Click here to switch to the map view.

The map label for this gene is hemY [H]

Identifier: 55980568

GI number: 55980568

Start: 566153

End: 567526

Strand: Reverse

Name: hemY [H]

Synonym: TTHA0599

Alternate gene names: 55980568

Gene position: 567526-566153 (Counterclockwise)

Preceding gene: 55980569

Following gene: 55980567

Centisome position: 30.68

GC content: 74.75

Gene sequence:

>1374_bases
GTGGCCGAGATAGGGGTGGCCGTGGTGGGCGGGGGGTGGGCGGGGCTGGCCGCCGCCCTGGCCCTCAAGGAGGCGGGGGC
GGACTTCCTCCTCCTGGAGGCCAGCCTCCGCCTCGGGGGGAAGGTGCGCACCGCCCGGCAGGAGGGCTTCCTGGTGGAGG
GGGGGCCTGACGCCAGCGTCCGCTACAAGAAGGAGGTGCTGGAGCTCGCCCAGGCCTTCGGCCTCGAGCCCATCGGCACC
CTTCCGGAAAAGCCCGCGGCCTACATCCTCTACCGGGGGAAGCGCCACCCCCTGCCCGAAGGCCTCCTCCAGGTGGTGCC
CGGGGACCTCAAGGCCCTGGCCCGCACCCCCCTCCTCTCCCTCCCGGGGAAGCTCCGGGCCCTCTACGACCTCTTCCTCC
CCCGGGGGGCGAAGGAGGACGAGACCCTGAGGGAGTTCGTGGAGAGGCGCCTGGGGCCCGAGGTCTACCGGGCCCTGGTG
GCCCCCCTGGCCGGGGGGGTGTACGGGGGGGAGCCCGACGACCTCTCCATGCGGGCCGCCTTTCCCCAGCTCTGGGAGCT
GGAGGGAAGGCACCGGAGCCTCCTCCTTGGGGCCATGCGGGTCCGGAAGGGGCGGGGAAGCCGGGAGGGGGGCAGCCTCT
TCTTCTCCTTCGCCGAGGGCCTCCAGGCCCTCACCCGGCGGATGGCCGAGGCCCTGGGGGAGCGGGTCCTGCGGGGCACC
CCTGTCCTCGGCCTGGAGCCAGCCCGCGGAAGGTGGCGCCTCCACACCCCTAAAGGGGCCCTCCTCGCCGAGGCCGTGGT
CCTCGCCATCCCCGCCCCCCAGGCGGCGGGCCTCCTCAGGCCCTTCCTCCCGGAGGCCACCGCTTTGCTCAAGGGGATCC
CCCACACCCCGGCGGCCACGGTGAGCCTGGCCTTCCCCGGGGCGCTCCCCGTGGAGGGGCACGGGCTGCTTGTGGCCAAG
GGGGAGGGGCTTCGGGCCCGGGGGTTCACCTGGACGCACCGGAAGTGGCCGGGGCGGGTCCCGGAGGGGTTCAGCCTGGT
GCGGGCCTACTTCTCGGGGGAGGCCGCCCGGCTTTCCGAGGAGGCCCTCATCCGGCTTGCCCTGGAGGACCTAGCCCGCC
TCCTCCCGGGCCTTCCCCGGGTCCACCGGGCCTGGGCCTTCCGCTTCCCCGAGGGGATGCCCGCCTACCGGGTGGGCCAC
CTGGACCGGGTGGAGCGGCTGGAGATGGCCCTGGTCAAGGCGCCCGGCCTCTTCCTCGCGGGGAACTACCTCCAGGGGGT
GGGCCTGCCCGAGGTGGTGCGCTCGGGGAGGCGGGCGGCGCAAAGGGCCCTGGCCCACCTCTCCCTAGGCGAGGCCCATG
GAGCTTCTCGGTGA

Upstream 100 bases:

>100_bases
AGGCCACGGCGAGGGAGCTCGGCCTGAGGCTCCTCAGGGCCCGGAGCCTGAACGCGGACCTGGACTACATCCAAGTCCTC
AAGGACCTGGTGGAGGCGGC

Downstream 100 bases:

>100_bases
GGAGGGAAGAAGGCTTCTTCGGCTCGGCCTCCTTCCCGGCCTCCTAGGCGGGGGGCTCGCGGTGGCCTTCCGCCTCCTCC
TGGACCTCCTCCTCCTGGTC

Product: protoporphyrinogen oxidase HemG

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MAEIGVAVVGGGWAGLAAALALKEAGADFLLLEASLRLGGKVRTARQEGFLVEGGPDASVRYKKEVLELAQAFGLEPIGT
LPEKPAAYILYRGKRHPLPEGLLQVVPGDLKALARTPLLSLPGKLRALYDLFLPRGAKEDETLREFVERRLGPEVYRALV
APLAGGVYGGEPDDLSMRAAFPQLWELEGRHRSLLLGAMRVRKGRGSREGGSLFFSFAEGLQALTRRMAEALGERVLRGT
PVLGLEPARGRWRLHTPKGALLAEAVVLAIPAPQAAGLLRPFLPEATALLKGIPHTPAATVSLAFPGALPVEGHGLLVAK
GEGLRARGFTWTHRKWPGRVPEGFSLVRAYFSGEAARLSEEALIRLALEDLARLLPGLPRVHRAWAFRFPEGMPAYRVGH
LDRVERLEMALVKAPGLFLAGNYLQGVGLPEVVRSGRRAAQRALAHLSLGEAHGASR

Sequences:

>Translated_457_residues
MAEIGVAVVGGGWAGLAAALALKEAGADFLLLEASLRLGGKVRTARQEGFLVEGGPDASVRYKKEVLELAQAFGLEPIGT
LPEKPAAYILYRGKRHPLPEGLLQVVPGDLKALARTPLLSLPGKLRALYDLFLPRGAKEDETLREFVERRLGPEVYRALV
APLAGGVYGGEPDDLSMRAAFPQLWELEGRHRSLLLGAMRVRKGRGSREGGSLFFSFAEGLQALTRRMAEALGERVLRGT
PVLGLEPARGRWRLHTPKGALLAEAVVLAIPAPQAAGLLRPFLPEATALLKGIPHTPAATVSLAFPGALPVEGHGLLVAK
GEGLRARGFTWTHRKWPGRVPEGFSLVRAYFSGEAARLSEEALIRLALEDLARLLPGLPRVHRAWAFRFPEGMPAYRVGH
LDRVERLEMALVKAPGLFLAGNYLQGVGLPEVVRSGRRAAQRALAHLSLGEAHGASR
>Mature_456_residues
AEIGVAVVGGGWAGLAAALALKEAGADFLLLEASLRLGGKVRTARQEGFLVEGGPDASVRYKKEVLELAQAFGLEPIGTL
PEKPAAYILYRGKRHPLPEGLLQVVPGDLKALARTPLLSLPGKLRALYDLFLPRGAKEDETLREFVERRLGPEVYRALVA
PLAGGVYGGEPDDLSMRAAFPQLWELEGRHRSLLLGAMRVRKGRGSREGGSLFFSFAEGLQALTRRMAEALGERVLRGTP
VLGLEPARGRWRLHTPKGALLAEAVVLAIPAPQAAGLLRPFLPEATALLKGIPHTPAATVSLAFPGALPVEGHGLLVAKG
EGLRARGFTWTHRKWPGRVPEGFSLVRAYFSGEAARLSEEALIRLALEDLARLLPGLPRVHRAWAFRFPEGMPAYRVGHL
DRVERLEMALVKAPGLFLAGNYLQGVGLPEVVRSGRRAAQRALAHLSLGEAHGASR

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=483, Percent_Identity=32.9192546583851, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4506001, Length=483, Percent_Identity=32.9192546583851, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24649745, Length=471, Percent_Identity=27.8131634819533, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 49202; Mature: 49071

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIGVAVVGGGWAGLAAALALKEAGADFLLLEASLRLGGKVRTARQEGFLVEGGPDASV
CCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCEEEHHHCCEEEECCCCCCH
RYKKEVLELAQAFGLEPIGTLPEKPAAYILYRGKRHPLPEGLLQVVPGDLKALARTPLLS
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHCCHHC
LPGKLRALYDLFLPRGAKEDETLREFVERRLGPEVYRALVAPLAGGVYGGEPDDLSMRAA
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
FPQLWELEGRHRSLLLGAMRVRKGRGSREGGSLFFSFAEGLQALTRRMAEALGERVLRGT
CCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVLGLEPARGRWRLHTPKGALLAEAVVLAIPAPQAAGLLRPFLPEATALLKGIPHTPAAT
CCCCCCCCCCCEEEECCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
VSLAFPGALPVEGHGLLVAKGEGLRARGFTWTHRKWPGRVPEGFSLVRAYFSGEAARLSE
EEEECCCCCCCCCCEEEEECCCCCEECCEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHH
EALIRLALEDLARLLPGLPRVHRAWAFRFPEGMPAYRVGHLDRVERLEMALVKAPGLFLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEE
GNYLQGVGLPEVVRSGRRAAQRALAHLSLGEAHGASR
CCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEIGVAVVGGGWAGLAAALALKEAGADFLLLEASLRLGGKVRTARQEGFLVEGGPDASV
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCEEEHHHCCEEEECCCCCCH
RYKKEVLELAQAFGLEPIGTLPEKPAAYILYRGKRHPLPEGLLQVVPGDLKALARTPLLS
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHCCHHC
LPGKLRALYDLFLPRGAKEDETLREFVERRLGPEVYRALVAPLAGGVYGGEPDDLSMRAA
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
FPQLWELEGRHRSLLLGAMRVRKGRGSREGGSLFFSFAEGLQALTRRMAEALGERVLRGT
CCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVLGLEPARGRWRLHTPKGALLAEAVVLAIPAPQAAGLLRPFLPEATALLKGIPHTPAAT
CCCCCCCCCCCEEEECCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
VSLAFPGALPVEGHGLLVAKGEGLRARGFTWTHRKWPGRVPEGFSLVRAYFSGEAARLSE
EEEECCCCCCCCCCEEEEECCCCCEECCEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHH
EALIRLALEDLARLLPGLPRVHRAWAFRFPEGMPAYRVGHLDRVERLEMALVKAPGLFLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEE
GNYLQGVGLPEVVRSGRRAAQRALAHLSLGEAHGASR
CCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]