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The map label for this gene is pgm [H]

Identifier: 55980322

GI number: 55980322

Start: 333867

End: 335441

Strand: Direct

Name: pgm [H]

Synonym: TTHA0353

Alternate gene names: 55980322

Gene position: 333867-335441 (Clockwise)

Preceding gene: 55980321

Following gene: 55980327

Centisome position: 18.05

GC content: 70.79

Gene sequence:

>1575_bases
ATGGAGATCACCCGGCTCCTCACCCTCTACTACGAGGCGACCCCAGACCCCCAAAACCCCTTGGAGGGGGTCCGCTTCGG
CACGAGCGGCCACCGGGGAAGCAGCCTCAAGGCCACTTTCACCGAGGCCCACGTCCTGGCCATCGCCCAGGCCATCGCCG
AGCTCCGGCCAAGCTTCGGGGCCACGGGGCCCCTCTTCCTGGCCAAGGACACCCACGCCCTCTCCGAGCCCGCCTGGGCC
ACGGCCCTCTCCGTCTTCGCCGCCCACGGAATAGAGGTCCGCGTGGAGGCGGACGGGGACTACACCCCCACGCCCCTCGT
CTCCCTGGCCATCCTGGAGCACAACGCCCACCACGAGGCCAAGGCCGATGGCGTCCTCCTCACCCCGAGCCACAACCCCC
CGGAGGACGGCGGCTTCAAGTACAACCCCCCCACGGGGGGTCCGGCGAACGCCCGCATCACCCGGGCCATAGAGGAGAGG
GCCAACGCCCTCCTCCAGGAGGGCCTCAAGGGCGTGAAGCGCCTCCCCCTCCGGGAGGCCCTGGCCCGGGCCAAGCCTTT
TGACTACGCGGGGCTTTACGTGGAAAAGGTGGCGGAGGCGGTGGACCTCGAGGCCATCCGGGCCTCGGGCCTTAGGATCG
GGGTGGACCCCTTAGGGGGGGCGAGCCTAAGGGTGTGGGAGCGGCTCGCCGAGTCCCACGGGCTCCCCCTGGAGGTGGTG
AACCCCACCCTAGACCCCACCTTCCGCTTCATGCCCAAGGACCACGACGGCAAGATCCGCATGGACTGCTCCAGCCCCTA
CGCCATGGCGGGCCTCCTCGCCCTCAAGGACCGCTTTGACCTCGCCATCGGCAACGACCCCGACGCCGACCGCCACGGGA
TCGTCACCCCGCGGGGCCTGATGAACCCCAACCACTACCTGGCCGCCGCCCTCCACCACCTCTACACCACCCGGTCCTGG
CCCGGGGCCAAGGTGGGGAAGACGGCGGTGACCAGCGCCCTCCTGGACCGGGTGGCCCAGGCCCTGGGGCGGGAGGTGTA
CGAGACCCCCGTGGGGTTCAAGCACTTCGTGGCGGGGCTCCTCGAGGGGTGGCTCGGCTTCGCCGGGGAGGAGAGCGCCG
GGGCAAGCTTCCTCCGCTTTGACGGGAGGCCCTTCTCCACCGACAAAGACGGGATCCTCATGGGCCTCCTCGCCGCCGAG
CTCATGGCCAAGCGAGGCCAGGCCCCGGACGCCCTTTACGAGGCCCTGGCGGAAAAGCTGGGCCGCCCCTACTACGCCCG
CAAGGACCTCCCCGTCTCCCCCGAGGCCAAGGCCCGCCTGGCCCGGCTCTCCGCCAAGGAGGTCCATCCCTCCACCCTCG
CCGGGGAGCCCGTCCTCCAGGTCCTGGACCGGGCCACGGGCAACGGGGAGCCTCTGGGCGGGATCAAGGTGGTGGCGGCC
AACGCCTGGTTCGCCGTGCGCCCAAGCGGCACCGAGGACGTGGCCAAGGTCTACGCGGAAAGCTTCCTCGGGGAAGCCCA
CCTGGAAAGGGTCCTGGAGGAAGCCACCGCCCTCCTCCACAAGGCCCTCGCCTGA

Upstream 100 bases:

>100_bases
CAGGAACAACCCCAGCCTGAAGAGGCCCCGGCCAACAACCCCTAACCCTGGGGCCCGGAGAGAAGGGGCGGGGGCTTCCC
CGCCCTTTTACAATGGCCCC

Downstream 100 bases:

>100_bases
ACCCCGGCTTTCGGGCCCCTAGCCCTTCACCGCCCCCGCGGTGAGGCCGGCGACAATCCTTTGCTGGAAGACGAGGACGA
GGACCACCAGGGGCACCGTG

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MEITRLLTLYYEATPDPQNPLEGVRFGTSGHRGSSLKATFTEAHVLAIAQAIAELRPSFGATGPLFLAKDTHALSEPAWA
TALSVFAAHGIEVRVEADGDYTPTPLVSLAILEHNAHHEAKADGVLLTPSHNPPEDGGFKYNPPTGGPANARITRAIEER
ANALLQEGLKGVKRLPLREALARAKPFDYAGLYVEKVAEAVDLEAIRASGLRIGVDPLGGASLRVWERLAESHGLPLEVV
NPTLDPTFRFMPKDHDGKIRMDCSSPYAMAGLLALKDRFDLAIGNDPDADRHGIVTPRGLMNPNHYLAAALHHLYTTRSW
PGAKVGKTAVTSALLDRVAQALGREVYETPVGFKHFVAGLLEGWLGFAGEESAGASFLRFDGRPFSTDKDGILMGLLAAE
LMAKRGQAPDALYEALAEKLGRPYYARKDLPVSPEAKARLARLSAKEVHPSTLAGEPVLQVLDRATGNGEPLGGIKVVAA
NAWFAVRPSGTEDVAKVYAESFLGEAHLERVLEEATALLHKALA

Sequences:

>Translated_524_residues
MEITRLLTLYYEATPDPQNPLEGVRFGTSGHRGSSLKATFTEAHVLAIAQAIAELRPSFGATGPLFLAKDTHALSEPAWA
TALSVFAAHGIEVRVEADGDYTPTPLVSLAILEHNAHHEAKADGVLLTPSHNPPEDGGFKYNPPTGGPANARITRAIEER
ANALLQEGLKGVKRLPLREALARAKPFDYAGLYVEKVAEAVDLEAIRASGLRIGVDPLGGASLRVWERLAESHGLPLEVV
NPTLDPTFRFMPKDHDGKIRMDCSSPYAMAGLLALKDRFDLAIGNDPDADRHGIVTPRGLMNPNHYLAAALHHLYTTRSW
PGAKVGKTAVTSALLDRVAQALGREVYETPVGFKHFVAGLLEGWLGFAGEESAGASFLRFDGRPFSTDKDGILMGLLAAE
LMAKRGQAPDALYEALAEKLGRPYYARKDLPVSPEAKARLARLSAKEVHPSTLAGEPVLQVLDRATGNGEPLGGIKVVAA
NAWFAVRPSGTEDVAKVYAESFLGEAHLERVLEEATALLHKALA
>Mature_524_residues
MEITRLLTLYYEATPDPQNPLEGVRFGTSGHRGSSLKATFTEAHVLAIAQAIAELRPSFGATGPLFLAKDTHALSEPAWA
TALSVFAAHGIEVRVEADGDYTPTPLVSLAILEHNAHHEAKADGVLLTPSHNPPEDGGFKYNPPTGGPANARITRAIEER
ANALLQEGLKGVKRLPLREALARAKPFDYAGLYVEKVAEAVDLEAIRASGLRIGVDPLGGASLRVWERLAESHGLPLEVV
NPTLDPTFRFMPKDHDGKIRMDCSSPYAMAGLLALKDRFDLAIGNDPDADRHGIVTPRGLMNPNHYLAAALHHLYTTRSW
PGAKVGKTAVTSALLDRVAQALGREVYETPVGFKHFVAGLLEGWLGFAGEESAGASFLRFDGRPFSTDKDGILMGLLAAE
LMAKRGQAPDALYEALAEKLGRPYYARKDLPVSPEAKARLARLSAKEVHPSTLAGEPVLQVLDRATGNGEPLGGIKVVAA
NAWFAVRPSGTEDVAKVYAESFLGEAHLERVLEEATALLHKALA

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI133922562, Length=494, Percent_Identity=25.1012145748988, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI290463102, Length=436, Percent_Identity=27.2935779816514, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI21361621, Length=456, Percent_Identity=26.0964912280702, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786904, Length=527, Percent_Identity=55.0284629981025, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6323752, Length=564, Percent_Identity=25.354609929078, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322722, Length=443, Percent_Identity=26.410835214447, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864244, Length=444, Percent_Identity=26.8018018018018, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 56250; Mature: 56250

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITRLLTLYYEATPDPQNPLEGVRFGTSGHRGSSLKATFTEAHVLAIAQAIAELRPSFG
CCHHHEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCC
ATGPLFLAKDTHALSEPAWATALSVFAAHGIEVRVEADGDYTPTPLVSLAILEHNAHHEA
CCCCEEEECCCHHHCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
KADGVLLTPSHNPPEDGGFKYNPPTGGPANARITRAIEERANALLQEGLKGVKRLPLREA
CCCCEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LARAKPFDYAGLYVEKVAEAVDLEAIRASGLRIGVDPLGGASLRVWERLAESHGLPLEVV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEE
NPTLDPTFRFMPKDHDGKIRMDCSSPYAMAGLLALKDRFDLAIGNDPDADRHGIVTPRGL
CCCCCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
MNPNHYLAAALHHLYTTRSWPGAKVGKTAVTSALLDRVAQALGREVYETPVGFKHFVAGL
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LEGWLGFAGEESAGASFLRFDGRPFSTDKDGILMGLLAAELMAKRGQAPDALYEALAEKL
HHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GRPYYARKDLPVSPEAKARLARLSAKEVHPSTLAGEPVLQVLDRATGNGEPLGGIKVVAA
CCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
NAWFAVRPSGTEDVAKVYAESFLGEAHLERVLEEATALLHKALA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEITRLLTLYYEATPDPQNPLEGVRFGTSGHRGSSLKATFTEAHVLAIAQAIAELRPSFG
CCHHHEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCC
ATGPLFLAKDTHALSEPAWATALSVFAAHGIEVRVEADGDYTPTPLVSLAILEHNAHHEA
CCCCEEEECCCHHHCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
KADGVLLTPSHNPPEDGGFKYNPPTGGPANARITRAIEERANALLQEGLKGVKRLPLREA
CCCCEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LARAKPFDYAGLYVEKVAEAVDLEAIRASGLRIGVDPLGGASLRVWERLAESHGLPLEVV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEE
NPTLDPTFRFMPKDHDGKIRMDCSSPYAMAGLLALKDRFDLAIGNDPDADRHGIVTPRGL
CCCCCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
MNPNHYLAAALHHLYTTRSWPGAKVGKTAVTSALLDRVAQALGREVYETPVGFKHFVAGL
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LEGWLGFAGEESAGASFLRFDGRPFSTDKDGILMGLLAAELMAKRGQAPDALYEALAEKL
HHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GRPYYARKDLPVSPEAKARLARLSAKEVHPSTLAGEPVLQVLDRATGNGEPLGGIKVVAA
CCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEE
NAWFAVRPSGTEDVAKVYAESFLGEAHLERVLEEATALLHKALA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]