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The map label for this gene is iclR [H]

Identifier: 55980476

GI number: 55980476

Start: 472179

End: 473003

Strand: Direct

Name: iclR [H]

Synonym: TTHA0507

Alternate gene names: 55980476

Gene position: 472179-473003 (Clockwise)

Preceding gene: 55980465

Following gene: 55980477

Centisome position: 25.53

GC content: 71.15

Gene sequence:

>825_bases
TTGTCAAGAAGCAAAAAGATTTTTTGTATCTTGAAAAACAGGGCCGCCCCCGTTACCCTAAGCGGCATGGCGCGTCCTCG
GGAGAAGCCGCCCCAGGCGGTGAAGACCCTGGAGAGGGGGCTTCGGGTCCTCGAGGCCCTGGCCCAGGCGGGGGAAAGCC
CCTTGGGCCCCTTGGCCGAACGGGTGGGCCTCGCCAAGAGCACCCTCTACCGCCTCCTCAGGGCCCTGGCCCAGGCGGGC
TTCGTGGAGGAGGAGGGCGGGGTCTACCGGGTGGGGCCCAAGGCCTTCGCCGTGGGCCAGGCCTACCCCAAGCGTTCGCT
TTCCCAGGCGGTCCGCCCCGAGATGGAGGCCTTGGCGAGGGAGACGGGGGAGAGCGTAAACCTGGCGGTGCCCCTGGGGC
GGGAGGCGTTGTACCTGGACCAGGTGGAGGGGACGAAGCTCGTCCGCCTCTTCACCGCCCCCGGCTCCCGGGCCCCCCTC
CACGCCACCGGGGTGGGCAAGGTCTTCCTGGCCTATCTGGGGGTGCCCGAGGGGCTTAGCCTCACGCCTTACACCCCCCA
CACCCTCACCCGGCTTCCCGACCTCCTCCGGGAGCTTGAGGCGGTGCGCGGGCGGGGCTACGCCCTGGACAACGAGGAGA
AGGAGCTCGGGGTGCGGTGCGTGGCCGCCCCCGTCTTCGGGGCCTCAGGGGGCGTGGTGGCCGCCCTCTCCCTCTCCGCC
CCCGCAAGCCGCCTCTCCCTGGAGGAGGCCCACCGCCTCGCCCCCCGGGTGGTGGAGGCGGCCCGGAGAGCTTCCCTGCG
CCTCGGGTACACAGGCGAGGTATAG

Upstream 100 bases:

>100_bases
CTCAGGGCCTCCTCCGTCAGGACCTCCTTCAGGAGGGGGTGGTCTTTCCGGATCTCCACGCCCTTCATGGTGGTCCGAGC
TTACGGGAGGCGGGGCGGGA

Downstream 100 bases:

>100_bases
TGTTTAAGGATAGAGGGGCTTAGCGGGAGGAGCTAAGGGCTTATGGACAAGGTGGTGGACAAGGACCGCCCCGTGTACGT
GATCTCGGTGGCGGCGGAGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSRSKKIFCILKNRAAPVTLSGMARPREKPPQAVKTLERGLRVLEALAQAGESPLGPLAERVGLAKSTLYRLLRALAQAG
FVEEEGGVYRVGPKAFAVGQAYPKRSLSQAVRPEMEALARETGESVNLAVPLGREALYLDQVEGTKLVRLFTAPGSRAPL
HATGVGKVFLAYLGVPEGLSLTPYTPHTLTRLPDLLRELEAVRGRGYALDNEEKELGVRCVAAPVFGASGGVVAALSLSA
PASRLSLEEAHRLAPRVVEAARRASLRLGYTGEV

Sequences:

>Translated_274_residues
MSRSKKIFCILKNRAAPVTLSGMARPREKPPQAVKTLERGLRVLEALAQAGESPLGPLAERVGLAKSTLYRLLRALAQAG
FVEEEGGVYRVGPKAFAVGQAYPKRSLSQAVRPEMEALARETGESVNLAVPLGREALYLDQVEGTKLVRLFTAPGSRAPL
HATGVGKVFLAYLGVPEGLSLTPYTPHTLTRLPDLLRELEAVRGRGYALDNEEKELGVRCVAAPVFGASGGVVAALSLSA
PASRLSLEEAHRLAPRVVEAARRASLRLGYTGEV
>Mature_273_residues
SRSKKIFCILKNRAAPVTLSGMARPREKPPQAVKTLERGLRVLEALAQAGESPLGPLAERVGLAKSTLYRLLRALAQAGF
VEEEGGVYRVGPKAFAVGQAYPKRSLSQAVRPEMEALARETGESVNLAVPLGREALYLDQVEGTKLVRLFTAPGSRAPLH
ATGVGKVFLAYLGVPEGLSLTPYTPHTLTRLPDLLRELEAVRGRGYALDNEEKELGVRCVAAPVFGASGGVVAALSLSAP
ASRLSLEEAHRLAPRVVEAARRASLRLGYTGEV

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=248, Percent_Identity=38.7096774193548, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786468, Length=251, Percent_Identity=36.2549800796813, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786715, Length=258, Percent_Identity=37.2093023255814, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1788131, Length=252, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789999, Length=263, Percent_Identity=34.9809885931559, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790752, Length=251, Percent_Identity=29.4820717131474, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788581, Length=247, Percent_Identity=30.3643724696356, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29267; Mature: 29136

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSKKIFCILKNRAAPVTLSGMARPREKPPQAVKTLERGLRVLEALAQAGESPLGPLAE
CCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RVGLAKSTLYRLLRALAQAGFVEEEGGVYRVGPKAFAVGQAYPKRSLSQAVRPEMEALAR
HHHHHHHHHHHHHHHHHHCCCEECCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHH
ETGESVNLAVPLGREALYLDQVEGTKLVRLFTAPGSRAPLHATGVGKVFLAYLGVPEGLS
HCCCCEEEEEECCCCEEEEECCCCCEEEEEEECCCCCCCEECCHHHHHHHHHHCCCCCCC
LTPYTPHTLTRLPDLLRELEAVRGRGYALDNEEKELGVRCVAAPVFGASGGVVAALSLSA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEEEEECCCCCCCCEEEEEECCC
PASRLSLEEAHRLAPRVVEAARRASLRLGYTGEV
CHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
SRSKKIFCILKNRAAPVTLSGMARPREKPPQAVKTLERGLRVLEALAQAGESPLGPLAE
CCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RVGLAKSTLYRLLRALAQAGFVEEEGGVYRVGPKAFAVGQAYPKRSLSQAVRPEMEALAR
HHHHHHHHHHHHHHHHHHCCCEECCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHH
ETGESVNLAVPLGREALYLDQVEGTKLVRLFTAPGSRAPLHATGVGKVFLAYLGVPEGLS
HCCCCEEEEEECCCCEEEEECCCCCEEEEEEECCCCCCCEECCHHHHHHHHHHCCCCCCC
LTPYTPHTLTRLPDLLRELEAVRGRGYALDNEEKELGVRCVAAPVFGASGGVVAALSLSA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEEEEECCCCCCCCEEEEEECCC
PASRLSLEEAHRLAPRVVEAARRASLRLGYTGEV
CHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]