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The map label for this gene is yhcR [H]

Identifier: 54295517

GI number: 54295517

Start: 2970737

End: 2972461

Strand: Direct

Name: yhcR [H]

Synonym: lpl2604

Alternate gene names: 54295517

Gene position: 2970737-2972461 (Clockwise)

Preceding gene: 54295516

Following gene: 54295520

Centisome position: 88.79

GC content: 38.61

Gene sequence:

>1725_bases
ATGTTTCACAGGAAATGCCTATACTATTTTTTTAATTTATTTATTTCGTTAATTTTAGGTTCTTCTCTCAATTGGGCTTC
CATCAATCAGCACAGCACTGATTCGCCAACCCTCGACATTAAAATTTTAGGCATTAATGATTTTCATGGGCAAATAAGCA
GTGGGAGAGCCGTAAAAAACGAACCGGTTGGCGGGGCAGCTGTCCTGGCTGCTTATCTTAAAGAAGCTCAATTGGGAATG
GAAGATCGATCAATAATTACCATCATGGGTGATTTGGTTGGAGCCTCCCCCCCTTCTTCAGGACTGTTGAATGATGAACC
CAGCATTTTATTCATTAATGGCTTGGGAAATAATCAATGCAAACCCGAATCAAGAATGGATCCTCTTTGCAACATTGTTG
CCACGGTAGGAAACCATGAGTTTGACAAGGGGCAAAAGGCCATGTTTGATTTAATTTATGGTACCAATAATCCACCGACT
GATTCATGGATCTCGTTACCCAATTATCCGGGTGCATCTTATCCCTATGTTTCTGCGAATATCGTTAACGCCAAGTCAGA
ACAACCTCTCTTCCCACCCTACATAATTAAACGGATACATAATACTCCCATAGCATTTATTGGCGCTGTTTTAAAAGATG
CGGCAGACTCGATGTTTCCAGCAAACGCAGAAGGAATTAAATTTTTAGATGAAGCAGACAGTATTAATCGTTACATCCCG
GAAATTAAAGCGAAAGGAGTCAATGTTATCATTGTCCTGATTCATGAAGGTGGGAATCAAATTCCTTATGAGGGAGACAC
CCAAACTGCCTCAGCAGTAGAAGGTCATATTAAAGAAATAGTTTATTCCCTTGGTGATGAAATCGACGTTGTTATGGGTG
GTCACACCCATCAATTTCTAAATGCTTTCCTTCCAAATCGCAATGGGCATAAGATCCTGGTCACACAAGCGAATAGTTAC
AGTGCTGCTTTTGCTGAAGTTACCCTTCAAATCGATACCAAAAATCATGCAGTAAAAAACAAATCAGCCAAAATTATTAC
AACTTATGCTAATCGATGGCCTGGAACAAATCCGGATACACAAGCCTTGGAAATTGTTAAATTGGCAGAAGATAAAATTG
GGCCAATAATAAATAGCCATGTAGGAACTGCAGGGCATGATCTGCTAAGAAAACAAAATAAAGATGGTGAATCGAGTTTA
GGGAATCTGATCGCAGATGCTTATAGAACTGTAATGGATACCGATCTGGGTATCACTAATCCCAATGGAATTCGTGATGA
TTTAAAAGCAGGGGAAGTTAACTGGGGAAATATCTATTCTATTTTACCCTTTTCCAACAGGATAGTTATAATTACCTTAA
CTGGAAATGATATTTATGACTTGTTAGAACAACAATGGATGGGTTCTTATATCAATATGTTACAAATTTCCGGGTTTGCC
TACACCTATGATTCACATCAACCTCTGGGACATAAAATAATTGAAATTAGACATCAAAACAAACCATTGCTTAGAGAAAA
GATGTATACCATAGCCACTTCAGATTTTCTTGCCAGCGGGAATGGAGTTTTTTCAGTTATGAAAAGAGGAAAAATAATCC
ATATTGGTCAAAGTGATCATGACACGGTAATCGCATATATTAAAAGTTTACCTCAACCCTTTCGCGCGTCTATTGAGGCA
AGGATAAAAGAATCAGAGACTGGATTAAAAACAGGAGTTGGATAG

Upstream 100 bases:

>100_bases
AGAATATCAACAATAATCAAAATTAATCTGCTTGCACTTGCCATAGAAAATCATTGATATACCACATATAAAACAATCAA
GATCAAGGATTTGATTCACG

Downstream 100 bases:

>100_bases
ATTAAATTCGTTTTACCGTCAGCCCCTGTTTTTATTATTTATTAATTAAATTTTGCTATTATTTTATGCATTCTAATCCA
GCACATAGTAGAATTTGTTT

Product: hypothetical protein

Products: Phosphate; Uridine [C]

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MFHRKCLYYFFNLFISLILGSSLNWASINQHSTDSPTLDIKILGINDFHGQISSGRAVKNEPVGGAAVLAAYLKEAQLGM
EDRSIITIMGDLVGASPPSSGLLNDEPSILFINGLGNNQCKPESRMDPLCNIVATVGNHEFDKGQKAMFDLIYGTNNPPT
DSWISLPNYPGASYPYVSANIVNAKSEQPLFPPYIIKRIHNTPIAFIGAVLKDAADSMFPANAEGIKFLDEADSINRYIP
EIKAKGVNVIIVLIHEGGNQIPYEGDTQTASAVEGHIKEIVYSLGDEIDVVMGGHTHQFLNAFLPNRNGHKILVTQANSY
SAAFAEVTLQIDTKNHAVKNKSAKIITTYANRWPGTNPDTQALEIVKLAEDKIGPIINSHVGTAGHDLLRKQNKDGESSL
GNLIADAYRTVMDTDLGITNPNGIRDDLKAGEVNWGNIYSILPFSNRIVIITLTGNDIYDLLEQQWMGSYINMLQISGFA
YTYDSHQPLGHKIIEIRHQNKPLLREKMYTIATSDFLASGNGVFSVMKRGKIIHIGQSDHDTVIAYIKSLPQPFRASIEA
RIKESETGLKTGVG

Sequences:

>Translated_574_residues
MFHRKCLYYFFNLFISLILGSSLNWASINQHSTDSPTLDIKILGINDFHGQISSGRAVKNEPVGGAAVLAAYLKEAQLGM
EDRSIITIMGDLVGASPPSSGLLNDEPSILFINGLGNNQCKPESRMDPLCNIVATVGNHEFDKGQKAMFDLIYGTNNPPT
DSWISLPNYPGASYPYVSANIVNAKSEQPLFPPYIIKRIHNTPIAFIGAVLKDAADSMFPANAEGIKFLDEADSINRYIP
EIKAKGVNVIIVLIHEGGNQIPYEGDTQTASAVEGHIKEIVYSLGDEIDVVMGGHTHQFLNAFLPNRNGHKILVTQANSY
SAAFAEVTLQIDTKNHAVKNKSAKIITTYANRWPGTNPDTQALEIVKLAEDKIGPIINSHVGTAGHDLLRKQNKDGESSL
GNLIADAYRTVMDTDLGITNPNGIRDDLKAGEVNWGNIYSILPFSNRIVIITLTGNDIYDLLEQQWMGSYINMLQISGFA
YTYDSHQPLGHKIIEIRHQNKPLLREKMYTIATSDFLASGNGVFSVMKRGKIIHIGQSDHDTVIAYIKSLPQPFRASIEA
RIKESETGLKTGVG
>Mature_574_residues
MFHRKCLYYFFNLFISLILGSSLNWASINQHSTDSPTLDIKILGINDFHGQISSGRAVKNEPVGGAAVLAAYLKEAQLGM
EDRSIITIMGDLVGASPPSSGLLNDEPSILFINGLGNNQCKPESRMDPLCNIVATVGNHEFDKGQKAMFDLIYGTNNPPT
DSWISLPNYPGASYPYVSANIVNAKSEQPLFPPYIIKRIHNTPIAFIGAVLKDAADSMFPANAEGIKFLDEADSINRYIP
EIKAKGVNVIIVLIHEGGNQIPYEGDTQTASAVEGHIKEIVYSLGDEIDVVMGGHTHQFLNAFLPNRNGHKILVTQANSY
SAAFAEVTLQIDTKNHAVKNKSAKIITTYANRWPGTNPDTQALEIVKLAEDKIGPIINSHVGTAGHDLLRKQNKDGESSL
GNLIADAYRTVMDTDLGITNPNGIRDDLKAGEVNWGNIYSILPFSNRIVIITLTGNDIYDLLEQQWMGSYINMLQISGFA
YTYDSHQPLGHKIIEIRHQNKPLLREKMYTIATSDFLASGNGVFSVMKRGKIIHIGQSDHDTVIAYIKSLPQPFRASIEA
RIKESETGLKTGVG

