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The map label for this gene is 55980221

Identifier: 55980221

GI number: 55980221

Start: 240650

End: 241945

Strand: Direct

Name: 55980221

Synonym: TTHA0252

Alternate gene names: NA

Gene position: 240650-241945 (Clockwise)

Preceding gene: 55980202

Following gene: 55980224

Centisome position: 13.01

GC content: 69.98

Gene sequence:

>1296_bases
ATGCGCATCGTACCTTTTGGGGCGGCCCGGGAGGTCACGGGAAGCGCCCACCTCCTCCTCGCCGGGGGCAGGCGCGTCCT
TCTGGACTGCGGGATGTTCCAAGGGAAGGAGGAGGCCAGGAACCACGCCCCCTTCGGCTTTGACCCTAAGGAGGTGGACG
CCGTCCTCCTCACCCACGCCCACCTGGACCACGTGGGGCGGCTGCCCAAGCTCTTCCGCGAAGGCTACCGGGGCCCCGTT
TACGCCACCCGGGCCACGGTCCTCCTCATGGAGATCGTCCTGGAGGACGCCCTCAAGGTGATGGACGAGCCCTTTTTCGG
CCCCGAGGACGTGGAGGAGGCCCTGGGGCACCTCAGGCCCCTGGAGTACGGGGAGTGGCTTCGGCTCGGGGCCTTAAGCC
TCGCCTTCGGCCAGGCGGGGCACCTCCCGGGAAGCGCCTTCGTGGTGGCCCAGGGGGAGGGGAGGACCCTGGTCTACAGC
GGGGACCTGGGCAACCGGGAAAAGGACGTCCTCCCCGACCCCTCTCTTCCTCCGCTCGCCGACCTGGTCCTCGCGGAGGG
GACCTACGGGGACCGCCCCCACCGCCCTTACCGGGAGACGGTCCGGGAGTTCCTGGAGATCCTGGAAAAAACCCTGAGCC
AGGGCGGGAAGGTCCTCATCCCCACCTTCGCCGTGGAGCGGGCGCAGGAGATCCTCTACGTCCTCTACACGCACGGCCAC
CGCCTCCCCCGGGCGCCCATCTACCTGGACTCCCCTATGGCGGGACGGGTCCTCTCCCTTTACCCCAGGTTGGTCCGCTA
CTTCAGCGAGGAGGTCCAGGCCCACTTCCTCCAGGGGAAGAACCCCTTCCGCCCTGCGGGCCTCGAGGTGGTGGAGCACA
CCGAGGCCTCCAAGGCCCTAAACCGCGCCCCCGGCCCCATGGTGGTCCTCGCGGGAAGCGGGATGCTCGCGGGGGGGCGG
ATCCTCCACCACCTCAAGCACGGCCTCTCCGACCCCAGAAACGCCCTCGTTTTCGTGGGCTACCAGCCCCAGGGAGGGCT
TGGGGCGGAGATCATCGCCCGCCCCCCCGCCGTGCGGATCCTGGGGGAAGAGGTGCCCTTGCGGGCGAGCGTCCACACCC
TGGGCGGCTTCTCCGGCCACGCCGGGCAGGACGAGCTTCTGGACTGGCTTCAGGGCGAGCCCCGCGTGGTCCTGGTCCAC
GGGGAAGAGGAAAAGCTCCTCGCCCTAGGCAAGCTCCTCGCCCTCCGCGGGCAGGAGGTGAGCCTGGCGCGCTTCGGGGA
GGGCGTGCCGGTGTAG

Upstream 100 bases:

>100_bases
CGGGTGCTCTGCCGGTTGAGCTAGGGTGGCAGGACGGGGGATGGGACCCTGTCCGAGGGTTTAGGCTAGCACACCCGCCC
GAGAGTGTCAAGATAAGGGC

Downstream 100 bases:

>100_bases
GTCACGCCTGGAGCCCCTCGGGCTCCGGGTCCGACCAGGCCAGCTCCACCAGCTGGACGAGCTCCCCCACGGGGACCCCG
TAGTCCCGGGCGAGCCGCGT

Product: metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPKEVDAVLLTHAHLDHVGRLPKLFREGYRGPV
YATRATVLLMEIVLEDALKVMDEPFFGPEDVEEALGHLRPLEYGEWLRLGALSLAFGQAGHLPGSAFVVAQGEGRTLVYS
GDLGNREKDVLPDPSLPPLADLVLAEGTYGDRPHRPYRETVREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGH
RLPRAPIYLDSPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKALNRAPGPMVVLAGSGMLAGGR
ILHHLKHGLSDPRNALVFVGYQPQGGLGAEIIARPPAVRILGEEVPLRASVHTLGGFSGHAGQDELLDWLQGEPRVVLVH
GEEEKLLALGKLLALRGQEVSLARFGEGVPV

Sequences:

>Translated_431_residues
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPKEVDAVLLTHAHLDHVGRLPKLFREGYRGPV
YATRATVLLMEIVLEDALKVMDEPFFGPEDVEEALGHLRPLEYGEWLRLGALSLAFGQAGHLPGSAFVVAQGEGRTLVYS
GDLGNREKDVLPDPSLPPLADLVLAEGTYGDRPHRPYRETVREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGH
RLPRAPIYLDSPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKALNRAPGPMVVLAGSGMLAGGR
ILHHLKHGLSDPRNALVFVGYQPQGGLGAEIIARPPAVRILGEEVPLRASVHTLGGFSGHAGQDELLDWLQGEPRVVLVH
GEEEKLLALGKLLALRGQEVSLARFGEGVPV
>Mature_431_residues
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPKEVDAVLLTHAHLDHVGRLPKLFREGYRGPV
YATRATVLLMEIVLEDALKVMDEPFFGPEDVEEALGHLRPLEYGEWLRLGALSLAFGQAGHLPGSAFVVAQGEGRTLVYS
GDLGNREKDVLPDPSLPPLADLVLAEGTYGDRPHRPYRETVREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGH
RLPRAPIYLDSPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKALNRAPGPMVVLAGSGMLAGGR
ILHHLKHGLSDPRNALVFVGYQPQGGLGAEIIARPPAVRILGEEVPLRASVHTLGGFSGHAGQDELLDWLQGEPRVVLVH
GEEEKLLALGKLLALRGQEVSLARFGEGVPV

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro)

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family

Homologues:

Organism=Homo sapiens, GI7706427, Length=427, Percent_Identity=29.7423887587822, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI33300633, Length=431, Percent_Identity=29.6983758700696, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32564696, Length=431, Percent_Identity=29.4663573085847, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI32566029, Length=419, Percent_Identity=28.8782816229117, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323307, Length=462, Percent_Identity=25.974025974026, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24648013, Length=422, Percent_Identity=27.2511848341232, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21358523, Length=429, Percent_Identity=30.0699300699301, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNSE_THET8 (Q5SLP1)

Other databases:

- EMBL:   AP008226
- RefSeq:   YP_143518.1
- PDB:   2DKF
- PDB:   3A4Y
- PDB:   3IDZ
- PDB:   3IE0
- PDB:   3IE1
- PDB:   3IE2
- PDB:   3IEK
- PDB:   3IEL
- PDB:   3IEM
- PDBsum:   2DKF
- PDBsum:   3A4Y
- PDBsum:   3IDZ
- PDBsum:   3IE0
- PDBsum:   3IE1
- PDBsum:   3IE2
- PDBsum:   3IEK
- PDBsum:   3IEL
- PDBsum:   3IEM
- ProteinModelPortal:   Q5SLP1
- SMR:   Q5SLP1
- STRING:   Q5SLP1
- GeneID:   3170139
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0252
- NMPDR:   fig|300852.3.peg.283
- eggNOG:   COG1236
- HOGENOM:   HBG402464
- OMA:   TVTGSCF
- ProtClustDB:   CLSK2516672
- BioCyc:   TTHE300852:TTHA0252-MONOMER
- GO:   GO:0005737
- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108
- SMART:   SM00849

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL

EC number: NA

Molecular weight: Translated: 47056; Mature: 47056

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPKEVDAVLLTHA
CEECCCCCCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHH
HLDHVGRLPKLFREGYRGPVYATRATVLLMEIVLEDALKVMDEPFFGPEDVEEALGHLRP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LEYGEWLRLGALSLAFGQAGHLPGSAFVVAQGEGRTLVYSGDLGNREKDVLPDPSLPPLA
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHH
DLVLAEGTYGDRPHRPYRETVREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGH
HHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCC
RLPRAPIYLDSPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKAL
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
NRAPGPMVVLAGSGMLAGGRILHHLKHGLSDPRNALVFVGYQPQGGLGAEIIARPPAVRI
HCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEECCCCCEEE
LGEEVPLRASVHTLGGFSGHAGQDELLDWLQGEPRVVLVHGEEEKLLALGKLLALRGQEV
ECCCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCE
SLARFGEGVPV
EHHHCCCCCCC
>Mature Secondary Structure
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPKEVDAVLLTHA
CEECCCCCCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHH
HLDHVGRLPKLFREGYRGPVYATRATVLLMEIVLEDALKVMDEPFFGPEDVEEALGHLRP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LEYGEWLRLGALSLAFGQAGHLPGSAFVVAQGEGRTLVYSGDLGNREKDVLPDPSLPPLA
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHH
DLVLAEGTYGDRPHRPYRETVREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGH
HHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCC
RLPRAPIYLDSPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKAL
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
NRAPGPMVVLAGSGMLAGGRILHHLKHGLSDPRNALVFVGYQPQGGLGAEIIARPPAVRI
HCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEECCCCCEEE
LGEEVPLRASVHTLGGFSGHAGQDELLDWLQGEPRVVLVHGEEEKLLALGKLLALRGQEV
ECCCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCE
SLARFGEGVPV
EHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA