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The map label for this gene is hofD [H]

Identifier: 55980238

GI number: 55980238

Start: 255678

End: 256745

Strand: Reverse

Name: hofD [H]

Synonym: TTHA0269

Alternate gene names: 55980238

Gene position: 256745-255678 (Counterclockwise)

Preceding gene: 55980240

Following gene: 55980237

Centisome position: 13.88

GC content: 70.41

Gene sequence:

>1068_bases
ATGTGGCCCCTCTTCGCCCTGCTCCTCGGCCTCGCGGTGGGTTCCTTTCTCAACGTGGTGGTCCACCGCCTGCCCCGGGG
GGAGTCCGTCGCCTACCCCCCGTCCCGCTGCCCCCAGTGCGGCCACCGCCTGGGGCCTTGGGACCTGGTCCCCGTCCTCT
CCTACCTCGCCCTAAAGGGGCGGTGCCGCTACTGCGCCCGTCCCATCTCCCCCCGCTACCCCCTGGTGGAGGCCCTCACG
GGGGGGCTTTTCCTCCTCGCAAGCCTCTTCTACCCCCCTGGGGTGGAGGCCCTCTTGGTCTTCCTCTTCCTCGCCTTTCT
CGTGGCCCTCGCCTTCATTGACGTGGACACCTTTGAGCTTCCCGATCCCCTCACCTACGGCCTCCTCTTCCTTGGGCTTT
TGGCCTCCTGGGCGCTGGCCTTCCCCCTCCCCTTTAGGGAGAGCCTGGACGGAAGCCTCATGGCCGCCGGGGGGCTCGCC
CTGGTGGCGGGGTACGGGAACCTCTTTCTGCGGCGCTTTAGGGAGGCCAGGGCCGAGGTCCCCGTGGGGCCCCACCAGGT
CCACATGGCGGCCCTCTTTGGGGCGCTCTTGGGCCCAGGGGTGGGGATGGCCCTCGCCTTCCTCGCTTGGGCCCTCTCCG
CCCGCACGGGGCGGGCGGTGGCCCTCCCCGACCGGCTCACCCTGCCCCTTTTGCCCCTCGCCTTCCTCCTTGCCCCCGCC
CTAGGCCTGGACTTCCTGGAAAGCCTTAAGGGAAGCCTCCTCGCTGCCGGGGGGCTCGCCCTCGCCGGGGGGCTTTACTG
GGCCTTCCGGCCCCTTCCCGAGGAGGGCGAGGAGGAGCCCGTGGCCATGGGCTACGGGGACGTGAAGCTTCTGGGGGCCC
TCGGGGCCTGGCTCGGCCCTTACGCCTTCCTCGCCCTCTTCCTCGGGGTCTTCGCCGGGGCGCTTTTGGGCCTTCTCCTT
AGGCAAAGGAAGCTCCCCTTCGGCCCCTACCTCGCCCTCGGGGGGGTGGTGGCCTTCTTCTTCGGGGAGGCCCTCTGGGG
GGCGTACCTGCGCCTTCTGGGCGTTTGA

Upstream 100 bases:

>100_bases
CCAGGAGGTTCTGGTAAGCGGCTTCCGGCGTCACGGGGCCATCCTACACCCAAACCCATAAAAGCGCTGTGAAAGCCCGG
CCACCCCGTAAAATGCCCCC

Downstream 100 bases:

>100_bases
ACCGGGAAGGGGAGTCTTCTTTTGCTATAAAGCGTTCATGGGACGCGCGGTCAAAGTGGCCCTTGCGGTCCTGGCCCTGG
GGCTTTCGGCCTTCGCCCTT

Product: type IV prepilin peptidase PilD

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MWPLFALLLGLAVGSFLNVVVHRLPRGESVAYPPSRCPQCGHRLGPWDLVPVLSYLALKGRCRYCARPISPRYPLVEALT
GGLFLLASLFYPPGVEALLVFLFLAFLVALAFIDVDTFELPDPLTYGLLFLGLLASWALAFPLPFRESLDGSLMAAGGLA
LVAGYGNLFLRRFREARAEVPVGPHQVHMAALFGALLGPGVGMALAFLAWALSARTGRAVALPDRLTLPLLPLAFLLAPA
LGLDFLESLKGSLLAAGGLALAGGLYWAFRPLPEEGEEEPVAMGYGDVKLLGALGAWLGPYAFLALFLGVFAGALLGLLL
RQRKLPFGPYLALGGVVAFFFGEALWGAYLRLLGV

Sequences:

>Translated_355_residues
MWPLFALLLGLAVGSFLNVVVHRLPRGESVAYPPSRCPQCGHRLGPWDLVPVLSYLALKGRCRYCARPISPRYPLVEALT
GGLFLLASLFYPPGVEALLVFLFLAFLVALAFIDVDTFELPDPLTYGLLFLGLLASWALAFPLPFRESLDGSLMAAGGLA
LVAGYGNLFLRRFREARAEVPVGPHQVHMAALFGALLGPGVGMALAFLAWALSARTGRAVALPDRLTLPLLPLAFLLAPA
LGLDFLESLKGSLLAAGGLALAGGLYWAFRPLPEEGEEEPVAMGYGDVKLLGALGAWLGPYAFLALFLGVFAGALLGLLL
RQRKLPFGPYLALGGVVAFFFGEALWGAYLRLLGV
>Mature_355_residues
MWPLFALLLGLAVGSFLNVVVHRLPRGESVAYPPSRCPQCGHRLGPWDLVPVLSYLALKGRCRYCARPISPRYPLVEALT
GGLFLLASLFYPPGVEALLVFLFLAFLVALAFIDVDTFELPDPLTYGLLFLGLLASWALAFPLPFRESLDGSLMAAGGLA
LVAGYGNLFLRRFREARAEVPVGPHQVHMAALFGALLGPGVGMALAFLAWALSARTGRAVALPDRLTLPLLPLAFLLAPA
LGLDFLESLKGSLLAAGGLALAGGLYWAFRPLPEEGEEEPVAMGYGDVKLLGALGAWLGPYAFLALFLGVFAGALLGLLL
RQRKLPFGPYLALGGVVAFFFGEALWGAYLRLLGV

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=170, Percent_Identity=42.9411764705882, Blast_Score=111, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 37889; Mature: 37889

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPLFALLLGLAVGSFLNVVVHRLPRGESVAYPPSRCPQCGHRLGPWDLVPVLSYLALKG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHC
RCRYCARPISPRYPLVEALTGGLFLLASLFYPPGVEALLVFLFLAFLVALAFIDVDTFEL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PDPLTYGLLFLGLLASWALAFPLPFRESLDGSLMAAGGLALVAGYGNLFLRRFREARAEV
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PVGPHQVHMAALFGALLGPGVGMALAFLAWALSARTGRAVALPDRLTLPLLPLAFLLAPA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHH
LGLDFLESLKGSLLAAGGLALAGGLYWAFRPLPEEGEEEPVAMGYGDVKLLGALGAWLGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
YAFLALFLGVFAGALLGLLLRQRKLPFGPYLALGGVVAFFFGEALWGAYLRLLGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWPLFALLLGLAVGSFLNVVVHRLPRGESVAYPPSRCPQCGHRLGPWDLVPVLSYLALKG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHC
RCRYCARPISPRYPLVEALTGGLFLLASLFYPPGVEALLVFLFLAFLVALAFIDVDTFEL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PDPLTYGLLFLGLLASWALAFPLPFRESLDGSLMAAGGLALVAGYGNLFLRRFREARAEV
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PVGPHQVHMAALFGALLGPGVGMALAFLAWALSARTGRAVALPDRLTLPLLPLAFLLAPA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHH
LGLDFLESLKGSLLAAGGLALAGGLYWAFRPLPEEGEEEPVAMGYGDVKLLGALGAWLGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
YAFLALFLGVFAGALLGLLLRQRKLPFGPYLALGGVVAFFFGEALWGAYLRLLGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]