Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 55980511

GI number: 55980511

Start: 504982

End: 507192

Strand: Reverse

Name: clpB [H]

Synonym: TTHA0542

Alternate gene names: 55980511

Gene position: 507192-504982 (Counterclockwise)

Preceding gene: 55980515

Following gene: 55980510

Centisome position: 27.42

GC content: 69.34

Gene sequence:

>2211_bases
ATGAACCGATACGACGACCGCGCCAGGCTGGTCTTTCACTACGCAAGAGAGGAGGGGAGCCGCTTAGGCCACTCCATGAT
CGGCCCGGAGCACCTCCTCCTGGGCCTGATGCGCGAGGGGGGGACGGCGGCCCGCATCCTCCAGGAGTACGGCGCGAGCC
TCGAGGCCATGCGCCGCATGGTGGAGGAGCTGGTGGGCCGGGGGGAGGGCGGGCGCACCGGGGAGCCCCCCGCCATCACC
CCGAGGGCGAGGCGGGTCATGGAGCTCGCCAGCGCCGAGGCCCGCAACATGGGCTCCCCCGTCATCGGCACGGAGCACAT
CCTCCTCGGCATCATCCGGGAGGGGGACGGGATCGCCTACCGCATCCTCAGCCACTTCGCCAAGGACGTGGACGCCATCC
GCTGGAGGGTCCTGGCCATGGCCGAGGGCCGCGAGCGGGAAAAGCCTGTGAACACCCCCTTCCTGGACGAGTACGGCCGC
GACCTCACCAAGGAGGCCCGGGAAGGAAAGCTGGACCCGGTGATCGGCCGCCAGGAGGAGATCAACCGGGTGATCCAGAT
CCTCGCCCGGCGCACCAAGAACAATCCCGTGCTCATCGGCGACCCCGGGGTGGGCAAGACGGCCATCGTGGAGGGCCTGG
CCCAGGCCATCGTGGAGGGCCGGGTCCCCCCCATCCTCAAGGGGGCCCGGGTGGTGGCCATTGACCTCGCCGGGGTGGTG
GCGGGGACCAAGTACCGGGGCGAGTTTGAGGAGCGCCTGCGGCAGATCATTGAGGAGCTCAAGAACGCCAAGGTCATCGC
CTTCATTGACGAGCTCCACACCCTGATCGGGGCGGGCGGGGCCGAGGGCACCCTGGACGCCGCCAACATCCTCAAGCCCG
CCCTGGCCCGCGGGGAGATCCAGGTGATCGGGGCCACCACCACCGGGGAGTACCACCGCTACATAGAGAAGGACGCGGCC
CTGGAGCGGCGCTTCCAGCCGGTGATCGTCCTCGAGCCTTCCCCGGAGGAGACCCTGGAGATCCTCAAGGGCCTCCGCCC
CCGGTACGAGGCCCACCACGGGGTGATCATCCCCGACGAGATCCTGGAGCTTGCGGTGAAGATCGGGATCCGCTCGCTTC
CCGGGCGCAACTTCCCCGACAAGGCCATTGACCTCATTGACGAGGCGGCCTCGAGGGTGCGCCTGAACGCCTCCTTGGGC
CTCCCCGTGGCGGAGGAAGAGGACGGCACCCCCATCGTCACCCGGGAGGACGTGGAGGCGGTGGTGGACTCCTGGGGCGG
GGTCTACGTGGACGACAAGGACGACGAGAAGCTCATGCGCCTGGAGGAGGAGCTCAGGAAGCGGGTGGTGGGCCAGGAGG
AGGCCATCCGCGCCCTGGCGAACGCCCTCCGCCGGGCCCGGGTGGGGCTTGGGGGAAGGACCCGGGTGGCGGCGAGCTTC
CTCTTCGTGGGGCAAAGCGGCGTGGGCAAGACCCAGCTCGCCAAGGCCCTGGCCGAGGTCCTCTTCGGCTCGGAGAGGGC
CCTCATCCGCTTTGACATGTCCGAGTTCCAGGAGCCCCACTCCATCTCCAAGCTCATCGGGGCCCCGCCGGGCTATGTGG
GCTACGAGCAGGGGGGCCGCCTCACCGAGGCCGTGCGCCGCCAGCCCTTCAGCGTGGTCCTCCTGGACGAGATTGAGAAG
GCCCACCCCGACATCTACAACACCTTCCTCCAGGTGCTGGACGAGGGCCGCCTCACGGACGGCATGGGCCGCACCGTGGA
CTTCCGCCGGGTCATCCTCATCATGACCTCCAACACCGGCTACAACGTGGGCCCCGCCATCGGCTTCACCTCCAAGGAGG
TGGACACGGAGTCCCCCCTGAAGGCCCTCTTCACCCCCGAGTTTCTGGACCGGCTGGACGAGGTCATCCGCTTCCGGCCC
CTCACGGAGGAGGAGCTGGTGCGGGTGGCCGAGATGATGCTGGAGGACATCCGCAAGGAGCTCCAGGCCCGGGACGTCCA
GGTGAGCTTCGCCCCCGAATTGGCCCGCTTCCTGGTGGACCAGGCCCCCAAGACGGGGAGCGCCCGCGCCCTGCGGAGCG
TCCTAAGGGAGCGCATAGAGGACCCCTTGGCCGTCGCCCTCCTGCGGAAGCCCACGGGCCGGATCCACGTGAGCGTGGAG
GGAGGCCAGGTGGCCTTCCACGAGGTGGAGGGGGAGGAGCTCCTCGTCTAG

