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The map label for this gene is yfnC [H]

Identifier: 55980320

GI number: 55980320

Start: 330627

End: 331763

Strand: Reverse

Name: yfnC [H]

Synonym: TTHA0351

Alternate gene names: 55980320

Gene position: 331763-330627 (Counterclockwise)

Preceding gene: 55980323

Following gene: 55980319

Centisome position: 17.94

GC content: 70.8

Gene sequence:

>1137_bases
GTGCTGCCCCTCCTTCTCGCCTGGCTCCACACCACCAACGACCTCTTCTCCAACTTCCTCACCCCCCTTCTGCCCAAGCT
CATGGACCGCTTCGGGGTCGGCCTAGGGACGGCGGGCCTTCTGGTTTCCGCCTACTCCCTCACGGGGAGCCTCCTTCAGC
CCTTCGCCGGCCTGGTGGCCGACCGGGTGGACCGGAGGCTCCTCGCGGCCCTCGGCCCCGTGCTGGTGGCTTTGGGCATG
GGTTCCATGGGCCTTTGGCCCCGGTTTGAGGCCCTGCTCTTCGTCCTGGCCCTGGCGGGCGTGGGCTCCGCCCTCTTTCA
CGCCTCCGGGGCGAGCCTCGTGGGGGAGTACGCCCCCACGGAAAGGAGGGGCTTCTGGCTTTCCTTCTTCGGCTCCGCGG
GGAACCTGGGGCTTTCCCTGGGGCCCATCGTGGCCCTGTACGTGGCGGGGCGGTGGGGCCTCGAGGCCCTCTTCTGGCTC
ACCCCCCTGGTCCTCCTCCCCGCCCTCGTCCTCCTCCGCCTGCCCCCGGTGCGCCGCGCGGGGAGGCCCGCGGGCTTCCG
GGACTTCCTGCGCGTCTTCCGGGGGGACGTGGCGCGGCTTTGGGGGATGGCCACCCTGCGGAGCCTGGTCTTCCTCAGCT
TCTCCACCACCCTGCCCTACTGGTACGCCACCAAGGGCCTTCCCGACGGGTACACGGCCCTCTCCCTCTCCATTTACAGC
CTCTCCGCCACCTTGGGCATCCTCGTCGGCGGGACCTTGTCGGACCGGCTGGGGCGGAAGGCGGTCTTGGTGGGCACCCT
CACCCTGGGCCTGCCCCTTTACCTGGGCCTCCTCTTCTTCCCCGCGGAAAACCCTTTGTACCTCCTCCTCCTTGCCGCCA
CCGGGGCCCTGATGAACGCGGGGATCCCCGTGGCCGTGGCCCTGGCCCAGGAGCTGGAGCCGGGGCAGACGGCCACGGTC
TCGGGCCTCCTCATGGGGTTCACCTGGGGCTTCGCCGGCCTCTTCTACGCCCCCATCGGGCGGCTCATTGAGGCCTTCGG
GGTCCTGCCGGTGCTCTTGGGCCTCGGGGTGTTGCTCCTGCCCGCCTGGGCCCTGGCCCGGGGGGTGCGGGAGCCTGCCC
GTACAATGGGGGTATGA

Upstream 100 bases:

>100_bases
TTTTCTTTTTTCCCCAAAGCCTTTGGGCATCCGAGCGAGATCCTTGCGCACGAAGGGATTGTAGCACACCTTCCGTGAGA
AGCCGTAATAGCATGGGGGG

Downstream 100 bases:

>100_bases
GGATCCTCCTCGCCACCGACGGCTCGCCCCAGGCGCGGGGGGCGGAGGCCTTGGCCGAGTGGCTGGCCTACAAGCTTTCC
GCCCCCCTCACGGTCCTCTT

Product: fosmidomycin resistance efflux protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLPLLLAWLHTTNDLFSNFLTPLLPKLMDRFGVGLGTAGLLVSAYSLTGSLLQPFAGLVADRVDRRLLAALGPVLVALGM
GSMGLWPRFEALLFVLALAGVGSALFHASGASLVGEYAPTERRGFWLSFFGSAGNLGLSLGPIVALYVAGRWGLEALFWL
TPLVLLPALVLLRLPPVRRAGRPAGFRDFLRVFRGDVARLWGMATLRSLVFLSFSTTLPYWYATKGLPDGYTALSLSIYS
LSATLGILVGGTLSDRLGRKAVLVGTLTLGLPLYLGLLFFPAENPLYLLLLAATGALMNAGIPVAVALAQELEPGQTATV
SGLLMGFTWGFAGLFYAPIGRLIEAFGVLPVLLGLGVLLLPAWALARGVREPARTMGV

