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The map label for this gene is tlyA [H]

Identifier: 55980515

GI number: 55980515

Start: 510237

End: 510944

Strand: Reverse

Name: tlyA [H]

Synonym: TTHA0546

Alternate gene names: 55980515

Gene position: 510944-510237 (Counterclockwise)

Preceding gene: 55980518

Following gene: 55980511

Centisome position: 27.62

GC content: 69.35

Gene sequence:

>708_bases
GTGCGCCTGGACCGCTACCTGGTGGAACGGGGCCTGGTGGAAAGCCGGGAGAAGGCCAAGCGCCTGATCCAGGAGGGCAA
GGTGCGGGTGGAGGGCAAGGTGGTGCAAAAGCCCGCCCACCCCGTGCCCGAAGGCGCCAGGGTGGAGCTCCTGGCGGAGG
AGCGCTACGTGGGCCGGGGGGCCTACAAGCTCCTCGGAGCCCTGGAGGCCTTCCCCGTGGAGCCCCGGGGCAAGGTCGCT
GCCGACCTCGGGGCGAGCACCGGGGGGTTCACGCAGGTCCTTTTGGAGCGGGGGGCGAGGCGGGTCTACGCCGTGGACGT
GGGCAAGGGCCAGCTCCACCCCCGCCTCCGGGAAGATCCCCGGGTGGTGGCCCTGGAGGAACAGGACGCCCGCACCCTGG
TCCTGCCCGAGCCCGTGGACCTCGTGGTGATGGACGTTTCCTTCATCTCCTCCACCCTCCTCCTCCCCAAGGTCCTGGAG
CTCCTCAAGCCCCAAGGGGAGGCCCTGGTCCTGGTGAAGCCCCAGTTTGAGCTGGGGCCAAAGGCCCACAAGGGGGTGGT
GCGGGAGGAGGCGAAGCGGCGGGAGGCCCTAAGGCGGGTGCGGGAAAAGGCCCTAGAGCTTGGCTTCCAGGTCCTGGGGG
AAAAGGAAAGCCCCCTCCCGGGAAAGGAGGGGAACCTAGAGTACTGGCTTTGGCTCAGGCGCCCTTAA

Upstream 100 bases:

>100_bases
CTCTCCCCCAAAGCCTCCACCACCAGGTGCTCCCCCGGGTCTCCCTCCAAAACGTACCAGGTCCCGGAAAGGTCAGGCGC
CACCCGCTCATAATACCCTC

Downstream 100 bases:

>100_bases
GCCACTCCTCGGCGATCTGCACGGCGTTTAAGGCGGCCCCCTTCAAGAGCTGGTCCCCCACCACGAAGAAGTCCAGGCCG
TTTTCAAAGGCGAGGCTTTT

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRLDRYLVERGLVESREKAKRLIQEGKVRVEGKVVQKPAHPVPEGARVELLAEERYVGRGAYKLLGALEAFPVEPRGKVA
ADLGASTGGFTQVLLERGARRVYAVDVGKGQLHPRLREDPRVVALEEQDARTLVLPEPVDLVVMDVSFISSTLLLPKVLE
LLKPQGEALVLVKPQFELGPKAHKGVVREEAKRREALRRVREKALELGFQVLGEKESPLPGKEGNLEYWLWLRRP

Sequences:

>Translated_235_residues
MRLDRYLVERGLVESREKAKRLIQEGKVRVEGKVVQKPAHPVPEGARVELLAEERYVGRGAYKLLGALEAFPVEPRGKVA
ADLGASTGGFTQVLLERGARRVYAVDVGKGQLHPRLREDPRVVALEEQDARTLVLPEPVDLVVMDVSFISSTLLLPKVLE
LLKPQGEALVLVKPQFELGPKAHKGVVREEAKRREALRRVREKALELGFQVLGEKESPLPGKEGNLEYWLWLRRP
>Mature_235_residues
MRLDRYLVERGLVESREKAKRLIQEGKVRVEGKVVQKPAHPVPEGARVELLAEERYVGRGAYKLLGALEAFPVEPRGKVA
ADLGASTGGFTQVLLERGARRVYAVDVGKGQLHPRLREDPRVVALEEQDARTLVLPEPVDLVVMDVSFISSTLLLPKVLE
LLKPQGEALVLVKPQFELGPKAHKGVVREEAKRREALRRVREKALELGFQVLGEKESPLPGKEGNLEYWLWLRRP

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1189

COG function: function code J; Predicted rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004538
- InterPro:   IPR002877
- InterPro:   IPR002942 [H]

Pfam domain/function: PF01728 FtsJ; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 26351; Mature: 26351

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDRYLVERGLVESREKAKRLIQEGKVRVEGKVVQKPAHPVPEGARVELLAEERYVGRG
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECEEEECCCCCCCCCCEEEEEEHHHHHCCH
AYKLLGALEAFPVEPRGKVAADLGASTGGFTQVLLERGARRVYAVDVGKGQLHPRLREDP
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
RVVALEEQDARTLVLPEPVDLVVMDVSFISSTLLLPKVLELLKPQGEALVLVKPQFELGP
CEEEEECCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
KAHKGVVREEAKRREALRRVREKALELGFQVLGEKESPLPGKEGNLEYWLWLRRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MRLDRYLVERGLVESREKAKRLIQEGKVRVEGKVVQKPAHPVPEGARVELLAEERYVGRG
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECEEEECCCCCCCCCCEEEEEEHHHHHCCH
AYKLLGALEAFPVEPRGKVAADLGASTGGFTQVLLERGARRVYAVDVGKGQLHPRLREDP
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
RVVALEEQDARTLVLPEPVDLVVMDVSFISSTLLLPKVLELLKPQGEALVLVKPQFELGP
CEEEEECCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
KAHKGVVREEAKRREALRRVREKALELGFQVLGEKESPLPGKEGNLEYWLWLRRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730486 [H]