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The map label for this gene is ywrD [H]

Identifier: 55980724

GI number: 55980724

Start: 720987

End: 722561

Strand: Direct

Name: ywrD [H]

Synonym: TTHA0755

Alternate gene names: 55980724

Gene position: 720987-722561 (Clockwise)

Preceding gene: 55980721

Following gene: 55980725

Centisome position: 38.98

GC content: 71.11

Gene sequence:

>1575_bases
ATGGACCTCACCCACTACCCCTACCCCTCCCGCCGCCACGTGGTCTTGGGAAGGCGGGGCGCGGTGGCCACGAGCCAGCC
CCTTGCCGCTTTGGCGGGGATGGAGATGCTCCAAAAGGGGGGAAGCGCCGTGGACGCCGCCGTTGCCATGGCCGCCTGCC
TCACCGTGGTGGAGCCCACCTCCAACGGGATCGGGGGGGACCTCTTCGCCCTGGTGTGGGACGGAACCCTCCACGGCCTG
AACGCCTCCGGGAAAAGCCCCATGGCCCTCACCCCGGAAAGGCTTCCCGGGAGGATGCCGGAGCGGGGCTGGCTTCCCGT
GACCGTGCCGGGGGCGGTCTCGGGGTGGCGGGCCCTGCACGAGCGCTGGGGCAGGCTTCCCTTCGCCGAGGTCCTCGTCC
CCGCCATCCGTTACGCCGAGGAAGGCTTCCCCGTGGGGCCGGAGACGGCGAGGAGCTGGCGGCGGGCAGAAGGCGTCTTC
CTCCCCCTGGAGGGGCCGGAGTTTGGGCCCTTCAAGGAGGTCTTCTTCCCCGGGGGGAGGGCCCCAAGGGCGGGAGAGGT
GTGGCGAAGCCCCCTCCACGCCAAGACCCTCAGGGAGATCGCCGGGTCCTACGGGGAAAGCCTTTACCGGGGAGCCCTGG
CCGAGGCCCTCCTCCGCTTCAGCGAGGCCACGGGGGGGCTCCTTACCCGGGAGGACCTCGAGGCCCACGCCCCGGAGTGG
GTGACGCCCCTTTCCACGGAGTACAAGGGGCTCACCGTCTGGGAGCTTCCCCCAAACGGCCAGGGGGTGGCGGTCCTCCT
CGCCCTGAACCTTCTGGAGGGGTTTGACCTGAGGCCGGAGGACCCTTGGAGCTACCACGTCCAGATTGAGGCCATGCGCC
TCGCTTTGGTGGACACCTACCGCTTCGTGGCCGACCCGCGGCACATGGAGCTCGCCCCCGAGGCCTTCCTCTCCAAGGCC
TACGCGGCGGAAAGGCGGAGGCTCATCGGGGAAAGGGCCCTTCCCCGGGTCCTTCCCGGCCTCCGCCCCGAGGGCACGGT
CTACCTCGCGGCGGCGGACGGGGAGGTGATGGTCTCCCTCATCCAGTCCAACTACCAGGGGTTCGGCTCCGGGGTTTTGG
TGCCGGGAACGGGGATCGCCCTGCAGAACCGGGGCCTGGGGTTTTCCCTGGAGGAGGGGCACCCGAACCGGGTGGGTCCG
GGAAAGAGGCCCTTCCACACCATCATCCCGGGCTTCCTCACCCGGGAGGGGAAGCCCCTTGGGCCCTTTGGGGTCATGGG
GGGGTTCATGCAGCCCCAGGGGCACGTCCAGGTGGTGGTGGGCCTGGCGGACTTCGGCCTGAACCCCCAGGCGGCCCTGG
ACCGGCCCCGCTGGCAGGTGGTGCCGGGGGACGAGGTGCTGCTTGAGCCCGGCATCCCCCAGGCCACGGCGCTTTTCCTC
AAGGACCTGGGGCATAGGGTGCGCTACGAGGCGGAGTACGGCCTCTTCGGGCGGGGGCAGGCGGTCTTCCGTCTCGGGGA
GGCCCTCGTGGGGGCGAGCGACCCCCGGGCCGAGGGGCTCGCCTTGGCGTGGTAG

Upstream 100 bases:

>100_bases
CCCCCGAGGGCCTCCTCCAGAAGAAAGAGGTGCTTTAGGTAATCCTCCTGGGCCTCGGTGAGGGGCGGCCTCGCCATCCC
CCTAAAGGTAGCATGGAAGC

Downstream 100 bases:

>100_bases
TTTGGAGCCATGAAGGCGAAGGGGTTTTTCTTGGGGCTACTCGCCCTCCTGGGCGGGTTCGGCGGGGCGGAGGGGCTTGG
GGACCCTATGGCGGGGAGGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDLTHYPYPSRRHVVLGRRGAVATSQPLAALAGMEMLQKGGSAVDAAVAMAACLTVVEPTSNGIGGDLFALVWDGTLHGL
NASGKSPMALTPERLPGRMPERGWLPVTVPGAVSGWRALHERWGRLPFAEVLVPAIRYAEEGFPVGPETARSWRRAEGVF
LPLEGPEFGPFKEVFFPGGRAPRAGEVWRSPLHAKTLREIAGSYGESLYRGALAEALLRFSEATGGLLTREDLEAHAPEW
VTPLSTEYKGLTVWELPPNGQGVAVLLALNLLEGFDLRPEDPWSYHVQIEAMRLALVDTYRFVADPRHMELAPEAFLSKA
YAAERRRLIGERALPRVLPGLRPEGTVYLAAADGEVMVSLIQSNYQGFGSGVLVPGTGIALQNRGLGFSLEEGHPNRVGP
GKRPFHTIIPGFLTREGKPLGPFGVMGGFMQPQGHVQVVVGLADFGLNPQAALDRPRWQVVPGDEVLLEPGIPQATALFL
KDLGHRVRYEAEYGLFGRGQAVFRLGEALVGASDPRAEGLALAW

Sequences:

>Translated_524_residues
MDLTHYPYPSRRHVVLGRRGAVATSQPLAALAGMEMLQKGGSAVDAAVAMAACLTVVEPTSNGIGGDLFALVWDGTLHGL
NASGKSPMALTPERLPGRMPERGWLPVTVPGAVSGWRALHERWGRLPFAEVLVPAIRYAEEGFPVGPETARSWRRAEGVF
LPLEGPEFGPFKEVFFPGGRAPRAGEVWRSPLHAKTLREIAGSYGESLYRGALAEALLRFSEATGGLLTREDLEAHAPEW
VTPLSTEYKGLTVWELPPNGQGVAVLLALNLLEGFDLRPEDPWSYHVQIEAMRLALVDTYRFVADPRHMELAPEAFLSKA
YAAERRRLIGERALPRVLPGLRPEGTVYLAAADGEVMVSLIQSNYQGFGSGVLVPGTGIALQNRGLGFSLEEGHPNRVGP
GKRPFHTIIPGFLTREGKPLGPFGVMGGFMQPQGHVQVVVGLADFGLNPQAALDRPRWQVVPGDEVLLEPGIPQATALFL
KDLGHRVRYEAEYGLFGRGQAVFRLGEALVGASDPRAEGLALAW
>Mature_524_residues
MDLTHYPYPSRRHVVLGRRGAVATSQPLAALAGMEMLQKGGSAVDAAVAMAACLTVVEPTSNGIGGDLFALVWDGTLHGL
NASGKSPMALTPERLPGRMPERGWLPVTVPGAVSGWRALHERWGRLPFAEVLVPAIRYAEEGFPVGPETARSWRRAEGVF
LPLEGPEFGPFKEVFFPGGRAPRAGEVWRSPLHAKTLREIAGSYGESLYRGALAEALLRFSEATGGLLTREDLEAHAPEW
VTPLSTEYKGLTVWELPPNGQGVAVLLALNLLEGFDLRPEDPWSYHVQIEAMRLALVDTYRFVADPRHMELAPEAFLSKA
YAAERRRLIGERALPRVLPGLRPEGTVYLAAADGEVMVSLIQSNYQGFGSGVLVPGTGIALQNRGLGFSLEEGHPNRVGP
GKRPFHTIIPGFLTREGKPLGPFGVMGGFMQPQGHVQVVVGLADFGLNPQAALDRPRWQVVPGDEVLLEPGIPQATALFL
KDLGHRVRYEAEYGLFGRGQAVFRLGEALVGASDPRAEGLALAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=537, Percent_Identity=28.1191806331471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI73915090, Length=537, Percent_Identity=28.1191806331471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI73915096, Length=537, Percent_Identity=28.1191806331471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI73915094, Length=537, Percent_Identity=28.1191806331471, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI113429326, Length=542, Percent_Identity=27.3062730627306, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI113429324, Length=537, Percent_Identity=26.8156424581006, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI109148539, Length=528, Percent_Identity=29.7348484848485, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI153266885, Length=539, Percent_Identity=26.7161410018553, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI153266901, Length=542, Percent_Identity=26.7527675276753, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI153266907, Length=532, Percent_Identity=26.1278195488722, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1789856, Length=540, Percent_Identity=28.5185185185185, Blast_Score=188, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17506189, Length=538, Percent_Identity=26.5799256505576, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=449, Percent_Identity=25.1670378619154, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI212646519, Length=449, Percent_Identity=25.1670378619154, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=444, Percent_Identity=25.4504504504505, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI193208247, Length=504, Percent_Identity=24.2063492063492, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193208245, Length=504, Percent_Identity=24.2063492063492, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642670, Length=513, Percent_Identity=25.3411306042885, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24642666, Length=513, Percent_Identity=25.3411306042885, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI161077878, Length=513, Percent_Identity=25.3411306042885, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI161077880, Length=513, Percent_Identity=25.3411306042885, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI45551474, Length=513, Percent_Identity=25.3411306042885, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI161077496, Length=548, Percent_Identity=26.2773722627737, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859741, Length=548, Percent_Identity=24.6350364963504, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859893, Length=510, Percent_Identity=26.2745098039216, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56674; Mature: 56674

