Click here to switch to the map view.

The map label for this gene is pyrP [H]

Identifier: 55980277

GI number: 55980277

Start: 294699

End: 295499

Strand: Direct

Name: pyrP [H]

Synonym: TTHA0308

Alternate gene names: 55980277

Gene position: 294699-295499 (Clockwise)

Preceding gene: 55980276

Following gene: 55980279

Centisome position: 15.93

GC content: 70.79

Gene sequence:

>801_bases
TTGGGGGCCGTGGCGAGCGCCGTCTTCTTCCGCGGCCTCTTCCAGATGGTCCCGGTGCTCGTGGGGGTGGGGGCGGGCTA
CCTCCTCGCCCTCCTCCTCGGCCGGGTGGACCTCTCCCCCGTGCGGGAGGCCCCCTGGTTCGCCCTCCCCGCCTTCACCC
CGGCCACCCTGGAGTGGGGAGCCGTCCTCCTCATCGCCCCCGTGGCCCTCGTCACGGTGATGGAGCACATCGGGGACATC
CTCACCAACGGCCGGGTGGTGGGGAAGGACTTCTTCGTCAAGCCCGGCCTCCACCGCACCCTCCTCGGGGACGGGCTCGC
CACAAGCCTCGCCGGGCTTTTAGGCGGCCCCGCCAACACCACCTACTCCGAAAACACCGGGGTCCTGGCGGTGACCCGGG
TGTACGACCCCTTGGTCCTCCGCATCGCCGCGGGCTTCGCCATCCTTCTCGCCTTCATCCCCAAGCTCTCCGCCCTTCTC
CAGACCCTGCCCCAGGGGGTGCTGGGGGGGATCTCCATGCTCCTCTTCGGGATGATCGCCTCCATCGGCATCCGCACCCT
GGCGGAAGCGGAGATTGACTTCACCCAAAGCCGCAACCTCATCGTGGTCTCGGCCATCCTCGTCCTGGGCCTGGGCGGGG
CCGTGGCCAACCTGGGGACGGTCCAGGTGGCCGGGGCGGCGGTGCCCCTCAAGGTGAGCGGCATGGCCCTGGCCGCCCTG
GTGGGGGTGGTCCTCAACCTCCTCCTGCCCCCCAGGCTGGAGCCCCGAACCCTCCTGGAGGAGGAGGAGCGGCTCCCCTG
A

Upstream 100 bases:

>100_bases
CGTGGTCACGGGCCCCGTGATCGTGGTCATCGGCCTCACCCTGGCCCCGGTGGCGGTGGAGATGGCGGGCAAGGACTGAC
TCCTCGCCGTCTTCACCTTC

Downstream 100 bases:

>100_bases
GGCCACCCCGTGCGGGCCCAAGCCCGCATGGGAGCCCCGGCAAAAGGGGGCTTCTTTCGGGCCAGCCGAGCCAAGGGAAG
GAGAAAGAACGGGAGGACCC

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MGAVASAVFFRGLFQMVPVLVGVGAGYLLALLLGRVDLSPVREAPWFALPAFTPATLEWGAVLLIAPVALVTVMEHIGDI
LTNGRVVGKDFFVKPGLHRTLLGDGLATSLAGLLGGPANTTYSENTGVLAVTRVYDPLVLRIAAGFAILLAFIPKLSALL
QTLPQGVLGGISMLLFGMIASIGIRTLAEAEIDFTQSRNLIVVSAILVLGLGGAVANLGTVQVAGAAVPLKVSGMALAAL
VGVVLNLLLPPRLEPRTLLEEEERLP

Sequences:

>Translated_266_residues
MGAVASAVFFRGLFQMVPVLVGVGAGYLLALLLGRVDLSPVREAPWFALPAFTPATLEWGAVLLIAPVALVTVMEHIGDI
LTNGRVVGKDFFVKPGLHRTLLGDGLATSLAGLLGGPANTTYSENTGVLAVTRVYDPLVLRIAAGFAILLAFIPKLSALL
QTLPQGVLGGISMLLFGMIASIGIRTLAEAEIDFTQSRNLIVVSAILVLGLGGAVANLGTVQVAGAAVPLKVSGMALAAL
VGVVLNLLLPPRLEPRTLLEEEERLP
>Mature_265_residues
GAVASAVFFRGLFQMVPVLVGVGAGYLLALLLGRVDLSPVREAPWFALPAFTPATLEWGAVLLIAPVALVTVMEHIGDIL
TNGRVVGKDFFVKPGLHRTLLGDGLATSLAGLLGGPANTTYSENTGVLAVTRVYDPLVLRIAAGFAILLAFIPKLSALLQ
TLPQGVLGGISMLLFGMIASIGIRTLAEAEIDFTQSRNLIVVSAILVLGLGGAVANLGTVQVAGAAVPLKVSGMALAALV
GVVLNLLLPPRLEPRTLLEEEERLP

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=285, Percent_Identity=27.719298245614, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI44680145, Length=285, Percent_Identity=27.719298245614, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI44680148, Length=228, Percent_Identity=29.8245614035088, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI40316845, Length=228, Percent_Identity=29.8245614035088, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788843, Length=262, Percent_Identity=42.3664122137405, Blast_Score=211, Evalue=3e-56,
Organism=Escherichia coli, GI87081818, Length=266, Percent_Identity=39.0977443609023, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87082181, Length=263, Percent_Identity=30.0380228136882, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790087, Length=244, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082178, Length=207, Percent_Identity=29.4685990338164, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71993493, Length=222, Percent_Identity=24.7747747747748, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=256, Percent_Identity=21.875, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17542260, Length=222, Percent_Identity=25.2252252252252, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17541904, Length=256, Percent_Identity=22.265625, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356175, Length=284, Percent_Identity=25.7042253521127, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 27584; Mature: 27453

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAVASAVFFRGLFQMVPVLVGVGAGYLLALLLGRVDLSPVREAPWFALPAFTPATLEWG
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHH
AVLLIAPVALVTVMEHIGDILTNGRVVGKDFFVKPGLHRTLLGDGLATSLAGLLGGPANT
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEECCCCHHHHHHCHHHHHHHHHHCCCCCC
TYSENTGVLAVTRVYDPLVLRIAAGFAILLAFIPKLSALLQTLPQGVLGGISMLLFGMIA
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGIRTLAEAEIDFTQSRNLIVVSAILVLGLGGAVANLGTVQVAGAAVPLKVSGMALAAL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCEEECCCCCCEEEHHHHHHHH
VGVVLNLLLPPRLEPRTLLEEEERLP
HHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GAVASAVFFRGLFQMVPVLVGVGAGYLLALLLGRVDLSPVREAPWFALPAFTPATLEWG
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHH
AVLLIAPVALVTVMEHIGDILTNGRVVGKDFFVKPGLHRTLLGDGLATSLAGLLGGPANT
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEECCCCHHHHHHCHHHHHHHHHHCCCCCC
TYSENTGVLAVTRVYDPLVLRIAAGFAILLAFIPKLSALLQTLPQGVLGGISMLLFGMIA
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGIRTLAEAEIDFTQSRNLIVVSAILVLGLGGAVANLGTVQVAGAAVPLKVSGMALAAL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCEEECCCCCCEEEHHHHHHHH
VGVVLNLLLPPRLEPRTLLEEEERLP
HHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]