Upstream 100 bases:

>100_bases
CGATTACCAGGCATCTTACCCAAAGGCCCCCCTAAGGTGAGCCGGGGCGCAAACGCCAAGCCGCCCTCTCCCTAGGCTAG
AATGTGAGGTAGAGGGGAGC

Downstream 100 bases:

>100_bases
CCCCCGGAGGATGGCCAAGGCCACCTACGCCTGCGTGGAGTGCGGCTACCGCACCCCCAAGCCCTTGGGGCGGTGCCCCT
CCTGCGGTTCCTGGGAGAGC

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MNRYDDRARLVFHYAREEGSRLGHSMIGPEHLLLGLMREGGTAARILQEYGASLEAMRRMVEELVGRGEGGRTGEPPAIT
PRARRVMELASAEARNMGSPVIGTEHILLGIIREGDGIAYRILSHFAKDVDAIRWRVLAMAEGREREKPVNTPFLDEYGR
DLTKEAREGKLDPVIGRQEEINRVIQILARRTKNNPVLIGDPGVGKTAIVEGLAQAIVEGRVPPILKGARVVAIDLAGVV
AGTKYRGEFEERLRQIIEELKNAKVIAFIDELHTLIGAGGAEGTLDAANILKPALARGEIQVIGATTTGEYHRYIEKDAA
LERRFQPVIVLEPSPEETLEILKGLRPRYEAHHGVIIPDEILELAVKIGIRSLPGRNFPDKAIDLIDEAASRVRLNASLG
LPVAEEEDGTPIVTREDVEAVVDSWGGVYVDDKDDEKLMRLEEELRKRVVGQEEAIRALANALRRARVGLGGRTRVAASF
LFVGQSGVGKTQLAKALAEVLFGSERALIRFDMSEFQEPHSISKLIGAPPGYVGYEQGGRLTEAVRRQPFSVVLLDEIEK
AHPDIYNTFLQVLDEGRLTDGMGRTVDFRRVILIMTSNTGYNVGPAIGFTSKEVDTESPLKALFTPEFLDRLDEVIRFRP
LTEEELVRVAEMMLEDIRKELQARDVQVSFAPELARFLVDQAPKTGSARALRSVLRERIEDPLAVALLRKPTGRIHVSVE
GGQVAFHEVEGEELLV

Sequences:

>Translated_736_residues
MNRYDDRARLVFHYAREEGSRLGHSMIGPEHLLLGLMREGGTAARILQEYGASLEAMRRMVEELVGRGEGGRTGEPPAIT
PRARRVMELASAEARNMGSPVIGTEHILLGIIREGDGIAYRILSHFAKDVDAIRWRVLAMAEGREREKPVNTPFLDEYGR
DLTKEAREGKLDPVIGRQEEINRVIQILARRTKNNPVLIGDPGVGKTAIVEGLAQAIVEGRVPPILKGARVVAIDLAGVV
AGTKYRGEFEERLRQIIEELKNAKVIAFIDELHTLIGAGGAEGTLDAANILKPALARGEIQVIGATTTGEYHRYIEKDAA
LERRFQPVIVLEPSPEETLEILKGLRPRYEAHHGVIIPDEILELAVKIGIRSLPGRNFPDKAIDLIDEAASRVRLNASLG
LPVAEEEDGTPIVTREDVEAVVDSWGGVYVDDKDDEKLMRLEEELRKRVVGQEEAIRALANALRRARVGLGGRTRVAASF
LFVGQSGVGKTQLAKALAEVLFGSERALIRFDMSEFQEPHSISKLIGAPPGYVGYEQGGRLTEAVRRQPFSVVLLDEIEK
AHPDIYNTFLQVLDEGRLTDGMGRTVDFRRVILIMTSNTGYNVGPAIGFTSKEVDTESPLKALFTPEFLDRLDEVIRFRP
LTEEELVRVAEMMLEDIRKELQARDVQVSFAPELARFLVDQAPKTGSARALRSVLRERIEDPLAVALLRKPTGRIHVSVE
GGQVAFHEVEGEELLV
>Mature_736_residues
MNRYDDRARLVFHYAREEGSRLGHSMIGPEHLLLGLMREGGTAARILQEYGASLEAMRRMVEELVGRGEGGRTGEPPAIT
PRARRVMELASAEARNMGSPVIGTEHILLGIIREGDGIAYRILSHFAKDVDAIRWRVLAMAEGREREKPVNTPFLDEYGR
DLTKEAREGKLDPVIGRQEEINRVIQILARRTKNNPVLIGDPGVGKTAIVEGLAQAIVEGRVPPILKGARVVAIDLAGVV
AGTKYRGEFEERLRQIIEELKNAKVIAFIDELHTLIGAGGAEGTLDAANILKPALARGEIQVIGATTTGEYHRYIEKDAA
LERRFQPVIVLEPSPEETLEILKGLRPRYEAHHGVIIPDEILELAVKIGIRSLPGRNFPDKAIDLIDEAASRVRLNASLG
LPVAEEEDGTPIVTREDVEAVVDSWGGVYVDDKDDEKLMRLEEELRKRVVGQEEAIRALANALRRARVGLGGRTRVAASF
LFVGQSGVGKTQLAKALAEVLFGSERALIRFDMSEFQEPHSISKLIGAPPGYVGYEQGGRLTEAVRRQPFSVVLLDEIEK
AHPDIYNTFLQVLDEGRLTDGMGRTVDFRRVILIMTSNTGYNVGPAIGFTSKEVDTESPLKALFTPEFLDRLDEVIRFRP
LTEEELVRVAEMMLEDIRKELQARDVQVSFAPELARFLVDQAPKTGSARALRSVLRERIEDPLAVALLRKPTGRIHVSVE
GGQVAFHEVEGEELLV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=37, Blast_Score=184, Evalue=4e-46,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=38.0187416331995, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788943, Length=392, Percent_Identity=47.4489795918367, Blast_Score=317, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323002, Length=405, Percent_Identity=39.7530864197531, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=245, Percent_Identity=58.3673469387755, Blast_Score=281, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 81426; Mature: 81426