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTHYPYPSRRHVVLGRRGAVATSQPLAALAGMEMLQKGGSAVDAAVAMAACLTVVEPT
CCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
SNGIGGDLFALVWDGTLHGLNASGKSPMALTPERLPGRMPERGWLPVTVPGAVSGWRALH
CCCCCCCEEEEEECCEEECCCCCCCCCCEECHHHCCCCCCCCCEEEEECCCHHHHHHHHH
ERWGRLPFAEVLVPAIRYAEEGFPVGPETARSWRRAEGVFLPLEGPEFGPFKEVFFPGGR
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCC
APRAGEVWRSPLHAKTLREIAGSYGESLYRGALAEALLRFSEATGGLLTREDLEAHAPEW
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCC
VTPLSTEYKGLTVWELPPNGQGVAVLLALNLLEGFDLRPEDPWSYHVQIEAMRLALVDTY
CCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHHHHHH
RFVADPRHMELAPEAFLSKAYAAERRRLIGERALPRVLPGLRPEGTVYLAAADGEVMVSL
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
IQSNYQGFGSGVLVPGTGIALQNRGLGFSLEEGHPNRVGPGKRPFHTIIPGFLTREGKPL
HHHCCCCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHCCHHHCCCCCCC
GPFGVMGGFMQPQGHVQVVVGLADFGLNPQAALDRPRWQVVPGDEVLLEPGIPQATALFL
CCHHHHCCCCCCCCCEEEEEEEECCCCCCHHHCCCCCEEECCCCCEEECCCCCHHHHHHH
KDLGHRVRYEAEYGLFGRGQAVFRLGEALVGASDPRAEGLALAW
HHHCHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure
MDLTHYPYPSRRHVVLGRRGAVATSQPLAALAGMEMLQKGGSAVDAAVAMAACLTVVEPT
CCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
SNGIGGDLFALVWDGTLHGLNASGKSPMALTPERLPGRMPERGWLPVTVPGAVSGWRALH
CCCCCCCEEEEEECCEEECCCCCCCCCCEECHHHCCCCCCCCCEEEEECCCHHHHHHHHH
ERWGRLPFAEVLVPAIRYAEEGFPVGPETARSWRRAEGVFLPLEGPEFGPFKEVFFPGGR
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCC
APRAGEVWRSPLHAKTLREIAGSYGESLYRGALAEALLRFSEATGGLLTREDLEAHAPEW
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCC
VTPLSTEYKGLTVWELPPNGQGVAVLLALNLLEGFDLRPEDPWSYHVQIEAMRLALVDTY
CCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHHHHHH
RFVADPRHMELAPEAFLSKAYAAERRRLIGERALPRVLPGLRPEGTVYLAAADGEVMVSL
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
IQSNYQGFGSGVLVPGTGIALQNRGLGFSLEEGHPNRVGPGKRPFHTIIPGFLTREGKPL
HHHCCCCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHCCHHHCCCCCCC
GPFGVMGGFMQPQGHVQVVVGLADFGLNPQAALDRPRWQVVPGDEVLLEPGIPQATALFL
CCHHHHCCCCCCCCCEEEEEEEECCCCCCHHHCCCCCEEECCCCCEEECCCCCHHHHHHH
KDLGHRVRYEAEYGLFGRGQAVFRLGEALVGASDPRAEGLALAW
HHHCHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]