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The map label for this gene is lspA [H]

Identifier: 55980012

GI number: 55980012

Start: 43731

End: 44183

Strand: Direct

Name: lspA [H]

Synonym: TTHA0043

Alternate gene names: 55980012

Gene position: 43731-44183 (Clockwise)

Preceding gene: 55980009

Following gene: 55980016

Centisome position: 2.36

GC content: 72.85

Gene sequence:

>453_bases
ATGCCCACGGTGCTCGTACCCCTCCTCCTCGCCTTGGACCAGACCCTCAAGCTCTGGGCCCTGGAACACCTCTCCCCCGT
CCCCAAGCCCCTCCTCGGCGACCTCCTCTACCTCACCCTGGTCCGGAACACGGGGGCGGGCTTCGGCCTCTTCCAGGGCC
AGGCCCCCCTCCTCGGCCTCCTCTCCTTCCTGGTGGGCGCGGGCCTCCTCCTCCTCCTCGCCAGGCGGCGCTACCCCCCC
CTCCCCGCCCTCGCCCTCTCCCTCCTGGCGGCGGGGGCCCTGGGGAACGGGGTGGACCGCCTGGGCCGGGGGTGGGTGGT
GGACTACCTGGACCTCGGCACCTCCCTCCCCCTCATCGCCAACTTCCCCGTCTTCAACCTGGCGGACGTGTGCGTGACCC
TGGGGGCGGTCCTCCTCCTCCTCGCCCCGAGGCGGAGGCGGCGCTGGATCTAA

Upstream 100 bases:

>100_bases
GGCCGCTTTCCGCTGATCTCGCACACCTTGGACATGGCTCTCCTCCCCTGCCCGAAGGCAAACCTTTAGGAGTATAGCAC
ACTGGGGTAGACTCTTGGGG

Downstream 100 bases:

>100_bases
AGGGGCCCCCCAAAGGCCTCAGCGCAGGAAGCGCAGGAGCATCTTGGCCGCCCACGGGAAGAGGAGGGAGGAGAGGGCGG
CGGCGAGAAGGAGGACGAGG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MPTVLVPLLLALDQTLKLWALEHLSPVPKPLLGDLLYLTLVRNTGAGFGLFQGQAPLLGLLSFLVGAGLLLLLARRRYPP
LPALALSLLAAGALGNGVDRLGRGWVVDYLDLGTSLPLIANFPVFNLADVCVTLGAVLLLLAPRRRRRWI

Sequences:

>Translated_150_residues
MPTVLVPLLLALDQTLKLWALEHLSPVPKPLLGDLLYLTLVRNTGAGFGLFQGQAPLLGLLSFLVGAGLLLLLARRRYPP
LPALALSLLAAGALGNGVDRLGRGWVVDYLDLGTSLPLIANFPVFNLADVCVTLGAVLLLLAPRRRRRWI
>Mature_149_residues
PTVLVPLLLALDQTLKLWALEHLSPVPKPLLGDLLYLTLVRNTGAGFGLFQGQAPLLGLLSFLVGAGLLLLLARRRYPPL
PALALSLLAAGALGNGVDRLGRGWVVDYLDLGTSLPLIANFPVFNLADVCVTLGAVLLLLAPRRRRRWI

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 16133; Mature: 16002

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVLVPLLLALDQTLKLWALEHLSPVPKPLLGDLLYLTLVRNTGAGFGLFQGQAPLLGL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LSFLVGAGLLLLLARRRYPPLPALALSLLAAGALGNGVDRLGRGWVVDYLDLGTSLPLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCHHC
NFPVFNLADVCVTLGAVLLLLAPRRRRRWI
CCCHHHHHHHHHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure 
PTVLVPLLLALDQTLKLWALEHLSPVPKPLLGDLLYLTLVRNTGAGFGLFQGQAPLLGL
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LSFLVGAGLLLLLARRRYPPLPALALSLLAAGALGNGVDRLGRGWVVDYLDLGTSLPLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCHHC
NFPVFNLADVCVTLGAVLLLLAPRRRRRWI
CCCHHHHHHHHHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]