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYDDRARLVFHYAREEGSRLGHSMIGPEHLLLGLMREGGTAARILQEYGASLEAMRRM
CCCCCCHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VEELVGRGEGGRTGEPPAITPRARRVMELASAEARNMGSPVIGTEHILLGIIREGDGIAY
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCHHH
RILSHFAKDVDAIRWRVLAMAEGREREKPVNTPFLDEYGRDLTKEAREGKLDPVIGRQEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCCHHH
INRVIQILARRTKNNPVLIGDPGVGKTAIVEGLAQAIVEGRVPPILKGARVVAIDLAGVV
HHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHH
AGTKYRGEFEERLRQIIEELKNAKVIAFIDELHTLIGAGGAEGTLDAANILKPALARGEI
HCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
QVIGATTTGEYHRYIEKDAALERRFQPVIVLEPSPEETLEILKGLRPRYEAHHGVIIPDE
EEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHCCCCEECHHH
ILELAVKIGIRSLPGRNFPDKAIDLIDEAASRVRLNASLGLPVAEEEDGTPIVTREDVEA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEHHHHHH
VVDSWGGVYVDDKDDEKLMRLEEELRKRVVGQEEAIRALANALRRARVGLGGRTRVAASF
HHHCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LFVGQSGVGKTQLAKALAEVLFGSERALIRFDMSEFQEPHSISKLIGAPPGYVGYEQGGR
HEECCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHCCCCCCCCCCCCCH
LTEAVRRQPFSVVLLDEIEKAHPDIYNTFLQVLDEGRLTDGMGRTVDFRRVILIMTSNTG
HHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCC
YNVGPAIGFTSKEVDTESPLKALFTPEFLDRLDEVIRFRPLTEEELVRVAEMMLEDIRKE
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LQARDVQVSFAPELARFLVDQAPKTGSARALRSVLRERIEDPLAVALLRKPTGRIHVSVE
HHHCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEE
GGQVAFHEVEGEELLV
CCEEEEEECCCCCCCC
>Mature Secondary Structure
MNRYDDRARLVFHYAREEGSRLGHSMIGPEHLLLGLMREGGTAARILQEYGASLEAMRRM
CCCCCCHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
VEELVGRGEGGRTGEPPAITPRARRVMELASAEARNMGSPVIGTEHILLGIIREGDGIAY
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCHHH
RILSHFAKDVDAIRWRVLAMAEGREREKPVNTPFLDEYGRDLTKEAREGKLDPVIGRQEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCCHHH
INRVIQILARRTKNNPVLIGDPGVGKTAIVEGLAQAIVEGRVPPILKGARVVAIDLAGVV
HHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHH
AGTKYRGEFEERLRQIIEELKNAKVIAFIDELHTLIGAGGAEGTLDAANILKPALARGEI
HCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
QVIGATTTGEYHRYIEKDAALERRFQPVIVLEPSPEETLEILKGLRPRYEAHHGVIIPDE
EEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHCCCCEECHHH
ILELAVKIGIRSLPGRNFPDKAIDLIDEAASRVRLNASLGLPVAEEEDGTPIVTREDVEA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEHHHHHH
VVDSWGGVYVDDKDDEKLMRLEEELRKRVVGQEEAIRALANALRRARVGLGGRTRVAASF
HHHCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LFVGQSGVGKTQLAKALAEVLFGSERALIRFDMSEFQEPHSISKLIGAPPGYVGYEQGGR
HEECCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHCCCCCCCCCCCCCH
LTEAVRRQPFSVVLLDEIEKAHPDIYNTFLQVLDEGRLTDGMGRTVDFRRVILIMTSNTG
HHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCC
YNVGPAIGFTSKEVDTESPLKALFTPEFLDRLDEVIRFRPLTEEELVRVAEMMLEDIRKE
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LQARDVQVSFAPELARFLVDQAPKTGSARALRSVLRERIEDPLAVALLRKPTGRIHVSVE
HHHCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEE
GGQVAFHEVEGEELLV
CCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]