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The map label for this gene is lpd [H]

Identifier: 55980202

GI number: 55980202

Start: 225850

End: 227244

Strand: Direct

Name: lpd [H]

Synonym: TTHA0233

Alternate gene names: 55980202

Gene position: 225850-227244 (Clockwise)

Preceding gene: 55980201

Following gene: 55980221

Centisome position: 12.21

GC content: 70.54

Gene sequence:

>1395_bases
ATGACGCCTATGAAGACCTACGACCTCATCGTGATCGGCACCGGCCCGGGGGGCTACCACGCCGCCATCCGGGCCGCCCA
GCTCGGCCTCAAGGTGCTGGCGGTGGAGGCGGGCGAGGTGGGGGGGGTCTGCCTCAACGTGGGCTGCATCCCCACCAAGG
CCCTCCTCCACGCCGCCGAGACCCTCCACCACCTGAAGGTGGCCGAGGGGTTCGGCCTGAAGGCCAAGCCGGAGCTGGAC
CTGAAGAAGCTCGGCGGCTGGCGGGATCAGGTGGTGAAAAAGCTCACCGGGGGCGTGGGCACCCTCCTCAAGGGGAACGG
GGTGGAGCTCCTCAGGGGCTTCGCCCGCTTGGTGGGCCCCAAGGAGGTGGAGGTAGGGGGCGAGCGTTACGGGGCAAAAA
GCCTGATCCTCGCCACGGGGAGCGAACCCCTGGAGCTCAAGGGCTTCCCCTTCGGCGAGGACGTCTGGGACTCCACCCGG
GCCCTTAAGGTAGAGGAGGGCCTCCCCAAGCGCCTCCTGGTCATCGGCGGGGGGGCGGTGGGCCTCGAGCTCGGCCAGGT
CTACCGCCGCCTGGGCGCGGAGGTCACCCTCATTGAGTACATGCCGGAGATCCTCCCCCAGGGCGACCCCGAGACCGCCG
CCCTCCTAAGGCGCGCCCTGGAAAAGGAGGGGATAAGGGTTCGCACCAAGACCAAGGCCGTGGGCTACGAGAAGAAGAAG
GACGGCCTCCACGTGCGCCTCGAGCCCGCCGAGGGCGGCGAGGGGGAGGAGGTGGTGGTGGACAAGGTCCTGGTGGCCGT
GGGCCGGAAGCCCCGCACGGAGGGCCTGGGCCTGGAGAAGGCCGGGGTCAAGGTGGACGAGCGGGGCTTCATCCGGGTGA
ACGCCCGGATGGAGACGAGCGTCCCCGGGGTCTACGCCATCGGCGACGCGGCCCGCCCCCCCCTCCTCGCCCACAAGGCC
ATGCGGGAGGGGCTCATCGCCGCCGAGAACGCCGCCGGCAAGGACAGCGCCTTTGACTACCAGGTCCCGAGCGTGGTCTA
CACCTCCCCCGAGTGGGCCGGGGTGGGCCTCACCGAGGAGGAAGCGAAGCGGGCGGGCTACAAGGTGAAGGTGGGGAAGT
TCCCCCTCGCCGCCAGTGGCCGGGCCCTCACCCTGGGCGGGGCCGAGGGGATGGTCAAGGTGGTGGGGGACGAGGAGACG
GACCTCCTCCTCGGGGTCTTCATCGTGGGGCCCCAGGCGGGGGAGCTCATCGCCGAGGCCGCCTTGGCCCTGGAGATGGG
GGCCACGCTCACCGACCTCGCCCTCACCGTCCACCCCCACCCCACCCTCTCGGAAAGCCTCATGGAGGCGGCGGAGGCCT
TCCACAAGCAGGCCATCCACATCCTGAACCGCTAG

Upstream 100 bases:

>100_bases
TTTGACCACCGCCTGGTGGACGGGGCCGAGGCGGCCATGTTCACCCGGGAGGTCATCAGGCTCTTGGAAAACCCCGACCT
GCTCCTTCTGGAAATGTAGG

Downstream 100 bases:

>100_bases
AGAAGGCCAAGAAGCCCGTAAAGCCCCGCCCCCAGGAAGACGGCAAGGCCCAGATTTCCCGTGAGGCGCGCCCCCATGTA
GGTGCCAAGAAGGGCCAAGA

Product: pyruvate dehydrogenase complex, dihydrolipoamide dehydrogenase E3 component

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAETLHHLKVAEGFGLKAKPELD
LKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGPKEVEVGGERYGAKSLILATGSEPLELKGFPFGEDVWDSTR
ALKVEEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKK
DGLHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKA
MREGLIAAENAAGKDSAFDYQVPSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEET
DLLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHILNR

Sequences:

>Translated_464_residues
MTPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAETLHHLKVAEGFGLKAKPELD
LKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGPKEVEVGGERYGAKSLILATGSEPLELKGFPFGEDVWDSTR
ALKVEEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKK
DGLHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKA
MREGLIAAENAAGKDSAFDYQVPSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEET
DLLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHILNR
>Mature_463_residues
TPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAETLHHLKVAEGFGLKAKPELDL
KKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGPKEVEVGGERYGAKSLILATGSEPLELKGFPFGEDVWDSTRA
LKVEEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKKD
GLHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKAM
REGLIAAENAAGKDSAFDYQVPSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETD
LLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHILNR

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=477, Percent_Identity=44.4444444444444, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=30.6521739130435, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI22035672, Length=460, Percent_Identity=31.304347826087, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI291045266, Length=468, Percent_Identity=29.9145299145299, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=29.3248945147679, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=29.3248945147679, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=29.3248945147679, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=29.3248945147679, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=29.3248945147679, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI291045268, Length=448, Percent_Identity=27.2321428571429, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=43.9393939393939, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=32.9519450800915, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=28.8747346072187, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=26.9396551724138, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1789065, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=45.4935622317597, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71983429, Length=461, Percent_Identity=30.58568329718, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983419, Length=461, Percent_Identity=30.58568329718, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=28.39248434238, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=27.7432712215321, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=479, Percent_Identity=39.874739039666, Blast_Score=321, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=31.2101910828025, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=29.0870488322718, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=48.8120950323974, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=30.8641975308642, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=31.0272536687631, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=31.0272536687631, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17737741, Length=479, Percent_Identity=30.8977035490605, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49085; Mature: 48953

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAE
CCCCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHH
TLHHLKVAEGFGLKAKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGP
HHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCC
KEVEVGGERYGAKSLILATGSEPLELKGFPFGEDVWDSTRALKVEEGLPKRLLVIGGGAV
CEEECCCCCCCCCEEEEEECCCCCEECCCCCCCHHHCCCCEEEECCCCCCEEEEEECCHH
GLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKK
HHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCC
DGLHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETS
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEEEEECC
VPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQVPSVVYTSPEWAGVGLTEE
CCCEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCEECCEEEEECCCCCCCCCCHH
EAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIVGPQAGELIAEA
HHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHH
ALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHILNR
HHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAE
CCCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHH
TLHHLKVAEGFGLKAKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGP
HHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCC
KEVEVGGERYGAKSLILATGSEPLELKGFPFGEDVWDSTRALKVEEGLPKRLLVIGGGAV
CEEECCCCCCCCCEEEEEECCCCCEECCCCCCCHHHCCCCEEEECCCCCCEEEEEECCHH
GLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKK
HHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCC
DGLHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETS
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEEEEECC
VPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQVPSVVYTSPEWAGVGLTEE
CCCEEEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCEECCEEEEECCCCCCCCCCHH
EAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIVGPQAGELIAEA
HHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEEECCCHHHHHHHH
ALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHILNR
HHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA