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The map label for this gene is hemE [H]

Identifier: 55980570

GI number: 55980570

Start: 568464

End: 569489

Strand: Reverse

Name: hemE [H]

Synonym: TTHA0601

Alternate gene names: 55980570

Gene position: 569489-568464 (Counterclockwise)

Preceding gene: 55980572

Following gene: 55980569

Centisome position: 30.79

GC content: 69.49

Gene sequence:

>1026_bases
ATGGACCTCGTGAACGACCTCATCCTCCGGGCCGCCCGGGGCGAGCCCACCCCGAGGCCCCCCGTGTGGTTCATGCGCCA
GGCCGGGCGCTACCAGAAGGCCTACCGGAAGCTCCGCGAGCGCTACACCCTCCCCGAGATCGTGCAAAACCCCGAGGTCT
GCGCCGAGGTGACCCTCCTCCCCGTGAAGGCGCTCGGGGTGGACGCGGCCATCCTCTTCGCCGACATCACCACCCCCCTC
TACGGCATGGGGGTGGACCTCTCCCTGGTGGAGAACAAGGGGCCGGTGATCCACAACCCCGTCCGGGACGAAAAGGGCGT
GGAGGCCTTGAGGCCCCTCGTGCCCGAGGAGGCCGTCCCCTTCGTCCTGGAGACGATCCGGATCCTCAAGCGGGAGCTTC
CCGTCCCCCTCATCGGCTTCGCCGGGGCCCCCTTCACCCTGGCGAGCTACCTGGTGGAGGGGGGGCCGAGCCGCCGCTTC
CTCCGGGTCAAGGCCCTGATGTACGGGGAGGAGGCCCTATGGCACCGCCTCATGGAGAAGCTCACCGAGGCCATGGCCCG
CTACCTCCGGGCCCAGGCCGAGGCGGGGGCCGATCTCCTCCAGGTCTTTGACTCCTGGGTGGGAGCGCTCTCCCCCGCGG
ACTACCGCCGCTACGTCAAGCCCCACATGGAAAGGCTCTTCCAAAGCCTCAGGCCCGTGGGGGTCCCCGTGATCCACTTC
GGCGTGGGCACCATGGGGCTCCTCGAGGACATGAAGGAGGCGGGCGGGGACGTCCTGGGCCTGGACCACCACACCCCCCT
CCCCTGGGCCCGCGCCCTCCTCGGGGCCACCCCCGTCCAGGGGAACCTGGACCCCGCCGTCCTCCTCGCCCCCAAAGGGG
TCATCCGCCGCGAGGTGCAGAGGATCCTGAAGGAGAACGGGGGTAAAAGCGGGCACATCTTCAACCTGGGGCACGGGATC
GTGCCCGAGACCCCCGAGGAGAACGTGCGCTACGTGGTAGAACTCATCCAGGAGGTAGCGGCATGA

Upstream 100 bases:

>100_bases
CTCGGGGCCCACCTGGGCCACCACCTCCCCCTGGGCCAGGGCCATGGGGACGAGGAGCAAGGTCAGGGCCAAAAGAAACG
CGCGCATGCCCCATGCTAGC

Downstream 100 bases:

>100_bases
ACGTCCTGCTCATGGCCTACGGCACCCCTTACGCCCCCGAGGAGGTGGAGCCTTACTACACGGACATCCGCCGGGGGCGC
CGCCCCTCGGAGGAGCTCCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLLPVKALGVDAAILFADITTPL
YGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVPFVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRF
LRVKALMYGEEALWHRLMEKLTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHF
GVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQRILKENGGKSGHIFNLGHGI
VPETPEENVRYVVELIQEVAA

Sequences:

>Translated_341_residues
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLLPVKALGVDAAILFADITTPL
YGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVPFVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRF
LRVKALMYGEEALWHRLMEKLTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHF
GVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQRILKENGGKSGHIFNLGHGI
VPETPEENVRYVVELIQEVAA
>Mature_341_residues
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLLPVKALGVDAAILFADITTPL
YGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVPFVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRF
LRVKALMYGEEALWHRLMEKLTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHF
GVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQRILKENGGKSGHIFNLGHGI
VPETPEENVRYVVELIQEVAA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=37.9310344827586, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI2367337, Length=347, Percent_Identity=39.7694524495677, Blast_Score=235, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=34.2776203966006, Blast_Score=203, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=35.1585014409222, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=35.1585014409222, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37813; Mature: 37813

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
PVKALGVDAAILFADITTPLYGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVP
HHHHHCCCHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHH
FVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRFLRVKALMYGEEALWHRLMEK
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQ
CCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHH
RILKENGGKSGHIFNLGHGIVPETPEENVRYVVELIQEVAA
HHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLVNDLILRAARGEPTPRPPVWFMRQAGRYQKAYRKLRERYTLPEIVQNPEVCAEVTLL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
PVKALGVDAAILFADITTPLYGMGVDLSLVENKGPVIHNPVRDEKGVEALRPLVPEEAVP
HHHHHCCCHHHHHHHHHCCHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHH
FVLETIRILKRELPVPLIGFAGAPFTLASYLVEGGPSRRFLRVKALMYGEEALWHRLMEK
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LTEAMARYLRAQAEAGADLLQVFDSWVGALSPADYRRYVKPHMERLFQSLRPVGVPVIHF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GVGTMGLLEDMKEAGGDVLGLDHHTPLPWARALLGATPVQGNLDPAVLLAPKGVIRREVQ
CCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHH
RILKENGGKSGHIFNLGHGIVPETPEENVRYVVELIQEVAA
HHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA