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The map label for this gene is hemH [H]

Identifier: 55980569

GI number: 55980569

Start: 567514

End: 568467

Strand: Reverse

Name: hemH [H]

Synonym: TTHA0600

Alternate gene names: 55980569

Gene position: 568467-567514 (Counterclockwise)

Preceding gene: 55980570

Following gene: 55980568

Centisome position: 30.73

GC content: 69.6

Gene sequence:

>954_bases
ATGAACGTCCTGCTCATGGCCTACGGCACCCCTTACGCCCCCGAGGAGGTGGAGCCTTACTACACGGACATCCGCCGGGG
GCGCCGCCCCTCGGAGGAGCTCCTCAAGGAGCTCGCCGAGCGGTACGAGGCCATCGGCAAAAGCCCCCTGAACGAGATCA
CCCTGGCCCAGGCGGTCCGCCTCCAGGCCCTCCTCAACCTGGAGGCCCCCCCCTACCCCAAGCGCCTCCTGAGCCCCTTC
CCTCCCCGCGCCCCCCACGGCCCCGCCCGGGTCTACGTGGGGACGAAGCACTGGCACCCCTCCATCGGGGAGGCGGTGGC
CGCCATGCACGAGGACGGGGTGCGGCGGGCCGTGGCCATCGTGGCCGCCCCCCACTACTCCCTGAGGAGCGTGGCCGAGT
ACCGGGAGAAGGTGGACTCGGCCCTAAAAGCCCTCCCCGAGCCCATAGACTTCGTATGGGTGGAAAGCTACGAGGCCCAC
CCCGGCCTCATCGCCGCCTACGCCCGGAGGCTTGAGGAGGTGATCTGGCGCCTGAAGAACCCGGGGAAGGCGGCCTACGT
CTTCACCGCCCACTCCATCCCCCTCTCCGCCGTGGAGAAGGGGGACCCCTACCCCAGGCAGGTGGAGAAGACGGCGGAAC
TCATCGCCAAAAAGCTCGCCCTCCCCCGCTTCCACGTGGCCTACCAGTCGGCAGGGCGCACCCCGGAGCCCTGGCTCGGC
CCCGACATCAACGAGCTTCTGCGCACGCTGAAGGAGGAGGGGTACGAGGAAGTGGCCGTCCAGGCGGTGGGCTTCCCCGC
CGACCACCTGGAGGTCTTCTACGACCTGGACCTCGAGGCCCAGGCCACGGCGAGGGAGCTCGGCCTGAGGCTCCTCAGGG
CCCGGAGCCTGAACGCGGACCTGGACTACATCCAAGTCCTCAAGGACCTGGTGGAGGCGGCGTGGCCGAGATAG

Upstream 100 bases:

>100_bases
GTAAAAGCGGGCACATCTTCAACCTGGGGCACGGGATCGTGCCCGAGACCCCCGAGGAGAACGTGCGCTACGTGGTAGAA
CTCATCCAGGAGGTAGCGGC

Downstream 100 bases:

>100_bases
GGGTGGCCGTGGTGGGCGGGGGGTGGGCGGGGCTGGCCGCCGCCCTGGCCCTCAAGGAGGCGGGGGCGGACTTCCTCCTC
CTGGAGGCCAGCCTCCGCCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVRLQALLNLEAPPYPKRLLSPF
PPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAIVAAPHYSLRSVAEYREKVDSALKALPEPIDFVWVESYEAH
PGLIAAYARRLEEVIWRLKNPGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLG
PDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNADLDYIQVLKDLVEAAWPR

Sequences:

>Translated_317_residues
MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVRLQALLNLEAPPYPKRLLSPF
PPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAIVAAPHYSLRSVAEYREKVDSALKALPEPIDFVWVESYEAH
PGLIAAYARRLEEVIWRLKNPGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLG
PDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNADLDYIQVLKDLVEAAWPR
>Mature_317_residues
MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVRLQALLNLEAPPYPKRLLSPF
PPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAIVAAPHYSLRSVAEYREKVDSALKALPEPIDFVWVESYEAH
PGLIAAYARRLEEVIWRLKNPGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLG
PDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNADLDYIQVLKDLVEAAWPR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=285, Percent_Identity=29.1228070175439, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI60499025, Length=285, Percent_Identity=29.1228070175439, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI1786681, Length=227, Percent_Identity=24.6696035242291, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324750, Length=285, Percent_Identity=27.3684210526316, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=27.906976744186, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=25.6603773584906, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35651; Mature: 35651

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVR
CCEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQALLNLEAPPYPKRLLSPFPPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAI
HHHHHCCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VAAPHYSLRSVAEYREKVDSALKALPEPIDFVWVESYEAHPGLIAAYARRLEEVIWRLKN
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLG
CCCEEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
PDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNAD
CCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCC
LDYIQVLKDLVEAAWPR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVR
CCEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQALLNLEAPPYPKRLLSPFPPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAI
HHHHHCCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VAAPHYSLRSVAEYREKVDSALKALPEPIDFVWVESYEAHPGLIAAYARRLEEVIWRLKN
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLG
CCCEEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
PDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNAD
CCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCC
LDYIQVLKDLVEAAWPR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA