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The map label for this gene is hslU [H]

Identifier: 55980599

GI number: 55980599

Start: 601219

End: 602469

Strand: Reverse

Name: hslU [H]

Synonym: TTHA0630

Alternate gene names: 55980599

Gene position: 602469-601219 (Counterclockwise)

Preceding gene: 55980600

Following gene: 55980598

Centisome position: 32.57

GC content: 68.59

Gene sequence:

>1251_bases
ATGAACCTGACGCCCGCCGAGATCGTCCGGGAGCTCTCCAAGCACATCGTGGGCCAGGAGGCGGCCAAGCGCGCGGTGGC
CGTGGCCTTAAGGAACCGCTACCGCCGCAAGAAGCTTCCCCCGGAGATCGCCCGGGAGGTCACCCCCAAGAACATCCTCA
TGATCGGGCCCACGGGGGTGGGAAAGACCGAGATCGCCCGCCGCCTCGCCCGCCTCGCCGGGGCCCCCTTCGTGAAGGTG
GAGGCCACCAAGTTCACCGAGGTGGGGTACGTGGGCCGGGACGTGGACTCCATCGTCCGCGACCTGGCGGAGGCGAGCTA
CCAGCTCGTGCTGGAGGAGATGAAGAAGAAGGTGGAGGAAAAGGCCCTGGCCCTCGCCGAGGAGGAGCTCGCCACCCTGC
TCCGCACCTCGGTGGCCGAGGTCCGCTCGGGCCGCCTGGACGGCCACTTTGTGGAGGTCCAGGTGGAGGAGGAGGTCGCC
CTCCCCTTCATGGGGGTCCTGGGGGGCGAGGCCTTCGGGGGCATGGGGGAGATGCTCAAAGGCCTCCTTCCCCGGCGCCC
GGTCCGCCGCCGCATGACCGTGAGGGAGGCCCGGGAGGTGCTGAAGAACCAGCACGCCGAGCGCCTTATAGACAAGGAGG
AGCTCAAGGAGGAGGCGAGGCGCCGCGCCCAGGAGGAGGGCATCGTCTTCATTGACGAGATTGACAAGGTGGCGCGGAGG
GAGGGGACCGTGGGCCCCGACGTCTCCGGGGAAGGGGTGCAGCGGGACCTCCTCCCCATCGTGGAGGGGACGGTGGTCTC
CACGAGGATCGGCCCCATCTCCACGGAGCACGTCCTCTTCATCGCCGCCGGGGCCTTCCACGTGGCCAAGCCCTCGGACC
TGATCCCCGAGCTCCAGGGGCGGTTTCCCATCAGGGTGGAGCTTTCCCCCTTGGGCCCCGAGGAGTTCTACCGCATCCTC
AAGGAGCCGGAGAACTCCCTCATCCGCCAGTACACGGAGCTCCTCAAGGCGGACGGCACCGAGCTCGTCTTTGAGGACGA
GGCCCTTTGGGCCATCGCGCAGGCGGCCCACCGGGCGAACCAAGAGCTCGAGGACATCGGGGCGAGGCGGCTCGCCACCG
TTTTGGAGAAGGTGCTGGAGGAGGTGAGCTTCCAGACGGACCTCGGCCGGGTGGAGATCACCCGGGCCTACGTGGAGAAG
CGGCTAGAGGCGGTCTTCGCCTCCCCGGACCTCACCCGCTTCGTGCTGTGA

Upstream 100 bases:

>100_bases
GGCTTTCCGCCAAGGAGATCGCCACGGAGGCCCTAAGGATCGCCGCCGAGGTGGACCTCTACACCTCGGGCCAGGTGACC
GTCCTCACTTTGGGGGAAGC

Downstream 100 bases:

>100_bases
AGGCTGTGAAGGAGGAAGGATGCGCTGGCTGTTGGTGGTCGCAGGACTTCTCGCCGCCGGGGGGCTGGCCCAGACGCCGC
CTCCCCCCGCGGCCCAGACG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNLTPAEIVRELSKHIVGQEAAKRAVAVALRNRYRRKKLPPEIAREVTPKNILMIGPTGVGKTEIARRLARLAGAPFVKV
EATKFTEVGYVGRDVDSIVRDLAEASYQLVLEEMKKKVEEKALALAEEELATLLRTSVAEVRSGRLDGHFVEVQVEEEVA
LPFMGVLGGEAFGGMGEMLKGLLPRRPVRRRMTVREAREVLKNQHAERLIDKEELKEEARRRAQEEGIVFIDEIDKVARR
EGTVGPDVSGEGVQRDLLPIVEGTVVSTRIGPISTEHVLFIAAGAFHVAKPSDLIPELQGRFPIRVELSPLGPEEFYRIL
KEPENSLIRQYTELLKADGTELVFEDEALWAIAQAAHRANQELEDIGARRLATVLEKVLEEVSFQTDLGRVEITRAYVEK
RLEAVFASPDLTRFVL

Sequences:

>Translated_416_residues
MNLTPAEIVRELSKHIVGQEAAKRAVAVALRNRYRRKKLPPEIAREVTPKNILMIGPTGVGKTEIARRLARLAGAPFVKV
EATKFTEVGYVGRDVDSIVRDLAEASYQLVLEEMKKKVEEKALALAEEELATLLRTSVAEVRSGRLDGHFVEVQVEEEVA
LPFMGVLGGEAFGGMGEMLKGLLPRRPVRRRMTVREAREVLKNQHAERLIDKEELKEEARRRAQEEGIVFIDEIDKVARR
EGTVGPDVSGEGVQRDLLPIVEGTVVSTRIGPISTEHVLFIAAGAFHVAKPSDLIPELQGRFPIRVELSPLGPEEFYRIL
KEPENSLIRQYTELLKADGTELVFEDEALWAIAQAAHRANQELEDIGARRLATVLEKVLEEVSFQTDLGRVEITRAYVEK
RLEAVFASPDLTRFVL
>Mature_416_residues
MNLTPAEIVRELSKHIVGQEAAKRAVAVALRNRYRRKKLPPEIAREVTPKNILMIGPTGVGKTEIARRLARLAGAPFVKV
EATKFTEVGYVGRDVDSIVRDLAEASYQLVLEEMKKKVEEKALALAEEELATLLRTSVAEVRSGRLDGHFVEVQVEEEVA
LPFMGVLGGEAFGGMGEMLKGLLPRRPVRRRMTVREAREVLKNQHAERLIDKEELKEEARRRAQEEGIVFIDEIDKVARR
EGTVGPDVSGEGVQRDLLPIVEGTVVSTRIGPISTEHVLFIAAGAFHVAKPSDLIPELQGRFPIRVELSPLGPEEFYRIL
KEPENSLIRQYTELLKADGTELVFEDEALWAIAQAAHRANQELEDIGARRLATVLEKVLEEVSFQTDLGRVEITRAYVEK
RLEAVFASPDLTRFVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=440, Percent_Identity=48.8636363636364, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1786642, Length=246, Percent_Identity=32.9268292682927, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=35.7723577235772, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 46513; Mature: 46513

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTPAEIVRELSKHIVGQEAAKRAVAVALRNRYRRKKLPPEIAREVTPKNILMIGPTGV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCC
GKTEIARRLARLAGAPFVKVEATKFTEVGYVGRDVDSIVRDLAEASYQLVLEEMKKKVEE
CHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KALALAEEELATLLRTSVAEVRSGRLDGHFVEVQVEEEVALPFMGVLGGEAFGGMGEMLK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCHHHHHHCCCCCCCHHHHHH
GLLPRRPVRRRMTVREAREVLKNQHAERLIDKEELKEEARRRAQEEGIVFIDEIDKVARR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHH
EGTVGPDVSGEGVQRDLLPIVEGTVVSTRIGPISTEHVLFIAAGAFHVAKPSDLIPELQG
CCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCC
RFPIRVELSPLGPEEFYRILKEPENSLIRQYTELLKADGTELVFEDEALWAIAQAAHRAN
CCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
QELEDIGARRLATVLEKVLEEVSFQTDLGRVEITRAYVEKRLEAVFASPDLTRFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MNLTPAEIVRELSKHIVGQEAAKRAVAVALRNRYRRKKLPPEIAREVTPKNILMIGPTGV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCC
GKTEIARRLARLAGAPFVKVEATKFTEVGYVGRDVDSIVRDLAEASYQLVLEEMKKKVEE
CHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KALALAEEELATLLRTSVAEVRSGRLDGHFVEVQVEEEVALPFMGVLGGEAFGGMGEMLK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCHHHHHHCCCCCCCHHHHHH
GLLPRRPVRRRMTVREAREVLKNQHAERLIDKEELKEEARRRAQEEGIVFIDEIDKVARR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHH
EGTVGPDVSGEGVQRDLLPIVEGTVVSTRIGPISTEHVLFIAAGAFHVAKPSDLIPELQG
CCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCC
RFPIRVELSPLGPEEFYRILKEPENSLIRQYTELLKADGTELVFEDEALWAIAQAAHRAN
CCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
QELEDIGARRLATVLEKVLEEVSFQTDLGRVEITRAYVEKRLEAVFASPDLTRFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA