAGLTLDQIALIEFNEAFAAQVLAVMRVLEMPEEKTNVNGGAIALGHPLGATGAKL
HHHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCCCHHHH
TAQLLSELSRRGGGYGLVTMCIGGGMGAAGVFEVYPA
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]