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The map label for this gene is strD [H]

Identifier: 55980193

GI number: 55980193

Start: 218605

End: 219651

Strand: Direct

Name: strD [H]

Synonym: TTHA0224

Alternate gene names: 55980193

Gene position: 218605-219651 (Clockwise)

Preceding gene: 55980191

Following gene: 55980194

Centisome position: 11.82

GC content: 70.49

Gene sequence:

>1047_bases
ATGAAAGGGCTCATCCTGGCCGCGGGAAGGGGCACGAGGCTCCGTCCCCTGACCCACACCCGCCCCAAGCCCGCCATCCG
GGTGGCGGGGCGGCCCATCATCCACTACGCCGTGGAGAACCTCCTGGAGGCCGGGGTCCGGGAGATCGGGGTCGTGGTCT
CCCCGGAGACGGAGCGGGACCTGAAGGTGGCCCTCGAGGGTTACCCCGTCCGCTACGTCCTTCAGGAGGAACCCCAGGGG
CTGGCCCACGCGGTGGACGTGGCCCGGGGCTTCCTGGGGGAAAGCCCCTTCGTCCTCTACCTGGGGGACAACCTCTTCCA
AAAGGGCATCCGGCGCTTCCTGGAGGCCTTCAAGCCCGGCGTAAGCGCCGTCATCGCCCTGGTGCGGGTGGAAGACCCAA
GGCAGTTCGGCGTGGCCGTCCTGGAGGGCAACCGGGTGGTGCGGCTTTTGGAAAAGCCCAAGGATCCCCCCTCGGACCTG
GCGGTGGCCGGGGTCTACGTCTTCTCCCCCGAGGTTTTGGAGGTCGTCCGGGGCCTCAAGCCCTCCGCCCGGGGAGAGTA
CGAGATCACCGACGCCATCCAGGGCCTCATTGACCGGGGCAAAACGGTGGTGGGCGTGGAGGTGGAGGGCTGGTGGAAGG
ACACGGGCCGCCACCAGGACCTCCTGGACGCGAACCGGCTCCTCCTCGAGGAGCTCACCCCCAAGGTGGAGGGGGACGTG
GTGGAGAGCCAGCTCACGGGCCGGGTGGTGGTGGAGAAGGGGGCGAAGGTGGTGCGGAGCACCGTGATCGGCCCCGCCCA
CATCGGCGCGGGCGCCGTGGTGGAGGAGGCCTTCGTGGGCCCCTTCACCTCCGTGGGGCCCCGGGCCCGGGTGGTGCGGT
CGGAGGTGGAGTACTCCCTCCTGGAGGAGGAGGCCGTGGTGGAGGAGGTCCGCCTCCGCCTCCAGGAGTGCATCCTCGGC
GTCCGGGCCGAAGTGAAGAGCCGGGACGGCCTCCCCCGGGCCCACCGCCTCATCCTCGGGGACCTCTCCCAGGTGGAGCT
AGCCTGA

Upstream 100 bases:

>100_bases
CCACCTCGGGCGGGTGGGCCCTCAGCCTGTCGTAGGCGTAGGCCGCCCTCAAGAGGGCGCTGGACATCCTTACCTTATTC
TAAGGGGTATGCTTTAGGGC

Downstream 100 bases:

>100_bases
GGGATGCCCGGGCTTTTGGACCTCCTCACGGAGTCCTGGCAAAGCGGCGAGGCCCTGGCCGAGCGGCTCGGGGTGAGCCG
GGCCGCCGTCTCCAAGGAGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKGLILAAGRGTRLRPLTHTRPKPAIRVAGRPIIHYAVENLLEAGVREIGVVVSPETERDLKVALEGYPVRYVLQEEPQG
LAHAVDVARGFLGESPFVLYLGDNLFQKGIRRFLEAFKPGVSAVIALVRVEDPRQFGVAVLEGNRVVRLLEKPKDPPSDL
AVAGVYVFSPEVLEVVRGLKPSARGEYEITDAIQGLIDRGKTVVGVEVEGWWKDTGRHQDLLDANRLLLEELTPKVEGDV
VESQLTGRVVVEKGAKVVRSTVIGPAHIGAGAVVEEAFVGPFTSVGPRARVVRSEVEYSLLEEEAVVEEVRLRLQECILG
VRAEVKSRDGLPRAHRLILGDLSQVELA

Sequences:

>Translated_348_residues
MKGLILAAGRGTRLRPLTHTRPKPAIRVAGRPIIHYAVENLLEAGVREIGVVVSPETERDLKVALEGYPVRYVLQEEPQG
LAHAVDVARGFLGESPFVLYLGDNLFQKGIRRFLEAFKPGVSAVIALVRVEDPRQFGVAVLEGNRVVRLLEKPKDPPSDL
AVAGVYVFSPEVLEVVRGLKPSARGEYEITDAIQGLIDRGKTVVGVEVEGWWKDTGRHQDLLDANRLLLEELTPKVEGDV
VESQLTGRVVVEKGAKVVRSTVIGPAHIGAGAVVEEAFVGPFTSVGPRARVVRSEVEYSLLEEEAVVEEVRLRLQECILG
VRAEVKSRDGLPRAHRLILGDLSQVELA
>Mature_348_residues
MKGLILAAGRGTRLRPLTHTRPKPAIRVAGRPIIHYAVENLLEAGVREIGVVVSPETERDLKVALEGYPVRYVLQEEPQG
LAHAVDVARGFLGESPFVLYLGDNLFQKGIRRFLEAFKPGVSAVIALVRVEDPRQFGVAVLEGNRVVRLLEKPKDPPSDL
AVAGVYVFSPEVLEVVRGLKPSARGEYEITDAIQGLIDRGKTVVGVEVEGWWKDTGRHQDLLDANRLLLEELTPKVEGDV
VESQLTGRVVVEKGAKVVRSTVIGPAHIGAGAVVEEAFVGPFTSVGPRARVVRSEVEYSLLEEEAVVEEVRLRLQECILG
VRAEVKSRDGLPRAHRLILGDLSQVELA

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=337, Percent_Identity=30.5637982195846, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI11761621, Length=337, Percent_Identity=30.5637982195846, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=36.6255144032922, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=34.7457627118644, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789837, Length=379, Percent_Identity=25.8575197889182, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787488, Length=260, Percent_Identity=28.0769230769231, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788355, Length=273, Percent_Identity=27.4725274725275, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=331, Percent_Identity=28.3987915407855, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320148, Length=308, Percent_Identity=29.2207792207792, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355443, Length=335, Percent_Identity=27.7611940298507, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644084, Length=335, Percent_Identity=27.7611940298507, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38029; Mature: 38029

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLILAAGRGTRLRPLTHTRPKPAIRVAGRPIIHYAVENLLEAGVREIGVVVSPETERD
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCCCC
LKVALEGYPVRYVLQEEPQGLAHAVDVARGFLGESPFVLYLGDNLFQKGIRRFLEAFKPG
CEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCC
VSAVIALVRVEDPRQFGVAVLEGNRVVRLLEKPKDPPSDLAVAGVYVFSPEVLEVVRGLK
HHHHHHHHEECCCHHHCEEEEECCHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHCCC
PSARGEYEITDAIQGLIDRGKTVVGVEVEGWWKDTGRHQDLLDANRLLLEELTPKVEGDV
CCCCCCEEHHHHHHHHHHCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHHHCCCCCCHH
VESQLTGRVVVEKGAKVVRSTVIGPAHIGAGAVVEEAFVGPFTSVGPRARVVRSEVEYSL
HHHHHCCHHEEHHHHHHHHHHCCCCHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LEEEAVVEEVRLRLQECILGVRAEVKSRDGLPRAHRLILGDLSQVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MKGLILAAGRGTRLRPLTHTRPKPAIRVAGRPIIHYAVENLLEAGVREIGVVVSPETERD
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCCCC
LKVALEGYPVRYVLQEEPQGLAHAVDVARGFLGESPFVLYLGDNLFQKGIRRFLEAFKPG
CEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCC
VSAVIALVRVEDPRQFGVAVLEGNRVVRLLEKPKDPPSDLAVAGVYVFSPEVLEVVRGLK
HHHHHHHHEECCCHHHCEEEEECCHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHCCC
PSARGEYEITDAIQGLIDRGKTVVGVEVEGWWKDTGRHQDLLDANRLLLEELTPKVEGDV
CCCCCCEEHHHHHHHHHHCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHHHCCCCCCHH
VESQLTGRVVVEKGAKVVRSTVIGPAHIGAGAVVEEAFVGPFTSVGPRARVVRSEVEYSL
HHHHHCCHHEEHHHHHHHHHHCCCCHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LEEEAVVEEVRLRLQECILGVRAEVKSRDGLPRAHRLILGDLSQVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]