Sequences:

>Translated_378_residues
MLPLLLAWLHTTNDLFSNFLTPLLPKLMDRFGVGLGTAGLLVSAYSLTGSLLQPFAGLVADRVDRRLLAALGPVLVALGM
GSMGLWPRFEALLFVLALAGVGSALFHASGASLVGEYAPTERRGFWLSFFGSAGNLGLSLGPIVALYVAGRWGLEALFWL
TPLVLLPALVLLRLPPVRRAGRPAGFRDFLRVFRGDVARLWGMATLRSLVFLSFSTTLPYWYATKGLPDGYTALSLSIYS
LSATLGILVGGTLSDRLGRKAVLVGTLTLGLPLYLGLLFFPAENPLYLLLLAATGALMNAGIPVAVALAQELEPGQTATV
SGLLMGFTWGFAGLFYAPIGRLIEAFGVLPVLLGLGVLLLPAWALARGVREPARTMGV
>Mature_378_residues
MLPLLLAWLHTTNDLFSNFLTPLLPKLMDRFGVGLGTAGLLVSAYSLTGSLLQPFAGLVADRVDRRLLAALGPVLVALGM
GSMGLWPRFEALLFVLALAGVGSALFHASGASLVGEYAPTERRGFWLSFFGSAGNLGLSLGPIVALYVAGRWGLEALFWL
TPLVLLPALVLLRLPPVRRAGRPAGFRDFLRVFRGDVARLWGMATLRSLVFLSFSTTLPYWYATKGLPDGYTALSLSIYS
LSATLGILVGGTLSDRLGRKAVLVGTLTLGLPLYLGLLFFPAENPLYLLLLAATGALMNAGIPVAVALAQELEPGQTATV
SGLLMGFTWGFAGLFYAPIGRLIEAFGVLPVLLGLGVLLLPAWALARGVREPARTMGV

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=325, Percent_Identity=26.7692307692308, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40093; Mature: 40093

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLLLAWLHTTNDLFSNFLTPLLPKLMDRFGVGLGTAGLLVSAYSLTGSLLQPFAGLVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DRVDRRLLAALGPVLVALGMGSMGLWPRFEALLFVLALAGVGSALFHASGASLVGEYAPT
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
ERRGFWLSFFGSAGNLGLSLGPIVALYVAGRWGLEALFWLTPLVLLPALVLLRLPPVRRA
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
GRPAGFRDFLRVFRGDVARLWGMATLRSLVFLSFSTTLPYWYATKGLPDGYTALSLSIYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHH
LSATLGILVGGTLSDRLGRKAVLVGTLTLGLPLYLGLLFFPAENPLYLLLLAATGALMNA
HHHHHHHHCCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHC
GIPVAVALAQELEPGQTATVSGLLMGFTWGFAGLFYAPIGRLIEAFGVLPVLLGLGVLLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAWALARGVREPARTMGV
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPLLLAWLHTTNDLFSNFLTPLLPKLMDRFGVGLGTAGLLVSAYSLTGSLLQPFAGLVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DRVDRRLLAALGPVLVALGMGSMGLWPRFEALLFVLALAGVGSALFHASGASLVGEYAPT
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
ERRGFWLSFFGSAGNLGLSLGPIVALYVAGRWGLEALFWLTPLVLLPALVLLRLPPVRRA
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
GRPAGFRDFLRVFRGDVARLWGMATLRSLVFLSFSTTLPYWYATKGLPDGYTALSLSIYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHH
LSATLGILVGGTLSDRLGRKAVLVGTLTLGLPLYLGLLFFPAENPLYLLLLAATGALMNA
HHHHHHHHCCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHC
GIPVAVALAQELEPGQTATVSGLLMGFTWGFAGLFYAPIGRLIEAFGVLPVLLGLGVLLL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAWALARGVREPARTMGV
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]