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The map label for this gene is ctaB [H]

Identifier: 55980279

GI number: 55980279

Start: 296888

End: 298714

Strand: Direct

Name: ctaB [H]

Synonym: TTHA0310

Alternate gene names: 55980279

Gene position: 296888-298714 (Clockwise)

Preceding gene: 55980277

Following gene: 55980280

Centisome position: 16.05

GC content: 69.79

Gene sequence:

>1827_bases
ATGAAGACCCCTGCTTGGTCCAGACTCGCCGGCTACGCCTGGGGCGTCCTCCTCTGGAACGTCCTCGTGGCCCTCTTCGG
GGCCTACGTGCGGGCCACGGGCTCGGGGGCGGGGTGCGGGGCCCACTGGCCCACCTGCAACGGGGAGGTGATCCCCCGCG
CGCCCCAGGTGGAGACCCTCATTGAGTTCACCCACCGGGCCACCTCGGGCCTGGCCTTCCTCTCCGTCCTCGCCCTCTTC
CTCTGGGCGCTCCGGGCCTTCCCCAAGGGGCACCCGGCCCGCTTCGGCGCCGGGCTTGCCCTCTTCTTCATGGTCACGGA
GAGCCTGGTGGGGGCCTCCCTGGTCCTCTTCGGCTGGACGGCGGACAACGTAAGCCGGGAAAGGGCCGTGGTCCAGATGG
TCCACCTGGCCAACACCTACTTCCTCCTCGCCGCCTTGGCCCTCACCGCCTGGTGGGCCTCCGGGGGAGGCCCCTTGCGC
CTTCGGGGACAGGGGGCCGTGGGGCTCGCCCTCTTCCTCGGGCTTCTCGCCCTCCTCTTCCTGGGGATGAGCGGGGCGGT
CACCGCCTTGGGAGACCTCCTCTTCCCCGTGGGGAGCACCCTCGAGGCCCTGGAGCGCTCCCTGACCCCGGGCGAGCACT
TCCTGGTGCGCCTCAGGGTCCTCCACCCCCTGATCGCCGTGAGCGTGGGGCTCTACGTGGTCTTCGCCGGGTATTTGGTG
GCCCACCTGCGGCCCTCTCCCCTCACAAGGCGCCTTGCCCAGGGGCTCGCGTACCTCTACGGGGCCCAGCTCCTCGCCGG
CCTCATCAACGTGGCCTTAAAGGCCCCGGTCTGGATGCAAATCCTCCACCTCCTCCTGGCCTACGCCATCTGGCTCCTCT
TCGTCTTCCTCGCCACCTCCGCCCTGGAACGGGGCGCGAAGCGGGTGGAGCTCGGCGAGGGCGGCGAGGCGGTCCACCGG
GGCACGGGCGGGGCCACCTGGCGGGACTACCTCGCCCTCACCAAGCCCAGGGTGATCAGCCTTCTCCTCTTCACCGCCCT
CTTCGGCGCCCTCATCGCCGCCAAGGGCTGGCCCGGCCTCGGGGTCTTTCTCGCCGTGGCCCTGGGAGGGTACATGATGG
CCGGGGCGGCCAACGCCATCAACATGGTGGTGGACCGGGACATTGACGCCCGCATGAAGCGGACCGCCAAGCGGCCCACC
GTAACCCAGCGGGTCTCCAGCCGGGACGCCCTCCTCTTCGCCTTCGCCCTCGCCGTCTTGGGGTTCGCCGTCCTCTGGTG
GGGGGCGAACCTCCTCGCCGCCACCCTCGCCCTCATGGGCCTCATCTGGTACGTGCTGGTCTACACCCTCTACCTCAAGC
GGCGCACCTGGCACAACATCGTCATCGGCGGGGCCGCCGGGGCCTTCCCGCCCCTCGTGGGCTGGGCTGCGGTCACCGGG
GAGCTCAGCCTCTTCGCCTGGTACCTCTTCGCCCTCATCTTCTTCTGGACCCCGGTGCACTTCTGGGCCCTGGCCCTCAT
GATCCAGGACGACTACCGGGCGGTGGGGGTGCCCATGCTCCCCGTGGTCCTGGGGGAGCGGGCCACGGTGATCCAGATCG
CCCTCTACGCCCTCCTCACCGCCCTGATCTCCCTGATGCCCCTCCTCCTCGGGGAGCTCGGCCTCCTCTACCTCGCGGCG
AGCCTCCTCCTCAACGCCCTTCTCCTTCTGAAAAGCCTGGCCCTCTACCGCCGGCCCGAGCGGAGAACCGCGGTTTCCCT
GTATAAATACTCCATGCTCTACCTGGCCCTGCTCTTCGCGGCCATGGCGGTAGACCGGGCAGTGTAA

Upstream 100 bases:

>100_bases
TATTACCCTGGGTGGGGTATAGCGGGGGTAAGGGACAAATGTACCCACCCACGCGGAGGGTCCCTGTGGCAGAATGGGAG
CCGCTGACGGGAGCGTAGGG

Downstream 100 bases:

>100_bases
AGGGAGGTAACGGGATGCAGAGAAGCTTCGCGGCGCTAGGTCTTTGGGGTCTGTCCCTGGCCCAGGAGGCCCACCGGGTG
GCCATCACCCACCCGGGCGG

Product: bifunctional cytochrome C oxidase assembly factor CtaA/protoheme IX farnesyltransferase CtaB

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETLIEFTHRATSGLAFLSVLALF
LWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWTADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLR
LRGQGAVGLALFLGLLALLFLGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLV
AHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATSALERGAKRVELGEGGEAVHR
GTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGLGVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPT
VTQRVSSRDALLFAFALAVLGFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTG
ELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLTALISLMPLLLGELGLLYLAA
SLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFAAMAVDRAV

Sequences:

>Translated_608_residues
MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETLIEFTHRATSGLAFLSVLALF
LWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWTADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLR
LRGQGAVGLALFLGLLALLFLGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLV
AHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATSALERGAKRVELGEGGEAVHR
GTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGLGVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPT
VTQRVSSRDALLFAFALAVLGFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTG
ELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLTALISLMPLLLGELGLLYLAA
SLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFAAMAVDRAV
>Mature_608_residues
MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETLIEFTHRATSGLAFLSVLALF
LWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWTADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLR
LRGQGAVGLALFLGLLALLFLGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLV
AHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATSALERGAKRVELGEGGEAVHR
GTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGLGVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPT
VTQRVSSRDALLFAFALAVLGFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTG
ELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLTALISLMPLLLGELGLLYLAA
SLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFAAMAVDRAV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=34.7150259067358, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=35.3571428571429, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71998235, Length=292, Percent_Identity=30.4794520547945, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325085, Length=191, Percent_Identity=33.5078534031414, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921064, Length=277, Percent_Identity=29.2418772563177, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003780
- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF02628 COX15-CtaA; PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 65785; Mature: 65785

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
IEFTHRATSGLAFLSVLALFLWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
ADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLRLRGQGAVGLALFLGLLALLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHH
LGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLV
HCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALERGAKRVELGEGGEAVHRGTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGL
HHHCCCCEEECCCCCCHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
GVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPTVTQRVSSRDALLFAFALAVL
HHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
GFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHH
ELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCHHHHHHHHHHHHH
ALISLMPLLLGELGLLYLAASLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMAVDRAV
HHHHHHCC
>Mature Secondary Structure
MKTPAWSRLAGYAWGVLLWNVLVALFGAYVRATGSGAGCGAHWPTCNGEVIPRAPQVETL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
IEFTHRATSGLAFLSVLALFLWALRAFPKGHPARFGAGLALFFMVTESLVGASLVLFGWT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
ADNVSRERAVVQMVHLANTYFLLAALALTAWWASGGGPLRLRGQGAVGLALFLGLLALLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHH
LGMSGAVTALGDLLFPVGSTLEALERSLTPGEHFLVRLRVLHPLIAVSVGLYVVFAGYLV
HCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLRPSPLTRRLAQGLAYLYGAQLLAGLINVALKAPVWMQILHLLLAYAIWLLFVFLATS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALERGAKRVELGEGGEAVHRGTGGATWRDYLALTKPRVISLLLFTALFGALIAAKGWPGL
HHHCCCCEEECCCCCCHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
GVFLAVALGGYMMAGAANAINMVVDRDIDARMKRTAKRPTVTQRVSSRDALLFAFALAVL
HHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
GFAVLWWGANLLAATLALMGLIWYVLVYTLYLKRRTWHNIVIGGAAGAFPPLVGWAAVTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHH
ELSLFAWYLFALIFFWTPVHFWALALMIQDDYRAVGVPMLPVVLGERATVIQIALYALLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCHHHHHHHHHHHHH
ALISLMPLLLGELGLLYLAASLLLNALLLLKSLALYRRPERRTAVSLYKYSMLYLALLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMAVDRAV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA