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The map label for this gene is aceE [H]

Identifier: 55980154

GI number: 55980154

Start: 180308

End: 183025

Strand: Reverse

Name: aceE [H]

Synonym: TTHA0185

Alternate gene names: 55980154

Gene position: 183025-180308 (Counterclockwise)

Preceding gene: 55980158

Following gene: 55980153

Centisome position: 9.89

GC content: 67.14

Gene sequence:

>2718_bases
ATGACGGAAAAGGAGCTGAAGGCGGCCTTCCAGGCCCTTTCGCCCGAGGAGAAGGCCCGCTTCCTAGAAATAGAGAACCG
GGAGTGGCTGGAGTCTTTGGAATACGTCCTCAAGGTGGAGGGCCCCGAGCGGGTGGAGGAGCTCTTGCGCCTTCTGGACG
AGTACCTCTTCCGCCATGGGGTCTACCCCGCAAACCGCCTCTCCACCCCCTACCTCAACACCCTCCCCAAGGAGAAAGAG
CCCCCTTACCCCGGGGACCTGGAGCTGGAGCGCCGCATCGCCAACATCCTCCGCTGGAACGTGGCCATGATGGTCACCCG
GGCCAACAAGAAGGCGGACGGCATCGGGGGGCACATCGCCACCTACGCCTCCATCGCCGAGCTTTACGAGGTGGGCTTCA
ACCACTTCTTCCGCGGGCCGGAGGCGGGGCTGGACCGGGACCTCGTCTTCTTCCAGGGCCACGCCTCCCCCGGGAACTAC
GCCCGGGCCTTTTTGGAGGGGCGGCTTAAGGAGGAGGACCTGGAGAACTTCCGCCGCGAGGTCCACCCCCCGGTGCCGGG
GGGCCGGGGGCTTTCCAGCTACCCCCACCCTTGGCTCATGCCCGACTTCTGGGAGTTCCCCACGGTCTCCATGGGCCTCG
GCCCCATCCAGGCCATCTACCAGGCGCGCTTCATGCGCTACCTCGAGGACCGAGGCCTCAAGCCCAAAAGCTCCGCCAAG
GTCTGGGCCTTCCTCGGGGACGGGGAGCACGACGAGCCCGAGACGGTGGGGGCGCTTCACCTCGCCGCCCGGGAGAACCT
GGACAACCTCATCTTCGTGGTGAACTGCAACCTCCAGCGCTTAGACGGCCCCGTGCGGGGCAACTCCAAGGTCATCCAGG
AGCTGGAAAGGCTCTACAGGGGCGCGGGCTGGCGCGTGATCAAGGTGGTCTGGGGTTCGGCCTGGGACGAGCTCCTCGCC
AAGGATAAGGAGGGCCACCTCCTCCGCCGCTTTGAGGCCCTGGTGGACGGGGAGAGCCAGCGCTACGCCGCCTTCGGGGG
CAAGGAGCTAAGGGAGCGCTTCTTCAACACCCCCGAGCTTAAGAAGCTCATTGAGGGGATGACGGACGAGGAGCTCACCG
AGCTCACCCGGTCCCGGGGCGGCCACGACATGGTCAAGATCTACGCCGCCTACAAGGCCGCGGTGGAGCACAGGGGAAGC
CCCGTGGTCATCCTCGCCCGGACCATCAAGGGCTACGGGATGGGCCCCACGGTCATGGCCAAGAACGTGGCCCACCAGGT
GAAGAAGCTCACCGAGGAGGACCTGAAGGAGGCGAGGCGCTTCCTCGGCATCCCCATTCCCGAGGAGAAGCTTCCCGAGC
TCCCCTACTACCACCCGGGGCCGGACTCCCCCGAGGTCCGCTACCTCCTGGAACGGAGGAAGGCCCTGGGCGGCTTCGTG
CCCGAAAGGAGGGTGCGCTTCCAGGGGGGCCTCGAGGTCCCGGAGGAGGAGTTCTTCCGGGAGTTCTACGAGGGCTCAGG
GGGGCGGGAGATCTCCACCACCATGGCCTTCGTGCGCATCCTCGCCAAGCTCCTCCGCCACCCCAAGATCGGCAAGTACA
TCGTCCCCATCGTCCCCGACGAGGCCCGCACCTTTGGCATGGAGGCCCTGATCGCCCAGGTGGGCGTCTACTCCCCCCAG
GGGCAGCTCTACGTCCCCGTGGACGCGGGCACCCTCACCGCCTACAAGGAGAGCCAGAAGGGGCAGATCCTGGAGGAGGG
GATCACCGAGGCCGGGGCCATGGCCGAGTTCATCGCCGCCGGGACCGCCTACGCCCACTGGGGCATCCCCACCATCCCCT
TCTTCATCACCTACTCCATGTTCGGCCTGCAAAGGATCGGGGACCTCGTCTGGGCCGCCGCCGACCAGCGCGCCCGGGGC
TTCTTCCTCGGGGCCACGGCGGGGCGCACCACCTTGGCGGGGGAGGGCCTTCAGCACCAGGACGGCCAAAGCCACGTCTA
CGCCCTGGCCGCCCCCAACCTCCTCGCCTACGATCCCGCCTTCGCCTACGAGTTCGCCGTGATCCTGGAGGACGGCCTCC
GCCGCATGTACGGCCGGGGGGAGGACGTCTTCTACTACATCACCATTGAGAACGAGAACTACGTCCACCCCCCCATGCCC
GAGCCCCGGGAAAAGGTCAAGGAGGGGATCCTAAAAGGGCTTTACCTCTTCCGGGCGGGGGAGGGGAAGGGCCCAAAAGT
GCAGCTTTTCGGCACCGGGCCCATCCTCAACGAGGCCCTGAAGGCCCAGGAGCTTTTGGCCAAGTACGGCGTGGTGGCGG
ACGTCTGGAGCGCCACCAGCTACAAGGCCCTCTATGTGGACGCCATTGAGGCCGAGCGGGAGACCCGCCTTTTGGGCAAG
GCCCGCAGGCCCTACGTGCAGGAGGCCCTCGAGGGCCACGAGGGGCCCATCGTGGCCGCCACCGACTACCTCAAGGCCCT
ACCCAACCTCATCCGGGGATACGTGGACCGGCCCTTCGCCGTCCTCGGCACGGACGGCTTCGGCCGCTCCGACACCCGGG
AGGCCCTTAGGGACTTCTTTGAGGTGGACGCCCGGCACATCGCCTACACCGCCCTGGCCCTGCTCCACGGGGAGGGCAAG
GTGACGAAGAGGACCCTGAACCAGGCGAGGAAGGACCTGGGCCTTAAGCTGGAGGAGGTGCCGCCCCACCGGCGGTAG

Upstream 100 bases:

>100_bases
AAGATCTTATCACAACCGCGGCGAAGGTCTTATTGGACGCGGGGACCTCCTCGAGGGCAGACTGGTCCTGGGAAGGTGTA
GTGTAGTTTTGGAGGAGGCC

Downstream 100 bases:

>100_bases
GGGGAGAGCATGGAGGTCAAGCTACCCGAACTCGGCGACAACGTAACGCAGGCGACCGTGGTGGGCGTCCTGGTGAAGGA
AGGGGACCGGGTGGAGCCGG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 905; Mature: 904

Protein sequence:

>905_residues
MTEKELKAAFQALSPEEKARFLEIENREWLESLEYVLKVEGPERVEELLRLLDEYLFRHGVYPANRLSTPYLNTLPKEKE
PPYPGDLELERRIANILRWNVAMMVTRANKKADGIGGHIATYASIAELYEVGFNHFFRGPEAGLDRDLVFFQGHASPGNY
ARAFLEGRLKEEDLENFRREVHPPVPGGRGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFMRYLEDRGLKPKSSAK
VWAFLGDGEHDEPETVGALHLAARENLDNLIFVVNCNLQRLDGPVRGNSKVIQELERLYRGAGWRVIKVVWGSAWDELLA
KDKEGHLLRRFEALVDGESQRYAAFGGKELRERFFNTPELKKLIEGMTDEELTELTRSRGGHDMVKIYAAYKAAVEHRGS
PVVILARTIKGYGMGPTVMAKNVAHQVKKLTEEDLKEARRFLGIPIPEEKLPELPYYHPGPDSPEVRYLLERRKALGGFV
PERRVRFQGGLEVPEEEFFREFYEGSGGREISTTMAFVRILAKLLRHPKIGKYIVPIVPDEARTFGMEALIAQVGVYSPQ
GQLYVPVDAGTLTAYKESQKGQILEEGITEAGAMAEFIAAGTAYAHWGIPTIPFFITYSMFGLQRIGDLVWAAADQRARG
FFLGATAGRTTLAGEGLQHQDGQSHVYALAAPNLLAYDPAFAYEFAVILEDGLRRMYGRGEDVFYYITIENENYVHPPMP
EPREKVKEGILKGLYLFRAGEGKGPKVQLFGTGPILNEALKAQELLAKYGVVADVWSATSYKALYVDAIEAERETRLLGK
ARRPYVQEALEGHEGPIVAATDYLKALPNLIRGYVDRPFAVLGTDGFGRSDTREALRDFFEVDARHIAYTALALLHGEGK
VTKRTLNQARKDLGLKLEEVPPHRR

Sequences:

>Translated_905_residues
MTEKELKAAFQALSPEEKARFLEIENREWLESLEYVLKVEGPERVEELLRLLDEYLFRHGVYPANRLSTPYLNTLPKEKE
PPYPGDLELERRIANILRWNVAMMVTRANKKADGIGGHIATYASIAELYEVGFNHFFRGPEAGLDRDLVFFQGHASPGNY
ARAFLEGRLKEEDLENFRREVHPPVPGGRGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFMRYLEDRGLKPKSSAK
VWAFLGDGEHDEPETVGALHLAARENLDNLIFVVNCNLQRLDGPVRGNSKVIQELERLYRGAGWRVIKVVWGSAWDELLA
KDKEGHLLRRFEALVDGESQRYAAFGGKELRERFFNTPELKKLIEGMTDEELTELTRSRGGHDMVKIYAAYKAAVEHRGS
PVVILARTIKGYGMGPTVMAKNVAHQVKKLTEEDLKEARRFLGIPIPEEKLPELPYYHPGPDSPEVRYLLERRKALGGFV
PERRVRFQGGLEVPEEEFFREFYEGSGGREISTTMAFVRILAKLLRHPKIGKYIVPIVPDEARTFGMEALIAQVGVYSPQ
GQLYVPVDAGTLTAYKESQKGQILEEGITEAGAMAEFIAAGTAYAHWGIPTIPFFITYSMFGLQRIGDLVWAAADQRARG
FFLGATAGRTTLAGEGLQHQDGQSHVYALAAPNLLAYDPAFAYEFAVILEDGLRRMYGRGEDVFYYITIENENYVHPPMP
EPREKVKEGILKGLYLFRAGEGKGPKVQLFGTGPILNEALKAQELLAKYGVVADVWSATSYKALYVDAIEAERETRLLGK
ARRPYVQEALEGHEGPIVAATDYLKALPNLIRGYVDRPFAVLGTDGFGRSDTREALRDFFEVDARHIAYTALALLHGEGK
VTKRTLNQARKDLGLKLEEVPPHRR
>Mature_904_residues
TEKELKAAFQALSPEEKARFLEIENREWLESLEYVLKVEGPERVEELLRLLDEYLFRHGVYPANRLSTPYLNTLPKEKEP
PYPGDLELERRIANILRWNVAMMVTRANKKADGIGGHIATYASIAELYEVGFNHFFRGPEAGLDRDLVFFQGHASPGNYA
RAFLEGRLKEEDLENFRREVHPPVPGGRGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFMRYLEDRGLKPKSSAKV
WAFLGDGEHDEPETVGALHLAARENLDNLIFVVNCNLQRLDGPVRGNSKVIQELERLYRGAGWRVIKVVWGSAWDELLAK
DKEGHLLRRFEALVDGESQRYAAFGGKELRERFFNTPELKKLIEGMTDEELTELTRSRGGHDMVKIYAAYKAAVEHRGSP
VVILARTIKGYGMGPTVMAKNVAHQVKKLTEEDLKEARRFLGIPIPEEKLPELPYYHPGPDSPEVRYLLERRKALGGFVP
ERRVRFQGGLEVPEEEFFREFYEGSGGREISTTMAFVRILAKLLRHPKIGKYIVPIVPDEARTFGMEALIAQVGVYSPQG
QLYVPVDAGTLTAYKESQKGQILEEGITEAGAMAEFIAAGTAYAHWGIPTIPFFITYSMFGLQRIGDLVWAAADQRARGF
FLGATAGRTTLAGEGLQHQDGQSHVYALAAPNLLAYDPAFAYEFAVILEDGLRRMYGRGEDVFYYITIENENYVHPPMPE
PREKVKEGILKGLYLFRAGEGKGPKVQLFGTGPILNEALKAQELLAKYGVVADVWSATSYKALYVDAIEAERETRLLGKA
RRPYVQEALEGHEGPIVAATDYLKALPNLIRGYVDRPFAVLGTDGFGRSDTREALRDFFEVDARHIAYTALALLHGEGKV
TKRTLNQARKDLGLKLEEVPPHRR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=886, Percent_Identity=51.8058690744921, Blast_Score=877, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 101999; Mature: 101868

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKELKAAFQALSPEEKARFLEIENREWLESLEYVLKVEGPERVEELLRLLDEYLFRHG
CCHHHHHHHHHHCCHHHHHHEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
VYPANRLSTPYLNTLPKEKEPPYPGDLELERRIANILRWNVAMMVTRANKKADGIGGHIA
CCCCHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHH
TYASIAELYEVGFNHFFRGPEAGLDRDLVFFQGHASPGNYARAFLEGRLKEEDLENFRRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
VHPPVPGGRGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFMRYLEDRGLKPKSSAK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCE
VWAFLGDGEHDEPETVGALHLAARENLDNLIFVVNCNLQRLDGPVRGNSKVIQELERLYR
EEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHC
GAGWRVIKVVWGSAWDELLAKDKEGHLLRRFEALVDGESQRYAAFGGKELRERFFNTPEL
CCCCEEEEEHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHCCCHHH
KKLIEGMTDEELTELTRSRGGHDMVKIYAAYKAAVEHRGSPVVILARTIKGYGMGPTVMA
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
KNVAHQVKKLTEEDLKEARRFLGIPIPEEKLPELPYYHPGPDSPEVRYLLERRKALGGFV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PERRVRFQGGLEVPEEEFFREFYEGSGGREISTTMAFVRILAKLLRHPKIGKYIVPIVPD
CCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
EARTFGMEALIAQVGVYSPQGQLYVPVDAGTLTAYKESQKGQILEEGITEAGAMAEFIAA
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GTAYAHWGIPTIPFFITYSMFGLQRIGDLVWAAADQRARGFFLGATAGRTTLAGEGLQHQ
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCC
DGQSHVYALAAPNLLAYDPAFAYEFAVILEDGLRRMYGRGEDVFYYITIENENYVHPPMP
CCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
EPREKVKEGILKGLYLFRAGEGKGPKVQLFGTGPILNEALKAQELLAKYGVVADVWSATS
CHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCCC
YKALYVDAIEAERETRLLGKARRPYVQEALEGHEGPIVAATDYLKALPNLIRGYVDRPFA
CEEEEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCEE
VLGTDGFGRSDTREALRDFFEVDARHIAYTALALLHGEGKVTKRTLNQARKDLGLKLEEV
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEECCC
PPHRR
CCCCC
>Mature Secondary Structure 
TEKELKAAFQALSPEEKARFLEIENREWLESLEYVLKVEGPERVEELLRLLDEYLFRHG
CHHHHHHHHHHCCHHHHHHEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
VYPANRLSTPYLNTLPKEKEPPYPGDLELERRIANILRWNVAMMVTRANKKADGIGGHIA
CCCCHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHH
TYASIAELYEVGFNHFFRGPEAGLDRDLVFFQGHASPGNYARAFLEGRLKEEDLENFRRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
VHPPVPGGRGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFMRYLEDRGLKPKSSAK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCE
VWAFLGDGEHDEPETVGALHLAARENLDNLIFVVNCNLQRLDGPVRGNSKVIQELERLYR
EEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHC
GAGWRVIKVVWGSAWDELLAKDKEGHLLRRFEALVDGESQRYAAFGGKELRERFFNTPEL
CCCCEEEEEHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHHHCCCHHH
KKLIEGMTDEELTELTRSRGGHDMVKIYAAYKAAVEHRGSPVVILARTIKGYGMGPTVMA
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
KNVAHQVKKLTEEDLKEARRFLGIPIPEEKLPELPYYHPGPDSPEVRYLLERRKALGGFV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PERRVRFQGGLEVPEEEFFREFYEGSGGREISTTMAFVRILAKLLRHPKIGKYIVPIVPD
CCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
EARTFGMEALIAQVGVYSPQGQLYVPVDAGTLTAYKESQKGQILEEGITEAGAMAEFIAA
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GTAYAHWGIPTIPFFITYSMFGLQRIGDLVWAAADQRARGFFLGATAGRTTLAGEGLQHQ
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCC
DGQSHVYALAAPNLLAYDPAFAYEFAVILEDGLRRMYGRGEDVFYYITIENENYVHPPMP
CCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
EPREKVKEGILKGLYLFRAGEGKGPKVQLFGTGPILNEALKAQELLAKYGVVADVWSATS
CHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCCC
YKALYVDAIEAERETRLLGKARRPYVQEALEGHEGPIVAATDYLKALPNLIRGYVDRPFA
CEEEEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCEE
VLGTDGFGRSDTREALRDFFEVDARHIAYTALALLHGEGKVTKRTLNQARKDLGLKLEEV
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEECCC
PPHRR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]