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The map label for this gene is trpE [H]

Identifier: 55980589

GI number: 55980589

Start: 591749

End: 593611

Strand: Direct

Name: trpE [H]

Synonym: TTHA0620

Alternate gene names: 55980589

Gene position: 591749-593611 (Clockwise)

Preceding gene: 55980587

Following gene: 55980590

Centisome position: 31.99

GC content: 71.71

Gene sequence:

>1863_bases
GTGGCCGGGGGTCTGCTTGGGCTCTACCACGCCGCCCGGTGCTCGGGCCTGAGGCCCGCCCTCCTGGAGTCCTTGGGGCC
GAGGACGCCCTTTTCCCGGCTTTCCCTCCTCGGGGTGGGCCCTGCGCACCGCCTCGAGGTCTGGGAGGGGAGGCTCTACC
TGGACGGCAGGCGGGTGGGGGAGGCCCTGGAGGTCTTCCGCTACCTGGAAAGGGGCCTGGGCAAGGGCTTCTTCCCCGCC
TGGATCGGGTTTTTCGCCTACGAGTTCGCCCGCCACCTGGGGCTTCCCGCCCACAAGCCCCTCCCCGGCCTCCCCGAGGC
CTTCTTCCTCTACTACCCCGAGGGGTACGCCCTCTTTGAGGGGAGGCTCGTGCAGGCCCCCTCCTTCCCCTTGCGGCCCC
TGCCCTACGCTCCCCCGCCCCTTCCCCGCCACCCCCTGGTCTCGGACTTCCCCCGGGAGGCCTTCTTGCGCGGGGTGGAG
GAGGTGCGGGAGAGGATCCGGGCCGGGGTGGTCTACCAGGTGAACCTCTCCCACCGCTTCCGCCTCCTAGGCCCCGTGGA
CCCCCTCCTCCTCTACGCCAGGCTTCGCGCCCTGAACCCCTCCCCCTTCATGGGGCTAGTGGAGGGGGAGGGGTGGGCCG
TGGTCTCGGGGAGCCCGGAGAGGCTCTTCCAGAAGGTGGGCCCCAGGGTCTTGGCCCGGCCCATCGCCGGGACGCGGCCT
AGGGGAAGGACGGAGGCGGAGGACCTGGCCTTAGAGCGGGAGCTCCTTGCCTCTACCAAGGAGCGGGCGGAGCACGTGAT
GCTCGTGGACCTCCTCCGGAACGACCTCGCCCGGGTGGCCCGGCCCGGAACAGTGCGGGTCCGGGAGCTTTTCACCGTGG
AGCGCTACGCCCACGTGATGCACCTGGTCTCCGAGGTGGAGGGCCGCACCGGGGCTTCCTTGGGGGAGGTCTTCCGGAGC
CTCTTCCCTGGGGGGACGATCACCGGGGCCCCCAAGGGAACGGTGATGGAGGCCATAAGGGACCTGGAGCCCGTCCCCCG
GGGGGCCTACACGGGGAGCCTGGGGTACGTCTCGGGGCGGGGGGCGGACTTCAACATCCTCATCCGCTCCTTCCAGAGGG
TGGGGGAGGAGGTCCTCTTCTCCGCGGGGGCGGGCGTGGTCATCGCCTCGGAGGCGGAGCGGGAGTACGAGGAGACCCTC
CACAAGGCACAAAGCCTCCTCCTGGCCCTGGAAAGGGGGAGGCCGGGGAAGCCCCCCGAGGCCCCGAGGCCCCGGGCCTC
CTGGAGCCCGCCCATGCCCTCGAGGCGGTACGGGGCCCGGGTCCTCTTCCTGGAGAACCGGGACTCCTTCAGCCACAACC
TGGTGGACTACCTGCGGGCCCTGGGGGCCGAGGTCGCGGTGGTGGACCAGGAGGAGGCCCCGGACCTCAAGGGCTTCACC
CACCTGGTGGTGGGCCCCGGGCCCAAGGACCCCTTCACCGCGGGGCGCGTCCTGGAGTGGACGGAGAAGGCCCTGGCGGC
GGGGCTTCCCCTCCTCGGGGTCTGCCTGGGCCACCAGGCCCTGGGGGTGGCCCTGGGGGCGGAGCTTTACCGGGAGGCCC
CCGTGCACGGGGAGGCCCACGCCGTCTTCCACACCGGGGAGGGCCTCTTTAGGGGGATCCCGAGCCCCGCCCCCTTCGCC
CGGTACCACTCCCTGGCCTTAAGGCGCCTTCCCCCGGGGCTTAGGCTCCTCGCCTGGACGGAAGACGGCGTGCCCATGGC
CATCTGGGACGGGAGGCGGGCCTACGGGGTCCAGTTCCACCCGGAAAGCCTCCTTTCCCCTTACGGCATGCTCCTTCTCG
CCCGGTTCCTGGAGGTGGGATGA

Upstream 100 bases:

>100_bases
GCTCCACCCGCTCAGGTAAGGCCCCGGCCTCGTAGGCCTTGCGGTAGGCCTCCACGGTGAAGCGGGGCTTGACCATCCTT
GCCCTCAATATACTGCGCCT

Downstream 100 bases:

>100_bases
GGCTTTTAAACGGCACGCCCCTCGCCCTCGCCCTCCCCGAGGCCTTCCTCTACCACGGGGCGAGCGTCTTCACCACGCTC
CGGGCGGAAGGGGGAAGGCC

Product: alternative anthranilate synthase component I+II TrpEG

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MAGGLLGLYHAARCSGLRPALLESLGPRTPFSRLSLLGVGPAHRLEVWEGRLYLDGRRVGEALEVFRYLERGLGKGFFPA
WIGFFAYEFARHLGLPAHKPLPGLPEAFFLYYPEGYALFEGRLVQAPSFPLRPLPYAPPPLPRHPLVSDFPREAFLRGVE
EVRERIRAGVVYQVNLSHRFRLLGPVDPLLLYARLRALNPSPFMGLVEGEGWAVVSGSPERLFQKVGPRVLARPIAGTRP
RGRTEAEDLALERELLASTKERAEHVMLVDLLRNDLARVARPGTVRVRELFTVERYAHVMHLVSEVEGRTGASLGEVFRS
LFPGGTITGAPKGTVMEAIRDLEPVPRGAYTGSLGYVSGRGADFNILIRSFQRVGEEVLFSAGAGVVIASEAEREYEETL
HKAQSLLLALERGRPGKPPEAPRPRASWSPPMPSRRYGARVLFLENRDSFSHNLVDYLRALGAEVAVVDQEEAPDLKGFT
HLVVGPGPKDPFTAGRVLEWTEKALAAGLPLLGVCLGHQALGVALGAELYREAPVHGEAHAVFHTGEGLFRGIPSPAPFA
RYHSLALRRLPPGLRLLAWTEDGVPMAIWDGRRAYGVQFHPESLLSPYGMLLLARFLEVG

Sequences:

>Translated_620_residues
MAGGLLGLYHAARCSGLRPALLESLGPRTPFSRLSLLGVGPAHRLEVWEGRLYLDGRRVGEALEVFRYLERGLGKGFFPA
WIGFFAYEFARHLGLPAHKPLPGLPEAFFLYYPEGYALFEGRLVQAPSFPLRPLPYAPPPLPRHPLVSDFPREAFLRGVE
EVRERIRAGVVYQVNLSHRFRLLGPVDPLLLYARLRALNPSPFMGLVEGEGWAVVSGSPERLFQKVGPRVLARPIAGTRP
RGRTEAEDLALERELLASTKERAEHVMLVDLLRNDLARVARPGTVRVRELFTVERYAHVMHLVSEVEGRTGASLGEVFRS
LFPGGTITGAPKGTVMEAIRDLEPVPRGAYTGSLGYVSGRGADFNILIRSFQRVGEEVLFSAGAGVVIASEAEREYEETL
HKAQSLLLALERGRPGKPPEAPRPRASWSPPMPSRRYGARVLFLENRDSFSHNLVDYLRALGAEVAVVDQEEAPDLKGFT
HLVVGPGPKDPFTAGRVLEWTEKALAAGLPLLGVCLGHQALGVALGAELYREAPVHGEAHAVFHTGEGLFRGIPSPAPFA
RYHSLALRRLPPGLRLLAWTEDGVPMAIWDGRRAYGVQFHPESLLSPYGMLLLARFLEVG
>Mature_619_residues
AGGLLGLYHAARCSGLRPALLESLGPRTPFSRLSLLGVGPAHRLEVWEGRLYLDGRRVGEALEVFRYLERGLGKGFFPAW
IGFFAYEFARHLGLPAHKPLPGLPEAFFLYYPEGYALFEGRLVQAPSFPLRPLPYAPPPLPRHPLVSDFPREAFLRGVEE
VRERIRAGVVYQVNLSHRFRLLGPVDPLLLYARLRALNPSPFMGLVEGEGWAVVSGSPERLFQKVGPRVLARPIAGTRPR
GRTEAEDLALERELLASTKERAEHVMLVDLLRNDLARVARPGTVRVRELFTVERYAHVMHLVSEVEGRTGASLGEVFRSL
FPGGTITGAPKGTVMEAIRDLEPVPRGAYTGSLGYVSGRGADFNILIRSFQRVGEEVLFSAGAGVVIASEAEREYEETLH
KAQSLLLALERGRPGKPPEAPRPRASWSPPMPSRRYGARVLFLENRDSFSHNLVDYLRALGAEVAVVDQEEAPDLKGFTH
LVVGPGPKDPFTAGRVLEWTEKALAAGLPLLGVCLGHQALGVALGAELYREAPVHGEAHAVFHTGEGLFRGIPSPAPFAR
YHSLALRRLPPGLRLLAWTEDGVPMAIWDGRRAYGVQFHPESLLSPYGMLLLARFLEVG

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=268, Percent_Identity=40.2985074626866, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787518, Length=295, Percent_Identity=37.9661016949153, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789760, Length=189, Percent_Identity=42.3280423280423, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1787517, Length=188, Percent_Identity=38.2978723404255, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI87082077, Length=216, Percent_Identity=26.3888888888889, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1786809, Length=226, Percent_Identity=28.3185840707965, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=426, Percent_Identity=32.3943661971831, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322638, Length=191, Percent_Identity=32.4607329842932, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324361, Length=286, Percent_Identity=27.6223776223776, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 68247; Mature: 68116

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGLLGLYHAARCSGLRPALLESLGPRTPFSRLSLLGVGPAHRLEVWEGRLYLDGRRVG
CCCCHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHEEECCCHHHEEEECCEEEECHHHHH
EALEVFRYLERGLGKGFFPAWIGFFAYEFARHLGLPAHKPLPGLPEAFFLYYPEGYALFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEC
GRLVQAPSFPLRPLPYAPPPLPRHPLVSDFPREAFLRGVEEVRERIRAGVVYQVNLSHRF
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCE
RLLGPVDPLLLYARLRALNPSPFMGLVEGEGWAVVSGSPERLFQKVGPRVLARPIAGTRP
EEECCCHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCHHHHHHHHCHHHHHCCCCCCCC
RGRTEAEDLALERELLASTKERAEHVMLVDLLRNDLARVARPGTVRVRELFTVERYAHVM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HLVSEVEGRTGASLGEVFRSLFPGGTITGAPKGTVMEAIRDLEPVPRGAYTGSLGYVSGR
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GADFNILIRSFQRVGEEVLFSAGAGVVIASEAEREYEETLHKAQSLLLALERGRPGKPPE
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
APRPRASWSPPMPSRRYGARVLFLENRDSFSHNLVDYLRALGAEVAVVDQEEAPDLKGFT
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCE
HLVVGPGPKDPFTAGRVLEWTEKALAAGLPLLGVCLGHQALGVALGAELYREAPVHGEAH
EEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
AVFHTGEGLFRGIPSPAPFARYHSLALRRLPPGLRLLAWTEDGVPMAIWDGRRAYGVQFH
EEEECCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCEEECEEEC
PESLLSPYGMLLLARFLEVG
HHHHHCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGGLLGLYHAARCSGLRPALLESLGPRTPFSRLSLLGVGPAHRLEVWEGRLYLDGRRVG
CCCHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHEEECCCHHHEEEECCEEEECHHHHH
EALEVFRYLERGLGKGFFPAWIGFFAYEFARHLGLPAHKPLPGLPEAFFLYYPEGYALFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEC
GRLVQAPSFPLRPLPYAPPPLPRHPLVSDFPREAFLRGVEEVRERIRAGVVYQVNLSHRF
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCE
RLLGPVDPLLLYARLRALNPSPFMGLVEGEGWAVVSGSPERLFQKVGPRVLARPIAGTRP
EEECCCHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCHHHHHHHHCHHHHHCCCCCCCC
RGRTEAEDLALERELLASTKERAEHVMLVDLLRNDLARVARPGTVRVRELFTVERYAHVM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HLVSEVEGRTGASLGEVFRSLFPGGTITGAPKGTVMEAIRDLEPVPRGAYTGSLGYVSGR
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GADFNILIRSFQRVGEEVLFSAGAGVVIASEAEREYEETLHKAQSLLLALERGRPGKPPE
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
APRPRASWSPPMPSRRYGARVLFLENRDSFSHNLVDYLRALGAEVAVVDQEEAPDLKGFT
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCE
HLVVGPGPKDPFTAGRVLEWTEKALAAGLPLLGVCLGHQALGVALGAELYREAPVHGEAH
EEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
AVFHTGEGLFRGIPSPAPFARYHSLALRRLPPGLRLLAWTEDGVPMAIWDGRRAYGVQFH
EEEECCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCEEECEEEC
PESLLSPYGMLLLARFLEVG
HHHHHCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571 [H]