Specific function: Sugar-nonspecific endonuclease that yields nucleotide 3'-monophosphate products. No 5'-nucleotidase activity was detected, using 5'-AMP as the substrate, in the presence of diverse divalent metals and with various pH values [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TNase-like domain [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=481, Percent_Identity=22.6611226611227, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1790658, Length=614, Percent_Identity=20.8469055374593, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641187, Length=476, Percent_Identity=25.8403361344538, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221329836, Length=476, Percent_Identity=24.5798319327731, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28573524, Length=459, Percent_Identity=23.7472766884532, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922444, Length=496, Percent_Identity=21.5725806451613, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922446, Length=505, Percent_Identity=22.7722772277228, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24654424, Length=505, Percent_Identity=22.7722772277228, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19921980, Length=505, Percent_Identity=21.3861386138614, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24652512, Length=505, Percent_Identity=21.3861386138614, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076508, Length=486, Percent_Identity=21.1934156378601, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019948
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR016071
- InterPro:   IPR006021 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00746 Gram_pos_anchor; PF00149 Metallophos; PF00565 SNase; PF01336 tRNA_anti [H]

EC number: 3.6.1.45; 3.1.3.5 [C]

Molecular weight: Translated: 62935; Mature: 62935

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHRKCLYYFFNLFISLILGSSLNWASINQHSTDSPTLDIKILGINDFHGQISSGRAVKN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC
EPVGGAAVLAAYLKEAQLGMEDRSIITIMGDLVGASPPSSGLLNDEPSILFINGLGNNQC
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
KPESRMDPLCNIVATVGNHEFDKGQKAMFDLIYGTNNPPTDSWISLPNYPGASYPYVSAN
CCHHHCCHHHHHHHHHCCCCCCCCHHHEEHEEECCCCCCCCCEEECCCCCCCCCCEEEEE
IVNAKSEQPLFPPYIIKRIHNTPIAFIGAVLKDAADSMFPANAEGIKFLDEADSINRYIP
EECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EIKAKGVNVIIVLIHEGGNQIPYEGDTQTASAVEGHIKEIVYSLGDEIDVVMGGHTHQFL
HHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
NAFLPNRNGHKILVTQANSYSAAFAEVTLQIDTKNHAVKNKSAKIITTYANRWPGTNPDT
HHHCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCEECCCCCEEEEEECCCCCCCCCCH
QALEIVKLAEDKIGPIINSHVGTAGHDLLRKQNKDGESSLGNLIADAYRTVMDTDLGITN
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PNGIRDDLKAGEVNWGNIYSILPFSNRIVIITLTGNDIYDLLEQQWMGSYINMLQISGFA
CCCCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCEE
YTYDSHQPLGHKIIEIRHQNKPLLREKMYTIATSDFLASGNGVFSVMKRGKIIHIGQSDH
EEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCCCC
DTVIAYIKSLPQPFRASIEARIKESETGLKTGVG
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MFHRKCLYYFFNLFISLILGSSLNWASINQHSTDSPTLDIKILGINDFHGQISSGRAVKN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC
EPVGGAAVLAAYLKEAQLGMEDRSIITIMGDLVGASPPSSGLLNDEPSILFINGLGNNQC
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
KPESRMDPLCNIVATVGNHEFDKGQKAMFDLIYGTNNPPTDSWISLPNYPGASYPYVSAN
CCHHHCCHHHHHHHHHCCCCCCCCHHHEEHEEECCCCCCCCCEEECCCCCCCCCCEEEEE
IVNAKSEQPLFPPYIIKRIHNTPIAFIGAVLKDAADSMFPANAEGIKFLDEADSINRYIP
EECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EIKAKGVNVIIVLIHEGGNQIPYEGDTQTASAVEGHIKEIVYSLGDEIDVVMGGHTHQFL
HHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
NAFLPNRNGHKILVTQANSYSAAFAEVTLQIDTKNHAVKNKSAKIITTYANRWPGTNPDT
HHHCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCEECCCCCEEEEEECCCCCCCCCCH
QALEIVKLAEDKIGPIINSHVGTAGHDLLRKQNKDGESSLGNLIADAYRTVMDTDLGITN
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PNGIRDDLKAGEVNWGNIYSILPFSNRIVIITLTGNDIYDLLEQQWMGSYINMLQISGFA
CCCCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCEE
YTYDSHQPLGHKIIEIRHQNKPLLREKMYTIATSDFLASGNGVFSVMKRGKIIHIGQSDH
EEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCCCC
DTVIAYIKSLPQPFRASIEARIKESETGLKTGVG
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UMP [C]

Specific reaction: H2O + UMP --> Phosphate + Uridine [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Inhibitor from Salmonella typhimurium cytoplasm [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]